Dr. Zhongquan Dai

Dr. Zhongquan Dai

China Astronaut Research and Training Center, China



Ph.D., Fourth Military Medical University, China

M.Sc., Chinese Agriculture University, China

B.Sc., Chinese Agriculture University, China

Publications (Selected)

1. Leung KS, Li Y, Liu Y, Wang H, Tam TF, Chow DHK, Wan Y, Ling S, Dai Z, Qin L, Cheung WH. Effect of daily short-duration weight-bearing on disuse-induced deterioration of musculoskeletal system. J Musculoskelet Neuronal Interact 2015; 15(2):207-214.  2.40

2. Qing Wan, Simon S. Yeung, Kwok-Kuen Cheung, Wing-NgorShannon, Wendy W.Lam, Yinghui Li, Zhongquan Dai, Ella W. Yeung. Optimizing Electrical Stimulation for Promoting Satellite Cell Proliferation in Muscle Disuse Atrophy. Am J Phys Med Rehabil. 2015 Apr 16. DOI: 10.1097/PHM.0000000000000307   2.01

3. Hongjie Xu, Feng Wu, Hongqing Cao, Guanghan Kan, Hongyu Zhang, Ella W. Yeung, Peng Shang, Zhongquan Dai*, Yinghui Li*. Effects of simulated microgravity on microRNA and mRNA expression profile of rat soleus. Acta Astronautica, 2015, 107:40-49.  0.82

4. Zhongquan Dai#*, Feima Guo#, Feng Wu, Hongjie Xu, Chao Yang, Jinqiao Li, Peilong Liang, Hongyu Zhang, Lina Qu, Yingjun Tan, Yumin Wan, Yinghui Li*. Integrin αvβ3 mediates the synergetic regulation of core-binding factor α1 transcriptional activity by gravity and insulin-like growth factor-1 through phosphoinositide 3-kinase signaling. Bone, 2014, 69:126-132. 4.46

5. Chao Yang#, Jian Chen #, Feng Wu, Jinqiao Li, Peilong Liang, Hongyu Zhang, Honghui Wang, Yu Li, Yumin Wan, Ling Qin, Kwok Sui Liang, Zhongquan Dai*, Yinghui Li*. Effects of 60-day Head-down Bed rest on Osteocalcin, Glycolipid Metabolism and their association with or without Resistance Training. Clinical endocrinology, 2014, 81(5):671-678.  3.35

6. Zhongquan Dai*, Feng Wu, Jian Chen, Hongjie Xu, Honghui Wang, Feima Guo, Yingjun Tan, Bai Ding, Jinfu Wang, Yumin Wan, Yinghui Li*. Actin Microfilament mediates Osteoblast Cbfa1 Responsiveness to BMP2 under Simulated Microgravity. Plos ONE, 2013, 8(5):e63661  3.73

7. Guo Feima, Dai Zhongquan*, Wu Feng, Liu Zhaoxia, Wan Yumin, Shang Peng, Li Yinghui*. Gravity affects the responsiveness of Runx2 to 1, 25-dihydroxyvitamin D3 (VD3). Acta Astronautica, 2013, 84:189–196   0.82

8. Kwok-Kuen Cheung,Simon S. Yeung,Shannon W. Au, Levina S. Lam, Zhong-Quan Dai,Ying-Hui Li,And Ella W. Yeung. Expression and association of trpc1 with trpc3 during skeletal myogenesis. Muscle Nerve, 2011, 44: 358–365.

9. Ling Shukuan, Wan Rui, Dai Zhongquan, Nie Jielin, Wang Honghui, Tan Yingjun, Cao Hongqing, Huang Zeming, Wan Yumin, Li Yinghui. Pretreatment of Rat Bone Marrow Mesenchymal Stem Cells with a Combination of Hypergravity and 5-Azacytidine Enhances Therapeutic E efficacy for Myocardial Infarction.Biotechnology Progress, 2011, 2011, 27(2):473-482.

10. Guo Feima, Dai Zhongquan, Wu Feng, Li Yinghui. Integrin and IGF-I signaling Response to gravity. Space Medicine & Medical Engineering, 2011, 24(1):75-78(Chinese) .

11. GUO Feima, DAI Zhongquan*, WU Feng, SHANG Peng, LI Yinghui*. Bone-specific Transcription Factor Runx2 on the Role of Antagonistic Bone Loss In Space.Chinese Journal Of Space Science,2011,31(5):627-634(Chinese)* Co-corresponding authors.

12. Dai Zhongquan, Tan Yingjun, Yangfen, Qu lina, Zhang Hongyu, Wan Yumin, Li Yinghui. Altered Actin Dynamics and Functions of Osteoblast-Like Cells in Parabolic Flight may Involve ERK1/2. Microgravity. Microgravity Sci Tech. 2011(23):19–27.

13. Dai Zhongquan, Wu Feng, Ella W Yeung, Li Yinghui. IGF-IEc expression, regulation and biological function in different tissues. Growth Horm IGF Res. 2010, 20:275-281.

14. Chengzhi Ni, Chunyan Wang, Yuan Li, Yinghui Li, Zhongquan Dai, Dongming Zhao, Hongyi Sun and Bin Wu. Detection of the quantity of kinesin and microgravity-sensitive kinesin genes in rat bone marrow stromal cells grown in a simulated microgravity environment. Acta Astronautic. 2011 Available online in press.

15. Tongfeifei, DAI Zhongquan*, GUO Feima, DING Bai, TAN Yingjun, LV Jinyin, LI Yinghui*. Establishment of an Osteoblastic Model Reflecting Cbfa1 Activity with Fluorescent Intensity.  Space Medicine & Medical Engineering, 2010, 23(1):15-19 * Co-corresponding authors.

16. Chuwen Lin*, Xuan Jiang*, Zhongquan Dai*, Xizhi Guo, Tujun Weng, Jun Wang, Yinghui Li, Guoyin Feng, Xiang Gao, Lin He. Sclerostin Mediates Bone Response to Mechanical Unloading Through Antagonizing Wnt/β-Catenin Signaling. Journal of Bone and Mineral Research. 2009, 24(10):1651-1661   * Equal contributors.

17. Huang Yan*, Dai Zhongquan*, Ling Shukuan, Zhang Hongyu, Wan Yumin, Li Yinghui. Gravity, a regulation factor in the differentiation of rat bone marrow mesenchymal stem cells. J Biomed Sci. 2009 Sep 21;16:87.Open access  * Equal contributors.

18. Fen Yang, Zhongquan Dai, Yingjun Tan, Yinghui Li. Effects of Altered Gravity on the Cytoskeleton of Neonatal Rat Cardiocytes. Microgravity Sci and Tech. 2010, 22:45–52.

19. YANG Fen, LI YingHui, DING Bai, NIE JieLin, WANG HongHui, ZHANG XiaoYou, WANG ChunYan, LING ShuKuan, NI ChengZhi, DAI ZhongQuan, TAN YingJun, WAN YuMin Reduced function and disassembled microtubules of cultured cardiomyocytes in spaceflight. Chinese Science Bulletin. 2008, 53(8):1185-1192.

20. DAI Zhongquan, WANG Rui, LING Shukuan, WAN Yumin, LI Yinghui. Simulated microgravity inhibits the proliferation and osteogenesis of rat bone marrow mesenchymal stem cells. Cell Proliferation, 2007, 40(5):671–684.

21. DAI Zhongquan, LI Yinghui, DING Bai, ZHANG Xiaoyou, TAN Yingjun, WAN Yumin. Actin microfilaments participate in the regulation of the COL1A1 promoter activity in ROS17/2.8 cells under simulated microgravity. Advances in Space Research. 2006, 38(6):1159-1167.

22. DAI Zhongquan, Li Yinghui, DING Bai, ZHANG Yuguo, LIU Weiquan, LIU Pengpeng. Effects of clinorotation on COL1A1- EGFP gene expression. Science in China Series C-Life Sciences, 2004, 47(3):203-210.

23. DAI Zhongquan, LI Yinghui, DING Bai, YANG Fen, TAN Yingjun, NIE Jielin, YU Jianru. Disruption of microfilament cytoskeleton induced by simulated microgravity increases the activity of COL1A1 promoter. Acta Physiologica Sinica, 2006, 58 (1):53-57 (Chinese).

24. DAI Zhongquan, LI Yinghui, WAN Yumin, NIE Jielin, LING Shukuan. The effects of microgravity on osteoblast and its differentiation process. Chinese Journal of Aerospace Medicine. 2005, 16(2):148-151 (Chinese).

25. DAI Zhongquan, LI Yinghui, DING Bai, ZHANG Yuguo, LIU Pengpeng. Establishment of COL1A1-EGFP Stably Transfected ROS17/2.8 cell lines. Space Medicine & Medical Engineering, 2004, 17(2):107-110 (Chinese).

26. DENG Jinping, DAI Zhongquan, LIU Shou, NIE Jielin, LI Yinghui. Isolation and culture of bone marrow mesenchymal stem cells by red blood cell lysis method. Zhongguo Zuzhi Gongcheng Yanjiu yu Linchuang Kangfu, 2007;11(3):579-582(English).

27. LIN Shukuan, LI Yinghui, DAI Zhongquan, Yang Fen, NIE Jielin. The Process of Mesenchymal Stem Cells and their Potential as Cardiac Therapeutics. China Biotechnology. 2007, 27(6):107-110 (Chinese).

28. LIU Xueyong, BAI Yanqiang, WANG Chunyan, DAI Zhongquan, LI Yinghui. Oligonucleotide Hybridization Detection Based on Surface Plasmon Resonance Technology. Space Medicine & Medical Engineering. 2007,20(1):16-18 (Chinese).

29. CAO Hongqing, KAN guanghan, LIU Yue, WAN Yumin, DAI Zhongquan, SONG Jinping, LI Yinghui. General analysis of rodents in the mission of Neurolab. Journal of Modern Clinical Medical Bioengineering. 2006, 12(5): 448-450 (Chinese).

30. HUANG Yan, LI Yinghui, YANG Fen, DAI Zhongquan. Induced Cardiomyogenic Differentiation of Bone Marrow Mesenchymal Stem Cells in Vitro. Space Medcine and Medico-engineering, 2006, 19(6):408-411 (Chinese).

31. HUANG Yan, LI Yinghui, YANG Fen, DAI Zhongquan, NIE Jielin. The Process of Mesenchymal Stem Cells and their Potential as Cardiac Therapeutics. Chinese Journal of Clinical Rhabilitation. 2006, 10(29):138-140 (Chinese).

32. HU Xinying, DAI Zhongquan, MA Changwei, LI Yinghui. Antiproliferative Effects of Serine Proteinase Inhibitor from Silver Carp (Hypophthalmichthys molitrix) Skeletal Muscle on Jarkat,Sp20 and MG63 Cells. Journal of Jilin Agriculture University. 2006, 28(1):32-34 (Chinese).

33. WANG Honghui, NIE Jielin, LI Yinghui, DAI Zhongquan. The Side Population Cells in the Adult Stem Cell Populations. China Biotechnology. 2005, 25(12):75-77, 85 (Chinese).