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Biography
Edward Lee Nelson
Dr. Edward Lee Nelson

Division of Hematology/Oncology, Medical Center

University of California, USA

Associate Professor

Email: enelson@uci.edu

Qualifications

1986 Ph.D., Medicine, Oregon Health Sciences University


Publications (Selected)

  1. Zhou C., Tabb M.M., Sadatrafiei1 A., Lin M., Nelson E.L., Forman B.M., and Blumberg B.Mutual repression between SXR and NF-kB signaling pathways mediates inflammation and xenobiotic metabolism. J Clin Invest. 2006 Aug;116(8):2280-2289. PMID: 16841097
  2. Nishimoto K.P., Laust A, Wang K, Van C., Kamrud K.I., Fralish B., Smith J.F., Nelson E.L. Restricted and selective tropism of a Venezuelan equine encephalitis virus-derived replicon vector for human dendritic cells. 2007 Viral Immunol 20, 88-104. PMID: 17425424
  3. Laust A.K., Wang K., Sur B.W.R., Hubby B., Smith J.F., Nelson E.L. VRP immunotherapy targeting neu: treatment efficacy and evidence for immunoediting in a stringent rat mammary tumor model. Breast Cancer Res Treat, Mar 10, 2007, doi:10.1007/s10549-007-9517-8, Dec 2007, 106 (3):371-82. PMID: 17351745
  4. Nishimoto K.P., Newkirk D, Hou S, Fruehauf J, Nelson E.L. Fluorescence Activated Cell Sorting (FACS) Using RNALater to Minimize RNA Degradation and Perturbation of mRNA Expression from Cells Involved in Initial Host Microbe Interactions. Journal ofMicrobiological Methods Ap 2007, doi:10.1016/j.mimet.2007.03.022. PMID: 17512621
  5. Moore J.C., Zhao X. Nelson E.L. A Case Report of a 33 Year Old Female with Concomitant Sinus Histiocytosis with Massive Lymphadenopathy (Rosai-Dorfman Disease) and Diffuse Large B-Cell Lymphoma. Journal of Medical Case Reports 2008, 2:70 (05 Mar 2008), http://www.jmedicalcasereports.com/content/2/1/70 PMID: 18321383
  6. Entringer S, Wüst S, Kumsta R, Layes I, Nelson EL, Hellhammer DH, and Wadhwa PD. Prenatal Stress Associated with Insulin Resistance in Young Adults. Am J Obstet Gynecol. March 6, 2008, doi: 10.1016/j.ajog.2008.03.006. PMID: 18448080
  7. Nelson E.L, Wenzel LB, Osann K, Dogan Ates A, Chantana N, Reina-Patton A, Laust AK, Nishimoto KP, Chicz-DeMet A, du Pont N, Monk BJ. Stress, Immunity, and Cervical Cancer: Biobehavioral Outcomes of a Randomized Clinical Trial. Clin Cancer Res. April 1, 2008;14(7):2111-18. PMID: 18381952
  8. Sur B.W.R., Nguyen P., Sun C.H., Tromberg B. J., Nelson E.L. Immunophototherapy, Combined Photodynamic Therapy and Intratumoral Administration of Dendritic Cells: Evidence for Retention of Dendritic Cell Functional Status and Improved Survival in Rats with Orthotopic Mammary Tumors. Photochemistry & Photobiology April 23, 2008 doi: 10.1111/j.1751-1097.2008.00356.x. PMID: 18435703
  9. Gunn N. M., Li G. P., Nelson E.L., Bachman M. Micropallet Technology for Investigating Tumor Cellular Profiles and Analysis of Rare Cell Subsets. Proceedings of BioMed2008, 3rd Frontiers in Biomedical Devices Conference, June 18-20, 2008, Irvine, California, USA.
  10. . Entringer S, Kumsta R, Nelson EL, Hellhammer DH, Wadhwa PD, and Wüst S. Influence of Prenatal Psychosocial Stress on Cytokine Production in Adult Women. Dev Psychobiol. 2008 Aug 5;50(6):579-587. PMID: 18683180
  11. Nishimoto K.P., Laust A.K., Nelson E.L. A Human Dendritic Cell Subset Receptive to the Venezuelan Equine Encephalitis Virus-Derived Replicon Particle Constitutively Expresses IL-32. Journal of Immunology, Sept 15 2008, 181: 4010–4018. PMID: 18768856
  12. Fraser D.A., Laust A.K., Nelson E.L., and Tenner A.J.. C1q differentially modulates phagocytosis and cytokine responses during ingestion of apoptotic cells by human monocytes, macrophages, and dendritic cells. J Immunol. 2009 Nov 15;183(10):6175-85. Epub 2009 Oct 28. PMID: 19864605
  13. Gunn N.M., MS; Bachman M., Li G.P., Nelson E.L. Fabrication and biological evaluation of uniform extracellular matrix coatings on discontinuous photolithography generated micropallet arrays. J Biomed Mater Res A. 2010 Nov;95(2):401-12. PMID: 20648537
  14. Nawarathna, D., Chang R., Nelson E. and Wickramasinghe H. Kumar. Targeted mRNA Profiling of Transfected Breast Cancer Gene in a Living Cell. Anal Biochem. 2010 Aug 17. doi:10.1016/j.ab.2010.08.014 PMID: 20723536
  15. Gunn NM, Chang R, Westerhof T, Li G.P., Mark Bachman M., Nelson E.L. Ferromagnetic Micropallets for Magnetic Capture of Single Adherent Cells. Langmuir 10/2010 doi:10.1021/la101960v. PMID: 20968293
  16. Denney J.M., Nelson E., Waters T.M., Wadhwa P., Mathew L., Goldenberg R.L. Culhane J.F. Longitudinal Modulation of Immune System Cytokine Profile During Pregnancy. Cytokine 11/2010 doi:10.1016/j.cyto.2010.11.005 PMID: 21123081
  17. Osann K., Wenzel L.B., Dogan Ates A., Hsieh S., Chase D.M., Monk B.J., Nelson E.L, Recruitment and Retention Results for a Population-based Cervical Cancer Biobehavioral Clinical Trial. Gynecologic Oncology 121 (2011), pp. 558-564. DOI:10.1016/j.ygyno.2011.02.007, June 1, 2011; 121(3):558-64. PMID: 21402400
  18. Casey S.C., Nelson E.L., Janes M.R., Fruman D.A., and Blumberg B. B-1 Cell Lymphoma and Leukemia in Mice Lacking the Steroid and Xenobiotic Receptor, SXR. Mol Endocrinol. 2011 Jun;25(6):933-43. Epub 2011 Mar 24. PMID: 21436254
  19. Mkrtichyan M., Ghochikyan A., Davtyan H., Movsesyan N., Loukinov D., Lobanenkov V., Cribbs D.H., Laust A.K., Nelson E.L. and Agadjanyan M.G. Cancer-testis antigen, BORIS based vaccine delivered by dendritic cells is extremely effective against a very aggressive and highly metastatic mouse mammary carcinoma. Cell Immunol. 2011 May 12. PMID: 21641588
  20. N. M. Gunn, T. Westerhof, G.P. Li, E. L. Nelson and M. Bachman. Glass Micropallets for adherent cell analysis and recovery. MicroTAS 2011 October 2-6, 2011, Seattle Washington
  21. Biegler K.A., Wenzel L.B., Osann K., Nelson E.L, Longitudinal Change in Telomere Length Associated with Decreased Chronic Stress Response and Shift in Immunologic Stance in Cervical Cancer Survivors. Submitted May 2011, Brain Behavior & Immunology.
  22. Martinez M, Ono N, Planutiene M, Planutis K, Nelson E.L., Holcombe R.F. Granulocytemacrophage stimulating factor (GM-CSF) increased circulating dendritic cells but does not abrogate suppression of adaptive cellular immunity in patients with metastatic colorectal cancer receiving chemotherapy. Submitted Cancer Immunology Immunotherapy July 2011