Dr. Liping Huang

USDA/ARS/Western Human Nutrition Research Center, USA

Email: Liping.Huang@ARS.USDA.GOV


1995 Ph.D., Molecular Virology, University of Iowa
1983 M.D., Medicine, Public Health, Shanghai Medical University

Publications (Selected)

  1. Stinski MF, Macias MP, Malone CL, Thrower AR, Huang L. 1993. Regulation of transcription from the cytomegalovirus major immediate early promoter by cellular and viral proteins, p.3-12. In S. Michelson and S.A. Plotkin (ed.), Multidisciplinary approach to Understanding Cytomegalovirus Disease. Elsevier Science Publishers B. V., Amsterdam, The Netherlands.
  2. Huang L, Malone CL, Stinski MF. Role of a CCAAT box-binding protein in an early promoter activation of human cytomegalovirus, p.17-20. In S. Michelson and S.A. Plotkin (ed.), Multidisciplinary approach to Understanding Cytomegalovirus Disease. Elsevier Science Publishers B. V., Amsterdam, The Netherlands. 1993.
  3. Huang L, Malone CL, Stinski MF. 1994. A human cytomegalovirus early promoter with upstream negative and positive cis-acting elements: IE2 negates the effect of the negative element, and NF-Y binds to the positive element. J. Virol. 68:2108-2117.
  4. Huang L, Stinski MF. 1995. Binding of cellular repressor protein of the IE2 protein to a cis-acting negative regulatory element upstream of a human cytomegalovirus early promoter. J. Virol. 69:7612-7621.
  5. Macias MP, Huang L, Lushmit P, Stinski MF. 1996. Cellular or viral protein binding to the cytomegalovirus promoter transcription initiation site: effects on transcription. J. Virol. 70:3628-3635.
  6. Huang L, Gitschier J. 1997. A novel gene involved in zinc transport is deficient in the lethal milk mouse. Nat. Genet. 17:292-297
  7. Huang L, Kuo YM, Gitschier J. 1999. The pallid gene encodes a novel, syntaxin 13-interacting protein involved in platelet storage pool deficiency. Nat. Genet. 23:329-332.
  8. Huang L, Kirschke CP, Gitschier J. 2002. Functional characterization of a novel mammalian zinc transporter, ZnT6. J. Biol. Chem. 277:26389-95.
  9. Kirschke CP, Huang L. 2003. ZnT7, a novel mammalian zinc transporter, accumulates zinc in the Golgi apparatus. J Biol Chem. 278:4096-102.
  10. Palmiter RD, Huang L. 2004. Efflux and compartmentalization of zinc by members of the SLC30 family of solute carriers. Pflugers Arch. European J. Physiology. 447:744-751.
  11. Wang ZY, Stoltenberg M, Jo SM, Huang L, Larsen A, Dahlstrom A, Danscher G. 2004 Dynamic zinc pools in mouse choroid plexus. Neuroreport. 15:1801-1804.
  12. Andree KB, Kim J, Kirschke CP, Gregg JP, Paik H, Joung H, Woodhouse L, King JC, Huang L. 2004 Investigation of lymphocyte gene expression for use as biomarkers for zinc status in humans. J Nutr. 134:1716-1723.
  13. Wang ZY, Stoltenberg M, Huang L, Danscher G, Dahlstrom A, Shia Y, Li JY. 2005. Abundant expression of zinc transporters in Bergman glia of mouse cerebellum. Brain Research Bulletin 64:441–448.
  14. Huang L, Kirschke CP, Zhang Y, Yu YY. 2005. The ZIP7 gene (Slc39a7) encodes a zinc transporter involved in zinc homeostasis of the Golgi apparatus. J. Biol Chem. 280:15456-15463.
  15. Huang L, Kirschke CP, Zhang Y. 2006. Decreased intracellular zinc in human tumorigenic prostate epithelial cells: a possible role in prostate cancer progression. Cancer Cell Int. 31;6:10.
  16. Wang X, Wang Z-Y, Gao H-L, Danscher G, Huang L. 2006. Localization of ZnT7 and zinc ions in mouse retina- Immunohistochemistry and selenium autometallography. Brain Res. Bull. 71:91-96.
  17. Chi Z., Wang X., Wang Z., Gao H., Dahlstrom A., Huang L. 2006. Zinc transporter 7 is located in the cis-Golgi apparatus of mouse choroid epithelial cells. NeuroReport 17:1807-1811.
  18. Magbanua MM, Dawson K, Huang L, Malyj W, Gregg J, Galvez A, Rodriguez RL. 2006. Nutrient-Gene Interactions Involving Soy Peptide and Chemopreventive Genes in Prostate Epithelial Cells. In J. Kaput and R. L. Rodriguez (ed.), Nutritional Genomics: Discovering the Path to Personalized Nutrition. John Wiley & Sons, Inc. p255-276.
  19. Yu YY, Kirschke CP, Huang L. 2007. Immunohistochemical analysis of ZnT1, 4, 5, 6, and 7 in the mouse gastrointestinal tract. J.Histochem. Cytochem. 55:223-234.
  20. Huang L, Kirschke CP. 2007. A di-leucine sorting signal in ZIP1 (SLC39A1) mediates endocytosis of the protein. FEBS J. 274:3986-3997.
  21. Zhang L, Chi ZH, Ren H, Rong M, Dahlstrom A, Huang L, Wang ZY. 2007. Immunoreactivity of zinc transporter 7 (ZNT7) in mouse dorsal root ganglia. Brain Res. Bull. 74:278-283.
  22. Huang L, Yu YY, Kirschke CP, Gertz ER, Lloyd KK. 2007. Znt7 (Slc30a7)-deficient mice display reduced body zinc status and body fat accumulation. J. Biol. Chem. 282:37053-37063.
  23. Chi Z-H, Ren H, Wang X, Rong M, Huang L, Wang Z-Y. 2008. The cellular and subcellular localization of zinc transporter 7 in the mouse spinal cord. Histol. Histopathol. 23:781-787.
  24. Zhang LH, Wang X, Zheng ZH, Ren H, Stoltenberg M, Danscher G, Huang L, Rong M, Wang ZY. 2008. Abundant expression of zinc transporters in the amyloid plaques of Alzheimer's disease brain. Brain Res. Bull. 77(1):55-60.
  25. Gao H-L, Xu H, Wang X, Dahlstrom A, Huang L, Wang Z-Y. 2008. Expression of zinc transporter ZnT7 in mouse superior cervical ganglion. Auton Neurosci. 140(1-2):59-65.
  26. Kirschke CP, Huang L. 2008. Expression of ZNT (SLC30) family members in the epithelium of the mouse prostate during sexual maturation. J. Mol. Histol. 39:359-370.
  27. Chi Z-H, Feng W-Y, Gao H-L, Zheng W, Huang L, Wang Z-Y. 2009. ZNT7 and Zn2++ are present in different cell populations in the mouse testis. Histol. Histopathol. 24:25-30.
  28. Zhang L-H, Wang X, Zheng Z-H, Ren H, Stoltenberg M, Danscher G, Huang L, Rong M, Wang Z-Y. 2010. Altered expression and distribution of zinc transporters in APP/PS1 transgenic mouse brain. Neurobiology of Aging 31:74-87.
  29. Huang, L, Yan M, Kirschke CP. 2010. Over-expression of ZnT7 increases insulin synthesis and secretion in pancreatic b-cells by promoting insulin gene transcription. Exp. Cell Res. 316:2630-43.
  30. Galvez AF, Huang L, Magbanua MJ, Dawson K, Rodriguez RL. 2010. Lunasin peptide upregulates thrombospondin 1 (THBS1) gene expression in non-tumorigenic prostate epithelial cells. Nutrition and Cancer, 63:623-36.
  31. Tepaamorndech S, Huang L, Kirschke CP. 2011. A null-mutation in theZnt7gene accelerates prostate tumor formation in a transgenic adenocarcinoma mouse prostate model. Cancer Lett. 308:33-42.