Prof. Amiram Goldblum

Molecular Modeling and Drug Design, Institute for Drug Discovery

University of Jerusalem, Israel



1977 Ph.D., Organic Chemistry, Hebrew University, Jerusalem
1972 M.Sc., Theoretical Organic Chemistry, Hebrew University, Jerusalem
1970 B.Sc., Chemistry and Physics, Hebrew University, Jerusalem

Publications (selected)

  1. Cern A, Golbraikh, A, Sedykh, A, Tropsha A., Barenholz Y andGoldblum A.(2011) Quantitative Structure – Property Relationship Modeling of Remote Liposome Loading Of Drugs, J. Control.
  2. Dorman, G et al. (2010). Towards accelerated anti-cancer drug discovery: integration of chemoinformatics, cell-based screening and grid computing. Medicinal Chemistry Research 19, S14-S15
  3. Ursu, O, Rayan, A,Goldblum, Aand Oprea, T (2011). Understanding Drug Likeness. Wiley Interdisciplinary Reviews - Computational Molecular Science 1, 760-781
  4. Noy, E andGoldblum, A. (2010) Flexible protein-protein docking based on best-First search algorithm, J. Comput. Chem. 31, 1929-1943 (cover of journal)
  5. Rayan, A, Marcus, D andGoldblum, A. (2010) Predicting Oral Drug-Likeness by Iterative Stochastic Elimination, J. Chem. Inf. Model. 50, 437-445
  6. Lavy, T, Harries, D andGoldblum, A(2011) Molecular properties from conformational ensembles: I. dipole moments of molecules with multiple internal rotations, J Phys Chem A, 115, 5794-5809
  7. Zucker, D, Marcus, D, Barenholz, Y andGoldblum, A. (2009) Liposome Drugs’ loading efficiency: A working model based on loading conditions and drug’s physicochemical properties. J. Control. Release 139, 73-80
  8. Marcus, D, Rayan, A, Barasch, D, Elias, M andGoldblum, A. (2008) Learning from failures: Discontinued Compounds as a source for knowledge in drug discovery. Abs. Pap. Amer. Chem. Soc. 236, 67-CINF
  9. Marcus, D andGoldblum, A(2008) Molecular Selectivity Index for Ligand Based Drug Design, Abs. Pap. Amer. Chem. Soc. 235, 61-CINF
  10. Gorelik, B andGoldblum, A(2008) High quality binding modes in docking ligands to proteins, Proteins 71, 1 1373-1386
  11. Noy, E, Tabakman, T andGoldblum, A. (2007) Constructing ensembles of flexible fragments in native proteins by iterative stochastic elimination is relevant to protein-protein interfaces, Proteins 68, 702-711
  12. Ittah, S., Michaeli, A.,Goldblum, A. and Gat, U. (2007) A model for the structure of the C-terminal domain of dragline spider silk and the role of its conserved cysteine. Biomacromolecules 8: 2768-73
  13. Goldberg, M. andGoldblum, A. (2006) Computational protein design: a novel path to future protein drugs. Current Pharmaceutical Design 12, 3973-3997
  14. Rayan, A., Noy, E., Chema, D., Levitzki, A. andGoldblum, A. (2004).Stochastic algorithm for kinase homology model construction. Current Medicinal Chemistry 11, 675-692
  15. Rayan, A., Senderowitz, H. andGoldblum, A. (2004) Exploring the conformational space of cyclic peptides by a stochastic search method. Journal of Molecular Graphics and Modelling 22, 319-333

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