Dr. Khalequz Zaman,

Dr. Khalequz Zaman

Department of Pediatric Respiratory Medicine, School of Medicine

University of Virginia , USA

Core Director and Assistant Professor




1989 Ph.D., Biochemistry, Department of Biochemistry, Jagiellonian University, Cracow, Poland

1984 M.S., Biochemistry, Department of Biochemistry & Chemistry, Marie Curie University, Poland

1982 B.S., Chemistry, Marie Curie University, Lublin, Poland


Publications (selected)

  1. Zaman, K., Miszta-Lane, H. and Dabrowski, Z. (1991). The effect of aluminum upon the activity of selected bone marrow enzymes in rats. Folia Hematol. (Germany)117: 307 - 318.
  2. Zaman, K., Mukhtar, M., Siddique, H. and Miszta-Lane, H. (1992). The effect of aluminum on stromal cells (in vitro) of bone marrow in rats. Toxicol.Ind.Health (U.S.A.)8: 103 - 109.
  3. Zaman, K., Zaman, W., Dabrowski, Z. and Miszta-Lane, H. (1993). Inhibition ofD aminolevulinic acid dehydratase by aluminum. Comp.Biochem.Physiol. (U.K.)104C: 126 - 133.
  4. Zaman, K., Zaman, W. and Siddique, H. (1993). Hematological and enzymatic results of aluminum intoxication in rats. Comp.Biochem.Physiol. (U.K.)105C: 73 - 76.
  5. Zaman, K., MacGill, R.S., Johnson, J., Ahmad, S. and Pardini, R.S. (1994). An insect model for assessing mercury toxicity: Effects of mercury on antioxidant enzyme activities of theMusca domesticaandTrichoplusia ni. Arch.Environ.Contam.Toxicol. (U.S.A.)26: 114 - 118.
  6. Batcabe, J., MacGill, R.S., Zaman, K., Ahmad, S. and Pardini, R.S. (1994). Mitomycin C induced alteration in antioxidant enzyme levels in a model insect species,Spodoptera eridania. Gen.Pharmacol. (U.K.)25: 569 - 575.
  7. Zaman, K., Batcabe, J., MacGill, R.S., Ahmad, S. and Pardini, R.S. (1994). An insect model for assessing mercury toxicity: Mercury induced lipid peroxidation, depletion of glutathione and induced protein oxidation inMusca domestica and Trichoplusia ni. Toxic Substances J. (U.S.A.)13: 129 - 142.
  8. Zaman, K., MacGill, R.S., Johnson, J., Ahmad, S. and Pardini, R.S. (1995). An insect model for assessing subacute arsenic toxicity. Arch.Insect Biochem.Physiol. (U.S.A.)29: 199 - 209.
  9. Zaman, K. and Pardini, R.S. (1995). An insect model for assessing arsenic toxicity: Arsenic elevated glutathione content in theM. domesticaandT. ni. Bull.Environ.Contam.Toxicol.(U.S.A.)55: 845 - 852.
  10. Ahmad, S., Zaman, K., Batcabe, J., MacGill, R.S. and Pardini, R.S. (1995). Dichlone-induced oxidative stress in an insect model. Arch.Environ.Contam.Toxicol. (U.S.A.) 29: 442 - 448.
  11. Esch, F., Lin, K., Hill, A., Zaman, K., Barban, J., Chatterjee, S., Rubin, L., Ash, D.E. and Ratan, R.R. (1998). Purification of a multipotent-death activity from bovine liver and its identifications as arginase: nitric oxide-dependent inhibition of neuronal apoptosis. J. Neurosci. (U.S.A.)18(11):4083 - 4095
  12. Shaikh, Z.A., Zaman, K., Tang, W. and Vu, A. T. (1999). Treatment of chronic cadmium nephrotoxicity by N-acetyl-cysteine. Toxicol. Lettl. (The Netherlands)104: 137 - 142.   
  13. Shaikh, Z.A., Vu, A.T., Zaman, K. and Tang, W. (1999). Oxidative stress mechanism of chronic cadmium-induced toxicity and renal toxicity and protection by antioxidants. Toxicol.Appl.Pharmacol.(U.S.A.)154: 256 - 263.
  14. Zaman, K., Ryu, H., Hall, D., O’Donovan, K., Lin, K., Miller, M., Marquis, J., Semenza, G., Barban, J. and Ratan, R.R. (1999). Protection from oxidative stress-induced apoptosis in cortical neurons by iron chelators is associated with enhanced DNA binding of hypoxia inducible factor-1 and ATF/CREB and increased p21 waf1/cip1 and erythropoietin. J. Neurosci. (U.S.A.)19(22): 9821 – 9830.
  15. Ratan, RR., Ryu, H., Zaman, K. and Chatterjee, S. (2000). Mithramycin: A prototypical sequence-specific DNA-binding drug and novel neuronal anti-apoptotic agent. Ann.Neurology (U.S.A.)48: 41.
  16. Zaman, K., Chatterjee, S., Conforto, A., Ryu, H., Ross, B. and Ratan, R.R. (2001). The sequence selective DNA binding drugs mithramycin A and chromomycin A3 are potent inhibitors of neuronal apoptosis induced by oxidative stress and DNA damage in cortical neurons. Ann Neurology (U.S.A.)49: 345 – 354.
  17.  Zaman, K., McPherson, M., Snyder, A., Li, G., Vaughan, J., Hunt, J., Gaston, B. and Palmer L. (2001). S-Nitrosoglutathione increases cystic fibrosis transmembrane regulator (CFTR) maturation. Biochem.Biophys.Res.Commun. (U.S.A.)284: 65 – 70.
  18. Ratan, R.R., Semenza, G., Ryu, H., Zaman, K., Aminoua, L., Lee, J., Jung, A. and Mwidau, A. (2002). Transcriptional mechanisms of neuroprotection by iron chelators. J.Neurochem. suppl. (U.S.A.)1:80.
  19. Ryu, H., Lee, J., Zaman, K., Kubilis, J., Ferrank, R., Ross, B., Neve, R. and Ratan, R. (2003). SP1 and SP3 are oxidative stress-inducible, antideath transcription factors in cortical neurons. J.Neurosci.23: 3597 – 3606.
  20. Zaman, K., Palmer, L., Doctor, A., Hunt, J. and Gaston, B. (2004). Concentration-dependent effects of endogenous S-Nitrosoglutathione on gene regulation by Sp3 and Sp1. Biochem. J. (U.K.)380:67 –74.
  21. Carraro, S., Doherty, J., Zaman, K., Gainov, I., Turner, R., Vaughan, J., Hunt., JF., Marquez, J. and Gaston. B. (2006). Inhibition of human airway epithelial cell pH buffering and ammonia production by Th1 cytokines and S-Nitrosothiols: Potential role in the immune response to rhinovirus. Am.J.Physiol.Lung Cell Mol. Physiol. (U.S.A.) 290: 827 - 832.
  22. Zaman, K., Hanigan, M., Smith, A., Vaughan, J., Mcdonald, T., Jones, D., Hunt, J. and Gaston, B. (2006). Endogenous S-Nitrosoglutthione modifies 5-lipoxygenase expression in airway epithelial cells. Am. J.Resp.Cell Mol.Biol. (U.S.A.) 34:387-393.
  23. Zaman, K., Carraro, S., Doherty, J., Henderson, E., Lendermon, E., Liu, L., Verghese, G., Shah, V., Zigler, M., Mendes, F., Park, E., Palmer, L., Doctor, A., Stamler, J. and Gaston, B. (2006). S-Nitrosylating agents: A novel class of compounds affecting CFTR expression and maturation. Mol. Pharmacology (U.S.A.)70: 1435 - 1442.
  24. Servetnyk, Z., Krjukova, J., Gaston, B., Zaman, K., Hjelte, L., Roomans, G. and Dragomir, A. (2006). Activation of chloride transport in CF epithelial cell lines and primary CF nasal epithelial cells by S-Nitrosoglutathione. Respir. Res. 7:124 - 133.
  25. Marozkina, N., Yemen, S., Borowitz, M., Liu, L., Plapp, M.,Sun, F., Islam, R., Erdmann-Gilmore, P., Townsend, R., Lichti, C., Mantri, S., Clapp, P., Randell, S., Gaston, B. andZaman, K. (2010). Hsp70/Hsp90 organizing protein as an S-nitrosylation target in cystic fibrosis therapy. Proc.Natl. Acad.Sci. USA 107: 11393 – 11398.

Profile Details