Dr. J. Nathan Davis
School of Medicine
Quinnipiac University, USA
1991 Ph.D., Microbiology, University of Texas
1985 B.Sc., Biology, University of Arkansas
Greer AH, Yong T, Fennell K, Moustafa YW, Fowler M, Galiano F, Ng S-W, Berkowitz RS, Cardelli J, Meyers S, Davis
of core binding factorβ alters
sphingolipid metabolism. J
Cell Physiol. 228(12):2350-64, 2013.
Muniz V, Barnes JM, Paliwal S, Zhang X, Tang
X, Chen S, Zamba KD, Cullen JJ, Meyerholz
DK, Meyers S, Davis JN, Grossman SR, Henry MD Quelle DE. The ARF
tumor suppressor inhibits tumor cell colonization independent of p53 in a novel mouse model of pancreatic ductal
adenocarcinoma metastasis. Mol. Cancer
Yong T, Meyers S, Henry MD, Davis JN. Down regulation of CSL activity inhibits cell proliferation in prostate and
breast cancer cells. J. Cell Biochem112(9):2340-51, 2011.
Davis JN, Rogers D, Adams L, Yong T, Jung JS,
Cheng B, Fennell K, Borazanci E, Moustafa
YW, Sun A, Shi R, Glass J, Mathis JM, Williams BJ, Meyers S.Association of core
binding factor beta with the malignant phenotype of prostate and ovarian cancer cells. J Cell Physiol. 2010
Fitzpatrick A, Galiano FJ, First EA, Davis JN. Phosphatidic acid regulates the affinity of the murine
phosphatidylinositol 4-phosphate 5-kinase-Ibeta
for phosphatidylinositol-4-phosphate. J Cell Biochem. 100; 112-128,
Fowler M, Borazanci E, McGhee L, Pylant SW, Willliams BJ, Glass J, Davis JN, and Meyers S. RUNX1 (AML-1) and RUNX2 (AML-3)
cooperate with prostate-derived Ets
factor to activate transcription from the PSAup stream regulatory region. J Cell
Biochem. 97:1-17, 2006.
McGhee L, Bryan J, Elliot L, Grimes HL,
Kazanjian A, Davis JN, Meyers S. Gfi-1 attaches to the nuclear matrix,
associates with ETO (MTG8) and histone deactylase
proteins and represses transcription using a TSA sensitive mechanism. J Cell Biochem. 89:1005-18, 2003.
Davis JN, McGhee L. and Meyers S. The ETO
(MTG8) gene family. Gene.303:1-10, 2003.
Galiano FJ, Ulug ET, and Davis JN. Overexpression of
murine phosphatidylinositol 4-phosphate
5-kinase disrupts a phosphatidylinositol 4, 5 bisphosphate
regulated endosomal pathway. J Cell Biochem.
Barbieri MA, Heath CM,
Peters EM, Wells A, Davis JN, and Stahl PD. Phosphatidylinositol-4-phosphate-5-kinase-1b
is essential for EGF-receptor mediated
endocytosis. J Biol Chem
Buijs A, van Rompaey L,
Molijn AC, Davis JN, Vertegaal AC, Potter MD, Adams
C, van Baal S, Zwarthoff EC, Roussel MF, Grosveld GC. The MN1-TEL fusion protein, encoded by the translocation
(12;22)(p13;q11) in myeloid leukemia,
is a transcription factor with transforming activity. Mol Cell Biol. 20:9281-93, 2000.
Shyng S-L, Barberi A,
Gumusboga A, Cukras C, Pike L, Davis JN, Stahl PD, Nichols CG. Modulation
of nucleotide sensitivity of ATP-sensitive potassium channels by phosophatidylinositol-4-phosphate 5-kinase. Proc Natl
Acad Sci., USA 97:937-941, 2000.
Davis JN, Williams BJ,
Herron JT, Galiano FJ, Meyers SM. ETO-2,
a new member of the ETO-family of
nuclear proteins. Oncogene, 18,
Davis JN, Rock CO, Cheng M, Ashmun RA, Kirk H, Kay R,
Roussel MF. Growth factor receptor-dependent mitogenic signaling mediated by
a truncated type I phosphatidylinositol-4 phosphate
5-kinase. Mol Cell Biol 17:7398-7406, 1997.
Hiebert SW, Sun W, Davis
JN, Golub T, Shurtleff S, Buijs A, Downing JR, Grosveld
G, Roussel MF, Gilliland DG, Lenny N, Meyers S. The t (12; 21) translocation converts AML-1B from an
activator to a repressor of transcription.
Mol Cell Biol 16: 1349-1355, 1996.
Ernst P, Hahm K, Trinh L,
Davis JN, Roussel MF, Turck CW, Smale ST. A potential
role for Elf-1 in terminal transferase gene regulation. Mol Cell Biol 16: 6121-6131, 1996.
Davis JN and Roussel
MF. Molecular cloning and expression of
the cDNA for murineElf-1. Gene:171:265-269, 1996.
Jeon IS, Davis JN, Braun
BS, Sublett JE, Roussel MF, Denny CT, Shapiro DN. A variant Ewing’s sarcoma translocation (7; 22) fuses theewsgene to theetsgeneetv1. Oncogene: 10: 1229-1234, 1995.
Roussel MF, Davis JN,
Cleveland JL, Ghysdael J, Hiebert SW. Dual control ofmycexpression through a single DNA
binding site targeted byetsfamily proteins and
E2F. Oncogene 10: 405-415, 1995.
Inoue J-I, Kerr LD,
Rashid, Davis N, Bose HR Jr., Verma IM. Direct association of pp40/IkB
with rel/NF-kB proteins: Role of ankyrin repeats in the inhibition of DNA binding activity. Proc Natl Acad Sci USA 89:4333-4337, 1992.
Davis N, Ghosh S, Simmons
D, Tempst P, Liou H-C, Baltimore D, Bose HR Jr. Rel-associated pp40: An inhibitor of therelfamily of transcription factors. Science 253:1268-1271, 1991.
Kerr LD, Inoue J-I, Davis
N, Link E, Bauerle PA, Bose HR Jr, Verma I. The rel-associated pp40
protein prevents DNA binding of REL and NF-kB: Relationship
with IkB and regulation by phosphorylation. Genes Devel 5:1464-1476,
Davis JN, Bargmann W, Bose
HR, Jr. Identification of protein
complexes containing the c-relproto-oncogene product in avian
hematopoetic cells. Oncogene 5:1109-1115, 1990.
Lim M-Y, Davis N, Zhang J,
Bose HR, Jr. The v-reloncogene product is complexed
with cellular proteins including its proto-oncogene product and heat shock protein 70. Virology 175:149-160, 1990.
Davis N, Bargmann W, Lim
M-Y, Bose HR, Jr. Avian
lymphoid cells contain multiple pp59v-relcomplexes. J Virol 64:584-591,