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Biography
Dr. Sachin A. Gupte
Dr. Sachin A. Gupte
College of Medicine

University of South Alabama, USA


Email: sachin_gupte@yahoo.com


Qualifications
2001 M.D., Ph.D., Juntendo University School of Medicine, Japan
2000 Post-doc New York Medical College, USA
1992 M.S., University of Bombay, India

1988 B.S., University of Bombay, India


Publications (Selected)
  1. Gupte S.A., Okada T., Ochi R. Superoxide and nitroglycerin stimulate release of PGF2 and TxB2 in isolated rat heart.a Am J Physiol., 271(6 Pt 2):H2447-53, 1996.
  2. Gupte S.A., Okada T., Tateyama M., Ochi R. Activation of TxA2/PGH2 receptors and protein kinase C contribute to coronary dysfunction in superoxide treated rat hearts. J Mol Cell Cardiol., 32:937-46, 2000.
  3. Gupte S.A., Okada T. Prostaglandins and nitric oxide mediate superoxide-induced myocardial contractile dysfunction in isolated rat heart. J Mol Cell Cardiol., 33:1107-17, 2001.
  4. Gupte S.A., Li K.X., Okada T., Sato K., Oka M. Inhibitors of pentose phosphate pathway cause vasodilation: Involvement of voltage-gated potassium channels. J Pharmacol Exp Ther., 301:299-305, 2002.
  5. Gupte S.A., Tateyama M., Okada T., Oka M., Ochi R. Epiandrosterone, a metabolite of testosterone precursor, blocks L-type calcium channels of ventricular myocytes and inhibits myocardial contractility. J Mol Cell Cardiol., 34:679-88, 2002.
  6. Lionetti V., Linke A., Chandler M.P., Young M.E., Penn M.S., Gupte S.A., d’Agostino C., Hintze T.H., Stanley W.C., Recchia F.A. Carnitine palmitoyl transferase-I inhibition prevents ventricular remodeling and delays decompensation in pacing-induced heart failure. Cardiovasc Res., 66:454-61, 2005.
  7. Wolin M.S., Gupte S.A. Novel Roles for Nox Oxidases in Cardiac Arrhythmia and Oxidized Glutathione Export in Endothelial Function. Circ Res., 97:612-4, 2005.
  8. Gupte S.A., Levine R., Young M.E., Lionetti V., Gupte R.S., Labinskyy V., Floyd B., Bellomo M., Marks B., Wolin M.S., Recchia F.A. Glucose 6-Phosphate dehydrogenase-derived NADPH fuels superoxide production in the failing heart. J Mol Cell Cardiol., 41:340-9, 2006.
  9. Gupte S.A., Okada T., McMurtry I.F., Oka M. Role of pentose phosphate pathway-derived NADPH in hypoxic pulmonary vasoconstriction. Pulm Pharmacol Ther., 19:303-9, 2006.
  10. Gupte RS, Vijay V, Marks B, Levine RJ, Sabbah HN, Wolin MS, Recchia FA, Gupte SA. Upregulation of glucose-6-phosphate dehydrogenase and NAD(P)H oxidase activity increases oxidative stress in failing human heart. J Card Fail., 13:497-506, 2007.
  11. Tsujikawa H, Song Y, Watanabe M, Masumiya H, Gupte S.A., Ochi R, Okada T. Cholesterol depletion modulates basal L-type Ca2+ current and abolishes its -adrenergic enhancement in ventricular myocytes. Am J Physiol Heart Circ Physiol., 294:H285-92, 2008.
  12. Qanud K, Mamdani M, Pepe M, Khairallah RJ, Gravel J, Lei B, Gupte S.A., Sharov VG, Sabbah HN, Stanley WC, Recchia FA. Reverse changes in cardiac substrate oxidation in dogs recovering from heart failure. Am J Physiol Heart Circ Physiol., 295:H2098-105, 2008. PMCID: PMC2614573
  13. Serpillon, S., Floyd B.C., Gupte R.S., George S., Kozicky. M., Neito V., Recchia F., Stanley W., Wolin M.S., Gupte S.A. Superoxide production by NAD(P)H oxidase and mitochondria is increased in genetically obese and hyperglycemic rat heart and aorta before the development of cardiac dysfunction. The role of glucose-6-phosphate dehydrogenase-derived NADPH. Am J Physiol Heart Circ Physiol., 297:H153-H162, 2009. PMCID: PMC2711743
  14. Csiszar A, Labinskyy N, Olson S, Pinto JT, Gupte S.A., Wu JM, Hu F, Ballabh P, Podlutsky A, Losonczy G, de Cabo R, Mathew R, Wolin MS, Ungvari Z. Resveratrol prevents monocrotaline-induced pulmonary hypertension in rats. Hypertension, 54:668-75, 2009. PMCID: PMC2745434
  15. Gupte RS, Rawat DK, Chettimada S, Cioffi DL, Wolin MS, Gerthoffer WT, McMurtry IF, Gupte SA. Activation of glucose-6-phosphate dehydrogenase promotes acute hypoxic pulmonary artery contraction. J Biol Chem. 285(25):19561-71, 2010. Epub 2010 Apr 2. PMCID: PMC2885235