Dr. Mitsuharu Yoshiyama

Prof. Mitsuharu Yoshiyama

Department of Urology

Interdisciplinary Graduate School of Medicine and Engineering

University of Yamanashi, Japan

Research Professor





1993 Ph.D., Graduate School of Medicine, Showa University, Japan

1989 M.D., School of Medicine, Showa University, Japan


Publications (Selected)

  1. Yoshiyama, M., Roppolo, J. R., Takeda, M., de Groat, W. C. Effects of urethane on reflex activity of lower urinary tract in decerebrate unanesthetized rats. Am. J. Physiol. Renal Physiol. 304: F390-F396, 2013.
  2. Zakoji, H., Kobayashi, H., Yoshiyama, M., Takeda, M., Araki, I. Expression of large conductance, voltage- and Ca2+-activated K+ (BK) channels in human urinary bladder: alteration of subunit expression profile in association with bladder outlet obstruction. Open J. Urol. 3:47-52, 2013.
  3. Kamiyama, M., Fukasawa, M., Takihana, Y., Sawada, N., Nakagomi, H., Yoshiyama, M., Araki, I., Takeda, M. Distribution and possible function of cannabinoid receptor subtype 1 in the human prostate. Open J. Urol. 3: 102-109, 2013.
  4. Yoshiyama, M., Mochizuki, T., Nakagomi, H., Miyamoto, T., Kira, S., Mizumachi, R., Sokabe, T., Takayama, Y., Tominaga, M., Takeda, M. Functional roles of TRPV1 and TRPV4 in control of lower urinary tract activity: dual analysis of behavior and reflex during the micturition cycle.  Am. J. Physiol. Renal Physiol. 308: F1128-F1134, 2015.
  5. Beppu, M., Araki, I., Yoshiyama, M., Du, S., Kobayashi, H., Zakoji, H., and Takeda, M. Bladder Outlet Obstruction-Induced Expression of Prostaglandin E2 Receptor Subtype EP4inthe Rat Urinary Bladder: a Possible Counteractive Mechanism against Detrusor Overactivity. J. Urol.186: 2463-2469, 2011.
  6. Takeda, M., Mochizuki, T., Yoshiyama, M., Nakagomi, H., Kobayashi, H., Sawada, N., Zakohji, H., Du, S., Araki, I. Sensor mechanism and afferent signal transduction of the urinary bladder: special focus on transient receptor potential ion channels. LUTS (Lower Urinary Tract Symptoms) 2: 51-60, 2010.
  7. Araki, I., Yoshiyama, M., Kobayashi, H., Mochizuki, T., Du, S., Okada, Y. and Takeda, M. Emerging families of ion channels involved in urinary bladder nociception. Pharmaceuticals 3: 2248-2267, 2010.
  8. Yoshiyama, M., Araki, I., Kobayashi, H., Zakoji, H. and Takeda, M. Functional roles of TRPV1 channels in lower urinary tract irritated by acetic acid: in vivo evaluations of the sex difference in decerebrate unanesthetized mice. Am. J. Physiol. Renal. Physiol. 298: F1351-F1359, 2010.
  9. Uchiyama, T., Sakakibara, R., Yoshiyama, M., Yamamoto, T., Ito, T., Liu, Z., Yamaguchi, C., Awa, Y., Yano, H.-M., Yanagisawa, M., Yamanishi, T., Hattori, T. and Kuwabara, S. Biphasic effect of apomorphine, an anti-parkinsonian drug, on bladder function in rats. Neuroscience 162:1333-1338, 2009.
  10. Kobayashi, H., Yoshiyama, M., Zakoji, H., Takeda, M. and Araki, I. Sex differences in the expression profile of acid-sensing ion channels in the mouse urinary bladder: a possible involvement in irritative bladder symptoms. BJU Int. 104:1746-1751, 2009.
  11. Yoshiyama, M. Glutamatergic mechanisms controlling lower urinary tract function. LUTS (Lower Urinary Tract Symptoms) 1:S101-S104, 2009.
  12. Kakizaki, H. and Yoshiyama, M. Role of central 5-hydroxytrypyamine receptors in micturition control. LUTS (Lower Urinary Tract Symptoms) 1:S36-S39, 2009.
  13. Araki, I., Du, S., Kobayashi, H., Yoshiyama, M. and Takeda, M. Mechanosensitive ion channels in bladder sensory transduction. LUTS (Lower Urinary Tract Symptoms) 1:S18-S21, 2009.
  14. Yoshiyama, M. and de Groat, W.C. The role of vasoactive intestinal polypeptide and pituitary adenylate cyclase-activating polypeptide in the neural pathways controlling the lower urinary tract. J. Mol. Neurosci. 36:227-240, 2008.
  15. Yoshiyama, M., Kobayashi, H., Araki, I., Du, S., Zakoji, H. and Takeda, M. Sex-related differences in activity of lower urinary tract in response to intravesical acid irritation in decerebrate unanesthetized mice. Am. J. Physiol. Regul. Integr. Comp. Physiol. 295:R954-R960, 2008.
  16. Yoshiyama, M. and de Groat, W.C. Effects of intrathecal administration of pituitary adenylate cyclase activating polypeptide on lower urinary tract functions in rats with intact or transected spinal cords. Exp. Neurol. 211:449-455, 2008.