Dr. Yoshihide Fujigaki

Teikyo University, Japan




1991 Ph.D., Hamamatsu University, Japan

1984 M.Sc., Hamamatsu University, Japan


  1. Sun Y, Fujigaki Y, Sakakima M, Fujikura T, Togawa A, Huang Y, Hishida A: Acquired resistance to rechallenge injury in rats that recovered from mild renal damage induced by uranyl acetate: accelerated proliferation and hepatocyte growth factor/c-Met axis. Clin Exp Nephrol. 15:666-75, 2011.
  2. Sakao Y, Kato A, Tsuji T, Yasuda H, Togawa A, Fujigaki Y, Kahyo T, Setou M, Hishida A: Cisplatin induces Sirt1 in association with histone deacetylation and increased Werner syndrome protein in the kidney. Clin Exp Nephrol. 15:363-72, 2011.
  3. Yasuda H, Kato A, Fujigaki Y, Hishida A: Incidence and clinical outcomes of acute kidney injury requiring renal replacement therapy in Japan. 2010. Ther Apher Dial 6:541-546.2010.
  4. Togawa A, Sfakianos J, Ishibe S, Suzuki S, Fujigaki Y, Kitagawa M, Mellman I, Cantley LG: Hepatocyte Growth Factor stimulated cell scattering requires ERK and Cdc42-dependent tight junction disassembly. Biochem Biophys Res Commun. 400:271-277,2010.
  5. Fujigaki Y, Sun Y, Fujikura T, Sakao Y, Togawa A, Suzuki H, Yasuda H, Hishida A: Immunohistochemical study of heat shock protein 27 with respect to survival and regeneration of proximal tubular cells after uranyl acetate-induced acute tubular injury in rats. Ren Fail 32:119-125, 2010.
  6. Fukasawa H, Yamamoto T, Fujigaki Y, Misaki T, Ohashi N, Uakayama T, Mugiya S, Oda T, Uchida C, Kitagawa K, Hattori T, Suzuki S, Hayashi H, Ozono S, Kitagawa M, Hishida A: Reduction of transforming growth factor-ß type II receptor is caused by the enhanced ubiquitin-dependent degradation in human renal cell carcinoma. Int J Cancer. 127:1517-1525, 2010.
  7. Sun Y, Fujigaki Y, Sakakima M, Hishida A: Acquired resistance to rechallenge injury in rats recovered from subclinical renal damage with uranyl acetate - Importance of proliferative activity of tubular cells. Toxicol Appl Pharmacol. 243:104-110, 2010.
  8. Misaki T, Yamamoto T, Suzuki S, Fukasawa H, Togawa A, Ohashi N, Suzuki H, Fujigaki Y, Oda T, Uchida C, Kitagawa K, Hattori T, Kitagawa M, Hishida A: Decrease in tumor necrosis factor-alpha receptor-associated death domain results from ubiquitin-dependent degradation in obstructive renal injury in rats. Am J Pathol 175:74-83, 2009.
  9. Ikegaya N, Yoshida T, Kohsaka T, Suzuki A, Kobayashi N, Yamamoto T, Fujigaki Y, Hishida A, Kumagai H: Effects of relaxin on development of mesangial proliferative nephritis. Ann N Y Acad Sci 1160:300-303, 2009.
  10. Fujigaki Y, Sakakima M, Sun Y, Fujikura T, Tsuji T, Yasuda H, Hishida A: Cell division and phenotypic regression of proximal tubular cells in response to uranyl acetate insult in rats. Nephrol Dial Transplant 24;2686-2692, 2009.
  11. Tsuji T, Kato A, Yasuda H, Miyaji T, Luo J, Sakao Y, Ito H, Fujigaki Y, Hishida A: The dimethylthiourea-induced attenuation of cisplatin nephrotoxicity is associated with the augmented induction of heat shock proteins. Toxicol Appl Pharmacol 234:202-208, 2009.
  12. Joh K, Taguchi T, Shigematsu H, Kobayashi Y, Sato H, Nishi S, Katafuchi R, Nomura S, Fujigaki Y, Utsunomiya Y, Sugiyama H, Saito T, Makino H: Proposal of podocytic infolding glomerulopathy as a new disease entity: a review of 25 cases from nationwide research in Japan. Clin Exp Nephrol 12:421-431, 2008.
  13. Fujigaki Y, Muranaka Y, Sakakima M, Ohta I, Sakao Y, Fujikura T, Sun Y, Katafuchi R, Joh K, Hishida A: Analysis of intra-GBM microstructures in a SLE case with glomerulopathy associated with podocytic infolding. Clin Exp Nephrol 12:509-512, 2008.
  14. Ohashi N, Yamamoto T, Huang Y, Misaki T, Fukasawa H, Suzuki H, Togawa A, Suzuki S, Fujigaki Y, Nakagawa T, Nakamura Y, Suzuki F, Kitagawa M, Hishida A: Intrarenal RAS activity and urinary angiotensinogen excretion in anti-thymocyte serum nephritis rats. Am J Physiol Renal Physiol 295:F1512-1518, 2008.
  15. Sakakima M, Fujigaki Y, Yamamoto T, Hishida A: A distinct population of tubular cells in the distal S3 segment contributes to S3 segment regeneration in rats following acute renal failure induced by uranyl acetate. Nephron Exp Nephrol 109:e57-70, 2008.
  16. Luo J, Tsuji T, Yasuda H, Sun Y, Fujigaki Y, Hishida A: The molecular mechanisms of the attenuation of cisplatin-induced acute renal failure by N-acetylcysteine in rats. Nephrol Dial Transplant 23:2198-205, 2008.
  17. Ohashi N, Kato A, Misaki T, Sakakima M, Fujigaki Y, Yamamoto T, Hishida A: Association of serum adiponectin levels with all-cause mortality in hemodialysis patients. Intern Med 47:485-491, 2008.
  18. Fujigaki Y, Sakakima M, Sun Y, Goto T, Ohashi N, Fukasawa H, Tsuji T, Yamamoto T, Hishida A: Immunohistochemical study on caveolin-1a regenerating process of tubular cells in gentamicin-induced acute tubular injury in rats. Virchows Arch 450:671-681, 2007.
  19. Yamamoto T, Nakagawa T, Suzuki H, Ohashi N, Fukasawa H, Fujigaki Y, Kato A, Nakamura Y, Suzuki F, Hishida A: Urinary Angiotensinogen as a Marker of Intrarenal Angiotensin II Activity Associated with Deterioration of Renal Function in Patients with Chronic Kidney Disease. J Am Soc Nephrol 18:1558-1565, 2007.