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Biography
zhao

Dr. Yunfeng Zhao

Department of Pharmacology, Toxicology & Neuroscience

LSU Health Sciences Center, USA


Email: yzhao1@lsuhsc.edu


Qualifications

2000 Postdoctoral fellow, Graduate Center for Toxicology, University of Kentucky, USA
1997 Ph.D., Changchun University of Agriculture and Animal Science (now part of Jilin University), China
1994 M.Sc., Department of Molecular biology, Jilin University, China
1991 B.Sc., Department of Molecular biology, Jilin University, China


Publications (Selected)

  1. Robbins D, Zhao Y. New Aspects of Mitochondrial Uncoupling Proteins (UCPs) and Their Roles in Tumorigenesis. Int J Mol Sci. 12: 5285-5293, 2011. Review.
  2. Robbins D, Zhao Y. Oxidative Stress Induced by MnSOD-p53 Interaction: Pro- or Anti-tumorigenic? J Signal Transduct. 2012: 101465, 2011. Review.
  3. Wittwer JA, Robbins D, Wang F, Codarin S, Shen X, Kevil C, Huang TT, Remmen H, Richardson A, Zhao Y. Enhancing Mitochondrial Respiration Suppresses Tumor Promoter TPA Induced PKM2 Expression and Cell Transformation in Skin Epidermal JB6 Cells. Cancer Prev Res 4: 1476-84, 2011.
  4. Robbins D, Zhao Y. The role of manganese superoxide dismutase in skin cancer. Enzyme Res. 2011: 409295, 2011.
  5. Wang F, Liu J, Robbins D, Morris K, Sit A, Liu YY, Zhao Y. Mutant p53 exhibits trivial effects on mitochondrial functions which can be reactivated by ellipticine in lymphoma cells. Apoptosis. 16: 301-10, 2011.
  6. Robbins D, Zhao Y. Imaging NF-kB signaling in mice for screening anticancer drugs. Methods Mol Biol. 716:169-177, 2011.
  7. Wang F, Fu X, Chen X, Chen X, Zhao Y. Mitochondrial uncoupling inhibits p53 mitochondrial translocation in TPA-challenged skin epidermal JB6 cells. PLoS One. 5: e13459, 2010.
  8. Robbins D, Gu X, Shi R, Liu J, Wang F, Ponville J, McCord JM, Zhao Y. The chemopreventive effects of Protandim: modulation of p53 mitochondrial translocation and apoptosis during skin carcinogenesis. PLoS One 5: e11902, 2010.
  9. Liu YY, Gupta V, Patwardhan GA, Bhinge K, Zhao Y, Bao J, Mehendale H, Cabot MC, Li YT, Jazwinski SM. Glucosylceramide synthase upregulates MDR1 expression in the regulation of cancer drug resistance through cSrc and beta-catenin signaling. Mol Cancer. 9: 145, 2010.
  10. Duan YF, Liu C, Zhao YF, Duan WM, Zhao LR. Thiopental exaggerates ischemic brain damage and neurological deficits after experimental stroke in spontaneously hypertensive rats. Brain Res. 1294:176-82, 2009.
  11. Liu J, Gu X, Robbins D, Li G, Shi R, McCord JM, Zhao Y. Protandim, a fundamentally new antioxidant approach in chemoprevention using mouse two-stage skin carcinogenesis as a model.. PLoS One 4: e5284, 2009.
  12. Liu J, St. Clair DK, Gu X, Zhao Y. Blocking mitochondrial permeability transition prevents p53 mitochondrial translocation during skin tumor promotion. FEBS Lett. 582: 1319-1324, 2008.
  13. Zhao Y, Liu J, McMartin KE. Inhibition of NADPH oxidase activity promotes differentiation of B16 melanoma cells. Oncol Rep. 19: 1225-1230, 2008.
  14. Spasojevic I, Chen Y, Noel T, Yu Y, Cole M, Zhang L, Zhao Y, St. Clair DK, Batinic-Haberle I. Mn porphyrin-based superoxide dismutase (SOD) mimic, MnTE-2-PyP5+, targets mouse heart mitochondria. Free Radic Biol Med. 42: 1193-1200, 2007.
  15. Zhao Y, Russ M, Retter M, Fanger G, Morgan C, Kohler H, Muller S. Endowing self-binding feature restores the activities of a loss-of-function chimerized anti-GM2 Antibody. Cancer Immunol Immunother 56: 147-154, 2007.
  16. Zhao Y, Chaiswing, L, Bakthavatchalu V, Oberley TD, St. Clair DK. Ras mutation promotes p53 activation and apoptosis of skin keratinocytes. Carcinogenesis. 27: 1692-1698, 2006.
  17. Zhao Y, Wang LM, Chaiswing L, Yen HC, Oberley TD, Lien YC, Lin SM, Mattson MP, St. Clair D. Tamoxifen protects against acute tumor necrosis factor alpha-induced cardiac injury via improving mitochondrial functions. Free Radic Biol Med. 40: 1234-1241, 2006.
  18. Grimes KR, Daosukho C, Zhao Y,Meigooni A, St. Clair W. Proteosome inhibition improves fractionated radiation treatment against non-small cell lung cancer: an antioxidant connection. Int J Oncol.27:1047-1052, 2005.
  19. Zhao Y, Russ M, Morgan C, Muller S, Kohler H.Therapeutic applications ofsuperantibodies. Drug Discov Today.10:1231-1236, 2005. Review.
  20. St. Clair D, Zhao Y, Chaiswing L, Oberley TD. Modulation of skin tumorigenesis by SOD. Biomed Pharmacother. 59:209-214, 2005. Review.
  21. Zhao Y, Chaiswing L,Velez JM, Batinic-Haberle I,Colburn NH, Oberley TD, St. Clair DK. p53 translocation to mitochondria precedes its nuclear translocation and targets mitochondrial oxidative defense protein - manganese superoxide dismutase. Cancer Res. 65:3745-3750, 2005.
  22. Muller S, Zhao Y, Brown TL, Morgan AC, Kohler H. TransMabs: cell-penetrating antibodies, the next generation. Expert Opin Biol Ther. 5:237-241, 2005. Review.
  23. Zhao Y, Chaiswing L, Oberley TD, Batinic-Haberle I, St. Clair W, Epstein CJ, St. Clair D. A mechanism-based antioxidant approach for the reduction of skin carcinogenesis. Cancer Res. 65:1401-1405, 2005.
  24. Oberley TD, Xue Y, Zhao Y, Kiningham K, Szweda LI, St. Clair DK.In situreduction of oxidative damage, increased cell turnover, and delay of mitochondrial injury by overexpression of manganese superoxide dismutase in a multistage skin carcinogenesis model. Antioxid Redox Signal. 6:537-548, 2004.
  25. Zhao Y, Brown TL, Kohler H, Muller S. MTS-conjugated-antiactive caspase 3 antibodies inhibit ctinomycin D-induced apoptosis. Apoptosis. 8:631-637, 2004.
  26. Zhao Y, St. Clair DK. Detection of the content and activity of the transcription factor AP-1 in a multistage skin carcinogenesis model. Methods Mol Biol, 218:177-184, 2003.
  27. Zhao Y, Kohler H. Enhancing tumor targeting and apoptosis using noncovalent antibody homodimers. J Immunother, 25:396-404, 2002.
  28. Zhao Y, Oberley TD, Chaiswing L, Lin SM, Epstein CJ, Huang TT, St Clair DK. Manganese superoxide dismutase deficiency enhances cell turnover via tumor promoter-induced alterations in AP-1 and p53-mediated pathways in a skin cancer model. Oncogene. 21:3836-3846, 2002.
  29. Zhao Y, Lou D, Burkett J, Kohler H. Enhanced anti-B-cell tumor effects with anti-CD20 superantibody. J Immunother. 25:57-62, 2002.
  30. Zhao Y, Xue Y, Oberley TD, Kiningham KK, Lin SM, Yen HC, Majima H, Hines J, St. Clair DK. Overexpression of manganese superoxide dismutase suppresses tumor formation by modulation of activator protein-1 signaling in a multistage skin carcinogenesis model. Cancer Res. 61:6082-6088, 2001.
  31. Zhao Y, Lou D, Burke J, Kohler H. Chemical engineering of cell penetrating antibodies. J Immunol Methods. 254: 137-145, 2001.
  32. Zhao Y, Kiningham KK, Lin SM, St. Clair DK. Overexpression of MnSOD protects murine fibrosarcoma cells (FSa-II) from apoptosis and promotes a differentiation program upon treatment with 5-Azacytidine: involvement of MAPK and NFkappaB pathways. Antioxid Redox Signal. 3:375-386, 2001.