Prof. Olga Zaborina

Prof. Olga Zaborina

University of Chicago, USA



1997  Ph.D., Institute of Biochemistry and Physiology of Microorganisms, Russia

1993  M.Sc., Moscow Technological Institute of Food Production, Russia

Publications (selected)

  1. Kathleen Romanowski, Alexander Zaborin, Hoylan Fernandez, Valeriy Poroyko, Vesta Valuckaite, Svetlana Gerdes, Donald C. Liu, Olga Zaborina, and John C. Alverdy. Prevention of siderophore-mediated gut-derived sepsis due to P. aeruginosa can be achieved without iron provision by maintaining local phosphate abundance: role of pH. BMC Microbiology, 2011, 11: 212., senior co-authors.
  2. Trissa Babrowski, Christopher Holbrook, Jonathan Moss, Lawrence Gottlieb, Vesta Valuckaite, Alexander Zaborin, Valeriy Poroyko, Donald C. Liu, Olga Zaborina, and John C. Alverdy*. Pseudomonas aeruginosa virulence expression is directly activated by morphine and is capable of causing lethal gut derived sepsis in mice during chronic morphine administration. Ann. Surg. 2011, (Epub ahead of print), senior co-authors.
  3. David Fink, Kathleen Romanowski, Vesta Valuckaite, Trissa Babrowski,  Moses Kim, Jeffrey B. Matthews, Don Liu, Olga Zaborina, and John C. Alverdy Pseudomonas aeruginosa potentiates the lethal effect of intestinal ischemia-reperfusion injury: The role of in vivo virulence activation. Journal of Trauma 2011, (Epub ahead of print), senior co-authors.
  4. Edelstein, A., Musch, M., Valuckaite, V.,  Zaborina, O., Grubjesic S, Firestone MA, Matthews JB, and Alverdy, JC. Protective effects of nonionic triblock copolymers on bile Acid-mediated epithelial barrier disruption. Shock, 2011, 36: 451-457.
  5. Seal, J. B., Alverdy, J. C., Zaborina, O., An, G. Agent-based dynamic knowledge representation of Pseudomonas aeruginosa virulence activation in the stressed gut: Towards characterizing host-pathogen interactions in gut-derived sepsis. Theor Biol Med Model, 2011, 8: 33.
  6. Zaborina, O., Zaborin, A., Romanowski, K., Babrowski, T., Alverdy, J. Host Stress and Virulence Expression in Intestinal Pathogens: Development of Therapeutic Strategies using Mice and C. elegans. Curr Pharm Des. 2011, 17: 1254-1260.
  7. Seal, J. B., Morowitz, M., Zaborina, O., An, G., Alverdy, J. C. The molecular Koch's postulates and surgical infection: a view forward. Surgery. 2010, 147: 757-765. PMID: 20494210.
  8. Valuckaite V, Zaborina O, Long J, Hauer-Jensen M, Wang J, Holbrook C, Zaborin A, Drabik K, Katdare M, Mauceri H, Weichselbaum R, Firestone MA, Lee KY, Chang EB, Matthews J, Alverdy JC. Oral PEG 15-20 protects the intestine against radiation: role of lipid rafts. Am J Physiol Gastrointest Liver Physiol. 2009 Dec;297(6): G1041-52. , contributed equally. PMCID: PMC2850088.
  9. Zaborin, A., Romanowski, K., Gerdes, S., Holbrook C., Lepine, F., Long J., Poroyko, V., Diggle SP., Wilke, A., Righetti, K., Morozova, I., Babrowski, T., Liu, DC., Zaborina, O., and Alverdy, JC. Red death in Caenorhabditis elegans caused by Pseudomonas aeruginosa PAO1. Proc Natl Acad Sci U S A. 2009 14; 106(15): 6327-32. contributed equally.
  10. Chiang ET, Camp SM, Dudek SM, Brown ME, Usatyuk PV, Zaborina O, Alverdy JC, Garcia JG. Protective effects of high-molecular weight Polyethylene Glycol (PEG) in human lung endothelial cell barrier regulation: Role of actin cytoskeletal rearrangement. Microvasc Res. 2008 Mar; 77(2): 174-86.
  11. Long, J., Zaborina, O., Holbrook, C., Zaborin, A., and Alverdy, J. 2008. Depletion of intestinal phosphate after operative injury activates the virulence of P aeruginosa causing lethal gut-derived sepsis. Surgery. 2008 Aug; 144(2): 189-97.
  12. Zaborina, O., Holbrook, C., Chen, Y., Long, J., Zaborin, A., Morozova, I., Fernandez, H., Wang, Y., Turner, JR., and Alverdy, JC. 2008. Structure-Function Aspects of PstS in Multi-Drug-Resistant Pseudomonas aeruginosa. PLoS Pathog. Feb 4(2): e43.
  13. Kolli BK, Kostal J, Zaborina O, Chakrabarty AM, Chang KP. Leishmania-released nucleoside diphosphate kinase prevents ATP-mediated cytolysis of macrophages. Mol Biochem Parasitol. 2007 Dec 25 [Epub ahead of print].
  14. Zaborina, O., Lepine, F., Xiao, G., Valuckaite, V., Chen, Y., Li, T., Ciancio, M., Zaborin, A., Petrof, E., Turner, J.R., Rahme, L., Chang, E.B., Alverdy, J.C. Dynorphin activates quorum sensing quinolone signaling in Pseudomonas aeruginosa. PLoS Pathogens, 2007, Mar 16; 3(3): e35.
  15. Patel, N., Zaborina, O., Wu, L., Wang, Y., Wolfgeher, D.J., Valuckaite, V., Ciancio, M., Kohler, J.E., Shevchenko, O., Colgan, S.P., Chang, E.B., Turner, J.R., Alverdy, J.C. Recognition of intestinal epithelial HIF-1α activation by Pseudomonas aeruginosa. Am J Physiol Gastrointest Liver Physiol. 2007 Jan; 292(1): G134-42.