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Biography
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Prof. Claudete J. Valduga

Institute of Health Sciences

Bandeirante University of Sao Paulo, Brazil


Email: cvalduga@usp.br


Qualifications

2000-2001  Postdoc, University of Sao Paulo, Brazil

1996-2000  Ph.D., University of São Paulo, Brazil and Università C’a Foscari di Venezia, Italy

1994-1996  M.Sc., Federal University of Santa Maria, Brazil

1990-1993  B.Sc., Federal University of Santa Maria, Brazil


Publications (selected)

  1. Chow JCL. Cone-beam CT dosimetry for the positional variation in isocenter: A Monte Carlo study. Med Phys, 36: 3512-3520 2009.
  2. Valduga CJ, Braibante HS, Braibante MEFReactivity ofp-Phenyl Substituted β-Enamino Compounds Using K-10/ Ultrasound. I. Synthesis of Pyrazoles and Pyrazolinones.J Heterocyclic Chem, 34:1453-1457 1997.
  3. Valduga CJ, Santis DB, Braibante HS, Braibante MEF Reactivity ofp-Phenil Substituted -Enamino Compounds Using K-10/ Ultrasound. II. Synthesis of Isoxazoles and Isoxazol-5-ones.J Heterocyclic Chem, 36: 505 1999.
  4. Stefani HA, PetragnaniN, Valduga CJ. Recent Advances in Selenocyclofunctionalization Reactions.Tetrahedron, 57:1411-1448 2001.
  5. Valduga CJ, Stefani HA, Petragnani N. Iodo Cyclofunctionalization of 2,4-Dialkenyl-1,3-Dicarbonyl Compounds: Synthesis of Substituted 3-(2-furylidene)- 2-furanones.J Het Chem, 39:639-644 2002.
  6. Valduga CJ, Fernandes DC, Lo Prete A C, Azevedo CHM, RodriguesDG, Maranhão RC. Use of a Cholesterol-Rich Microemulsion that Binds to Low-Density Lipoprotein Receptors as Vehicle for Etoposide.J Pharm Pharmacol, 55:1615-1622 2003.
  7. Rodrigues DG, Maria DA, Fernandes DC, Valduga CJ, Couto RD, Ibañez OCM, Maranhão RC. Improvement of Paclitaxel Therapeutic Index by Derivatization and Association to a Cholesterol-Rich Microemulsion:In VitroandIn VivoStudies.Cancer Chemother Pharmacol, 55:565-576 2004.
  8. Azevedo CHM, Carvalho JP, Valduga CJ, Maranhão RC. Plasma Kinetics and Uptake by the Tumor of a Cholesterol-rich Microemulsion (LDE) Associated to Etoposide Oleate in Patients with Ovarian Carcinoma.Gynecol Oncol,  97:178-182 2005.
  9. Lo Prete AC, MariaDA, Rodrigues DG, Valduga CJ, Ibañez OCM, Maranhão RC. Evaluation in melanoma-bearing mice of an etoposide derivative associated toa cholesterol rich-microemulsion.J Pharm Pharmacol, 58:801-808 2006.
  10. Pinheiro KV, Hungria VTM, Ficker ES, Valduga CJ, Maranhao RC. Plasma kinetics of a cholesterol-rich microemulsion (LDE) in patients with Hodgkin’s and non-Hodgkin’s lymphoma and a preliminary study on the toxicity of etoposide associated with LDE.Cancer Chemother Pharmacol, 57:624-630 2006.
  11. Pires LA, Hegg R, Valduga CJ, Graziani S, Maranhão RC. Use of cholesterol-rich nanoparticles that bind to lipoprotein receptors as a vehicle to paclitaxel in the treatment of breast cancer: pharmacokinetics, tumor uptake and a pilot clinical study.Cancer Chemother Pharmacol, 63:281-287 2008.
  12. Teixeira R, Valduga CJ, Benvenutti LA, Schreier S, Maranhão RC. Delivery of daunorubicin to cancer cells with decreased toxicity by association with a lipidic nanoemulsion that binds to LDL receptors.J Pharm Pharmacol, 60:1287-1295 2008.
  13. Maranhão RC, Tavares ER,Padoveze AF, Valduga CJ, Rodrigues DG, Pereira MD. Paclitaxel associated with cholesterol-rich nanoemulsions promotes atherosclerosis regression in the rabbit.Atherosclerosis(Amsterdam), 197:959-966 2008.
  14. Moura JA, Valduga CJ, Tavares ER, Kretzer IF, Maria DA, Maranhão RC. A Novel Formulation Of A Methotrexate Derivative Associated With A Lipidic Nanoemulsion.Int J Nanomedicine, 6:2285-2295 2011.
  15. Valduga CJ, Santos MA, Gonçalves ID, Pardi PC, Marques AS, Guerrieri BC, Rocha OV, Mendes WK, Suárez JAQ. In vitro and in vivo antitumor studies of a lipophilic curcumin derivative loaded lipid-based nanoemulsion. Proceedings of the American Association for Cancer Research, 2011, 102nd AACR Annual Meeting, Orlando. (abstract) 2011.
  16. Bitencourt JJG, Santos MA, Marques AS, Guerrieri BC, Valduga CJ. Propriedades físico-químicas de uma nanoemulsão lipídica contendo miltefosine para tratamento da leishmaniose. Anais da 34a Reunião Anual da SBQ, Florianópolis, (Abstract) 2011.
  17. Santos MA, Rocha OV, Diniz SN, Adelk I, Valduga CJ. Uso de nanoemulsão baseada em lipídeos como veículo para a 1,5-bis(4-oleil-3-metoxifenil)- penta-1,4-dien-3-ona. Anais da 34a Reunião Anual da SBQ, Florianópolis. (Abstract) 2011.
  18. Santos MA, Gonçalves ID, Rocha OV, Valduga CJ. Nanoemulsão lipídica como veículo para um derivado lipofílico de um análogo da curcumina. Livro de Resumos do 55º Encontro Nacional de Inovação em Fármacos e Medicamentos (5º ENIFarMed), São Paulo. (Abstract) 2011.
  19. Arvati IAZ, Leonardo G, Maria DA, Valduga CJ. Pharmacokinetic and metabolites analysis of sodium 4-[5-(4-hydroxy-3-methoxyphenyl)-3-oxo-penta-1,4-dienyl]- 2-methoxy-phenolate in mice. Ann. of 23rd International Symposium on Pharmaceutical and Biomedical Analysis, João Pessoa. (Abstract) 2011.
  20. Valduga CJ, Bitencourt JJG, Santos MA, Medeiros AC, Santos MRM. An Oral Lipid-Based Formulation of Miltefosine, an Antileishmanial Drug. BIT's 1st Annual Symposium of Drug Delivery Systems, Shenzhen. (Abstract) p. 75, 2011.
  21. Bitencourt JJG, Medeiros AC, Silva ES, Pinto CP, Rocha OV, Santos MRM, Valduga CJ. In vitro studies of a Lipid-Based Formulation of Miltefosine. Livro de resumos do II Simpósio brasileiro de planejamento e desenvolvimento de fármacos para doenças negligenciadas, São Paulo. (abstrat) 2011.
  22. Valduga CJ, Leonardo G, Maria DA, Santos RP, Santos RM, Santos MA, Suárez JAQ. Pharmacokinetic and biodistribution in mice of sodium 4-[5-(4-hydroxy-3-methoxyphenyl)-3-oxo-penta-1,4-dienyl]-2-methoxy-phenolate, a curcumin derivative. Proceedings of the American Association for Cancer Research, 2010, 101st AACR Annual Meeting, Washington. (abstract) 2011.
  23. Leonardo G, Maria DA, Santos RM, Santos RP, Santos MA, Suárez JAQ, Valduga CJ. Análise de metabólitos do sal sódico da 1,5-bis(4-hidroxi-3- metoxifenil)-penta-1,4-dien-3-ona após injeção em camundongos. Anais da 33ª Reunião Anual da Sociedade Brasileira de Química, Águas de Lindóia. (abstract) 2010.
  24. Bitencourt JJG, Medeiros AC, Santos MRM, Marques AS, Guerrieri BC, Santos MA, Mendes WK, Valduga CJ, In vitro activity of miltefosine plus itraconazole-loaded lipid-based nanoemulsion against L. (V.) braziliensis and L. (L.) chagasi. Libro de Resúmenes da 2da Escuela de Nanomedicinas - 1er Simposio Latinoamericano de nanomedicinas, La Plata. (abstract) 2010.
  25. Santos MA, Gonçalves ID, Rocha OV, Pardi PC, Guerrieri BC, Marques AS, Magalhães C, Mendes WK, Valduga CJ. Lipid nanoemulsion as a vehicle for a lipophilic curcumin derivative. Libro de Resúmenes da 2da Escuela de Nanomedicinas - 1er Simposio Latinoamericano de nanomedicinas, La Plata. (abstract) 2010.
  26. Santos MA, Medeiros AC, Rocha OV, Santos MRM, Suárez JAQ, Valduga CJ. Synthesis and activity of curcumin derivatives against L. (V.) braziliensis and L. (L.) chagasi. Ann. of of 5th Brazilian Symposium on Medicinal Chemistry, Ouro Preto. (abstract) 2010.


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