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Biography
Michel Goldberg

Prof. Michel Goldberg

Faculty of Dental Medicine

University René Descartes, France


Email: michel.goldberg@parisdescartes.fr


Qualifications


2000  HUHSDM, Endodontics graduate program

1985  HUHSDM, Dental Medicine

1982  HUHSDM, Basic Medical sciences


Publications (Selected)

  1. S. Opsahl, D. Septier, I. Aubin, J-L. Guenet, T. Sreenath, A. Kulkarni, L. Vermelin, M. Goldberg. (2005) Is the lingual forming part of the incisor a structural entity? Evidences from the fragilitas ossium (fro/fro) mouse mutation and the TGFb1 over-expressing transgenic strain Archs Oral Biol 50: 279-286.
  2. F. Priam, V. Ronco, M. Locker, K. Bourd, M. Bonnefoix, T. Duchêne, J. Bitard, T. Wurtz, O. Kellermann , M. Goldberg, A. Poliard (2005) New cellular models for tracking the odontoblast phenotype Arch Oral Biol 50: 271-277.
  3. Bourd-Boittin K, Fridman R, Fanchon S, Septier D, Goldberg M, Menashi S. (2005) Matrix metalloproteinase inhibition impairs processing formation and mineralization of dental tissues during mouse molar development. Experimental Cell Research 304: 493-505.
  4. Lefeuvre M, Amjaad W, Goldberg M, Stanislawski L. (2005) TEGDMA induces mitochondrial damage and oxidative stress in human gingival fibroblasts. Biomaterials 26; 5130-5137.
  5. Aubin I, Adams CP, Opsahl S, Septier D, Bishop CE, Auge N, Salvayre R, Negre-Salvayre A, Goldberg M, Guenet JL, Poirier C. (2005) A deletion in the gene encoding sphingomyelin phosphodiesterase 3 (Smpd 3) results in osteogenesis and dentinogenesis imperfecta in the mouse. Nature Genetics 37: 803-805.
  6. Goldberg M., Septier D., Rapoport O., Iozzo R.V., Young M.F., Ameye LG.(2005)Targeted disruption of two small leucine-rich proteoglycans, biglycan and decorin, excerpts divergent effects on enamel and dentin formation. Calcif. Tissue Int 77: 297-310.
  7. GoldbergM, Septier D, Oldberg A, YoungMF, AmeyeLG (2006) Fibromodulin-deficient mice display impaired collagen fibrillogenesis in predentin as well as altered dentin mineralization and enamel formation J Histochem Cytochem 54: 525-537.
  8. Goldberg M, Septier D, Limaye A, SreenathT, Kulkarni A.B. (2005) Dentin and enamel phenotype in Fabry mice. Oral Biosciences & Medicine 2 : 265-271.
  9. Goldberg M, Lacerda-Pinheiro S, Chardin H, Jegat N, Septier D, Bonnefoix M, Tompkin K, Veis A. (2004) Implantation of Two Low Molecular Weight Amelogenins (A+4 and A-4) in the Pulp of Rat’s Maxillary Molars and in an Oral Mucosa Ectopic Site. Proceedings of the 8th International Conference on the Chemistry and Biology of Mineralized Tissues. W. Landis & J Sodek (co-chairs), pp 115-117.
  10. Moradian-OldakJ , GoldbergM.  (2006) Amelogenin Supra-Molecular Assembly In Vitro Compared to the Architecture of the Forming Enamel Matrix Cell Tissue Organ 181 : 202-218.
  11. M. Goldberg, S. Lacerda–Pinheiro, N. Jegat, N. Six , D. Septier, F. Priam, M. Bonnefoix, K. Tompkins, H. Chardin, P. Denbesten, A. Veis, A. Poliard. (2006) The impact of bioactive molecules to stimulate tooth repair and regeneration as part of restorative dentistry. Dental Clinics of North America – (Special Issue on Tissue Engineering) 50 : 277-298.
  12. Bartlett JD, Ganss B, Goldberg M, Moradian-Oldak J, Paine ML, Snead ML, Wen X, White SN, Zhou YL Protein-protein interactions of developing enamel matrix. Chap. 3 In “Current topics in developmental biology”. Vol 74, Elsevier 2006, pp 57-115.
  13. Chaussain-MillerC, FiorettiF, GoldbergM, Menashi S. (2006) The role of matrix metalloproteinases (MMPs) in human caries Crit Rev Oral Biol Med 85: 22-32.
  14. Lacerda-PinheiroS, JegatN, SeptierD, PriamF, Bonnefoix M, Bitard J, KellermannO, TompkinsK, VeisA, GoldbergM, Poliard A. (2006) Early in vivo and in vitro effects of amelogenin gene splice products on pulp cells Eur J Oral Sciences 114 (suppl 1) 232-238
  15. Haruyama N, Thyagarajan T, Skobe Z, Wright JT, Septier D, Sreenath TL, Goldberg M, Kulkarni AB (2006) Overexpression of transforming growth factor-b1 in teeth results in detachment of ameloblasts and enamel defects. Eur J Oral Sci 114 (suppl 1) 30-34.
  16. Lacerda-Pinheiro S, Septier D, Tompkins K, Veis A, Goldberg M, Chardin H Amelogenin gene splice products A+4 and A-4 implanted in soft tissue determine the reorientation of CD45-positive cells to an osteo-chondrogenic lineage J Biomat Med Res 2006 ; 79 : 1015-22.
  17. Boskey AL, Goldberg M, Kulkarni A, Gomez S (2006) Infrared imaging microscopy of bone : illustrations from a mouse model of Fabry disease. Biochim Biophys Acta 1758 : 942-947.
  18. Priam F, Lacerda S, Bonnefoix M, Veis A, Goldberg M, Poliard A The Phenotype of Immortalized Odontoblast Progenitors. Adv Dent Res (in press)
  19. BoukpessiT, SeptierD, BaggaS, GarabedianM, Goldberg M, Chaussain-MillerC (2006) Dentin alteration of deciduous teeth in human hypophosphatemic ricketsCalcif Tissue Int79 : 294-300.
  20. Chaussain-Miller C, SindingC, Septier D, Wolikow M, Goldberg M, Garabedian M. (2007) Dentin Structure in Familial Hypophosphatemic Rickets: Benefits of Vitamin D and Phosphate treatment Oral Diseases 13 : 482-489.
  21. Shapiro JL, Wen X, Okamoto CT, Wang HJ, Lyngstadaas SP, Goldberg M, Snead ML, Paine ML. (2007) Cellular uptake of amelogenin, and its localization to CD63, and Lamp1-positive vesicles Cellular Molecular Life Sciences 64 : 244-256.
  22. SixN, SeptierD, Chaussain-MillerC, Blacher R, DenBesten P, GoldbergM. Dentonin, a MEPE fragment, initiates pulp healing response to injury J Dent Res 2007; 86: 780-785.
  23. JegatN, SeptierD, VeisA, PoliardA , GoldbergM. Short-term effects of amelogenin gene splice products A+4 and A-4 implanted in the exposed rat molar pulp. Head & Face Medicine 2007 ; 30, 40
  24. Goldberg M In vitro and in vivo studies on the toxicity of dental resin components:a review. Clinical Oral Investigation 2008 ; 12 : 1-8.
  25. Goldberg M, Lacerda-Pinheiro S, Priam F, Jegat N, Six N, Bonnefoix M, Septier D, Chaussain-Miller C, Veis A, Denbesten P, Poliard A. Matricellular molecules and odontoblast progenitors as tools for dentin repair and regeneration. Clinical Oral Investigation 2008 ;12 : 109-112.
  26. GoldbergM, Ono M, Septier D, Bonnefoix M, Kilts TM, Bi Y, Embree M, Ameye L, Young MF. Fibromodulin-deficient mice reveal dual functions for fibromodulin in regulating dental tissue and alveolar bone formation. Cells Tissues Organs (DOI/ 10.1159/000151370)
  27. Lacerda-PinheiroS, MarchadierA, DonãsP, SeptierD, Benhamou L , KellermannO, GoldbergM, PoliardA. An in vivo model for short-term evaluation of the implantation effects of biomolecules or stem cells in the dental pulp Open Dent Journal 2008 ; 2 :67-72.
  28. GaucherC , BoukpessiT, SeptierD, Jehan F, RowePS, GarabédianM, GoldbergM, Chaussain-MillerC. Dentin non-collagenous matrix proteins in familial hypophosphatemic rickets.Cells Tissues Organs (DOI : 10.1159/000151382).
  29. Goldberg M, Farges J-C, Lacerda-Pinheiro S, Six N, Jegat N, Decup F, Septier D, Carrouel F, Durand S, Chaussain-Miller C, DenBesten P, Veis A, Poliard A. Inflammatory and immunological aspects of dental pulp repair Pharmacological Research 2008 ; 58 : 137-147.
  30. Wen X, Zou YM, Luo W, Goldberg M, Moats R, Conti PS, Snead ML, Paine ML. Biglycan overexpression on tooth enamel formation in transgenic mice. Anat Rec 2008 ; 291: 1246-1253.
  31. Boukpessi T, Menashi S , Camoin L,  TenCate JM, Goldberg M, Chaussain-Miller C The effects of stromelysin-1 (MMP-3) on non-collagenous extracellular matrix proteins of demineralized dentin and the adhesive properties of restorative resins. Biomaterials (doi : 10.1016/j.biomaterials.2008.07.035).
  32. GoldbergM, SixN, Chaussain C, DenBestenP, VeisA, PoliardA.Dentin extracellular matrix molecules implanted into exposed pulps generate reparative dentin: a novel strategy in regenerative dentistry. J Dent Res 2009 ; 88 : 396-399.
  33. SuzukiS, SreenathT, HaruyamaN, HoneycuttC, Terse A, Cho A, Kohler T, Müller R, Goldberg M, and. KulkarniAB. Dentin sialoprotein and dentin phosphoprotein have distinct roles in dentin mineralization Matrix Biol doi: 10.1016/j.matbio.2009.03.006
  34. Goldberg M. Enamel, dentin and cementum : structure and composition- potential consequences of resorative materials on the dental pulp and gingival margin. In « Biocompatibility or cytotoxic effects of dental composites » Goldberg M. editor. Oxford, COXMOOR PUBLISHING Company 2009, pp 53- 71.
  35. Goldberg M. Short-term release of free monomers and long-term degradation of resin-based materials. In « Biocompatibility or cytotoxic effects of dental composites » Goldberg M. editor. Oxford, COXMOOR PUBLISHING Company 2009, pp 75-79.
  36. Goldberg M . Repair or regeneration, a short review. In « Biocompatibility or cytotoxic effects of dental composites » Goldberg M. editor. Oxford, COXMOOR PUBLISHING Company 2009, pp 181-184.
  37. Boukpessi T, Septier D, Goldberg M. Animal studies. In « Biocompatibility or cytotoxic effects of dental composites » Goldberg M. editor. Oxford, COXMOOR PUBLISHING Company 2009, pp 200-203.
  38. Goldberg M, Grootveld M, Lynch E. Undesirable and adverse effects of Tooth Whitening Products - a review. Clinical Oral Investigation 2010 ;14 : 1-10.
  39. Li W, Sire J-Y, Takano Y, MacDougall M, Goldberg M, DenBesten P. Amelogenin exon 8 and 9. In  « Amelogenins : multifaceted proteins for dental and bone formation and repair. M. Goldberg ed Bentham 2010, pp 163 - 173
  40. Harichane Y, Dimitrova-Nakov S, Poliard A, Veis A, DenBesten P, Kellermann, Goldberg M. In vivo effects of amelogenins on reparative dentin formation. In  « Amelogenins : multifaceted proteins for dental and bone formation and repair. M. Goldberg ed. Bentham 2010, pp 174- 190.
  41. GoldbergM, KulkarniAB, YoungM, BoskeyA.Dentin: Structure, Composition and ineralization.- The role of dentin ECM in dentin formation and mineralization. Front BioSci (Elite Ed). 2011 Jan 1;3:711-735.
  42. Goldberg M, Schmalz G. Editorial : Toward a strategic plan for pulp healing: from repair to regeneration. Clinical Oral Investigation 2011; 15:1-2.
  43. Goldberg M.Pulp Healing and Regeneration: More Questions Than Answers. Advances in Dental Research/J Dent Res 2011, accepted for publication.
  44. GoldbergM, MarchadierA, VidalC, HarrichaneY, Kamoun-GoldratA, KellermannO, KiltsT, YoungM. Differential effects of fibromodulin deficiency on mouse mandibular bones and teeth - a microCT time course study. Cells, Tissues, Organs, accepted for publication.
  45. Harichane Y, Hirata A, Dimitrova-Nakov S, Granja I, Goldberg M, Kellermann O, Poliard A. Pulpal progenitors and dentin repair. Advances in Dental Research/Journal Dental Research, accepted for publication.