Prof. Mirko Diksic

Department of Neurology and Neurosurgery

McGill University, Canada



1970  Ph.D., University of Zagreb, Zagreb, Croatia

1968  M.Sc., University of Zagreb, Zagreb, Croatia

1966  B.Sc., University of Zagreb, Croatia

Publications (selected)

  1. TOHYAMA Y, YAMANE F, FIKRE-MERID M, BLIER P, DIKSIC M: Effects of serotonin receptor agonists, TFMP and CGS12066B, on regional serotonin synthesis in the rat brain: An autoradiographic study. J Neurochem 80:788-98, 2002.
  2. TOHYAMA Y, TAKAHASHI S, FIKRE-MERID M, WATANABE A, DIKSIC M: The inhibition of tryptophan hydroxylase, and not protein synthesis, reduces the brain trapping of Methyl-L-Tryptophan: An autoradiographic study. Neurochem Int 40:603-10, 2002.
  3. FEDI M, REUTENS D, OKAZAWA H, ANDERMANN F, BOLING W, DUBEAU F, WHITE C, NAKAI A, GROSS DW, ANDERMANN E, DIKSIC M: Localizing value of Methyl-L-Tryptophan PET in Intractable Epilepsy of Neocortical Origin. Neurology 57: 1629-1636, 2001.
  4. YAMANE F, OKAZAWA H, BLIER P, DIKSIC M. Reduction in Serotonin Synthesis Following Acute and Chronic Treatments with the Selective Serotonin Reuptake Inhibitor Paroxetine in the Rat Brain: Autoradiographic Study withα-[14C]methyl-L-tryptophan. Biochemical Pharmacology 62: 1481-1489, 2001.
  5. LEYTON M, OKAZAWA H, DIKSIC M, PARIS J, MZENGEZA S, YOUNG SN, ROSA P, BLIER P, and BENKELFAT C. Brain regional [11C]methyl-L-tryptophan trapping in impulsive subjects with borderline personality disorder. Am J Psychiatry 158: 775-782, 2001.
  6. TOHYAMA Y, YAMANE F, MERID MF, and DIKSIC M Effects of Selective 5-HT1A Antagonists on Regional Serotonin Synthesis in the Rat Brain: An Autoradiographic Study withα-[14C]Methyl-L-Tryptophan. Europ Neuropsychopharmacol 11: 193-202, 2001.
  7. TSUIKI T, BLIER P, DIKSIC M. Effect of the β-adrenoreceptor agonist flerobuterol on brain serotonin synthesis in the rat brain. Bichemical Pharmacology 59:673-679, 2000.
  8. OKAZAWA H., LEYTON M., BENKELFAT C., MZENGEZA S., DIKSIC M. Statistical mapping analysis of serotonin synthesis images generated in healthy volunteers using positron emission tomography and α-[11C]methyl-L-tryptophan. J Psychiatry and Neuroscience 25: 359-370, 2000.
  9. MZENGEZA S, VENKATACHALAM TK, DIKSIC M. Stereospecific Synthesis of α-Methylated Amino Acids. Amino Acids 18: 81-88, 2000.
  10. DIKSIC M, TOHYAMA Y, TAKADA A. Brain Uptake and Trapping of α-[14C]methyl-L-tryptophan (α-MTrp) and its Correlation with Regional Serotonin Synthesis, Tryptophan Incorporation into Proteins, and Permeability Surface Area Products of Tryptophan and α-MTrp. Neurochem Research 25: 1537-1546, 2000.
  11. DIKSIC M: Does Labelled α-Methyl-L-Tryptophan Images ONLY Blood Brain Barrier Transport of Tryptophan? J Cerebral Blood Flow Metab 20: 1508-1510, 2000.
  12. Radiopharmaceuticals and Brain Pathology Studied with PET and SPECT. CRC Press Inc., Editors, M. Diksic and R.C. Reba., CRC Press Inc., Boca Raton, FL, 1991.

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