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Biography
Dr.Kailash C. Chadha

Dr. Kailash C. Chadha

Roswell Park Cancer Institute, USA

 

Email: kailash.Chadha@roswellpark.org

 

Qualifications

1968  Ph.D., University of Guelph, Canada

1965  M.Sc., I.A.R.I., India

1962  B.Sc., University of Rajasthan, India

 

Publications (Selected)

  1. Chadha KC, Sykes DE, Dembinski WE, Ambrus JL, Sr. Why do most cancer patients respond poorly to interferon therapy? Proceedings Intl. Symposium on Recent aAdvances in Molecular Biology, Allergy & Immunology, 3-5th Sept 2000 Baroda India, pg. 179-185.
  2. Nair MPN, Mahajan S, Chadha K, Nair N, Hewitt R, Pillai SK, Chadha P, Sukumaran PC, Schwartz SA. Effect of cocaine on chemokine and CCR-5 gene expression by mononuclear cells from normal donors and HIV-1 infected patients. In “Neuroimmune Circuits, Drugs of Abuse and Infectious Diseases.” Adv Exp Med Biol. 493:235-40, 2001.
  3. Chadha KC, Kawinski E, Sulkowski E. Thiophilic interaction chromatography of prostate-specific antigen. J Chromatog. B. 754(2): 521-525, 2001.
  4. Kawinski E, Levine E, Chadha K. Thiophilic interaction chromatography facilities detection of various molecular complexes of prostate-specific antigen in biological fluids. Prostate 50(3): 145-153, 2002.
  5. Nair MPN, Kaudaswami C, Mahajan S, Chadha KC, Chawda R, Nair N, Kumar N, Schwartz SA. The flavonoid, Quecertin, differentially regulates Th-1 (IFN-y) and Th-2 (IL4) cytokine gene expression by normal peripheral blood mononuclear cells. Biochem Biophys Acta 1593(1): 29-36, 2002.
  6. Aalinkeel RK, Nair MPN, Sufrin G, Mahajan SD, Chadha KC, Schwartz, SA. Antisense inhibition of the cyclo-oxygenase-2 gene modulates the expression of pro-angiogenic molecules in prostate cancer cell lines. J Urol 169:220, 2003.
  7. Ambrus JL Sr, Dembinski W, Ambrus JL Jr, Sykes DE, Akhter S, Kulaylat MN, Islam A, Chadha KC. Free interferon -alpha/beta receptors in the circulation of patients with adenocarcinomas. Cancer 98:2730-2733, 2003.
  8. Chadha KC, Schwartz SA, Nair MPN, Demeter LR, Hewitt RG. Serum interferon inhibitor declines in patients with HIV-1 infection after a change in antiretroviral therapy. Immunol Invest 32:299-312, 2003.
  9. Ambrus JL Sr, Dembinski W, Ambrus JL Jr, Sykes DE, Akhter S, Kulaylat MN, Islam A, Chadha KC. Free interferon -alpha/beta receptors in the circulation of patients with adenocarcinomas. Cancer 98:2730-2733, 2003.
  10. Chadha KC, Ambrus JL Jr, Dembinski W, Ambrus JL Sr. Interferon and interferon inhibitory activity in disease and therapy. Mini Review. Exp Biol Med 229(4):285-290, 2004.
  11. Sulkowski E, Chadha K, Kawinski E.  A method for detecting PSA and its molecular forms using thiophilic gel on magnetic beads. U.S. Patent No. 6,692,643, issued February 17, 2004.
  12. Aalinkeel R, Nair MPN, Sufrin G, Mahajan SD, Chadha KC, Chawda RP, Schwartz SA. Gene expression of angiogenic factors correlates with metastatic potential of prostate cancer cells. Cancer Res 64:5311-5321, 2004.
  13. Chadha KC, Dembinski WE, Dunn CB, Ardi J, Bardos TJ, Dunn JA, Ambrus Sr JL. Effect of increasing thiolation of the polycytidylic acid strand of poly I:poly C on the alpha, beta and gamma interferon inducing properties, antiviral and antiproliferative activities. Antiviral Res. 64: 171-177, 2004.
  14. Bindukumar B, Kawinski E, Cherrin C, Gambino LM, Nair MPN, Schwartz SA, Chadha KC. Two-step procedure for purification and characterization of enzymatically active prostate-specific antigen from seminal plasma. J Chromatogr B. 813: 113-120, 2004.
  15. Ambrus JL Sr, Dembinski WD, Chadha Kunal, Ambrus JL Jr, Chadha KC. Resistance to interferons, Discovery Medicine, 4: 310-314, 2004.