Elias Said

Dr. Elias Said

Department of Microbiology and Immunology, College of Medicine

Sultan Qaboos University, Oman



2004 Ph.D., Microbiology&Virology, Pasteur Institute of Paris, Paris Diderot University
2000 M.Sc., Medical Virology, Pasteur Institute of Paris, Paris Diderot University
1998 B.Sc., Biology, University of Aleppo

Publications (Selected)

  1. Van Grevenynghe J., Cubas R.A., Noto A., Dafonseca S., He Z., Peretz Y., Filali-Mouhim A., Dupuy F.P., Procopio F.A., Chomont N., Balderas R.S., Said E.A., Boulassel M.R., Tremblay C.L., Routy J.P., Sékaly R.P., Haddad E.K. Loss of memory B cells during chronic HIV infection is driven by Foxo3a- and TRAIL-mediated apoptosis. Journal of Clinical Investigation. 2011: Epub.
  2. Monteiro P., Gosselin A., Sue Wacleche V., El-Far M., Said E.A., Kared H., Grandvaux N., Boulassel M.R., Routy J.P. and Ancuta P. Memory CCR6+CD4+ T Cells Are Preferential Targets for Productive HIV Type 1 Infection Regardless of Their Expression of Integrin β7. Journal of Immunology. 2011: 4618-30.
  3. Said E.A. The Need for New Anti-Hepatitis C Virus Therapeutic Strategies Targeting the cellular micro-ribonucleic acids? SQU Med J. 2010; 312-17; Invited article.
  4. Said E.A., Dupuy F.P., Trautmann L., Zhang Y., Shi Y., Hill B.J., El-Far M., Ancuta P., Boulassel M.R., Routy J.P., Douek D.C., El-Haddad E.K. and Sekaly R.P. PD-1 Induced IL10 Production by Monocytes Impairs T-cell Activation in a Reversible Fashion. Nature Medicine. 2010; 452-9.
  5. Gosselin A.*, Monteiro P.*, Chomont N., Diaz-Griffero F., Said E.A. , Fonseca S., Wacleche V., El-Far M., Boulassel M.R., Routy J.P., Sekaly R.P., Ancuta P. Peripheral blood CCR4+CCR6+ and CXCR3+CCR6+ CD4+ T-cells are highly permissive to HIV-1 infection. Journal of Immunology. 2010; 1604-16. *Co-first author.
  6. Dekaban G.A., Snir J., Shrum B., Merrill M., Said E.A., Sekaly R.P., Foster P.J., O'Connell P.J., Willert C. Semi-quantitation of mouse dendritic cell migration in vivo using cellular MRI. Journal of Immunotherapy. 2009; 240-51.
  7. Gaucher D., Therrien R., Kettaf N., Angermann B.R., Boucher G., Filali-Mouhim A., Moser J.M., Mehta R.S., Drake D.R. 3rd, Castro E., Akondy R., Rinfret A., Yassine-Diab B., Said E.A., Chouikh Y., Cameron M.J., Clum R., Kelvin D., Somogyi R., Greller L.D., Balderas R.S., Wilkinson P., Pantaleo G., Tartaglia J., Haddad E.K., Sekaly R.P. Yellow fever vaccine induces integrated multilineage and polyfunctional immune responses. Journal of Experimental Medicine. 2008; 3119-31.
  8. Van Grevenynghe J., Halwani R., Chomont N., Ancuta P., Peretz Y., Tanel A., Procopio F.A., Shi Y., Said E.A., Haddad E.K., Sekaly R.P. Lymph node architecture collapse and consequent modulation of FOXO3a pathway on memory T- and B-cells during HIV infection. Seminars in Immunology. 2008; 196-203.
  9. El-Far M., Halwani R., Said E.A., Trautmann L., Doroudchi M., Janbazian L., Fonseca S., Van grevenynghe J., Yassine-Diab B., Sékaly R.P., Haddad E.K. T-cell exhaustion in HIV infection. Current HIV/AIDS Reports. 2008; 9 -13.
  10. Van grevenynghe J., Procopio F.A., He Z., Chomont N., Riou C., Zhang Y., Gimmig S., Boucher G., Wilkinson P., Shi Y., Yassine-Diab B., Said E.A., Trautmann L., El Far M., Balderas R.S., Boulassel M.R., Routy J.P., Haddad E.K., Sekaly R.P. Transcription factor FOXO3a controls the persistence of memory CD4(+) T cells during HIV infection. Nature Medicine. 2008; 266-74.
  11. Trautmann L., Said E.A., Halwani R., Janbazian L., Chomont N., El-Far M., Breton G., Haddad E.K. and Sekaly R.P. PD-1: a critical regulator of T cell function and a strong target for immunotherapies for chronic viral infections. Current Opinion in HIV and AIDS. 2007; 219-227.
  12. Trautmann, L, Janbazian, L.*, Chomont, N.*, Said E.A., Gimmig, S, Bessette, B, Boulassel, M, Delwart, M, Sepulveda, H, Balderas, R, Routy, J.P, Elias K.H. and Sekaly, R.P. Upregulation of PD-1 expression in HIV specific CD8 T cells leads to reversible immune dysfunction. Nature Medicine. 2006; 1198-1202. (* Co-second authors).
  13. Halwani R., Doroudchi M., Yassine-Diab B., Janbazian L., Shi Y., Said E.A., Haddad E.K., and Sékaly R.P. Generation and maintenance of human memory cells during viral infection. Springer Seminars in Immunopathology. 2006 ; 197-208.
  14. Said E.A.*, Courty J., Svab J., Delbé J., Krust B., and Hovanessian A.G. Pleiotrophin Inhibits HIV Infection by Binding The Cell Surface-Expressed Nucleolin. FEBS Journal. 2005; 4646 -4659.
  15. (*Corresponding author).
  16. Hovanessian A.G., Briand J.P., Said E.A., Svab J., Ferris S., Dali H., Muller S., Desgranges C., Krust B. The Caveolin-1 binding domain of HIV-1 glycoprotein gp41 is an efficient B-cell epitope vaccine candidate against virus infection. Immunity. 2004; 617-27.
  17. Legrand D., Vigie K., Said E.A., Elass E., Masson M., Slomianny M.C., Carpentier M., Briand J.P., Mazurier J., Hovanessian A.G..Surface nucleolin participates in both the binding and endocytosis of lactoferrin in target cells. Eur J Biochem. 2004; 303-317.
  18. Said E.A., Krust B., Nisole S., Svab J., Briand J.P., Hovanessian A.G. The anti-HIV cytokine midkine binds the cell surface-expressed nucleolin as a low affinity receptor. J Biol Chem. 2002; 37492-502.
  19. Nisole S., Said E.A., Mische C., Prevost M.C., Krust B., Bouvet P., Bianco A., Briand J.P., Hovanessian A.G.The anti-HIV pentameric pseudopeptide HB-19 binds the C-terminal end of nucleolin and prevents anchorage of virus particles in the plasma membrane of target cells. J Biol Chem. 2002; 20877-86.