Dr. Yoshimasa Maniwa

Dr. Yoshimasa Maniwa

Division of Thoracic Surgery

Kobe University, Japan



1998  Ph.D., Kobe University School of Medicine

1990  M.D., Kobe University School of Medicine

Publications (Selected)

  1. Harada N, Maniwa Y*, Yoshimura M, Nagata M, Hamada H, Yokono K, Okita Y. E1B-deleted Adenovirus replicates in p53-Deficient Lung Cancer Cells because of the Absence of Apoptosis. Oncol Rep 2005, 14: 1155-1163.
  2. Maniwa Y*, Yoshimura M, Bermudez VP, Okada K, Kanomata N, Obayashi C, Nishimura Y, Hayashi Y, Hurwitz J, Okita Y. The His239Arg SNP of HRAD9 is associated with Lung Adenocarcinoma. Cancer 2006, 106: 1117-1122.
  3. Haraguchi T, Okada K, Tabata Y, Maniwa Y, Hayashi Y, Okita Y. Controlled release of basic fibroblast growth factor from gelatin hydrogel sheet improves structural and physiological properties of vein graft in rat. Arterioscler Thromb Vasc Biol 2007, 27: 548-555.
  4. Yamada K, Moriyama H, Yasuda H, Hara K, Maniwa Y, Hamada H, Yokono K, Nagata M. Modification of the Rb-inding domain of replication-competent adenoviral vector enhances cytotoxicity against human esophageal cancers via NF-kappaB Activity. Hum Gene Ther 2007, 18:389-400.
  5. Tanaka Y, Maniwa Y*, Yoshimura M, Okita Y. Successful treatment of descending necrotizing mediastinitis. Gen Thorac Cardiovasc Surg 2007, 55: 366-369.
  6. Takata M, Maniwa Y*, Doi T, Tanaka Y, Okada K, Nishio W, Ohbayashi C, Yoshimura M, Hayashi Y, Okita Y. Double-layered collagen gel hemisphere for cell invasion assay: Successful visualization and quantification of cell invasion activity. Cell commun adhes 2007, 14: 157-167.
  7. Tanaka Y, Maniwa Y*, Nishio W, Yoshimura M, Okita Y. The optimal timing to resect pulmonary metastasis. Eur J Cardiothorac Surg 2008, 33: 1135-1138.
  8. Ohno Y, Koyama H, Takenaka D, Nogami M, Maniwa Y, Nishimura Y, Ohbayashi C, Sugimura K. Dynamic MRI, dynamic multidetector-row computed tomography (MDCT), and coregistered 2-[fluorine-18]-fluoro-2-deoxy-D-glucose-positron emission tomography (FDG-PET)/CT: comparative study of capability for management of pulmonary nodules. J Magn Reson Imaging 2008, 27: 1284-95.
  9. Koyama H, Ohno Y, Kono A, Takenaka D, Maniwa Y, Nishimura Y, Ohbayashi C, Sugimura K. Quantitative and qualitative assessment of non-contrast-enhanced pulmonary MR imaging for management of pulmonary nodules in 161 subjects. Eur Radiol 2008, 18: 2120-31.
  10. Yamamoto M, Nishiuma T, Kobayashi K, Maniwa Y, Sakashita A, Funada Y, Kotani Y, Nishimura Y. Rad9 is upregulated and plays protective roles in an acute lung injury model. Biochem Biophys Res Commun 2008, 376:590-594.
  11. Maniwa Y*, Yoshimura M, Takata M, Nishimura Y, Ohno Y. Effective chemotherapy based on a chemosensitivity test for malignant pleural mesothelioma. Ann Thorac Cardiovasc Surg. 2008, 14: 319-321.
  12. Yuki T, Maniwa Y*, Doi T, Nishio W, Yoshimura M, Ohbayashi C, Hayashi Y, Okita Y. DNA damage sensor protein hRad9-a novel molecular target for lung cancer treatment. Oncol Rep 2008, 20: 1047-1052.
  13. Maekawa T, Maniwa Y*, Doi T, Okada K, Nishio W, Yoshimura M, Ohbayashi C, Hayashi Y, Okita Y. Expression and localization of FOXO1 in non-small cell lung cancer. Oncol Rep 2009, 22: 57-64.
  14. Tanaka Y, Maniwa Y*, Bermudez VP, Doi T, Nishio W, Ohbayashi C, Okita Y, Hurwitz J, Hayashi Y, Yoshimura M. Non-synonymous SNPs in DNA damage repair pathways and lung cancer risk. Cancer 2010, 116:896-902.
  15. Maniwa Y*, Yoshimura M, Hashimoto S, Takata M, Nishio W. Chemosensitivity of Lung Cancer: Differences between Primary Tumor and Lymph Node Metastasis. Oncology Letters. 2010, 1: 345-349.
  16. Nakai R, Maniwa Y*, Tanaka Y, Nishio W, Yoshimura M, Okita Y, Ohbayashi C, Satoh N, Ogita H, Takai Y, Hayashi Y, Overexpression of Necl-5 correlates with unfavorable prognosis in patients with lung adenocarcinoma. Cancer Sci 2010, 101:1326-1330.
  17. Onishi Y, Ohno Y, Koyama H, Nogami M, Takenaka D, Matsumoto K, Yoshikawa T, Matsumoto S, Maniwa Y, Nishimura Y, Sugimura K. Non-small cell carcinoma: Comparison of postoperative intra- and extrathoracic recurrence assessment capability of qualitatively and/or quantitatively assessed FDG-PET/CT and standard radiological examinations. Eur J Radiol. 2010 [Epub ahead of print].
  18. Doi T, Maniwa Y*, Tanaka Y, Tane S, Hashimoto S, Ohno Y, Nishio W, Nishimura Y, Ohbayashi C, Okita Y, Hayashi Y, Yoshimura M. MT1-MMP plays an important role in an invasive activity of malignant pleural mesothelioma cell. Exp Mol Pathol, 2011, 90: 91-96.
  19. Ohno Y, Koyama H, Nogami M, Takenaka D, Onishi Y, Matsumoto K, Matsumoto S, Maniwa Y, Yoshimura M, Nishimura Y, Sugimura K. State-of-the-art radiological techniques improve the assessment of postoperative lung function in patients with non-small cell lung cancer. Eur J Radiol. 2011, 77: 97-104.
  20. Ohno Y, Koyama H, Matsumoto K, Onishi Y, Takenaka D, Fujisawa Y, Yoshikawa T, Konishi M, Maniwa Y, Nishimura Y, Ito T, Sugimura K. Differentiation of Malignant and Benign Pulmonary Nodules with Quantitative First-Pass 320-Detector Row Perfusion CT versus FDG PET/CT. Radiology 2011, 258: 599-609.
  21. Maniwa Y*, Nishio W, Yoshimura M. Application of hRad9 to lung cancer treatment as a molecular marker and a molecular target. Thoracic Cancer, 2011, 2: 7-15.
  22. Sakai Y, Ohbayashi C, Kanomata N, Kajimoto K, Sakuma T, Maniwa Y, Nishio W, Tauchi S, Uchino K, Yoshimura M. Significance of microscopic invasion into hilar peribronchovascular soft tissue in resection specimens of primary non-small cell lung cancer. Lung Cancer. 2011 73: 89-95.
  23. Satoh N, Maniwa Y*, Bermudez VP, Nishimura K, Nishio W, Yoshimura M, Okita Y, Ohbayashi C, Hurwitz J, Hayashi Y. The Oncogenic Phosphatase Wip1 is a Novel Prognostic Marker for Lung Adenocarcinoma Patient Survival. Cancer Sci. 102:1101-6.
  24. Hori S, Nishiumi S, Kobayashi K, Shinohara M, Hatakeyama Y, Kotani Y, Hatano N, Maniwa Y, Nishio W, Bamba T, Fukusaki E, Azuma T, Takenawa T, Nishimura Y, Yoshida M. A metabolomic approach to detect early stages of lung cancers. Lung Cancer, in press.
  25. Wakahara T, ManiwaY*, Tanaka Y, Nishio W, Yoshimura M. Successful management of descending necrotizing mediastinitis. Asian Cardiovasc Thoracic Ann. 2011 19: 228-231.
  26. Ohno Y, Koyama H, Yoshikawa T, Nishio M, Aoyama N, Onishi Y, Takenaka D, Matsumoto S, Maniwa Y, Nishio W, Nishimura Y, Itoh T, Sugimura K. N Stage Disease in Patients with Non-Small Cell Lung Cancer: Efficacy of Quantitative and Qualitative Assessment with STIR Turbo Spin-Echo Imaging, Diffusion-weighted MR Imaging, and Fluorodeoxyglucose PET/CT. Radiology. 2011 Sep 16. [Epub ahead of print].