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Biography
Dr. Laimute Taraseviciene-Stewart

Dr. Laimute Taraseviciene-Stewart

School of Medicine

University of Colorado, Denver, USA

Assistant Professor


Email: Laima.Taraseviciene@ucdenver.edu


Qualifications

1993 Ph.D., Institute of Biochemistry, Lithuanian Academy of Sciences, Lithuania

1977 Ph.D., Institute of Molecular Biology and Genetics, Ukrainian Academy of Sciences, Kiev, Ukraine

1971 M.S., Vilnius University, Lithuania


Publications  (selected)

  1. K-H. Choe,L. Taraseviciene-Stewart,R. Scerbavicius, L. Gera, R.M. Tuder, N.F. Voelkel.Methylprednisolone Causes Matrix Metalloproteinase-dependent Emphysema in Adult Rat. Amer. J. Resp. Crit. Care Med. 167(11):1516-21, 2003
  2. R.M. Tuder, L. Zhen, C.Y. Cho,L. Taraseviciene-Stewart, Y. Kasahara, D. Salvemini, N.F. Voelkel, S. Flores. Oxidative Stress and Apoptosis Interact and Cause Emphysema Due to VEGF Receptor Blockade: Prevention of emphysema with a superoxide dismutase mimetic. Am J Resp Cell Mol Biol 29(1):88-97, 2003
  3. Norbert F. Voelkel,Laima Taraseviciene-Stewart,Rubin Tuder. Emphysema – a vascular disease? Drug Discovery Today: Disease Mechanisms, 1(1):145-149, October, 2004
  4. Golpon HA, Fadok VA, Taraseviciene-Stewart L, Scerbavicius R, Henson PM, Voelkel NF. Life After Corpse Engulfment. FASEB J, 2004 Nov;18(14):1716-8.
  5. Y. Demura,L. Taraseviciene-Stewart,R. Scerbavicius, R.M. Tuder, N.F. Voelkel. N-acetylcysteine Treatment Protects Against VEGF-Receptor Blockade-Related Emphysema. COPD, 1(1):25-32, 2004
  6. J.M. Stewart, L. Gera, D.C. Chan, E.J. York,L. Taraseviciene-Stewart, V. Simkeviciene, B. Helfrich. New Lung Cancer Drugs from Bradykinin Antagonists. CHEST 2004; 125:148S
  7. Norbert F. Voelkel,Laima Taraseviciene-Stewart. Emphysema – an Autoimmune Vascular Disease. Proc. Am. Thor. Soc. Apr 2005;2: 23 - 25.
  8. Taraseviciene-Stewart L, Scerbavicius R, Choe KH, Moore M, Sullivan A, Nicolls MR, Fontenot AP, Tuder RM, Voelkel NF. An Animal Model of Autoimmune Emphysema. Am J Respir Crit Care Med. 2005 Apr 1;171(7):734-42.
  9. John M. Stewart, Lajos Gera, Daniel C. Chan, Eunice J. York, Vitalija Simkeviciene, Paul Bunn Jr.,Laimute Taraseviciene-Stewart. Combination Cancer Chemotherapy with one compound: Pluripotent Bradykinin Antagonist. Peptides, 2005 Aug; 26(8):1288-91.
  10. Laimute Taraseviciene-Stewart,Robertas Scerbavicius, John M. Stewart, Lajos Gera, Yoshiki Demura, Carlyne Cool, Michael Kasper and Norbert F. Voelkel. Treatment of Severe Pulmonary Hypertension: a bradykinin receptor 2 agonist B9972 causes reduction of pulmonary artery pressure and right ventricular hypertrophy. Peptides, 2005 Aug; 26(8):1292-300.
  11. Sakao S,Taraseviciene-Stewart L, Lee JD, Wood K, Cool CD, Voelkel NF. Initial apoptosis is followed by increased proliferation of apoptosis-resistant endothelial cells. FASEB J. 2005 Jul;19(9):1178-80.
  12. Mark R. Nicolls,Laima Taraseviciene-Stewart,Pradeep R. Rai, David B. Badesch, Norbert F. Voelkel. Autoimmunity and Pulmonary Hypertension:A Perspective,Eur. Resp. J. 2005 Dec;26(6):1110-8.
  13. Irina Petrache, Iwona Fijalkowska, Lijie Zhen, Terry R. Medler, Jarrett Skirball, Terrence Flotte, Kang- Hyeon Choe,Laimute Taraseviciene-Stewart, Robertas Scerbavicius, Lee Shapiro, Norbert Voelkel, Rubin Tuder. A novel antiapoptotic role for alpha 1 antitrypsin in the prevention of emphysema. Am J Respir Crit Care Med. 2006 Jun 1; 173(11):1222-1228.
  14. Achcar,R.O., Demura,Y., Rai,P.R.,Taraseviciene-Stewart,L.,Kasper,M., Voelkel,N.F. and Cool,C.D. Loss of caveolin and heme oxygenase expression in severe pulmonary hypertension, Chest,129:696- 05, 2006.
  15. Sakao, S.,Taraseviciene-Stewart, L., Wood, K., Cool, C. D., and Voelkel, N. F. Apoptosis of Pulmonary Microvascular Endothelial Cells Stimulates Vascular Smooth Muscle Cell Growth. Am.J Physiol Lung Cell Mol.Physiol 2006;291(3):L362-L368.
  16. Taraseviciene-Stewart, L.,Burns, N., Kraskauskas, D., Nicolls, M. R., Tuder, R. M., and Voelkel, N. F. Mechanisms of Autoimmune Emphysema. Proc.Am.Thorac.Soc. 2006;3(6):486-7.
  17. Taraseviciene-Stewart, L.,Scerbavicius, R., Choe, K. H., Cool, C., Wood, K., Tuder, R. M., Burns, N., Kasper, M., and Voelkel, N. F. Simvastatin Causes Endothelial Cell Apoptosis and Attenuates Severe Pulmonary Hypertension. Am.J Physiol Lung Cell Mol.Physiol 2006;291(4):L668-L676.
  18. Taraseviciene-Stewart L, Douglas IS, Nana-Sinkam PS, Lee JD, Tuder RM, Nicolls MR, Voelkel NF. Is alveolar destruction and emphysema in chronic obstructive pulmonary disease an immune disease? Proc Am Thorac Soc. 2006 Nov;3(8):687-90
  19. Masahiko Oka, Noriyuki Homma,Laimute Taraseviciene-Stewart, Kenneth G. Morris, DonatasKraskauskas, Nana Burns, Norbert F. Voelkel, Ivan F. McMurtry. Rho kinase-mediated vasoconstriction is important in severe occlusive pulmonary arterial hypertension in rats. Circ Res. 2007 Mar 30;100(6):923-9.
  20. Laimute Taraseviciene-Stewart, Mark R. Nicolls, Donatas Kraskauskas, Robertas Scerbavicius, Nana Burns, Carlyne Cool, Kathy Wood, Jane E. Parr, Susan Boackle and Norbert F. Voelkel. Absence of T Cells Confers an Increased Pulmonary Arterial Hypertension and Vascular Remodeling. Am J RespirCrit Care Med. 2007 Jun 15; 175(12): 1280-9.
  21. Sakao S,Taraseviciene-Stewart L, Cool CD, Tada Y, Kasahara Y, Kurosu K, Tanabe N, Takiguchi Y, Tatsumi K, Kuriyama T, Voelkel NF. VEGF-R blockade causes endothelial cell apoptosis, expansion of surviving CD34+ precursor cells and transdifferentiation to smooth muscle-like and neuronal-like cells. FASEB J. 2007 Nov; 21(13):3640-52.
  22. Daley E, Emson C, Guignabert C, de Waal Malefyt R, Louten J, Kurup VP, Hogaboam C,Taraseviciene-Stewart L, NF, Voelkel NF, Rabinovitch M, Grunig E, Grunig G. Pulmonary arterial remodeling induced by a Th2 immune response. J Exp Med. Vol. 205, No. 2, 361-372, 2008
  23. Taraseviciene-Stewart, L. and Voelkel, N. F. Molecular Pathogenesis of Emphysema. JCI, 2008; 118(2):354-402.
  24. Silvia Ulrich, Mark R. Nicolls,Laima Taraseviciene, Rudolf Speich, Norbert Voelkel. IncreasedRegulatory and Decreased CD8+ Cytotoxic T Cells in the Blood of Patients with Idiopathic Pulmonary Arterial Hypertension.Respiration2008;75:272-280
  25. Silvia Ulrich,Laima Taraseviciene-Stewart, Lars C Huber, Rudolf Speich and Norbert VoelkelPeripheral blood B lymphocytes derived from patients with idiopathic pulmonary arterial hypertension express a different RNA pattern compared with healthy controls: a cross sectional study.Respiratory Research2008, 9:20
  26. Homma N, Nagaoka T, Karoor V, Imamura M,Taraseviciene-Stewart L, Walker LA, Fagan KA,McMurtry IF, Oka M., Involvement of RhoA/Rho kinase signaling indehydroepiandrosterone'sprotection against monocrotaline-induced pulmonary hypertension in pneumonectomized rats.Am J Physiol Lung Cell Mol Physiol.2008 Jul;295(1):L71-8.
  27. Woodward,H.N., Anwar,A., Riddle,S.,Taraseviciene-Stewart,L., Fragoso,M., Stenmark,K.R., and Gerasimovskaya,E.V., PI3K, Rho and ROCK play a key role in hypoxia-induced ATP release and ATPstimulated angiogenic responses in pulmonary artery vasa vasorum endothelial cells.Am.J Physiol Lung Cell Mol.Physiol, 2009 Nov;297(5):L954-64.
  28. Masayuki Hanaoka, Mark R. Nicolls, Andrew P. Fontenot, Donatas Kraskauskas, Douglas G.Mack, Adelheid Kratzer, Vita Kraskauskiene, Nana Burns, Norbert F. Voelkel, andLaimuteTaraseviciene-Stewart.Immunomodulatory Strategies Prevent the Development of Autoimmune Emphysema.Respiratory Research2010, 11:179
  29. Kearns MT, Dalal S, Horstmann SA, Richens TR, Tanaka T, Doe JM, Boe DM, Voelkel NF,Taraseviciene-StewartL, Janssen WJ, Lee CG, Elias JA, Bratton D, Tuder RM, Henson PM, Vandivier RW.Vascular endothelial growth factor enhances macrophage clearance of apoptotic cells.Am J Physiol Lung Cell Mol Physiol. 2012 Apr;302(7):L711-8.
  30. Gerasimovskaya E, Kratzer A, Sidiakova A, Salys J, Zamora M,Taraseviciene-StewartL.Interplay of macrophages and T cells in the lung vasculature.Am J Physiol Lung Cell Mol Physiol.2012 Apr 1;302(7):L711-8.


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