Prof. Hung-Jen Liu

Prof. Hung-Jen Liu

Institute of Molecular Biology

National Chung Hsing University, Chinese Taipei



1996 Ph.D., Auburn University, USA
1993 M.Sc., Auburn University, USA
1984 DVM, National Pingtung University of Science and Technology, Chinese Taipei

Publications (selected)

  1. Pei-I Chi, Wei-Ru Huang, Hung-Chuan Chiu, Brent L. Nielsen, Hung-Jen Liu*. Avian reovirus σA-modulated suppression of lactate dehydrogenase and upregulation of glutaminolysis and the mTOC1/eIF4E/HIF-1α pathway to enhance ATP production are essential for virus replication. Cellular Microbiol. 20(12): e12946, 2018.
  2. Hung-Chuan Chiu, Wei-Ru Huang, Jyung-Hurng Liu, Pei-I Chi, Brent L. Nielsen, Tsai-Ling Liao, Hung-Jen Liu*. Mechanistic insights into avian reovirus p17-modulated suppression of cell-cycle CDK/cyclin complexes and enhancement of p53 and cyclin H interaction. Journal of Biological Chemistry 293(32):12542-12562, 2018.
  3. Yu-Hsiu Su, Tai-Yun Lin,Hung-Jen Liu*, Chin-kai Chuang*. A set of cancer stem cell homing peptides associating with the glycan moieties of glycosphingolipids. Oncotarget 9(29): 20490-20507, 2018.
  4. Tsai-Ling Liao, Shie-Liang Hsieh, Yi-Ming Chen, Hsin-Hua Chen, Hung-Jen Liu, Hsiu-Chin Lee, Der-Yuan Chen. Rituximab may cause increased hepatitis C virus viremia in rheumatoid arthritis patients through declining exosomal microRNA-155. Arthritis & Rheumatology 70(8):1209-1219, 2018.
  5. Wei-Ru Huang, Pei-I Chi, Hung-Chuan Chiu, Jue-Liang Hsu, Brent L. Nielsen, Tsai-Ling Liao, Hung-Jen Liu*. Avian reovirus p17 and σA act cooperatively to downregulate Akt by suppressing mTORC2 and CDK2/cyclinA2 and upregulating proteasome subunit PSMB6. Scientific Reports 7: 5226-5244, 2017.
  6. Wu Y, Cui L, Zhu E, Zhou W, Wang Q, Wu X, Wu B, Huang Y, Liu HJ*. Muscovy duck reovirus σNS protein triggers autophagy enhancing virus replication.Virol J. 14(1):53, 2017.
  7. Hung-Chuan Chiu, Wei-Ru Huang, Tsai-Ling Liao, Hung-Yi Wu, Muhammad Munir, Wing-Ling Shih, Hung-Jen Liu*. Suppression of vimentin phosphorylation by the avian reovirus p17 through inhibition of CDK1 and Plk1 impacting the G2/M phase of the cell cycle. PLos One 11(9):e0162356, 2016.
  8. Daniel J Klionsky, HJ Liu et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy 12(1):1-222, 2016.
  9. Cheng, CY., Huang, WR., Chi, PI., Chiu, HC., Liu, HJ *. Cell entry of bovine ephemeral fever virus requires activation of Src-JNK-AP1 and PI3K-Akt-NFκB pathways as well as Cox-2-mediated PGE2/EP receptor signaling to enhance clathrin-mediated virus endocytosis. Cellular Microbiol 17(7): 967-987, 2015.
  10. Huang, W. R., Chiu, H. C., Liao, T. L., Chuang, K. P., Shih, W. L., Liu, H. J*. Avian reovirus protein p17 functions as a nucleoporin Tpr suppressor leading to activation of p53, p21 and PTEN and inactivation of PI3K/AKT/mTOR and ERK signaling pathways. PLos One 10(8): e0133699, 2015.
  11. Jing-Yu Wang, Wan-Hua Liu, Juan-Juan Ren, Pan Tang, Ning Wu, Hung-Yi Wu ,Ching-Dong Chang, Hung-Jen Liu*. Characterization of emerging Newcastle disease virus isolates in China. Virology Journal 12:119, 2015.
  12. Wang, JY., Chen, Z L., Li, CS., Cao, XL., Wang, R., Tang, C., Huang, JJ., Chang, CD. Liu*, HJ. The distribution of sialic acid receptors of avian influenza virus in the reproductive tract of laying hens. Molecular and Cellular Probes 29(2): 129-134, 2015.
  13. Jing-Yu Wang, Ning Wu,Wan-Hua Liu, Juan-Juan Ren, Pan Tang, Yuan-Hao Qiu, Chi-Young Wang, Ching-Dong Chang, Hung-Jen Liu*.A repA-based ELISA for discriminating cattle vaccinated with Brucella suis 2 from those naturally infected with Brucella abortus and Brucella melitensis. Molecular and Cellular Probes 28: 251-254, 2014.
  14. Hung-Chuan Chiu, Sarah Richart, Fong-Yuan Lin, Wei-Li Hsu, and Hung-Jen Liu*. The interplay of reovirus with autophagy. BioMed Research International (Formerly titled Journal of Biomedicine and Biotechnology) Vol. 2014, 2014. Ching-Yuan Cheng, Pei-I Chi, and Hung-Jen Liu*. Commentary on the regulation of viral proteins in autophagy BioMed Research International (Formerly titled Journal of Biomedicine and Biotechnology) Vol. 2014, 2014.
  15. Pei I. Chi, Wei R. Huang , I-Hsiang Lai, Wei R. Huang , Ching Y. Cheng, Hung J. Liu*. The p17 nonstructural protein of avian reovirus triggers autophagy enhancing virus replication via activation of PTEN and AMPK as well as PKR/eIF2α signaling pathways. Journal of Biological Chemistry 288 (5):3571-3584, 2013.
  16. Xingang Xu , Honglei Zhang, Qi Zhang, Jie Dong, Yabing Liang, Yong Huang, Hung-Jen Liu* , Dewen Tong*. Porcine epidemic diarrhea virus M protein blocking cell cycle progression at S-phaseand its subcellular localization in the porcine intestinal epithelial cells. Veterinary Microbiology 164: 212-221, 2013.
  17. Xingang Xu, Honglei Zhang , Qi Zhang, Jie Dong, Yabing Liang, Yong Huang, Hung-Jen Liu*, Dewen Tong. Porcine epidemic diarrhea virus E protein causes endoplasmic reticulum stress and up-regulates interleukin-8 expression. Virology Journal 10:26, 2013.
  18. Ching Y. Cheng, Wing L. Shih, Wei R. Huang, Pei-I Chi, Hung J. Liu*. Bovine ephemeral fever virus uses a clathrin-mediated and dynamin 2-dependent endocytosis pathway that requires Rab5 and Rab7 as well as microtubules. Journal of Virology 86 (24):13653-13661, 2012.
  19. Xin-Gang Xu, Hong-Ni Zhao, Qi Zhang, Li Ding, Zhao-Cai Li, Wei Li, Hung-Yi Wu, Kuo Pin Chuang, De-Wen Tong, Hung-Jen Liu*. Oral vaccination with attenuated Salmonella enterica serovar Typhimurium expressing Cap protein of PCV2 and its immunogenicity in mouse and swine models. Veterinary Microbiology 157, 294-303, 2012.
  20. Xin-Gang Xu, Guang-Da Chen, Yong Huang, Li Ding, Zhao-Cai Li, Ching-Dong Chang, Chi-Young Wang, De-Wen Tong, Hung-Jen Liu*. Development of multiplex PCR for simultaneous detection of six swine DNA and RNA viruses. Journal of Virological Methods183, 69-74, 2012.
  21. Wei R. Huang, Ying C. Wang, Pei-I Chi , Lai Wang, Chi Y. Wang, Chi H. Lin, Hung J. Liu*. Cell entry of avian reovirus follows a caveolin-1-mediated and dynamin-2-dependent endocytic p athway that requires activation of p38 MAPK and Src signaling pathways as well as microtubules and small GTPase Rab5 protein. Journal of Biological Chemistry 286: 30780-30794, 2011.
  22. Xin-Gang Xu, Zhi- Sheng Wang, Qi Zhang, Zhao-Cai Li, Hong-Ni Zhao, Wei Li , De-Wen Tong, Hung-Jen Liu*. Baculovirus surface display of E envelope glycoprotein of Japanese encephalitis virus and its immunogenicity of the displayed proteins in mouse and swine models. Vaccine 29:636-643, 2011. Xin-Gang Xu, Zhi-Sheng Wang, Qi Zhang, Zhao-Cai Li, Li Ding, Wei Li, Hong-Yi Wu, Ching-Dong Chang, Long-Huw, Lee, De-Wen Tong, Hung-Jen Liu*. Baculovirus as a PRRSV and PCV2 bivalent vaccine vector: baculovirus virions displaying simultaneously GP5 glycoprotein of PRRSV and capsid protein of PCV2. Journal of Virological Methods 179: 359-366, 2012.