Back
Return
Biography
Prof. Hung-Jen Liu


Prof. Hung-Jen Liu

Institute of Molecular Biology

National Chung Hsing University, Chinese Taipei

Email: hjliu5257@nchu.edu.tw

Qualifications

1996 Ph.D., Auburn University, USA
1993 M.Sc., Auburn University, USA
1984 DVM, National Pingtung University of Science and Technology, Chinese Taipei

Publications (selected)

  1. Pei-I Chi, Wei-Ru Huang, Hung-Chuan Chiu, Brent L. Nielsen, Hung-Jen Liu*. Avian reovirus σA-modulated suppression of lactate dehydrogenase and upregulation of glutaminolysis and the mTOC1/eIF4E/HIF-1α pathway to enhance ATP production are essential for virus replication. Cellular Microbiol. 20(12): e12946, 2018.
  2. Hung-Chuan Chiu, Wei-Ru Huang, Jyung-Hurng Liu, Pei-I Chi, Brent L. Nielsen, Tsai-Ling Liao, Hung-Jen Liu*. Mechanistic insights into avian reovirus p17-modulated suppression of cell-cycle CDK/cyclin complexes and enhancement of p53 and cyclin H interaction. Journal of Biological Chemistry 293(32):12542-12562, 2018.
  3. Yu-Hsiu Su, Tai-Yun Lin,Hung-Jen Liu*, Chin-kai Chuang*. A set of cancer stem cell homing peptides associating with the glycan moieties of glycosphingolipids. Oncotarget 9(29): 20490-20507, 2018.
  4. Tsai-Ling Liao, Shie-Liang Hsieh, Yi-Ming Chen, Hsin-Hua Chen, Hung-Jen Liu, Hsiu-Chin Lee, Der-Yuan Chen. Rituximab may cause increased hepatitis C virus viremia in rheumatoid arthritis patients through declining exosomal microRNA-155. Arthritis & Rheumatology 70(8):1209-1219, 2018.
  5. Wei-Ru Huang, Pei-I Chi, Hung-Chuan Chiu, Jue-Liang Hsu, Brent L. Nielsen, Tsai-Ling Liao, Hung-Jen Liu*. Avian reovirus p17 and σA act cooperatively to downregulate Akt by suppressing mTORC2 and CDK2/cyclinA2 and upregulating proteasome subunit PSMB6. Scientific Reports 7: 5226-5244, 2017.
  6. Wu Y, Cui L, Zhu E, Zhou W, Wang Q, Wu X, Wu B, Huang Y, Liu HJ*. Muscovy duck reovirus σNS protein triggers autophagy enhancing virus replication.Virol J. 14(1):53, 2017.
  7. Hung-Chuan Chiu, Wei-Ru Huang, Tsai-Ling Liao, Hung-Yi Wu, Muhammad Munir, Wing-Ling Shih, Hung-Jen Liu*. Suppression of vimentin phosphorylation by the avian reovirus p17 through inhibition of CDK1 and Plk1 impacting the G2/M phase of the cell cycle. PLos One 11(9):e0162356, 2016.
  8. Daniel J Klionsky, HJ Liu et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy 12(1):1-222, 2016.
  9. Cheng, CY., Huang, WR., Chi, PI., Chiu, HC., Liu, HJ *. Cell entry of bovine ephemeral fever virus requires activation of Src-JNK-AP1 and PI3K-Akt-NFκB pathways as well as Cox-2-mediated PGE2/EP receptor signaling to enhance clathrin-mediated virus endocytosis. Cellular Microbiol 17(7): 967-987, 2015.
  10. Huang, W. R., Chiu, H. C., Liao, T. L., Chuang, K. P., Shih, W. L., Liu, H. J*. Avian reovirus protein p17 functions as a nucleoporin Tpr suppressor leading to activation of p53, p21 and PTEN and inactivation of PI3K/AKT/mTOR and ERK signaling pathways. PLos One 10(8): e0133699, 2015.
  11. Jing-Yu Wang, Wan-Hua Liu, Juan-Juan Ren, Pan Tang, Ning Wu, Hung-Yi Wu ,Ching-Dong Chang, Hung-Jen Liu*. Characterization of emerging Newcastle disease virus isolates in China. Virology Journal 12:119, 2015.
  12. Wang, JY., Chen, Z L., Li, CS., Cao, XL., Wang, R., Tang, C., Huang, JJ., Chang, CD. Liu*, HJ. The distribution of sialic acid receptors of avian influenza virus in the reproductive tract of laying hens. Molecular and Cellular Probes 29(2): 129-134, 2015.
  13. Jing-Yu Wang, Ning Wu,Wan-Hua Liu, Juan-Juan Ren, Pan Tang, Yuan-Hao Qiu, Chi-Young Wang, Ching-Dong Chang, Hung-Jen Liu*.A repA-based ELISA for discriminating cattle vaccinated with Brucella suis 2 from those naturally infected with Brucella abortus and Brucella melitensis. Molecular and Cellular Probes 28: 251-254, 2014.
  14. Hung-Chuan Chiu, Sarah Richart, Fong-Yuan Lin, Wei-Li Hsu, and Hung-Jen Liu*. The interplay of reovirus with autophagy. BioMed Research International (Formerly titled Journal of Biomedicine and Biotechnology) Vol. 2014, 2014. Ching-Yuan Cheng, Pei-I Chi, and Hung-Jen Liu*. Commentary on the regulation of viral proteins in autophagy BioMed Research International (Formerly titled Journal of Biomedicine and Biotechnology) Vol. 2014, 2014.
  15. Pei I. Chi, Wei R. Huang , I-Hsiang Lai, Wei R. Huang , Ching Y. Cheng, Hung J. Liu*. The p17 nonstructural protein of avian reovirus triggers autophagy enhancing virus replication via activation of PTEN and AMPK as well as PKR/eIF2α signaling pathways. Journal of Biological Chemistry 288 (5):3571-3584, 2013.
  16. Xingang Xu , Honglei Zhang, Qi Zhang, Jie Dong, Yabing Liang, Yong Huang, Hung-Jen Liu* , Dewen Tong*. Porcine epidemic diarrhea virus M protein blocking cell cycle progression at S-phaseand its subcellular localization in the porcine intestinal epithelial cells. Veterinary Microbiology 164: 212-221, 2013.
  17. Xingang Xu, Honglei Zhang , Qi Zhang, Jie Dong, Yabing Liang, Yong Huang, Hung-Jen Liu*, Dewen Tong. Porcine epidemic diarrhea virus E protein causes endoplasmic reticulum stress and up-regulates interleukin-8 expression. Virology Journal 10:26, 2013.
  18. Ching Y. Cheng, Wing L. Shih, Wei R. Huang, Pei-I Chi, Hung J. Liu*. Bovine ephemeral fever virus uses a clathrin-mediated and dynamin 2-dependent endocytosis pathway that requires Rab5 and Rab7 as well as microtubules. Journal of Virology 86 (24):13653-13661, 2012.
  19. Xin-Gang Xu, Hong-Ni Zhao, Qi Zhang, Li Ding, Zhao-Cai Li, Wei Li, Hung-Yi Wu, Kuo Pin Chuang, De-Wen Tong, Hung-Jen Liu*. Oral vaccination with attenuated Salmonella enterica serovar Typhimurium expressing Cap protein of PCV2 and its immunogenicity in mouse and swine models. Veterinary Microbiology 157, 294-303, 2012.
  20. Xin-Gang Xu, Guang-Da Chen, Yong Huang, Li Ding, Zhao-Cai Li, Ching-Dong Chang, Chi-Young Wang, De-Wen Tong, Hung-Jen Liu*. Development of multiplex PCR for simultaneous detection of six swine DNA and RNA viruses. Journal of Virological Methods183, 69-74, 2012.
  21. Wei R. Huang, Ying C. Wang, Pei-I Chi , Lai Wang, Chi Y. Wang, Chi H. Lin, Hung J. Liu*. Cell entry of avian reovirus follows a caveolin-1-mediated and dynamin-2-dependent endocytic p athway that requires activation of p38 MAPK and Src signaling pathways as well as microtubules and small GTPase Rab5 protein. Journal of Biological Chemistry 286: 30780-30794, 2011.
  22. Xin-Gang Xu, Zhi- Sheng Wang, Qi Zhang, Zhao-Cai Li, Hong-Ni Zhao, Wei Li , De-Wen Tong, Hung-Jen Liu*. Baculovirus surface display of E envelope glycoprotein of Japanese encephalitis virus and its immunogenicity of the displayed proteins in mouse and swine models. Vaccine 29:636-643, 2011. Xin-Gang Xu, Zhi-Sheng Wang, Qi Zhang, Zhao-Cai Li, Li Ding, Wei Li, Hong-Yi Wu, Ching-Dong Chang, Long-Huw, Lee, De-Wen Tong, Hung-Jen Liu*. Baculovirus as a PRRSV and PCV2 bivalent vaccine vector: baculovirus virions displaying simultaneously GP5 glycoprotein of PRRSV and capsid protein of PCV2. Journal of Virological Methods 179: 359-366, 2012.