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Biography
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Dr. Lanrong Bi

Chemistry Department
Michigan Technological University, USA

Assistant Professor


Email: lanrong@mtu.edu


Qualifications

2005 Postdoctoral, Genomic Engineering, Columbia University, USA
2004 Postdoctoral, Chemical Biology, City University of New York, USA
2002 Postdoctoral, Medicinal Chemistry, National Center for Scientific Research, France
2000 Ph.D., Pharmaceutical Sciences, Peking University, China
1995 M.Sc., Organic Chemistry, HeBei Normal University, China
1992 B.Sc., Chemistry, HeBei Normal University, China

Publications (selected)

  1. New rhodamine-triazole based fluorescent probes for intracellular hydroxyl radical identification in living cells. Yapici, N. B., Jockusch, S., Moscatelli, A., Mandalapu, S. R., Itagaki, Y., Bates, D. K.,Wiseman, S., Gibson, K. M. Turro, N. J.,Bi, L*.Organic Letters.2012, 14 (1), 50-3.
  2. Novel Tempo-PEG-RGDs conjugates remediate tissue damage induced by acute limb ischemia/reperfusion. Bi W, Bi Y, Xue P, Zhang Y, Gao X, Wang Z, Li M, Itagaki, Y.,Bi L*.Journal of Medicinal Chemistry.2012.
  3. Determination of intracellular pH using sensitive, clickable fluorescent probes. Yapici, N. B., Mandalapu, S. R.,Bi, L*.Bioorganic and Medicinal Chemistry Letters.2012, 22, 2440-2443.
  4. Synthetic oligodeoxynucleotide purification by polymerization of failure sequences. Fang S*, Fueangfung S, Lin X, Zhang X, Mai W,Bi L,Green SA.Chem Commun(Camb).2011. 47, 1345-1347.
  5. A new class ofβ-carboline alkaloid-peptide conjugates with therapeutic efficacy in acute limb ischemia/reperfusion injury. Bi W, Bi Y, Xue P, Zhang Y, Gao X, Wang Z, Li M, Baudy-Floc'h M, Ngerebara N, Gibson KM,Bi L*.European Journal of Medicinal Chemistry.2011. 46, 1453-1462.
  6. Novelβ-carboline-tripeptide conjugates attenuate mesenteric ischemia/reperfusion injury in the rat. Bi W, Bi Y, Xue P, Zhang Y, Gao X, Wang Z, Li M, Baudy-Floc'h M, Ngerebara N, Gibson KM,Bi L*.European Journal of Medicinal Chemistry.2011. 46, 2441-2452.
  7. Synthesis and characterization of novel indole derivatives reveal improved therapeutic agents for treatment of ischemia/reperfusion (I/R) injury. Bi W, Bi Y, Xue P, Zhang Y, Gao X, Wang Z, Li M, Baudy-Floc'h M, Ngerebara N, Gibson KM,Bi L*.Journal of Medicinal Chemistry.2010; 53: 6763-7.
  8. Renal ischemia/reperfusion injury in rats is attenuated by a synthetic glycine derivative.Bi, W.; Cai, J.; Xue, P.; Zhang, Y.; Liu, S.; Gao, X.; Wang, Z.; Baudy-Floch, M.; Robinson, S; Ngerebara, N;Bi, L*.European Journal of Pharmacology.2009. 616(1-3): 256-64.
  9. Protective effect of nitronyl nitroxide-amino acid conjugates on liver ischemia-reperfusion induced injury in rats.Bi, W.; Cai, J.; Xue, P.; Zhang, Y.; Liu, S.; Gao, X.; Wang, Z.; Baudy-Floch, M.; Green, S.A.;Bi, L*.Bioorganic & Medicinal ChemistryLetters. 200818(6): 1788-94. 2.
  10. Toward the development of chemoprevention agents (III): Synthesis and anti-inflammatory activities of a new class of 5-glycylamino-2-substituted-phenyl-1,3-dioxacycloalkanes.Bi, L.;Zhao, M.; Gu, K.; Wang, C.; Ju, J.; Peng, S*.Bioorganic & Medicinal Chemistry.2008,16(4): 1764-74.
  11. Design, synthesis and cardioprotective effect of a new class of dual-acting agents: Phenolic tetrahydrobetacarboline RGD peptidomimetic conjugates.”Bi, W.; Cai, J.; Liu, S.; Baudy-Floch, M.;Bi, L*.Bioorganic & Medicinal Chemistry.2007, 15, 6909-19.
  12. Lysosomal targeting with sensitive fluorescent probes: application for organelle labeling. Yapici, N. B., Mandalapu, S.R.,Bi, L. *(submitted to J. Am. Chem. Soc., Under review).
  13. Novel mitochondria-targeting dural fluorescence/EPR probes for the detection of mitochondrial oxidative stress in the living cells and tissues. Yapici, N. B., Mandalapu, S.R.,Bi, L.*(submitted to J. Am. Chem. Soc., Under review).
  14. Attenuation of ischemia/reperfusion-induced remote organ injury in rat using novel indole-tempol conjugates. Bi W, Bi Y, Xue P, Zhang Y, Gao X, Wang Z, Li M, Itagaki, Y.,Bi L*.(Submitted to J. Med. Chem. Under review).
  15. 3’-O-Modified Nucleotides as Reversible Terminators for PyrosequencingWu, J.; Zhang, S.; Meng, Q.; Cao, H.; Li, Z.; Li, X.; Shi, S.; Kim, D.;Bi, L.;Turro, Nicholas J.; Ju, J*.Proceedings of the National Academy of Sciences USA, 2007,104, 16462-7.
  16. Design and Synthesis of Pentahydroxylhexylamino Acids and Their Effect on Lead Decorporation.Wang, Y.;Bi, L.;Hou, B.; Chen, Y.; Zhao, M.; Wang, C.; Ju, J.; Peng,*S.Chemical Research in Toxicology.2007, 20, 609-615.
  17. Heteroclitic properties of mixed alpha- and aza-beta(3)-peptides mimicking a supradominant CD4 T cell epitope presented by nucleosome.Dali, H.; Busnel, O.; Hoebeke, J.;Bi, L.;Decker, P.; Briand, J.P.; Baudy-Floch, M.; Muller,*S.Molecular Immunology.2007; 44, 3024-3036.
  18. Toward breast cancer resistance protein (BCRP) inhibitors: design, synthesis of a series of new simplified fumitremorgin C analogues.Wu, G.;Bi, L..; Zhao, M.; Wang, C.; Baudy-Floch, M.; Ju, J.; Peng,*S.Tetrahedron,2007, 63, 5510-5528.
  19. Toward the development of chemoprevention agents. Part 1: Design, synthesis, and anti-inflammatory activities of a new class of 2,5-disubstituted-dioxacycloalkanes.Gu, K.;Bi, L.; Zhao, M.; Wang, C.; Ju, J.; Peng,*S.Bioorganic & Medicinal Chemistry.2007, 15, 4775-99.
  20. Toward the development of chemoprevention agents. Part II: Chemo-enzymatic synthesis and anti-inflammatory activities of a new class of 5-amino-2-substitutedphenyl-1,3-dioxacycloalkanes.Gu, K.;Bi, L.; Zhao, M.; Wang, C.; Ju, J.; Peng,*S.Bioorganic & Medicinal Chemistry.2007, 15, 6273-90.
  21. Four-color DNA sequencing by synthesis using cleavable fluorescent nucleotide reversible terminators.Ju*, J.; Kim, D.;Bi, L.; Meng, Q.; Bai, X.; Li, Z.; Li, X.; Marma, M.; Shi, S.; Romu, A.; Turro,*Nicholas J.Proceedings of the National Academy of Sciences USA2006,103, 19635-40.
  22. Design and Synthesis of a Chemically Cleavable Fluorescent Nucleotide, 3’-O-Allyl-dGTP-allyl-Bodipy-FL-510, as a Reversible Terminator for DNA Sequencing by Synthesis.Bi, L.; Kim, D.; Ju, J*.Journal of American Chemistry Society.2006,128, 2542-2543.
  23. Novel 2-Substitutednitronyl Nitroxides as Free Radical Scavengers: Synthesis, Biological Evaluation and Structure-Activity Relationship.Wu, Y.;Bi, LBi, W.; Zhao, M.; Wang, C.; Ju, J.; Peng,*S.Bioorganic & Medicinal Chemistry.2006, 14, 5711-20.
  24. Synthesis and Cytotoxic Activities of β-Carboline Amino Acid Ester Conjugates.Zhao, M.;Bi, L.; Wang, C.; Ju, J.; Peng,*S.Bioorganic & Medicinal Chemistry.2006, 14, 6998-7010.
  25. Synthesis and Antithrombotic Activity of a New Class of Dipeptide Analogues With Improved Permeability.Zhao, M.;Bi, L.; Bi, W.; Wang, C.; Yang, Z.; Ju, J.; Peng,*S.Bioorganic & Medicinal Chemistry. 2006,14, 4761-4774.


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