wei du

Prof. Wei Du

Ben May Department for Cancer Research
The University of Chicago, USA



1997 Postdoc., MGH Cancer Center, Harvard Medical School
1994 Ph.D., Biochemistry & Molecular Biology, Harvard University
1986 B.Sc., Biochemistry, Fudan University

Publications (Selected)

  1. Jin, HR, Zhao, J, Zhang, Z, Liao, Y, Wang, CZ, Huang, WH, Li, SP, He, TC, Yuan, CS and Du, W (2012) Falcarindiol induces cancer cell death and inhibits cancer growth through induction of ER stress. Cell Death and Disease, 3, e376. PMCID: PMC3434669.
  2. Sukhanova, MJ., Steele, LJ., Zhang, T., Gordon, GM., Du, W. (2011) RBF and Rno promote photoreceptor differentiation onset through modulating EGFR signaling in the Drosophila developing eye. Dev Biol. 359, 190.
  3. Binghui Li, Jiong Zhao, Chong-Zhi Wang, Jennifer Searle, Tong-Chuan He, Chun-Su Yuan, and Wei Du (2011) Ginsenoside Rh2 induces apoptosis and paraptosis-like cell death in colorectal cancer cells through activation of p53. Cancer Letters. 301, 185-192. PMCID: PMC3022099.
  4. Gordon, GM and Du, W. (2011) Targeting Rb Inactivation in Cancers by Synthetic Lethality. American J. Cancer Research. 1, 773-786. NIHMSID: NIHMS309955.
  5. Gordon, GM and Du, W. (2011) Conserved RB Functions in Development and Tumor Suppression. Protein & Cell. In Press.
  6. Li, B., Gordon, GM., Du, CH., Xu, J., and Du, W. (2010) Specific killing of Rb mutant cancer cells by inactivating TSC2. Cancer Cell. 17, 469–480. PMCID: PMC2873973.
  7. Searle, J.S., Li, B., and Du, W. (2010) Targeting Rb mutant cancers by inactivating TSC2. Oncotarget. 1, 228-232. PMCID: PMC2920149.
  8. HE, BC, GAO, JL, LUO, XJ, LUO, JY, SHEN, JK, WANG, LY, ZHOU, QX, WANG, YT, LUU, HH, HAYDON, RC, WANG, CZ, DU, W, YUAN, CS, HE, TC, and ZHANG, BQ (2011) Ginsenoside Rg3 inhibits colorectal tumor growth through the down-regulation of Wnt/ß-catenin signaling. International J. of Oncology. 38: 437-445.
  9. Li, B, Wang, CZ, He, TC, Yuan, CS, Du, W. (2010) Antioxidants potentiate American ginseng-induced apoptosis in colorectal cancer cells. Cancer Lett. 289, 62-70. [Epub 2009 Aug 27]. NIHMSID: NIHMS141750
  10. Li, F., Duman-Scheel, M., Yang, D., Du, W., Zhang, J., Zhao, C., Qin, L., Xin, SJ. (2010) Sonic Hedgehog Signaling Induces Vascular Smooth Muscle Cell Proliferation via Induction of the G1 Cyclin-Retinoblastoma Axis. Arteriosclerosis, Thrombosis, and Vascular Biology. 30:1787-1794.
  11. Tanaka-Matakatsu, M., Xu, J., Cheng, L., and Du, W. (2009) Regulation of apoptosis of rbf mutant cells during Drosophila development. Dev Biol. 326, 347-56. NIHMSID # 84081.
  12. Steele, L., Sukhanova, MJ., Xu, J., Gordon, GM., Huang, Y, Yu, L., and Du, W. (2009) Retinoblastoma family protein promotes normal R8-photoreceptor differentiation in the absence of rhinoceros by inhibiting dE2F1 activity. Dev Biol. 335, 228–236. NIHMSID: NIHMS144795.
  13. Wei Du and Jennifer S. Searle (2009) The Rb Pathway and Cancer Therapeutics. Current Drug Targets. 10, 581-589.
  14. Matakatsu, MT, and Du, W. (2008) Direct control of proneural gene atonal by retinal determination factors during Drosophila eye development. Dev Biol. 313, 787-801. PMCID: PMC2231519.
  15. Dai, HZ, Chen, Y., Chen, S., Mao, Q., Kennedy, D., Landback, P., Eyre-Walker, A., Du, W, Long, M. (2008) The evolution of courtship behaviors through the origination of a new Gene in Drosophila. PNAS. 105, 7478-7483. PMCID: PMC2396706.
  16. Deb,DK, Matakatsu, MT, Jones, L., Richardson, HE, and Du, W. (2008) Wingless signaling directly regulates cyclin E expression in proliferating embryonic PNS precursor cells. Mechanisms of Dev. 125, 857-64. NIHMSID # 71787.
  17. Sukhanova, MJ and Du, W. (2008) Control of Cell Cycle Entry and Exiting from the Second Mitotic Wave in the Drosophila Developing Eye. BMC Developmental Biology. 8, 7. PMCID: PMC2267170.
  18. Sukhanova, M. Deb, D.K., Gordon, G.M., Matakatsu, MT, and Du, W. (2007) Proneural bHLH proteins and EGFR signaling coordinately regulate cell type specification and cdk inhibitor expression in Drosophila. MCB, 27, 2987-96. PMCID: PMC1899942.
  19. Matakatsu, MT, Thomas, BJ, and Du, W. (2007) Mutation of the Apc1 homologue shattered disrupts normal eye development by disrupting G1 cell cycle arrest and progression through mitosis. Dev Biol. 309, 222-235. (Epub 2007 Jul 14). PMCID: PMC2080841.
  20. Du, W. and Pogoriler, J (2006) Retinoblastoma Family Genes. Oncogene, 25, 5190-5200. PMCID: PMC1899835).
  21. Shafaee, Z., Schmidt, H., Du, W., Posner, M., Weichselbaum, R., (2006) Cyclopamine increases the cytotoxic effects of taxol and radiation in Hedgehog expressing pancreatic cancer. Cancer Chemother Pharmacol. 58, 765-70.
  22. Pogoriler J., Millen, K., Utset, M., and Du, W. (2006) Loss of cyclin D1 impairs cerebellar development and suppresses medulloblastoma formation. Development, 133, 3929-3937. (PMCID: PMC1868525).
  23. Lee, S., Zhang, X., Zhou, G., Shapino, J., Bao, J., Xu, J., Sun, M., Shi, R., Chen, J., Clark, T., Johnson, D., Tseng, C., Yang, H., Du, W., Wu, C., Wang, J., and Wang, S. (2005) Detecting novel low-abundant transcripts in Drosophila. RNA, 11, 939–946.
  24. Duman-Scheel, M., Johnston, L., and Du, W. (2004) Repression of dMyc expression by Wingless promotes RBF-induced G1 arrest in the Presumptive Drosophila Wing Margin. PNAS, 101, 3857–3862.
  25. Pogoriler, J and Du, W. (2004) Chk1 activation and the nuclear/cytoplasmic ratio. Developmental Cell, 7, 147-148.
  26. Xu, J. and Du, W. (2003) Drosophila chk2 plays an important role in a mitotic checkpoint in syncytial embryos. FEBS letter, 545, 209-212.
  27. Weng, L., Zhu, C., Xu, J. and Du, W. (2003) Critical role of active repression by E2F and Rb proteins in endoreplication during Drosophila development. EMBO J., 22, 3865-3875.
  28. Du, W. (2003) Endocycle and E2F-dependent transcriptional activation and repression. Cell Cycle, 2, 515-516.
  29. Xin, S., Weng, L., Xu, J., and Du, W. (2002) The role of RBF in developmentally regulated cell proliferation in the eye disc and in Cyclin D/Cdk4 induced cellular growth. Development. 129, 1345-1356.
  30. Duman-Scheel, M., Weng, L., Xin, S., and Du, W. (2002) Hedgehog signaling controls cell proliferation and growth through upregulation of Cyclin D and Cyclin E. Nature, 417, 299-304.
  31. Bosco G., Du, W., Orr-Weaver, T. (2001) DNA replication control through interaction of E2F–RB and the origin recognition complex.Nature Cell Biology, 3, 289-295.
  32. Xu, J., S. Xin, and W. Du. (2001). Drosophila Chk2 is required for DNA damage-mediated cell cycle arrest and apoptosis. FEBS Letters 508, 394-398.
  33. Du, W. (2000) Suppression of the rbf null mutants by a de2f1 allele that lacks transactivation domain. Development. 127, 367-379.
  34. Meyer, C.A., Jacobs, H.W., Datar, S.A., Du, W., Edgar, B.A., Christian F. Lehner, C.F. (2000) Drosophila Cdk4 stimulates growth and is dispensable for cell cycle progression. EMBO J. 19, 4533-4542.
  35. Du, W*. and Dyson, N. (1999) The role of RBF in the introduction of G1 regulation during Drosophila embryogenesis.EMBO J. 18, 916-925.(*corresponding author).
  36. Brook, A., Xie, J., Du, W., and Dyson, N. (1996) Requirements for dE2F function in proliferating cells and in post-mitotic differentiating cells.EMBO J. 15, 3676-3683.
  37. Du, W., Vidal, M., Xie, J., and Dyson, N. (1996) RBF, a novel RB-related gene that regulates E2F activity and interacts with cyclin E in Drosophila.Genes & Dev. 10, 1206-1218.
  38. Du, W., Xie, J., and Dyson, N. (1996) Ectopic expression of dE2F and dDP induces cell proliferation and death in the Drosophila eye. EMBO J. 15, 3684-3692.
  39. Du, W. and Maniatis, T. (1994) The high Mobility group protein HMG I(Y) can stimulate or inhibit DNA binding of distinct transcription factor ATF-2 isoforms. Proc. Natl. Acad. Sci. USA 91. 11318-11322.
  40. Du, W., Thanos, D., and Maniatis, T. (1993) Mechanisms of Transcriptional Synergism between Distinct Virus Inducible Enhancer Elements. Cell 74, 887-898.
  41. Du, W. and Maniatis, T. (1992) An ATF/CREB binding site is required for virus induction of the human interferon ß gene. Proc. Natl. Acad. Sci. USA 89. 2150-2154.

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