Dr. Wan-Fai Ng

Musculoskeletal Research Group

Institute of Cellular Medicine

Newcastle University, UK





2010    FRCP, Royal College of Physicians, London

2006    CCT (Rheumatology), Postgraduate Medical Education & Training Board, UK
2003    Ph.D., Immunology, Imperial College, London
1997    MRCP, Royal College of Physicians, London
1995    M.B., Neurology Prize, University of Cambridge, UK 
1992    B.A., Pathology, University of Cambridge, UK 


Publications (Selected)

  1. Hackett KL, Newton JL, Ng WF. Occupational therapy: A potentially valuable intervention for people with primary Sjögren’s syndrome. Br J Occup Ther (in press)  
  2. Ng WF, Bowman SJ. United Kingdom primary Sjögren's syndrome registry (UKPSSR) - Design and future outcomes? J Clin Rheumatol Musculoskeletal Med (in press)  
  3. Ng WF. Primary Sjögren’s syndrome research and therapy: has a new dawn arrived? Curr Pharm Biotechnol. 2012 Jan 2. [Epub ahead of print] PMID:22208650.  
  4. Cooles FAH, Pratt AG, Wilson G, Isaacs JD and Ng WF. Prevalence and diagnostic outcome relating to vitamin D deficiency in new patients presenting to an early arthritis clinic over 12 months. Clin Rheumatol 2011. Aug;30(8):1137-8.  
  5. Ng WF, Bowman SJ. Biological therapies in primary Sjögren's syndrome. Expert Opin Biol Ther. 2011 Jul;11(7):921-36. [Epub Apr 4, 2011]  
  6. Ng WF, Tudhope SJ, von Delwig A, Lilic D. Invariant natural killer T (iNKT) cell deficiency in Chronic Mucocutaneous Candidiasis - a consequence or a cause? Immunol Letts. 2011 Mar 30;135(1-2):180-3.  
  7. Ng WF, Bowman SJ, Griffiths B on behalf of the UKPSSR study group. United Kingdom primary Sjögren's syndrome registry (UKPSSR) - A united effort to tackle an orphan rheumatic disease. Rheumatology (Oxford). 2011 Jan;50(1):32-9.  
  8. Ng WF, von Delwig A, Carmichael AJ, Arkwright PD, Abinun M, Jolles S, Lilic D. Impaired Th-17 in Patients with Chronic Mucocutaneous Candidiasis with and without APECED. J Allergy Clin Immunol. 2010 Nov;126(5):1006-15, 1015.e1-4.  
  9. Tudhope SJ, von Delwig A, Falconer J, Pratt A, Woolridge T, Wilson G, Isaacs JD, Ng WF. Profound invariant natural killer T-cell deficiency in inflammatory arthritis. Ann Rheum Dis. 2010 Oct;69(10):1873-9 
  10. von Delwig A, Locke J, Robinson JH, Ng WF. Response of Th17 cells to a citrullinated arthritogenic aggrecan peptide in patients with rheumatoid arthritis. Arthritis Rheum. 2010; 62(1):143-149.  
  11. Ng WF, Bowman SJ. Primary Sjögren’s syndrome: too tired and too dry. Rheumatology (Oxford). 2010 May;49(5):844-53.  
  12. Hassan B, Maxwell JR, Hyrich KL; Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate, Barton A, et al. Genotype at the sIL-6R A358C polymorphism does not influence response to anti-TNF therapy in patients with rheumatoid arthritis. Rheumatology. 2010 Jan;49(1):43-7.  
  13. Raychaudhuri S, Thomson BP, Remmers EF, Eyre S, Hinks A, Guiducci C, et al. Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk. Nat Genet. 2009 Dec;41(12):1313-8.  
  14. Bracewell C, Isaacs JD, Emery P, Ng WF. Atacicept, a novel B cell-targeting biological therapy for the treatment of rheumatoid arthritis. Expert Opin Biol Ther. 2009 Jul;9(7):909-19.  
  15. Ng WF, Godkin A, Gallagher K, Betts G, Thomas HC, Lechler RI. Expansion of hepatitis C-specific CD4(+)CD25(+) regulatory T cells after viral clearance: A mechanism to limit collateral damage? J Allergy Clin Immunol. 2008 May;121(5):1277-1284.
  16. Datta HK, Ng WF, Walker JA, Tuck SP, Varanasi SS. The cell biology of bone metabolism. J Clin Pathol. 2008;61(5):577-87.  
  17. Hepburn AL, Lampert IA, Boyle JJ, Horncastle D, Ng WF, Layton M, Vyse TJ, Botto M, Mason JC. In vivo evidence for apoptosis in the bone marrow in systemic lupus erythematosus. Ann Rheum Dis. 2007;66(8):1106-9.  
  18. Ng WF, Naughton M. Fluoroquinolone-associated tendinopathy: a case report. J Med Case Reports. 2007 Jul 23;1:55.  
  19. Ng WF, Fantin F, Ng C, Dockery F, Schiff R, Davies KA, Rajkumar C, Mason JC. Takayasu's arteritis: a cause of prolonged arterial stiffness. Rheumatology. 2006;45(6):741-5.  
  20. Bonnefoix T, Bonnefoix P, Perron P, Mi JQ, Ng WF, Lechler R, Bensa JC, Cahn JY, Leroux D. Quantitating effector and regulatory T lymphocytes in immune responses by limiting dilution analysis modeling. J Immunol. 2005;174(6):3421-31.  
  21. Ng WF; Schiff R; Dockery F; Davies KA; Rajkumar C; Mason JC. Takayasu's arteritis is associated with reduced aortic compliance Ann Rheum Dis. 2005;64: 261-261.  
  22. Ng WF, Cohen P, Hepburn A, Hamdulay S, Carpani M & Mason JC. A case of eosinophilic enteritis and rheumatoid arthritis. Rheumatology (Oxford). 2005 Dec; 44(12):1585-6.  
  23. Camara NO, Ng WF, Hernandez-Fuentes MP, Eren E & Lechler RI. Human CD4(+)CD25(+) T cells regulate CD8(+) T-cell activation. Transplant Proc. 2002 Nov; 34(7):2858-60.  
  24. Schneider H, Mandelbrot DA, Greenwald RJ, Ng F, Lechler R, Sharpe AH, Rudd CE. Cutting edge: CTLA-4 (CD152) differentially regulates mitogen-activated protein kinases (extracellular signal-regulated kinase and c-Jun N-terminal kinase) in CD4+ T cells from receptor/ligand-deficient mice. J Immunol. 2002;169(7):3475-9. 
  25. Ng WF, Hernandez-Fuentes M, Baker R, Chaudhry A, Lechler RI. Reversibility with interleukin-2 suggests that T cell anergy contributes to donor-specific hyporesponsiveness in renal transplant patients. J Am Soc Nephrol. 2002;13(12):2983-9.  
  26. Ng WF, Duggan PJ, Ponchel F, Matarese G, Lombardi G, Edwards AD, Isaacs JD, Lechler RI. Human CD4(+)CD25(+) cells: a naturally occurring population of regulatory T cells. Blood. 2001 Nov 1;98(9):2736-44.  
  27. Ng WF, Baker RJ, Hernandez-Fuentes M, Chaudhry A, Lechler RI. The role of T-cell anergy in the maintenance of donor-specific hyporesponsiveness in renal transplant recipients. Transplant Proc. 2001 Feb-Mar;33(1-2):154-5.  
  28. Ng WF, Hernandez-Fuentes M & Lombardi G. Predictive value of in vitro assessment of direct alloresponses in transplant recipients. Transplantation. 2001;72(5):772-3.  
  29. Lechler RI, Ng WF & Camara NO. Infectious tolerance? Mechanisms and implications. Transplantation. 2001 Oct 27; 72(8 Suppl):S29-31.  
  30. Lechler R, Ng WF, Steinman RM. Dendritic cells in transplantation--friend or foe? Immunity. 2001 Apr;14(4):357-68.