Dr. Nicholas R. Forsyth

Institute for Science & Technology in Medicine

Keele University Medical School,UK



2002 Ph.D., Beatson Institute for Cancer Research, UK

1994 B.Sc., Molecular Biology Upper Second Class, Glasgow University, Glasgow

Publications (Selected)

  1. Kay A., Richardson J.B., Forsyth N.R. Physiological normoxia suppresses dedifferentiation and promotes chondrogenic potential of human articular chondrocytes. Manuscript accepted. Frontiers in Bioscience.
  2. Khondoker A, Kumar D, Mohan P, Forsyth NR. Stem cell-based therapy for the older patient. Invited review. Aging Health.
  3. Pijanka JK, Kumar D, Yousef I, Parkes G, Untereiner V, Yang Y, Dumas D, Collins C, Sockalingum GD, Forsyth NR, and Sulé-Suso J. Vibrational spectroscopy differentiates between multipotent and pluripotent stem cells. Analyst. In Press
  4. Wimpenny I, Hampson K, Yang Y, Ashammakhi N, Forsyth NR. One step recovery of marrow stromal cells on nanofibers. Tissue Engineering. 2009 Aug 17. [Epub ahead of print]
  5. Forsyth NR*, et al Transcriptome alterations due to physiological normoxic (2% O2) culture of human embryonic stem cells. Regenerative Medicine (2008). Nov;3(6):817-33.* indicates communicating author.
  6. Bullough R*, Finnigan T*, Kay A, Maffulli N, Forsyth NR. Tendon Repair through Stem Cell Intervention: Cellular and Molecular Approaches. Disability and Rehabilitation. 2008 Jul 5:1-6.* indicates equal author contribution.
  7. Rahman R, Forsyth NR, & Cui W. Telomeric 3 '-overhang length is associated with the size of telomeres. Experimental Gerontology. 2008 April; 43 (4): 258-265.
  8. Tremoleda JL, Forsyth NR, et al Bone tissue formation from Human embryonic stem cells in vivo. Cloning and Stem Cells. 2008 March;10(1): 119-131.
  9. Forsyth N. R* and McWhir J. Human Embryonic Stem Cell Telomere Length Impacts Directly on Clonal Progenitor Isolation Frequency. Rejuvenation Research. 2008 Feb;11(1): 5-17. * indicates communicating author.
  10. Maida Y, Kyo S, Forsyth NR, et al. Distinct telomere length regulation in premalignant cervical and endometrial lesions: implications for the roles of telomeres in uterine carcinogenesis. J Pathol. 2006 Oct;210(2):214-23.
  11. Hewitt Z*, Forsyth NR*, et al Fluorescence-activated single cell sorting of human embryonic stem cells. Cloning Stem Cells. 2006 Fall;8(3):225-34. * indicates equal author contribution.
  12. Forsyth N. R*., et al Low oxygen enhances hESC clonal recovery and reduces chromosomal abnormalities. 2006. Cloning and Stem Cells 2006;8(1):16-23. * indicates communicating author.
  13. Forsyth N. R., et al Lagomorphs do not exhibit telomere-directed aging in vitro. 2005 Jun-Jul;126(6-7):685-91.Mechanisms of Ageing and Development.
  14. Forsyth N. R., et al Spontaneous Immortalization of Clinically normal Colon-derived fibroblasts from a Familial Adenomatous Polyposis (FAP) Patient. 2004 May-Jun;6(3):258-65. Neoplasia
  15. Walter, M., Forsyth, N. R., et al The establishment of telomerase-immortalized tangier disease cell lines indicates the existence of an apolipoprotein A-I-inducible but ABCA1-independent cholesterol efflux pathway. 2004 May 14;279(20):20866-73.. JBC.
  16. 16) Forsyth, N. R., et al Developmental differences in the immortalization of lung fibroblasts by telomerase. Aging Cell 2 (5): 235-243. 2003
  17. Forsyth, N. R., et al Telomerase and differentiation in multicellular organisms: Turn it off, turn it on, and turn it off again. Differentiation 69 (4-5), 188-197. 2002
  18. Bryce, S. D., Morrison, V., Craig, N. J., Forsyth, N. R., et alA Mortality Gene(s) for the Human Adenocarcinoma Line HeLa Maps to a 130kb Region of Human Chromosome 4q22-q23.  Neoplasia 4 (6): 544-550. 2002
  19. Forsyth, N. R., et al Functional evidence for squamous cell carcinoma mortality gene(s) on human chromosome 4. Oncogene 21(33): 5135-47. 2002
  20. Parkinson E. K., Munro J., Steeghs K., Morrison V., Ireland H., Forsyth N. R., Fitzsimmons S. A., Bryce S.D. Replicative Senescence as a Barrier to Human Cancer. Biochemical Society Transactions 28, 226-233, 2000