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Biography
Dr. Alexander A. Konstantinov

Dr. Alexander A. Konstantinov

Moscow State University, Russia


E-mail: konst@genebee.msu.su


Qualifications


1987  Doctor of Biological Sciences (the highest scientific degree in Russia; approx. equivalent to British “Doctor of Sciences”); speciality, Biochemistry and Biophysics

1985  PhD in Biochemistry, Moscow State University

1972  BS/MS summa cum laude in Biochemistry, School of Biology, Moscow State University


Publications (Selected)

  1. Arutjunjan,A.M., Konstantinov,A.A. and Sharonov,Yu.A. Magnetic circular dichroism and magnetooptical rotatory dispersion of submitochondrial particles at room and liquid nitrogen temperatures. (1974) FEBS Lett. 46, 317-320.
  2. Konstantinov,A.A. On the mechanism of H+-electrochemical potential generation in the first two sites of the respiratory chain. (1975) Dokl.Akad.Nauk SSSR 220, 736-739 (in Russian).
  3. Konstantinov,A.A., Maslov,S.P., Severina,I.I. and Skulachev,V.P. Protamine as a specific inhibitor of electron transfer from cytochrome c to cytochrome a at the outer face of the mitochondrial membrane (1975) Biokhimiya 40, 401-407 (in Russian).
  4. Kamensky,Yu.A., Konstantinov,A.A. and Jasaitis,A.A. Studies on cytochromes b in beef heart submitochondrial particles in the presence of the succinate/fumarate redox buffer (1975) Biokhimiya 40, 1022-1031 (in Russian).
  5. Kiselev,A.V. and Konstantinov,A.A. Studies on the nature of redox equivalents transferred by cytochrome c and localization of this respiratory chain component at the outer face of the mitochondrial membrane. (1976) Bioorg.Chem.(USSR) 2, 253-258 (in Russian).
  6. Artzatbanov,V.Yu., Konstantinov,A.A. and Skulachev,V.P. Localization of cytochrome a at the inner side of the mitochondrial coupling membrane.(1976) Dokl.Akad.Nauk SSSR, 228, 1222-1225 (in Russian).
  7. Ruuge,E.K. and Konstantinov,A.A. EPR signal of Q semiquinone with unusual relaxation characteristics. (1976) Biofizika 21, 586-588 (in Russian).
  8. Peskin,A.V., Zbarsky,I.B. and Konstantinov,A.A. Studies on superoxide dismutase activity in tumour tissues. (1976) Dokl.Akad.Nauk SSSR 220, 751-754 (in Russian).
  9. Tikhonov,A.N., Burbaev,D.Sh., Grigolava,I.V., Konstantinov,A.A., Ksenzenko,M.Yu. and Ruuge,E.K. Interaction of ubisemiquinone with the high-potential iron-sulfur centre of succinate dehydrogenase of submitochondrial particles. EPR study at 240 and 12 K. (1977) Biofizika 22, 734-736 (in Russian).
  10. Konstantinov,A.A. and Ruuge,E.K. ESR studies on the coenzyme Q semiquinone in submitochondrial particles from beef heart (1977) Bioorg.Chem. (USSR) 3, 787-799 (in Russian).
  11. Peskin,A.V., Koen,Ya.M., Zbarsky,I.B. and Konstantinov,A.A. Superoxide dismutase and glutathione peroxidase activities in tumors. (1977) FEBS Lett. 78, 41-45.
  12. Grigolava,I.V. and Konstantinov,A.A. Components of coupling site II accesible to p-diazobenzenesulfonate from the outside of mitochondria. (1977) FEBS Lett. 78, 36-40.
  13. Konstantinov,A.A. and Ruuge,E.K. Semiquinone Q in the respiratory chain of electron transfer particles. (1977) FEBS Lett. 81, 137-141.
  14. Artzatbanov,V.Yu., Konstantinov,A.A.and Skulachev,V.P. Studies on cytochrome oxidase localization in the coupling membrane: interaction of cytochrome a with H+-ions from mitochondrial matrix.(1977) Dokl.Akad.Nauk SSSR 237, 461-464 (in Russian).
  15. Konstantinov,A.A. Role of protons in the mitochondrial respiratory chain coupling site 3 mechanism: cytochrome oxidase as an electron-proton generator of membrane potential. (1977) Dokl.Akad.Nauk USSR 237, 713-716 (in Russian).
  16. Subchinsky,V.K., Konstantinov,A.A. and Ruuge,E.K. Studies on the spin probes interaction with the submitochondrial particle membrane (1978) Biofizika 23, 57-60 (in Russian).
  17. Smirnova,I.A., Konstantinov,A.A. and Skulachev,V.P. Direct measurement of membrane potential generation by submitochondrial particles (1978) Dokl.Akad.Nauk SSSR 241, 970-973 (in Russian).
  18. Artzatbanov,V.Yu., Konstantinov,A.A. and Skulachev,V.P. Involvement of intramitochondrial protons in redox reactions of cytochrome a.(1978). FEBS Lett.87, 180-185.
  19. Arutjunjan,A.M., Kamensky,Yu.A., Milgrom,E., Surkov,S., Konstantinov,A.A. and Sharonov,Yu.A. Is mitochondrial cytochrome b-566/558 a single hemoprotein or two individual components? A magnetic circular dichroism study.(1978) FEBS Lett.95, 40-44.
  20. Koen,Ya.M., Peskin,A.V., Baru,V.A., Fedorchenko,V.V., Zbarsky,I.B. and Konstantinov,A.A. Transport of RNA from rat liver cell nuclei in vitro. Effect of superoxide dismutase on the release of rapidly labeled RNA from isolated nuclei (1978) Biokhimiya 43, 2124-2129 (in Russian).
  21. Grigolava,I,V. and Konstantinov,A.A. Localization of cytochrome b-566 at the outer side of the coupling mitochondrial membrane. (1979) Biokhimiya 44, 1329-1332 (in Russian).
  22. Andreev,I.M, Artzatbanov,V.Yu.,Konstantinov,A.A. and Skulachev,V.P. Cyanide binding with ferricytochrome a in rat liver mitochondria. (1979) Dokl.Akad.Nauk SSSR 244, 1013-1017 (in Russian).
  23. Kamensky Yu.A., Artzatbanov, V.Yu., Shevchenko,D.V. and Konstantinov,A.A. Effect of antimycin on the redox-linked protonation of cytochromes b in the mitochondrial respiratory chain. (1979) Dokl.Akad.Nauk SSSR 249, 994-997 (in Russian).
  24. Smirnova,I.A., Tikhonov,A.N., Konstantinov, A.A. and Ruuge,E.K. On the free radical centres in chromatophores and reaction centre preparations from Rhodospirillum rubrum . (1979) Biofizika 24, 761-762 (in Russian).
  25. Surkov,S.A. and Konstantinov,A.A. Dibromothymoquinone interaction with the mitochondrial respiratory chain. Further evidence for the Q-cycle. (1980) FEBS Lett. 109, 283-288.
  26. Konstantinov,A.A., Skulachev,V.P. and Smirnova,I.A. Membrane potential generation by submitochondrial particles associated with a lipid-impregnated filter. (1980) FEBS Lett. 114, 302-306.
  27. Peskin,A.V., Zbarsky,I.B. and Konstantinov,A.A. A novel type of superoxide generating system in nuclear membranes from Hepatoma 22a ascites cells. (1980) FEBS Lett. 17, 44-48.
  28. Konstantinov,A.A., Kamensky,Yu.A., Ksenzenko,M.Yu. and Surkov,S. Studies on the Q-cycle in the mitochondrial respiratory chain. (1980) EBEC Reports, v.1, 63-64.
  29. Artzatbanov,V.Yu. and Konstantinov,A.A. Effect of antimycin on the Em/pH-dependence of b cytochromes in beef heart submitochondrial particles. (1980) EBEC Reports, v.1, 73-74.
  30. Grigolava,I.V., Ksenzenko,M.Yu., Konstantinov,A.A., Tikhonov,A.N., Kerimov,T.M. and Ruuge,E.K. Tiron as a spin-trap for superoxide radicals generated by the respiratory chain of submitochondrial particles. (1980) Biokhimiya 45, 75-81 (in Russian).
  31. Ksenzenko,M.Yu.and Konstantinov,A.A. Effect of 2,3-dimercaptopropanol on electron transfer in the coupling site 2 of the respiratory chain: evidence for the Q-cycle. (1980) Biokhimiya 45, 343-354 (in Russian).
  32. Peskin,A.V., Zbarsky, I.B.and Konstantinov,A.A. Studies on the electron transfer systems in the microsomal and nuclear membranes from rat liver and Hepatoma 22a. (1981) Biokhimiya 46, 579-589 (in Russian).
  33. Smirnova,I.A., Konstantinov,A.A. and Skulachev,V.P. The role of cofactors in membrane potential generation by Rhodospirillun rubrum chromatophores incorporated into a teflon filter. (1981) Biokhimiya 46, 1155-1166 (in Russian).
  34. Konstantinov,A.A., Kunz,W.S. and Kamensky,Yu.A. The Q cycle in the mitochondrial respiratory chain. (1981) In:"Chemiosmotic Proton Circuits in Biological Membranes" (Skulachev,V.P. and Hinkle,P.C., eds.) pp.123-146, Addison-Wesley, Reading.
  35. Kunz,W.S., Ksenzenko,M.Yu. and Konstantinov,A.A. Different effects of antimycin, HOQNO and mucidin on electron transfer in bc -site of the mitochondrial respiratory chain. (1982) EBEC Reports, v.2, 381-382.
  36. Konstantinov,A.A., Kaminskaya,O.P. and Grigoriev,V.A. Photochemical injection of protons into ice (1982) Dokl.Akad.Nauk SSSR 264, 488-490 (In Russian).
  37. Ksenzenko,M.Yu., Konstantinov,A.A.,Tikhonov,A.N. and Ruuge,E.K. Inhibition of H2O2 and O2- generation in the respiratory chain treated by 2,3-dimercaptopropanol. (1982) Biokhimiya 47, 1570-1572 (in Russian).
  38. Grigolava,I.V., Konstantinov,A.A., Ksenzenko,M.Yu., Tikhonov,A.N. and Ruuge,E.K. Interaction of ubisemiquinone with succinate dehydrogenase and the cytochrome chain of mitochondria. (1982) Biokhimiya 47, 1970-1982 (in Russian).
  39. Artzatbanov,V.Yu., Grigoriev,V.A. and Konstantinov,A.A. Redox-dependent protonation of cytochrome oxidase hemes in beef heart submitochondrial particles. (1983) Biokhimiya 48, 48-53 (in Russian).
  40. Andreev,I.M., Myakotina,O.L., Popova,E.Yu. and Konstantinov,A.A. Acceleration of cyanide binding with cytochrome c oxidase by cytochrome c.(1983) Biokhimiya 48, 219-223 (in Russian).
  41. Andreev,I.M. and Konstantinov,A.A. Reaction of the oxidized cytochrome oxidase with cyanide. Effects of pH, cytochrome c and membrane environment. (1983) Bioorg.Chem. (Moscow) 9, 216-227 (in Russian).
  42. Kunz,W.S. and Konstantinov,A.A. Energy-linked spectral shift of ferrocytochrome b in beef heart submitochondrial particles. (1983) FEBS Lett. 152, 53-56.
  43. Ksenzenko,M.Yu., Konstantinov,A.A., Khomutov,G.B., Tikhonov,A.N. and Ruuge,E.K. Effect of electron transfer inhibitors on superoxide generation in the cytochrome bc1 site of the mitochondrial respiratory chain. (1983) FEBS Lett. 155, 19-24.
  44. Kunz,W.S. and Konstantinov,A.A. Effect of bc1 -site inhibitors on the midpoint potentials of mitochondrial cytochromes b. (1983) FEBS Lett. 155, 237-240.
  45. Kunz,W.S., Kushnarenko,S.V. and Konstantinov,A.A. Differences in the effects of antimycin and 2-nonyl-4-hydroxyquinoline-N-oxide on the oxidation-reduction of mitocondrial cytochromes b. (1983) Biokhimiya 48, 1456-1462 (in Russian).
  46. Tkachenko,T.A., Kunz,W.S. and Konstantinov,A.A. Localization of the interaction site of the oxidized form of N,N,N’,N’-tetramethyl-p-phenylene diamine (Wurster’s Blue) with bc1 site of the mitochondrial respiratory chain. (1983) Dokl.Akad.Nauk SSSR 273, 242-245 (in Russian).
  47. Kunz,W.S., Konstantinov,A.A. Cytochrome b reduction in mitochondria and submitochondrial particles. Evidence for heme b-562 localisation at the M-side of the mitochondrial membrane. (1984) FEBS Lett. 175, 100-104.
  48. Peskin,A.V., Zbarsky,I.B. and Konstantinov,A.A. Superoxide dismutase-sensitive NADP(H) dependent reduction of oxygen by the membrane-bound redox chains of liver microsomes and Hepatoma nuclei in the presence of adrenaline. (1984) Biochem.Internat. 8, 733-738.
  49. Kunz,W.S., Konstantinov,A.A., Tsofina,L. and Liberman,E,A. Localization of a ferricyanide-reactive site of cytochrome bc1 complex, possibly of cytochrome b or ubisemiquinone,at the outer face of submitochondrial particles. (1984) FEBS Lett. 172, 261-266.
  50. Peskin,A.V., Zbarsky,I.B. and Konstantinov,A.A. HAD(P)H-dependent oxidation of adrenaline by nuclear membranes from Hepatoma 22a. (1984) Biol.Membr.(Moscow) 1, 721-727 (in Russian).