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Biography
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Prof. Mirko Diksic

Department of Neurology and Neurosurgery

McGill University, Canada


Email: mirko.diksic@mcgill.ca


Qualifications

1970  Ph.D., University of Zagreb, Zagreb, Croatia

1968  M.Sc., University of Zagreb, Zagreb, Croatia

1966  B.Sc., University of Zagreb, Croatia


Publications (selected)

  1. TOHYAMA Y, YAMANE F, FIKRE-MERID M, BLIER P, DIKSIC M: Effects of serotonin receptor agonists, TFMP and CGS12066B, on regional serotonin synthesis in the rat brain: An autoradiographic study. J Neurochem 80:788-98, 2002.
  2. TOHYAMA Y, TAKAHASHI S, FIKRE-MERID M, WATANABE A, DIKSIC M: The inhibition of tryptophan hydroxylase, and not protein synthesis, reduces the brain trapping of Methyl-L-Tryptophan: An autoradiographic study. Neurochem Int 40:603-10, 2002.
  3. FEDI M, REUTENS D, OKAZAWA H, ANDERMANN F, BOLING W, DUBEAU F, WHITE C, NAKAI A, GROSS DW, ANDERMANN E, DIKSIC M: Localizing value of Methyl-L-Tryptophan PET in Intractable Epilepsy of Neocortical Origin. Neurology 57: 1629-1636, 2001.
  4. YAMANE F, OKAZAWA H, BLIER P, DIKSIC M. Reduction in Serotonin Synthesis Following Acute and Chronic Treatments with the Selective Serotonin Reuptake Inhibitor Paroxetine in the Rat Brain: Autoradiographic Study withα-[14C]methyl-L-tryptophan. Biochemical Pharmacology 62: 1481-1489, 2001.
  5. LEYTON M, OKAZAWA H, DIKSIC M, PARIS J, MZENGEZA S, YOUNG SN, ROSA P, BLIER P, and BENKELFAT C. Brain regional [11C]methyl-L-tryptophan trapping in impulsive subjects with borderline personality disorder. Am J Psychiatry 158: 775-782, 2001.
  6. TOHYAMA Y, YAMANE F, MERID MF, and DIKSIC M Effects of Selective 5-HT1A Antagonists on Regional Serotonin Synthesis in the Rat Brain: An Autoradiographic Study withα-[14C]Methyl-L-Tryptophan. Europ Neuropsychopharmacol 11: 193-202, 2001.
  7. TSUIKI T, BLIER P, DIKSIC M. Effect of the β-adrenoreceptor agonist flerobuterol on brain serotonin synthesis in the rat brain. Bichemical Pharmacology 59:673-679, 2000.
  8. OKAZAWA H., LEYTON M., BENKELFAT C., MZENGEZA S., DIKSIC M. Statistical mapping analysis of serotonin synthesis images generated in healthy volunteers using positron emission tomography and α-[11C]methyl-L-tryptophan. J Psychiatry and Neuroscience 25: 359-370, 2000.
  9. MZENGEZA S, VENKATACHALAM TK, DIKSIC M. Stereospecific Synthesis of α-Methylated Amino Acids. Amino Acids 18: 81-88, 2000.
  10. DIKSIC M, TOHYAMA Y, TAKADA A. Brain Uptake and Trapping of α-[14C]methyl-L-tryptophan (α-MTrp) and its Correlation with Regional Serotonin Synthesis, Tryptophan Incorporation into Proteins, and Permeability Surface Area Products of Tryptophan and α-MTrp. Neurochem Research 25: 1537-1546, 2000.
  11. DIKSIC M: Does Labelled α-Methyl-L-Tryptophan Images ONLY Blood Brain Barrier Transport of Tryptophan? J Cerebral Blood Flow Metab 20: 1508-1510, 2000.
  12. Radiopharmaceuticals and Brain Pathology Studied with PET and SPECT. CRC Press Inc., Editors, M. Diksic and R.C. Reba., CRC Press Inc., Boca Raton, FL, 1991.


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