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Biography
Dr. Li-Ru Zhao
Dr. Li-Ru Zhao

Dept. of Neurosurgery
SUNY Upstate Medical University, USA
Associate Professor, Director for Stroke Research and Brain Repair


Email: zhaol@upstate.edu


Qualifications

2004 Ph.D., Neuroscience/Neurobiology, Lund University, Sweden

1982 M.D., Medicine, Hebei Medical University, China


Publications (Selected)

  1. Piao CS, Li B, Zhang Li, and Zhao LR. (2012), Stem Cell Factor and Granulocyte-Colony Stimulating Factor Promotes Neurogenesis and Inhibits Glial Differentiation, Differentiation, 83, 1, 17-25.
  2. Gu X, Liu XY, Fagan A, Gonzalez-Toldo ME, and Zhao LR. (2012) Ultrastructural changes in cerebral capillary pericytes in aged Notch3 mutant transgenic mice, Ultrastructural Pathology, in press.
  3. Li B, Gonzalez-Toledo ME, Piao CS, Gu A, Kelley RE, and Zhao LR. (2011), Stem cell factor and granulocyte-colony stimulating factor reduce β-amyloid deposits in the brains of APP/PS1 transgenic mice. Alzheimer's Research & Therapy, 3, 8.
  4. Wang D, Dayton R, Henning P, Cain C, Zhao LR, Schrott L, Orchard E, Knight D, and Klein RL. (2010), Widespread TDP-43 gene transfer to rats induces disease sequelae relevant to amyotrophic lateral sclerosis, Molecular Therapy, 18, 12, 2064-2074.
  5. Li B, Piao CS, Liu XY, Guo WP, Xue YQ, Duan WM, Gonzalez-Toledo M, and Zhao L-R. (2010), Brain self-protection: the role of endogenous neural progenitor cells in adult brain after cerebral cortical ischemia, Brain Research, 1327, 91-102.
  6. Xue Y-Q, Zhao L-R, Tatom JB, Jiang LX, Klein RL, and Duan W-M. (2010), AAV9-mediated erythropoietin gene delivery into the brain protects nigral dopaminergic neurons in a rat model of Parkinson’s disease, Gene Therapy, 17, 1, 83-94.
  7. Duan Y-F, Liu C, Zhao Y-F, Duan WM, and Zhao L-R. (2009), Thiopental exaggerates ischemic brain damage and neurological deficits after experimental stroke in spontaneously hypertensive rats, Brain Research, 1294, 176-182.
  8. Piao C-S, Gonzalez-Toledo ME, Xue Y-Q, Duan W-M, Terao S, Granger DN, Kelley RE and Zhao L-R. (2009), The role of stem cell factor and granulocyte-colony stimulation factor in brain repair during chronic stroke, Journal of Cerebral Blood Flow & Metabolism, 29, 4, 759-770.
  9. Zhao LR, and Nam SC, Multiphoton microscope imaging: the behavior of neural progenitor cells in the rostral migratory stream, Neuroscience Letters, 425, 2, 83-88.
  10. Zhao LR, Berra HH, Duan WM, Singhal S, Mehta J, Apkarian AV, and Kessler JA (2007), Beneficial effects of hematopoietic growth factor therapy in chronic ischemic stroke in rats, Stroke, 38, 10, 2804-2811.
  11. Xue Y-Q, Zhao L-R, Guo W-P, and Duan W-M. (2007), Erythropoietin protects dopaminergic neurons and improves neurobehavioral outcome in a rat model of Parkinson’s disease. Neuroscience, 146, 3, 1245-1258.
  12. Zhao LR, Singhal S, Duan WM, Mehta J, and Kessler JA. (2007), Brain repair by hematopoietic growth factors in a rat model of stroke, Stroke, 38, 9, 2584-2591.
  13. Kan LX, Jalali A, Zhao Li-Ru, Zhou XJ, McGuire T, Kazanis L, Episkopou V, Bassuk AG, and Kessler JA. (2007), Dual function of Sox1 in telencephalic progenitor cells, Developmental Biology, 310, 1, 85-98.
  14. Zhao LR, Navalitloha Y, Singhal S, Mehta J, Kessler JA, Piao CS, Guo WP, and Groothuis DR. (2007), Hematopoietic growth factors pass through the brain-blood barrier in intact rats, Experimental Neurology, 204, 2, 569-573.
  15. Zhao LR, Spellman S, Kim J, and Low WC. (2005), PRARIY, anti-adhesion peptide, neuroprotective effect on transient focal brain ischemia in rats, Brain Research.
  16. Komitova M, Zhao LR, Gido G, Eriksson PS, and Johansson BB. (2005), Postischemic exercise attenuates while enriched environment has certain enhancing effects on lesion-induced subventricular zone activation in the adult rat, European Journal ofNeurology, 21, 9, 2397-2405.
  17. Zhao, LR. (2004), Post-ischemic housing conditions influence on gene transcription and translation after permanent focal brain ischemia in rats, Lund University Dissertations.
  18. Kan L., Israsena IV., Zhang Z., Hu M., Zhao LR., Jalali A., Sahni V., and Kessler JA. (2004), Sox1 acts through multiple pathways to promote neurogenesis, Developmental Biology, 269, 2, 580-594.
  19. Zhao L.-R., Duan W.-M., Reyes M., Verfaille C.M. and Low W.C. (2003), Immunohistochemical identification of multipotent adult progenitor cells from human bone marrow after transplantation into the rat brain, Brain Research Protocols, 2003; 11, 1, 38-45.
  20. Duan W.-M., Rodrigures C.M.P., Zhao L.-R., Steer C.J. and Low W.C. (2002), Tauroursodeoxycholic acid Improves the survival and function of nigral transplants in a rat model of Parkinson’s disease, Cell Transplantation, 11, 3, 195-205.
  21. Zhao L.-R., Duan W.-M., Reyes M., Keene C.D., Verfaille C.M. and Low W.C. (2002), Human bone marrow stem cells exhibit neural phenotypes and ameliorate neurological deficits after grafting to ischemic brain in rats, Experimental Neurology, 174,1, 11-20.
  22. Zhao L.-R., Risedal A., Wojcik A., Hejzlar J., Johansson B.B. and Kokaia Z. (2001), Enriched environment influences brain-derived neurotrophic factor levels in rat forebrain after focal stroke, Neuroscience Letters, 305, 3,169-172.
  23. Duan W.-M., Zhao L.-R., Westerman M., Lovick D., Furcht L. T, McCarthy J. B., and Low W. C. (2000), Enhancement of nigral graft survival in rat brain with the systemic administration of synthetic fibronectin peptide V, Neuroscience, 100, 3, 521-530.
  24. Zhao L.-R., Mattsson B., and Johansson B.B. (2000), Environmental influence on brain-derived neurotrophic factor messenger RNA expression after middle cerebral artery occlusion in rats, Neuroscience, 97, 1, 177-184.
  25. Dahlqvist P, Zhao L, Johansson IM, Mattsson B, Johansson BB, Seckl JR, and Olsson T. (1999), Environmental enrichment alters nerve growth factor-induced gene A and glucocorticoid receptor messenger RNA expression after middle cerebral artery occlusion in rats, Neuroscience, 93, 2, 527-535.
  26. Johansson BB, Zhao L-R, and Mattsson B. (1999), Environmental influence on gene expression and recovery from cerebral ischemia, Acta Neurochirurgica, Supplement, 73, 51-55.
  27. Zeng J., Zhao L.-R., Nordborg C., Mattsson B., and Johansson B.B. (1999), Are neuronal markers neocortical graft-host interface influenced by housing conditions in rats with cortical infarct cavity? Brain Research Bulletin, 48, 2, 165-171.