Dr. Joy Sinha
ANDalyze, Inc., USA
ANDalyze, Inc., USA
2006-2011 Postdoctoral Fellow, Emory
2001-2006 Doctoral Candidate, University of Kentucky, USA
2000-2001 Junior Research Fellow, Indian Institute of Technology, India
Sinha, J., Topp, S. & Gallivan,
J.P. From SELEX to Cell: Dual Selections for Synthetic riboswitches. Methods
Enzymol. 497, 207-220 (2011).
Sinha, J., Reyes, S.J. & Gallivan,
J.P. Reprogramming bacteria to seek and destroy an herbicide. Nat. Chem. Biol. 6,
This research has been listed among
the key discoveries in chemical biology of the past decade by Nature Chemical
Biology. Also mentioned in "Breakthrough of the Year" feature.
Sinha, J., Dotson, P.P. & Testa,
S.M. Kinetic characterization of the first step of the ribozyme-catalyzed trans
excision-splicing reaction. FEBS J. 275, 3110-3122 (2008).
Dotson, P.P., Sinha, J. &
Testa, S.M. A Pneumocystis carinii group I intron-derived ribozyme utilizes an
endogenous guanosine as the first reaction step nucleophile in the trans
excision-splicing reaction. Biochemistry 47, 4780-4787 (2008).
Johnson, A.K., Sinha, J. &
Testa, S.M. Trans Insertion-Splicing: Ribozyme catalyzed insertion of targeted
sequences into RNAs. Biochemistry 44, 10702-10710 (2005).
Sinha, J., Baum, D.A. & Testa,
S.M. Molecular recognition in a trans excision-splicing ribozyme:
Non-Watson-Crick base pairs at the 5′-splice site and ωG at the 3′-splice site
can play a role in determining the binding register of reaction substrates.
Biochemistry 44, 1067-1077 (2005). (Joint first author)
Bell, M.A., Sinha, J., Johnson,
A.K. & Testa, S.M. Enhancing the second step of the trans excision-splicing
reaction of a group I ribozyme by exploiting P9.0 and P10 for intermolecular
recognition. Biochemistry 43, 4323-4331 (2004).
Sinha, J., Layek, S., Mandal, G.C.
& Bhattacharjee, M. A green Hünsdiecker reaction: synthesis of
β-bromostyrenes from the reaction of α, β-unsaturated aromatic carboxylic acids
with KBr and H2O2 catalyzed by Na2MoO4. H2o in aqueous medium. Chem. Comm. 19,