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Biography
Prof. Jian-Zhi Wang

Prof. Jianzhi Wang

Pathophysiology Department, Key Laboratory of Ministry of Education of China for Neurological Disorders

Professor and director

Faculty of Basic Medicine and Research Institutes for Medical Science.

Deputy director


Email: wangjz@mails.tjmu.edu.cn


Qualifications

1993-1996 Postdoctoral training, NYS Institute for Basic Research, SI, NY, USA

1992-1993 Visiting scholars, Biochemistry Institute, Siena University, Siena, Italy

1989-1990 Visiting scholars, Biochemistry Institute of Shanghai, Academy of Science

1985-1988 M.S., Tongji Medical University, Wuhan, China

1975-1978 M.D. (equivalence), Wuhan Medical College (Tongji Medical College)


Publications (Selected)

  1. Liu GP, Wei W, Zhou X, Shi HR, Liu XH, Chai GS, Yao XQ, Zhang JY, Peng CX, Hu J, Li XC, Wang Q, Wang JZ. Silencing PP2A Inhibitor by Lenti-shRNA Interference Ameliorates Neuropathologies and Memory Deficits in tg2576 Mice. Mol Ther. 2013 Aug 7. doi: 10.1038/mt.2013.189. [Epub ahead of print].
  2. Yu G, Yan T, Feng Y, Liu X, Xia Y, Luo H, Wang JZ, Wang X . Ser9 phosphorylation causes cytoplasmic detention of I2PP2A/SET in Alzheimer disease.Neurobiol Aging. 2013 Jul;34(7):1748-58.
  3. Xiong Y, Jing XP, Zhou XW, Wang XL, Yang Y, Sun XY, Qiu M, Cao FY, Lu YM, Liu R, Wang JZ. Zinc induces protein phosphatase 2A inactivation and tau hyperphosphorylation through Src dependent PP2A (tyrosine 307) phosphorylation. Neurobiol Aging. 2013 Mar;34(3):745-56.
  4. Peng CX, Hu J, Liu D, Hong XP, Wu YY, Zhu LQ, Wang JZ. Disease-modified glycogen synthase kinase-3β intervention by melatonin arrests the pathology and memory deficits in an Alzheimer's animal model. Neurobiol Aging. 2013 Jun;34(6):1555-63.
  5. Li XH, Du LL, Cheng XS, Jiang X, Zhang Y, Lv BL, Liu R, Wang JZ, Zhou XW. Glycation exacerbates the neuronal toxicity of β-amyloid. Cell Death Dis. 2013 Jun 13;4:e673. doi: 10.1038/cddis.2013.180.
  6. Yang Y, Shu X, Liu D, Shang Y, Wu Y, Pei L, Xu X, Tian Q, Zhang J, Qian K, Wang YX, Petralia RS, Tu W, Zhu LQ, Wang JZ, Lu Y. EPAC null mutation impairs learning and social interactions via aberrant regulation of miR-124 and Zif268 translation. Neuron. 2012 Feb 23;73(4):774-88.
  7. Sun XY, Wei YP, Xiong Y, Wang XC, Xie AJ, Wang XL, Yang Y, Wang Q, Lu YM, Liu R, Wang JZ. Synaptic released zinc promotes tauhyperphosphorylation by inhibition of protein phosphatase 2A (PP2A). J Biol Chem. 2012 Mar 30;287(14):11174-82.
  8. Li XH, Zhou XW, Wang JZ*. AGEs induce Alzheimer-like tau pathology and memory deficit via RAGE-mediated GSK-3 activation. Neurobiol Aging. 2012 Jul;33(7):1400-10.
  9. Liu X, Bates R, Yin DM, Shen C, Wang F, Su N, Kirov SA, Luo Y, Wang JZ, Xiong WC, Mei L. Specific regulation of NRG1 isoform expression by neuronal activity. J Neurosci. 2011 Jun 8;31(23):8491-501.
  10. Zhu LQ, Zheng HY, Peng CX, Liu D, Li HL, Wang Q and Wang JZ. Protein Phosphatase 2A Facilitates Axonogenesis by Dephosphorylating CRMP2. J Neurosci. 2010, 30:3839-3848.
  11. Zhu LQ, Liu D, Hu J, Cheng J, Wang SH, Wang Q, Wang F, Chen JG, and Wang JZ. GSK-3 inhibits presynaptic vesicle exocytosis by phosphorylating P/Q-type calcium channel and interrupting SNARE complex formation. J Neurosci. 2010, 30:3824-3833.
  12. Hong XP, Peng CX, Wei W, Tian Q, Liu YH, Yao XQ, Zhang Y, Cao FY, Wang Q, Wang JZ. Essential role of tau phosphorylation in adult hippocampal neurogenesis. Hippocampus. 2010, 20(12):1339-49.
  13. Liu YH, Wei W, Yin J, Liu GP, Wang Q, Cao FY, Wang JZ. Proteasome inhibition increases tau accumulation independent of phosphorylation. Neurobiol Aging. 2009 Dec;30(12):1949-61.
  14. Zhang CE, Wei W, Liu YH, Peng JH, Tian Q, Liu GP, Zhang Y, Wang JZ. Hyperhomocysteinemia increases beta-amyloid by enhancing expression of gamma-secretase and phosphorylation of amyloid precursor protein in rat brain. Am J Pathol. 2009,74(4):1481-1491.
  15. Wang JZ, Liu F. Microtubule-associated protein tau in development, degeneration and protection of neurons. Prog Neurobiol. 2008, 85(2):148-175. An invited review.
  16. Zhang CE, Tian Q, Wei W, Peng JH, Liu GP, Zhou XW, Wang Q, Wang DW, Wang JZ. Homocysteine induces tau phosphorylation by inactivating protein phosphatase 2A in rat hippocampus. Neurobiol Aging. 2008 Nov;29(11):1654-65.
  17. Liu GP, Zhang Y, Yao XQ, Zhang CE, Fang J, Wang Q, Wang JZ. Activation of glycogen synthase kinase-3 inhibits protein phosphatase-2A and the underlying mechanisms. Neurobiol Aging. 2008 Sep;29(9):1348-58.
  18. 18. Li HL, Wang HH, Liu SJ, Deng YQ, Zhang YJ, Tian Q, Wang XC, Chen XQ, Yang Y, Zhang JY, Wang Q, Xu H, Liao FF, Wang JZ. Phosphorylation of tau antagonizes apoptosis by stabilizing beta-catenin, a mechanism involved in Alzheimer's neurodegeneration. Proc Natl Acad Sci U S A. 2007, 104(9):3591-3596.
  19. Zhu LQ, Wang SH, Yin YY, Liu D, Zheng HY, Shi HR, Tian Q, Wang XC, Wang Q, Chen JG, Wang JZ. Activation of glycogen synthase kinase-3 inhibits long term potentiation with synapse-associated impairments. J Neurosci. 2007, 27:12211–12220.
  20. Wang D, Qian L, Xiong H, Liu J, Neckameyer WS, Oldham S, Xia K, Wang J, Bodmer R, Zhang Z.Antioxidants protect PINK1-dependent dopaminergic neurons in Drosophila. Proc Natl Acad Sci U S A. 2006, 103(36):13520-13525.
  21. Zhang YJ, Xu YF, Liu YH, Yin J, Li HL, Wang Q and Wang JZ. Peroxynitrite induces Alzheimer-like tau modifications and accumulation in rat brain and its underlying mechanisms. FASEB J. 2006, 20(9):1431-1442.
  22. Liu SJ, Zhang JY, Li HJ, Fang ZY, Wang Q, Deng HM, Gong C, Iqbal K, Wang JZ. Tau becomes a more favorable substrate for GSK-3 when it is prephosphorylated by PKA in rat brain. J Biol Chem. 2004, 279(48):50078-50088.
  23. Hu YY, He SS, Wang XC, Duan QH, Grundke-Iqbal I, Iqbal K, Wang JZ. Level of nonphosphorylated tau in CSF of Alzhemer disease: An Ultrasensitive bienzyme-substrate-recycle ELISA. Am J Pathol. 2002, 160(4): 1269-1278.
  24. Wang JZ, Grundke-Iqbal I, Iqbal K. Glycosylation of microtubule-associated protein tau: an abnormal posttranslational modification in Alzheimer disease. Nat Med. 1996,2(8): 870-876. 25. Wang JZ, Gong CX, Zaidi T, Grundke-Iqbal I, Iqbal K. Dephosphorylation of Alzheimer paired helical filaments by protein phosphatase-2A and -2B. J Biol Chem. 1995, 270(9):4854-4860.


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