Dr. Joy Sinha

ANDalyze, Inc., USA



2011-Present Scientist, ANDalyze, Inc., USA

2006-2011 Postdoctoral Fellow, Emory University, USA

2001-2006 Doctoral Candidate, University of Kentucky, USA

2000-2001 Junior Research Fellow, Indian Institute of Technology, India

Publications (Selected)

  1. Sinha, J., Topp, S. & Gallivan, J.P. From SELEX to Cell: Dual Selections for Synthetic riboswitches. Methods Enzymol. 497, 207-220 (2011).
  2. Sinha, J., Reyes, S.J. & Gallivan, J.P. Reprogramming bacteria to seek and destroy an herbicide. Nat. Chem. Biol. 6, 464-470 (2010).
  3. This research has been listed among the key discoveries in chemical biology of the past decade by Nature Chemical Biology. Also mentioned in "Breakthrough of the Year" feature. Science magazine's
  4. Sinha, J., Dotson, P.P. & Testa, S.M. Kinetic characterization of the first step of the ribozyme-catalyzed trans excision-splicing reaction. FEBS J. 275, 3110-3122 (2008).
  5. Dotson, P.P., Sinha, J. & Testa, S.M. A Pneumocystis carinii group I intron-derived ribozyme utilizes an endogenous guanosine as the first reaction step nucleophile in the trans excision-splicing reaction. Biochemistry 47, 4780-4787 (2008).
  6. Johnson, A.K., Sinha, J. & Testa, S.M. Trans Insertion-Splicing: Ribozyme catalyzed insertion of targeted sequences into RNAs. Biochemistry 44, 10702-10710 (2005).
  7. Sinha, J., Baum, D.A. & Testa, S.M. Molecular recognition in a trans excision-splicing ribozyme: Non-Watson-Crick base pairs at the 5′-splice site and ωG at the 3′-splice site can play a role in determining the binding register of reaction substrates. Biochemistry 44, 1067-1077 (2005). (Joint first author)
  8. Bell, M.A., Sinha, J., Johnson, A.K. & Testa, S.M. Enhancing the second step of the trans excision-splicing reaction of a group I ribozyme by exploiting P9.0 and P10 for intermolecular recognition. Biochemistry 43, 4323-4331 (2004).
  9. Sinha, J., Layek, S., Mandal, G.C. & Bhattacharjee, M. A green Hünsdiecker reaction: synthesis of β-bromostyrenes from the reaction of α, β-unsaturated aromatic carboxylic acids with KBr and H2O2 catalyzed by Na2MoO4. H2o in aqueous medium. Chem. Comm. 19, 1916-1917 (2001).