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Biography
Prof. Akira Sugawara

Prof. Akira Sugawara

Tohoku University Graduate School of Medicine, Japan


E-mail: akiras2i@med.tohoku.ac.jp


Qualifications


1991 PH.D., Tohoku University Graduate School of Medicine (Internal Medicine), Japan

1987 M.D., Tohoku University School of Medicine, Japan


Publications (Selected)

  1. Sasaki A, Sato S, Shinkawa O, Go M, Otsuka T, Sugawara A, Shimizu Y, Murakami O, Hanew K, Andoh N, Sasano N, Yoshinaga K: Peptide histidine methionine may be a prolactin-releasing hormone in humans. J Clin Endocrinol Metab. 1988; 66: 1202-1207.
  2. Hanew K, Sato S, Goh M, Sasaki A, Shimizu Y, Sugawara A, Otsuka T, Yoshinaga K: The spectrum of GH responses to GHRH and somatostatin in patients with acromegaly. Tohoku J Exp Med. 1988; 155: 233-239.
  3. Hanew K, Sugawara A, Shimizu Y, Sato S, Sasaki A, Tazawa S, Ishii K, Saitoh T, Saso S, Yoshinaga K: The combination therapy with bromocriptine and cyproheptadine in patients with acromegaly. Endocrinol Jpn. 1989; 36: 429-438.
  4. Sugawara A, Nata K, Inoue C, Takasawa S, Yamamoto H, Okamoto H: Nucleotide sequence determination of mouse, chicken and Xenopus laevis rig cDNAs: the rig-encoded protein is extremely conserved during vertebrate evolution.Biochem Biophys Res Commun. 1990; 166: 1501-1507.
  5. Hanew K, Sugawara A, Utsumi A, Shimizu Y, Yoshinaga K: GHRH and TRH tests in patients with idiopathic and secondary GH deficiency -with special reference to GH response patterns to GHRH-. Tohoku J Exp Med. 1990; 160: 189-202.
  6. Hanew K, Utsumi A, Sugawara A, Shimizu Y, Yoshinaga K: Evidence for dopamine-related pituitary TSH and PRL pools in patients with prolactinoma. Acta Endocrinol (Copenh). 1991; 124: 545-552.
  7. Sugawara A, Shiga K, Takasawa S, Yonekura H, Yamamoto H, Okamoto H: Sequence of the chicken rig/ribosomal protein S15 gene. Gene. 1991; 108: 313-314.
  8. Hanew K, Utsumi A, Sugawara A, Shimizu Y, Tazawa S, Yoshinaga K: The relation between pituitary magnetic resonance imaging findings and GH, TSH, PRL dynamics in patients with idiopathic GH deficiency. Acta Endocrinol (Copenh). 1991; 125: 342-347.
  9. Utsumi A, Hanew K, Sugawara A, Shimizu Y, Murakami O, Ikeda H, Yoshinaga K: Plasma growth hormone (GH) responses to corticotropin-releasing hormone in patients with acromegaly -the effect of dexamethasone pretreatment and the comparison with GH responses to thyrotropin-releasing hormone, gonadotropin-releasing hormone, and GH-releasing hormone. J Endocrinol Invest. 1992; 15: 167-171.
  10. Hanew K, Utsumi A, Sugawara A, Shimizu Y, Yoshinaga K: Simultaneous administration of TRH and sulpiride caused additive but not synergistic PRL responses in normal subjects. Endocrinol Jpn. 1992; 39: 465-468.
  11. Yen PM, Sugawara A, Refetoff S, Chin WW: New insights on the mechanism(s) of the dominant negative effect of mutant thyroid hormone receptor in generalized resistance to thyroid hormone (GRTH). J Clin Invest. 1992; 90: 1825-1831.
  12. Yen PM, Sugawara A, Chin WW: Triiodothyronine (T3) differentially decreases T3-receptor/retinoic acid receptor and T3-receptor/retinoid X receptor heterodimer binding to DNA. J Biol Chem. 1992; 267: 23248-23252.
  13. Hanew K, Utsumi A, Sugawara A, Shimizu Y, Tazawa S, Abe K: Plasma GH responses to the sequential 3 day administrations of GHRH followed by arginine infusion in patients with idiopathic GH deficiency and normal short children.Tohoku J Exp Med. 1993; 169: 91-101.
  14. Sugawara A, Yen PM, Darling DS, Chin WW: Characterization and tissue expression of multiple triiodothyronine (T3) receptor-auxiliary proteins (TRAPs), and their relationship to the retinoid X receptors (RXRs). Endocrinology.1993; 133: 965-971.
  15. Yen PM, Sugawara A, Forgione M, Spanjaard RA, Macchia E, Cheng S-Y, Chin WW: Region-specific anti-thyroid hormone receptor (TR) antibodies detect changes in TR structure due to ligand-binding and dimerization. Mol Cell Endocrinol. 1993; 97: 93-99.
  16. Yen PM, Spanjaard RA, Sugawara A, Darling DS, Nguyen VP, Chin WW: Orientation and spacing of half-sites differentially affect T3-receptor (TR) monomer, homodimer, and heterodimer binding to thyroid hormone response elements (TREs). Endocrine J. 1993; 1: 461-466.
  17. Sugawara A, Yen PM, Apriletti JW, Ribeiro RC, Sacks DB, Baxter JD, Chin WW: Phosphorylation selectively increases triiodothyronine (T3)-receptor homodimer binding to DNA. J Biol Chem. 1994; 269: 433-437.
  18. Yen PM, Ikeda M, Brubaker JH, Forgione M, Sugawara A, Chin WW: Roles of v-erbA homodimers and heterodimers in mediating dominant negative activity by v-erbA. J Biol Chem. 1994; 269: 903-909.
  19. Yen PM, Ikeda M, Wilcox EC, Brubaker J, Spanjaard RA, Sugawara A, Chin WW: Half-site arrangement of hybrid glucocorticoid and thyroid hormone response elements specifies thyroid hormone receptor complex binding to DNA and transcriptional activity. J Biol Chem. 1994; 269: 12704-12709.
  20. Hanew K, Utsumi A, Sugawara A, Shimizu Y, Abe K: Enhanced GH responses to combined administration of GHRP and GHRH in patients with acromegaly. J Clin Endocrinol Metab. 1994; 78: 509-512.
  21. Hanew K, Utsumi A, Sugawara A, Shimizu Y, Ikeda H, Abe K: The evaluation of hypothalamic somatostatin tone using pyridostigmine and thyrotropin releasing hormone in patients with acromegaly. J Endocrinol Invest. 1994; 17: 313-321.
  22. Sugawara A, Yen PM, Chin WW: 9-cis retinoic acid regulation of rat growth hormone gene expression: potential roles of multiple nuclear hormone receptors. Endocrinology. 1994; 135: 1956-1962.
  23. Hanew K, Utsumi A, Sugawara A, Tanaka A, Fukazawa H, Yoshida K, Abe K: Enhanced plasma GH responses to simultaneous administration of TRH and GHRH in patients with primary hypothyroidism. Endocrine J. 1995; 42: 43-47.
  24. Sugawara A, Yen PM, Qi Y, Lechan RM, Chin WW: Isoform-specific retinoid-X receptor (RXR) antibodies detect differential expression of RXR proteins in the pituitary gland. Endocrinology. 1995; 136: 1766-1774.
  25. Spanjaard RA, Sugawara A, Ikeda M, Chin WW: Evidence that retinoid X receptors mediate retinoid-dependent transcriptional activation of the retinoic acid receptor β gene in S91 melanoma cells. J Biol Chem. 1995; 270: 17429-17436.
  26. Yen PM, Sugawara A, Liu Y, Whang J, Chin WW: Factors that enhance E. coli expressed TRβ binding to T3 and DNA. Thyroid. 1995; 5: 309-313.
  27. Hanew K, Tanaka A, Utsumi A, Sugawara A, Abe K: Plasma GH responses to human GHRH-agonist in nomal subjects. Eur J Endocrinol. 1996; 134: 67-72.
  28. Yen PM, Liu Y, Sugawara A, Chin WW: Vitamin D receptors repress basal transcription and exert dominant negative activity on triiodothyronine-mediated transcriptional activity. J Biol Chem. 1996; 271: 10910-10916.
  29. Hanew K, Tanaka A, Utsumi A, Sugawara A, Abe K: The inhibitory effects of growth hormone-releasing hormone (GHRH)-antagonist on GHRH, L-dopa, and clonidine-induced GH secretion in normal subjects. J Clin Endocrinol Metab.1996; 81: 1952-1955.
  30. Takahashi N, Takeuchi K, Abe T, Sugawara A, Abe K: Immunolocalization of rat thromboxane receptor in the kidney. Endocrinology. 1996; 137: 5170-5173.
  31. Hanew K, Tanaka A, Sugawara A, Itoi K, Abe K: Plasma GH, TSH, and PRL responses to recombinant human insulin-like growth factor-I (IGF-I) in normal and acromegalic subjects. Endocrine J. 1996; 43 Suppl.: S81-S83.
  32. Sanno N, Sugawara A, Teramoto A, Abe Y, Yen PM, Chin WW, Osamura RY: Immunohistochemical expression of retinoid-X receptor (RXR) isoforms in human pituitaries and pituitary adenomas. Neuroendocrinology. 1997; 65: 299-306.
  33. Sugawara A, Sanno N, Takahashi N, Osamura RY, Abe K: Retinoid X receptors (RXRs) in the kidney: their protein expression and functional significance. Endocrinology. 1997; 138: 3175-3180.
  34. Takahashi N, Takeuchi K, Sugawara A, Taniyama Y, Kato T, Wilcox CS, Abe K, Ito S: Structure and transcriptional function of the 5'-flanking region of rat thromboxane receptor gene. Biochem Biophys Res Commun. 1998; 244: 489-493.
  35. Sugawara A, Uruno A, Nagata T, Taketo MM, Takeuchi K, Ito S: Characterization of mouse retinoid X receptor (RXR)-β gene promoter: negative regulation by tumor necrosis factor (TNF)-α. Endocrinology. 1998; 139: 3030-3033.
  36. Imaizumi M, Suzuki H, Yoshinari M, Sato A, Saito T, Sugawara A, Tsuchiya S, Hatae Y, Fujimoto T, Kakizuka A, Konno T, Iinuma K: Mutations in the E-domain of RARα portion of the PML/RARα chimeric gene may confer clinical resistance to all-trans retinoic acid in acute promyelocytic leukemia. Blood. 1998; 92: 374-382.
  37. Sugawara A, Hanew K, Ogawa M, Kamijo T, Tanaka A, Itoi K, Igarashi Y, Iwatani N, Kohno H, Koga J, Ito S: A Case of Inherited GH Deficiency with a 6.7-kb Deletion of GH-1 Gene. Clin Pediatr Endocrinol. 1998; 7: 41-46.
  38. Sanno N, Sugawara A, Tahara S, Osamura RY, Teramoto A: Retinoid X receptors (RXRs) mRNA expression in human pituitary adenomas. Endocrine Pathology. 1999; 10: 73-83.
  39. Duncan KG, Jumper MD, Ribeiro RC, Bailey KR, Yen PM, Sugawara A, Patel A, Stern R, Chin WW, Baxter JD, Schwartz DM: Human trabecular meshwork cells as a thyroid hormone target tissue: presence of functional thyroid hormone receptors. Graefes Arch Clin Exp Ophthalmol. 1999; 237: 231-240.
  40. Ikeda Y, Takeuchi K, Kato T, Taniyama Y, Sato K, Takahashi N, Sugawara A, Ito S: Transcriptional suppression of rat angiotensin AT1a receptor gene expression by interferon-γ in vascular smooth muscle cells. Biochem Biophys Res Commun. 1999; 262: 494-498.
  41. Ikeda Y, Sugawara A, Taniyama Y, Uruno A, Igarashi K, Arima S, Ito S, Takeuchi K. Suppression of rat thromboxane synthase gene transcription by peroxiosme proliferator-activated receptor γ in macrophages via an interaction with NF-E2 related factor 2. J Biol Chem. 2000; 275: 33142-33150.
  42. Taniyama Y, Takeuchi K, Sugawara A, Ikeda Y, Sato K, Ito S: Loss of function by a mutation in thiazide-sensitive Na-Cl cotransporter found in Gitelman's syndrome. In: Control and Diseases of Sodium Dependent Transporter Proteins and Ion Channels. ed. by E.; E. Carafoli, M. Lazdunski, M. Mikoshiba, Y. Okada, Y. Suketa and E.M. Wright, Elsevier Science B.V., Amsterdam, The Netherlands, pp. 55-56, 2000
  43. Taniyama Y, Takeuchi K, Sugawara A, Ikeda Y, Sato K, Kondo Y, Kudo M, Uruno A, Ito S: Effect of steroid hormones on gene transcription of thiazide-sensitive Na-Cl cotransporter. In: Control and Diseases of Sodium Dependent Transporter Proteins and Ion Channels. ed. by E.; E. Carafoli, M. Lazdunski, M. Mikoshiba, Y. Okada, Y. Suketa and E.M. Wright, Elsevier Science B.V., Amsterdam, The Netherlands, pp.53-54, 2000
  44. Suzuki T, Moriya T, Sugawara A, Ariga N, Takabayashi H, Sasano H. Retinoid receptors in human breast carcinoma: possible modulators of in situ estrogen metabolism. Br Cancer Res Treat. 2001; 65: 31-40.
  45. Sugawara A, Takeuchi K, Uruno A, Ikeda Y, Arima S, Sato K, Kudo M, Taniyama Y, Ito S. Differential effects among thiazolidinediones on the transcription of thromboxane receptor and angiotensin II type 1 receptor genes.Hypertens Res. 2001; 24: 229-233.
  46. Ito K, Suzuki T, Moriya T, Utsunomiya H, Sugawara A, Konno R, Sato S, Sasano H. Retinoid receptors in the human endometrium and its disorders: a possible modulator of 17β-hydroxysteroid dehydrogenase. J Clin Endocrinol Metab.2001; 86: 2721-2727.
  47. Sugawara A, Takeuchi K, Uruno A, Ikeda Y, Arima S, Kudo M, Sato K, Taniyama Y, Ito S. Transcriptional suppression of type-1 angiotensin II receptor gene expression by peroxisome proliferator-activated receptor-γ in vascular smooth muscle cells. Endocrinology. 2001; 142: 3125-3134.
  48. Taniyama Y, Sato K, Sugawara A, Uruno A, Ikeda Y, Kudo M, Ito S, Takeuchi K. Renal tubule-specific transcription and chromosomal localization of rat thiazide-sensitive Na-Cl cotransporter gene. J Biol Chem. 2001; 276: 26260-26268.
  49. Arima S, Kohagura K, Takeuchi K, Taniyama Y, Sugawara A, Ikeda Y, Abe M, Omata K, Ito S. Biphasic vasodilator action of troglitazone on the renal microcirculation. J Am Soc Nephrol. 2002; 13: 342-349.
  50. Sugawara A, Uruno A, Ikeda Y, Kudo M, Sato K, Taniyama Y, Ito S, Takeuchi K. Transcription suppression of thromboxane receptor gene by peroxisome proliferator-activated receptor-γ via an interaction with Sp1 in vascular smooth muscle cells. J Biol Chem. 2002; 277: 9676-9683.
  51. Sugawara T, Sato M, Itoi K, Sugawara A, Matsuda Y, Shimada K, Sado T, Wu S, Kondo T. Successful localization and treatment for ectopic adrenocorticotrophic hormone secretion in a rare case of possible Tx N2 M0 carcinoid tumor with Cushing syndrome. J Thorac Cardiovasc Surg. 2002; 124: 1237-1238.
  52. Kawamura T, Yoshida K, Sugawara A, Nagasaka M, Mori N, Takeuchi K, Kohzuki M. Impact of exercise and angiotensin converting enzyme inhibition on tumor necrosis factor-alpha and leptin in fructose-fed hypertensive rats.Hypertens Res. 2002; 25: 919-926.
  53. Sugawara A, Takeuchi K, Uruno A, Kudo M, Sato K, Ito S. Effects of MAP kinase pathway and co-activator CBP on peroxisome proliferator-activated receptor-γ-mediated transcription suppression of angiotensin II type 1 receptorgene. Hypertens Res. 2003; 26: 623-628.
  54. Sugawara A, Takeuchi K, Suzuki T, Itoi K, Sasano H, Ito S. A case of aldosterone-producing adrenocortical adenoma associated with a probable post-operative adrenal crisis: histopathological analyses of the adrenal gland.Hypertens Res. 2003; 26: 663-668.
  55. Uruno A, Sugawara A, Kudo M, Sato M, Sato K, Ito S, Takeuchi K. Transcription suppression of thromboxane receptor gene expression by retinoids in vascular smooth muscle cells. Hypertens Res. 2003; 26: 815-821.
  56. Arima S, Kohagura K, Xu H-L, Sugawara A, Abe T, Satoh F, Takeuchi K, Ito S. Nongenomic vascular action of aldosterone in the glomerular microcirculation. J Am Soc Nephrol. 2003; 14: 2255-2263.
  57. Arima S, Kohagura K, Xu HL, Sugawara A, Uruno A, Satoh F, Takeuchi K, Ito S: Endothelium-derived nitric oxide modulates vascular action of aldosterone in renal arteriole. Hypertension. 2004; 43[part 2]: 1-6.
  58. Kawamura T, Yoshida K, Sugawara A, Nagasaka M, Mori N, Takeuchi K, Kohzuki M. Regulation of skeletal muscle peroxisome proliferator-activated receptor γ expression by exercise and angiotensin-converting enzyme inhibition in fructose-fed hypertensive rats. Hypertens Res. 2004; 27: 61-70.
  59. Sato K, Sugawara A, Kudo M, Uruno A, Ito S, Takeuchi K. Expression of peroxisome proliferator-activated receptor isoform proteins in the rat kidney. Hypertens Res. 2004; 27: 417-425.
  60. Lee Y-M, Fujiwara J, Munakata Y, Ishii T, Sugawara A, Kaku M, Kokubun S, Sasaki T, Funato T: Mutation of the glucocorticoid receptor gene in patients with systemic lupus erythematosus. Tohoku J Exp Med. 2004; 203: 69-76.
  61. Kudo M, Sugawara A, Uruno A, Takeuchi K, Ito S: Transcription suppression of peroxisome proliferator-activated receptor γ2 gene expression by tumor necrosis factor α via an inhibition of CCAAT/enhancer-binding protein δ during the early stage of adipocyte differentiation. Endocrinology. 2004; 145: 4948-4956.
  62. Takiyama Y, Miyokawa N, Sugawara A, Kato S, Ito K, Sato K, Oikawa K, Kobayashi H, Kimura S, Tateno M: Decreased expression of retinoid X receptor (RXR) isoforms in human thyroid carcinomas. J Clin Endocrinol Metab. 2004; 89:5851-5861.
  63. Uruno A, Sugawara A, Kanatsuka H, Arima S, Taniyama Y, Kudo M, Takeuchi K, Ito S: HGF stimulates NO production through eNOS phosphorylation by PI3K and MAPK pathways. Hypertens Res. 2004; 27: 887-895.
  64. Sato M, Sugawara A, Egawa N, Yajima Y, Kato H, Kagechika H: Nobel RXR antagonists enhance transactivation of PPARg and ST 13 preadipocyte differentiation. 12th Internatinal Congress of Endocrinology International Proceedings.2004; 547-551.
  65. Hongo M, Kanatsuka H, Sugawara A, Nagasaki Y, Endo Y, Karahashi K, Shoji T, Sagami Y, Aoki I. Primary care in the treatment of functional gastrointestinal symptoms in Japan: prescription preferences and impression of results. Aliment Pharmacol Ther. 2005; 21 Suppl 2: 47-54.
  66. Chung BH, Li C, Sun BK, Lim SW, Ahn KO, Yang JH, Choi YH, Yoon KH, Sugawara A, Ito S, Kim J, Yang CW: Rosiglitazone protects against cyclosporine-induced pancreatic and renal injury in rats. Am J Transplant. 2005; 5: 1856-1867.
  67. Uruno A, Sugawara A, Kanatsuka H, Kagechika H, Saito A, Sato K, Kudo M, Takeuchi K, Ito S: Up-regulation of nitric oxide production in vascular endothelial cells by all-trans retinoic acid through the phosphoinositide 3-kinase/Akt pathway. Circulation. 2005; 112: 727-736.
  68. Chung BH, Lim SW, Ahn KO, Sugawara A, Ito S, Choi BS, Kim YS, Bang BK, Yang CW: Protective effects of peroxisome proliferators activated receptor gamma agonists on diabetic and non-diabetic renal diseases. Nephrology. 2005; 10: S40-S43. (review)
  69. Park CW, Kim HW, Ko SH, Chung HW, Lim SW, Yang CW, Chang YS, Sugawara A, Guan Y, Breyer MD: Accelerated diabetic nephropathy in mice lacking the peroxisome proliferator-activated receptor {alpha}. Diabetes. 2006; 55: 885-893.
  70. Suzuki T, Hayashi S, Miki Y, Ono K, Nakamura Y, Moriya T, Sugawara A, Ishida T, Ohuchi N, Sasano H: Peroxisome proliferator-activated receptorγ(PPARγ) in human breast carcinoma: a possible modulator of estrogenic actions.Endocr Relat Cancer. 2006; 13: 233-250.
  71. Hoshi K, Kawakami J, Sato W, Sato K, Sugawara A, Saito Y, Yoshida K: Assisting the diagnosis of thyroid disease with a neural network making use of routine test data: identification of highly suspected patients with hyperthyroidism. Chem Pharm Bull. 2006; 54: 1162-1169.
  72. Saito A, Sugawara A, Uruno A, Kudo M, Kagechika H, Sato Y, Owada Y, Kondo H, Sato M, Kurabayashi M, Imaizumi M, Tsuchiya S, Ito S: All-trans retinoic acid induces in vitro angiogenesis via retinoic acid receptor: possible involvement of endogenous vascular endothelial growth factor signaling. Endocrinology. 2007; 148: 1412-1423.
  73. Suzuki K, Awata S, Oyama Y, Fujiyama M, Takano T, Sugawara A, Matsuoka H: Agitated depression successfully treated with electroconvulsive therapy combined with steroid cover in a patient with Addison's disease. Prog Neuropsychopharmacol Biol Psychiatry. 2007; 31: 956-958.
  74. Ahn KO, Lim SW, Yang HJ, Li C, Sugawara A, Ito S, Choi BS, Kim YS, Kim J, Yang CW: Induction of PPAR gamma mRNA and protein expression by rosiglitazone in chronic cyclosporine nephropathy in the rat. Yonsei Med J. 2007; 48:308-316.
  75. Obara W, Konda R, Akasaka S, Nakamura S, Sugawara A, Fujioka T. Prognostic significance of vitamin D receptor and retinoid X receptor expression in renal cell carcinoma. J Urol. 2007; 178: 1497-1503.
  76. Noguchi N, Yoshikawa T, Ikeda T, Takahashi I, Shervani NJ, Uruno A, Yamauchi A, Nata K, Takasawa S, Okamoto H, Sugawara A. FK506 disruption impairs glucose-induced insulin secretion. Biochem Biophys Res Commun. 2008; 371: 735-740.
  77. Bluth M, Mueller CM, Pierre J, Callender G, Kandil E, Viterbo D, Fu SL, Sugawara A, Okamoto H, Zenilman ME. Pancreatic reg I in chronic pancreatitis and aging: implications for new therapeutic approaches to diabetes. Pancreas.2008; 37: 386-395.
  78. Uruno A, Sugawara A, Kudo M, Satoh F, Saito A, Ito S. Stimulatory effects of low-dose HMG-CoA reductase inhibitor fluvastatin on hepatocyte growth factor-induced angiogenesis: involvement of p38 mitogen-activated protein kinase. Hypertens Res. 2008; 31: 2085-2096.
  79. Yamauchi A, Takahashi I, Takasawa S, Nata K, Noguchi N, Ikeda I, Yoshikawa T, Shervani NJ, Suzuki I, Uruno A, Unno M, Okamoto H, Sugawara A. Thiazolidinediones inhibit REG Iα gene transcription in gastrointestinal cancer cells. Biochem Biophys Res Commun. 2009; 379: 743-748.
  80. Takahashi I, Noguchi N, Nata K, Yamada S, Kaneiwa T, Mizumoto S, Ikeda T, Sugihara K, Asano M, Yoshikawa T, Yamauchi A, Shervani NJ, Uruno A, Kato I, Unno M, Sugahara K, Takasawa S, Okamoto H, Sugawara A. Important role of heparan sulfate in the morphogenesis, ß-cell proliferation, and insulin secretion of mouse pancreatic islets. Biochem Biophys Res Commun. 2009; 383: 113-118.
  81. Nakamura Y, Suzuki T, Sugawara A, Arai Y, Sasano H. Peroxisome proliferator-activated receptor gamma (PPARγ) in human prostate carcinoma. Pathol Int. 2009; 59: 288-293.
  82. Kaur S, Kumar TR, Uruno A, Sugawara A, Jayakumar K, Kartha CC. Genetic engineering with endothelial nitric oxide synthase improves functional properties of endothelial progenitor cells from patients with coronary artery disease: an in vitro study. Basic Res Cardiol. 2009; 104: 739-749.
  83. Sato W, Hoshi K, Kawakami J, Sato K, Sugawara A, Saito Y, Yoshida K. Assisting the diagnosis of Graves’ hyperthyroidism with Bayesian-type and SOM-type neural networks by making use of a set of three routine tests and their correlation with free T4. Biomed Pharmacother. 2010; 64: 7-15.