Dr. Victor E. Laubach

Prof. Victor E. Laubach

Department of Surgery

University of Virginia Health System, USA




1996 Postdoctoral Research Associate, Department of Cell Biology Glaxo Wellcome, Inc., Research Triangle Park, USA

1993 Ph.D., The George Washington University, USA, Genetics

1985 B.Sc., The Pennsylvania State University, USA, Biology

Publications (selected)

  1. Sharma AK, Laubach VE, Ramos SI, Zhao Y, Stukenborg G, Linden J, Kron IL, Yang Z. Adenosine A2A receptor activation on CD4+ T lymphocytes and neutrophils attenuates lung ischemia-reperfusion injury. J Thorac Cardiovasc Surg 139(2): 474-82, 2010.
  2. Gazoni LM, Walters DM, Linden J, Kron IL, Laubach VE. Activation of A1, A2A, or A3 adenosine receptors attenuates lung ischemia-reperfusion injury. J Thorac Cardiovasc Surg 140(2): 440-446, 2010.
  3. Anvari F, Sharma AK, Fernandez LG, Hranjec T, Ravid K, Kron IL and Laubach VE. Tissue-derived proinflammatory effect of adenosine A2B receptor in lung ischemia-reperfusion injury. J Thorac Cardiovasc Surg 140: 871-7, 2010.
  4. Laubach VE, French BA and Okusa MD. [Invited Review] Targeting of adenosine receptors in ischemiareperfusion injury. Expert Opin Ther Targets 15(1): 103-18, 2011.
  5. Zhao Y, Sharma AK, LaPar DJ, Kron IL, Ailawadi G, Liu Y, Jones DR, Laubach VE, Lau CL. Depletion of tissue plasminogen activator attenuates lung ischemia-reperfusion injury via inhibition of neutrophil extravasation. Am J Physiol Lung Cell Mol Physiol 300(5): L718-29, 2011.
  6. Sharma AK, LaPar DJ, Zhao Y, Kron IL, Iwakura Y, Okusa MD, Laubach VE. Natural killer T cell-derived IL-17 mediates lung ischemia-reperfusion injury. Am J Respir Crit Care Med 183(11): 1539-49, 2011.
  7. Samlowski WE, Kondapaneni M, McGregor JR, Tharkar S, Laubach VE, Salvemini D. Endothelial nitric oxide synthase is a key mediator of interleukin-2-induced hypotension and vascular leak syndrome. J Immunother 34(5): 419-27, 2011.
  8. Sun J, Cardani A, Sharma AK, Laubach VE, Jack RS, Müller W, Braciale TJ. Autocrine regulation of pulmonary inflammation by effector T-cell derived IL-10 during infection with respiratory syncytial virus. PloS Pathogens 7(8): e1002173, 2011.
  9. LaPar DJ, Laubach VE, Emaminia A, Crosby IK, Hajzus VA, Sharma AK, Sumner HM, Webb DV, Lau CL, Kron IL. Pretreatment strategy with adenosine A(2A) receptor agonist attenuates reperfusion injury in a preclinical porcine lung transplantation model. J Thorac Cardiovasc Surg 142(4): 887-94, 2011. Curriculum Vitae - Victor E. Laubach, PhD Page 14.
  10. Emaminia A, LaPar DJ, Zhao Y, Steidle JF, Harris DA, Laubach VE, Linden J, Kron IL, Lau CL. Adenosine A(2A) agonist improves lung function during ex-vivo lung perfusion. Ann Thorac Surg 92: 1840-6, 2011.
  11. Lapar DJ, Sharma AK, Hajzus VA, Zhao Y, Lau CL, French BA, Kron IL, Laubach VE. Acute hyperglycemic exacerbation of lung ischemia-reperfusion injury is mediated by receptor for advanced glycation end-products signaling. Am J Respir Cell Mol Biol. 46(3): 299-305, 2011.
  12. Sharma AK, Lu G, Jester A, Johnston WF, Zhao Y, Hajzus VA, Saadatzadeh MR, Su G, Bhamidipati CM, Mehta GS, Kron IL, Laubach VE, Murphy MP, Ailawadi G, Upchurch GR Jr. Experimental abdominal aortic aneurysm formation is mediated by IL-17 and attenuated by mesenchymal stem cell treatment. Circulation 126(11 Suppl 1): S38-45, 2012.
  13. Mulloy DP, Stone ML, Crosby IK, LaPar DJ, Sharma AK, Webb DV, Lau CL, Laubach VE, Kron IL. Ex vivo rehabilitation of non-heart-beating donor lungs in a preclinical porcine model: delayed perfusion results in superior lung function. J Thorac Cardiovasc Surg 144:1208-16, 2012.
  14. Mulloy DP, Sharma AK, Fernandez LG, Zhao Y, Lau CL, Kron IL, Laubach VE. Adenosine A3 receptor activation attenuates lung ischemia-reperfusion injury. Ann Thorac Surg 95: 1762-7, 2013.
  15. Fernandez LG, Sharma AK, LaPar DJ, Kron IL, Laubach VE. Adenosine A1 receptor activation attenuates lung ischemia-reperfusion injury. J Thorac Cardiovasc Surg 145: 1654-9, 2013.
  16. Bhamidipati CM, Mehta GS, Moehle CW, Meher AK, Su G, Vigneshwar NG, Barbery C, Sharma AK, Kron IL, Laubach VE, Owens GK, Upchurch GR Jr, Ailawadi G. Adenosine 2A receptor modulates inflammation and phenotype in experimental abdominal aortic aneurysms. FASEB J 27(6): 2122-31, 2013.
  17. Sharma AK, LaPar DJ, Stone ML, Zhao Y, Kron IL, Laubach VE. Receptor for advanced glycation end products (RAGE) on iNKT cells mediates lung ischemia-reperfusion injury. Amer J Transplant 13: 2255-67, 2013.
  18. Sharma AK, Mulloy DP, Le LT, Laubach VE. NADPH oxidase mediates synergistic effects of IL-17 and TNF-α on CXCL1 expression by epithelial cells after lung ischemia-reperfusion. Am J Physiol Lung Cell Mol Physiol 306: L69-79, 2014.
  19. Stone ML, Sharma AK, Zhao Y, Charles EJ, Johnston WF, Kron IL, Lynch KR, Laubach VE. Sphingosine-1-phosphate receptor 1 agonism attenuates lung ischemia-reperfusion injury. Am J Physiol Lung Cell Mol Physiol 308: L1245-52, 2015.
  20. Stone ML, Sharma AK, Mas VR, Gehrau RC, Mulloy DP, Zhao Y, Lau CL, Kron IL, Laubach VE. Ex vivo perfusion with adenosine A2A receptor agonist enhances rehabilitation of murine donor lungs after circulatory death. Transplantation (In Press) 2015.