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Biography
Dr. Juan B. Grau
Dr. Juan B. Grau
Department of Surgery, Division of Cardiac Surgery

Columbia University College of Physicians and Surgeons, USA


Email: grauju@valleyhealth.com


Qualifications
2003  Cardiothoracic Surgery Fellow, NYU Medical Center, Division of Cardiothoracic Surgery, Department of Surgery, New York.
2000  Attending Surgeon and Clinical Fellow, Hospital Ruber Internacional, Department of Cardiothoracic Surgery and Department of Intensive Care Medicine, Madrid, Spain.
1990  M.D., Alcala de Henares University, School of Medicine, Madrid, Spain.

1984  Luis Vives High School, Palma de Mallorca, Baleares, Spain.


Publications (Selected)
  1. Schwartz C, Grossi E, Grau J, Ribakove G, Crooke GA, Baumann G, Ursomanno P, Gogoladze G, Culliford A, Colvin SB, Galloway AC. “Minimally Invasive Approach for Aortic Valve Replacement In The Elderly Is Associated With Lower Mortality: A Case Matched Study”. J. Am. Coll. Cardiol., March 11, 2008; 51: A271-277.
  2. DiGiorgi P.L., Baumann F.G., Schwartz C.F., Grossi E.A., Ribakove G.H., Galloway A.C., Colvin S.B., Grau J.B. Ethnicity Differences in Mitral Valve Disease Presentation and Surgical Treatment Outcome. Ethnicity & Disease, Volume 18: 306-310, summer 2008.
  3. Grossi E.A., Crooke G.A., Ribakove G.H., Ursomanno P., Grau J.B., Gogoladze G., Schwartz C.F., Colvin S.B., Galloway A.C. Perfusion Strategy Not Operative Approach Determines Risk of Stroke in Reoperative Mitral Valve Surgery 34th Western Thoracic Surgical Association Annual Meeting, June 25-28, 2008 Hawaii.
  4. Yu P.,Skolnick A., Ferrari G., Haretis K., Mignatti P., Pintucci G., Rosenzweig B., Diaz-Cartelle J., Kronzon I., Perk G., Pass H.I., Galloway A., Grossi E.A., Grau J.B. Correlation Between Osteopontin Levels And Aortic Valve Calcification: Potential Insights Into The Pathogenesis Of Aortic Calcification. Oral presentation and poster to the 34th Western Thoracic Surgical Association Annual Meeting, June 25-28, 2008 Hawaii.
  5. Gulkarov I., Bohmann K., Cinnante K.M., Pirelli L., Yu P.J., Grau J.B., Pintucci G, Galloway A.C., Mignatti P. Topical Mitogen Activated Protein Kinases Inhibition Reduces Intimal Hyperplasia in Arterialized Vein Grafts. Journal of Surgical Research. 2009 Jun 1;154(1):150-6.
  6. Yu P.,Skolnick A., Ferrari G., Haretis K., Mignatti P., Pintucci G., Rosenzweig B., Diaz-Cartelle J., Kronzon I., Perk G., Pass H.I., Galloway A., Grossi E.A., Grau J.B. Correlation Between Osteopontin Levels And Aortic Valve Calcification: Potential Insights Into The Pathogenesis Of Aortic Calcification. Journal of Cardiovascular and Thoracic Surgery 2009 Jul;138(1):196-9.
  7. Erik Beckmann, Juan B. Grau , Paolo Poggio, and Giovanni Ferrari. State-of-Art Review Insights into the Use of Biomarkers in Calcific Aortic Valve Disease. Journal of Heart and Valve Disease 2010, Jul;19(4):441-52.
  8. G. Ferrari, E. Beckmann, R. Sainger, G. Keller, P. Yu, M. Monti, A. C. Galloway, and J. B. Grau. Validation of Plasma Biomarkers in Degenerative Calcific Aortic Stenosis,. Journal of Surgical research 2010 Sep;163(1):12-7.
  9. J.B. Grau, P. Poggio, R. Sainger, W.F. Seefried, B. Field, C.W. Hargrove III, and G. Ferrari. Comparison of Gene Expression Profiles Between Normal and Prolapsed P2 Segments of Myxomatous Mitral Valves Leaflets American Heart Association Basic Cardiovascular Sciences 2010. Technological and Conceptual Advances in Cardiovascular Disease to be held in July 19-22nd 2010 Rancho Mirage, CA
  10. Ferrari G., R. Sainger, E. Beckmann, K.B. Margulies, J.B. Grau. Differential Expression of Osteopontin mRNA Splice Variants in Aortic Valve Leaflets of Patients with Calcific Aortic Valve Disease Compared to Healthy Subjects World Congress of Cardiology 2010, June 16-19, 2010 in Beijing, China.
  11. J.B. Grau, B. Field, R. Hinmon, R. Sainger, W. Seefried, P. Poggio, and G Ferrari. p38MAPK Controls Angiogenesis in Degenerative Aortic Valve Degeneration. European Society of Cardiology. ESC 2010. August 28 – Sept 01, 2010 Stockholm – Sweden.
  12. P. Poggio, JB Grau, R Sainger, B. Field, WF Seefried, F. Rizzolio and G. Ferrari Osteopontin (OPN) controls endothelial cell activation and in vitro angiogenesis of excised tissue from patients with Calcific Aortic Stenosis and controls. Journal of Cellular Physiology, 2011 Aug;226(8):2139-49. doi: 10.1002/jcp.22540.PMID:21520066
  13. Grau JB, Poggio P, Sainger R, Vernick WJ, Seefried WF, Branchetti E, Field BC, Bavaria JE, Acker MA, and Ferrari G. Analysis of Osteopontin Levels for the Identification of Asymptomatic Patients with Calcific Aortic Valve Disease. Annals of Thoracic Surgery, 2011, Nov 15. PMID 22093695
  14. Sainger R, Grau JB, Poggio P, Seefried WF, Field B, Acker M, Gorman RC, Gorman JH III, Hargrove C III, Bavaria JE, and Ferrari G. Human myxomatous Mitral Valve Prolapse: Role of Bone Morphogenetic Protein 4 on valvular interstitial cell activation. Journal of Cellular Physiology, 2011, doi: 10.1002/jcp.22999.PMID:22105615
  15. Puras E, Criado F, Grau JB, Fiuza MC. Endovascular treatment of two aortoduodenalfistulae Vascular Journal, 2011 Sep-Oct;19(5):277-81 2011.
  16. JB Grau, G Ferrari, AWC Mak, RE Shaw, ME Brizzio, JS Sperling, J Strobeck, AK Zapolanski Propensity matched analysis of BIMA versus single LIMA at 17 years follow up. Validation of a contemporary surgical experience. Interactive CardioVascular and Thoracic Surgery Vol. 13 Suppl. 2 September 15 2011
  17. Branchetti E, Milewski KR, Grau JB, Sainger R, Poggio P, Gorman RC, Gorman JH III, Bavaria JE and Ferrari G. The Role of Connective Tissue Growth Factor (CTGF) on aortic wall homestasis: insights into the molecular determinants of Thoracic Ascending Aortic Aneurysm in Bicuspid Aortic Valve patients. Journal of Thoracic and Cardiovascular Surgery, 2011
  18. Grau JB, Ferrari G, Mak AW, Shaw R, Brizzo ME, Mindich BP and Zapolanski A. Propensitymatched analysis of bilateral internal mammary artery versus single left internal mammary artery grafting at 17 years follow-up: validation of a contemporary surgical experience. European Journal of Cardiothoracic Surgery, 2011
  19. European Society of Cardiology, August 27th, September 1st , 2011, Paris, France G. Ferrari, E. Branchetti, KR. Milewski, WF. Seefried, R. Sainger, JB. Grau, A. Parolari, JE. Bavaria CTGF regulates VSMC phenotypic differentiation and ECM organization, and contributes to the development of thoracic aortic aneurysm in bicuspid and trileaflets aortic valve patients
  20. 6th Biennial Meeting of the Society, 25th-28th June 2011, Barcelona Spain G.Ferrari, E. Branchetti, KR. Milewski, JB. Grau, JE. Bavaria Differential Expression of Cell Adhesion Molecules in Thoracic Aortic Aneurysms from Bicuspid Aortic Valve and Trileaflet Aortic Valve Patients
  21. 6th Biennial Meeting of the Society, 25th-28th June 2011, Barcelona Spain G Ferrari, JB. Grau, R Sainger, BC. Field, WF. Seefried, E Branchetti, JE. Bavaria Comparison of Transesophageal Echocardiographic Analysis and Osteopontin Levels for the Identification of Asymptomatic Aortic Valve Sclerosis Patients during Calcific Aortic Valve Degeneration
  22. 6th Biennial Meeting of the Society, 25th-28th June 2011, Barcelona Spain JB Grau, G Ferrari, AWC Mak, RE. Shaw, ME. Brizzio, B Mindich, A Zapolanski Should Very Elderly Patients Be Offered The Same Surgical Options As Their Younger Counterparts? A Comparison of Outcomes Among Patients Below And Over 80 Years Of Age Undergoing AVR With Or Without CABG
  23. Grau JB, Ferrari G, Mak AW, Shaw R, Brizzo ME, and Zapolanski A. Influence of advance heart failure, patient prosthesis mismatch and age on short term and long-term outcomes after AVR with or without CABG. Annals of Thoracic Surgery, 2011
  24. Brizzo ME, Shaw R, Bosticco B, Collins M, Grau JB, Mak A, Zapolanski A. Use of an objective tool to assess platelet inhibition prior to off-pump coronary surgery to reduce blood usage and cost. Journal of Interventional Cardiology, 2011
  25. JB Grau, R Sainger, P Poggio, WF Seefried, B. Field, E Koka, and G Ferrari Dephosphorylation of circulating human Osteopontin correlates with severe valvular calcification in patients with Calcific Aortic Valve Degeneration Biomarkers
  26. E. Branchetti, JB. Grau, KR. Milewski, WF. Seefried, R. Sainger, A. Parolari, JE. Bavaria, G. Ferrari, CTGF regulates VSMC phenotypic differentiation and ECM organization, and contributes to the development of thoracic aortic aneurysm in bicuspid and trileaflets aortic valve patient