Dr. Teruko Taketo

Urology Research Laboratory, Department of Surgery, Faculty of Medicine

McGill University, Canada



1978 Ph.D., Pharmacology, Kyoto University 

1975 M.S., Pharmacology, Kyoto University

1973 B.S., Pharmaceutical Sciences, Kyoto University

Publications (Selected)

  1. Misu, Y., Nishio, H., Hosotani, T. and Hamano, S. A new guanidine derivative: Dissociation of the adrenergic neuron blocking activity from local anesthetic activity. Japanese Journal of Pharmacology 26: 367-375 (1976).
  2. Hosotani, T. and Misu, Y. Sodium sensitive active transport of bretylium into adrenergic neurons for the development of blockade in rabbit ilium. Archives internationales de Pharmacodynamie et de Therapie (Gent) 226: 235-245 (1977).
  3. Misu, Y., Hosotani, T., Nakashima, E. and Nishio, H. Effects of calcium and guanethidine on noradrenaline output induced by sodium reduction in rabbit atria. Japanese Journal of Pharmacology 27: 745-748 (1977).
  4. Hosotani, T. and Misu, Y. Prevention by guanethidine analogue of output of noradrenaline induced by sodium reduction in rabbit ventricular slices. British Journal of Pharmacology 64: 37-45 (1978).
  5. Hosotani, T. and Misu, Y. Further evidence for the prevention by guanethidine of noradrenaline efflux from rabbit ventricular slices induced by a low external sodium concentration. British Journal of Pharmacology 64: 163-165 (1978).
  6. Taketo, T. and Koide, S.S. In vitro development of testis and ovary from indifferent fetal mouse gonads. Developmental Biology 84: 61-66 (1981).
  7. Taketo, T., Thau, R.B., Adeyamo, O. and Koide, S.S. Influence of cyclic AMP analogues on testicular organization of fetal mouse gonads in vitro. Biology of Reproduction 30: 189-198 (1984).
  8. Taketo, T., Merchant-Larios, H. and Koide, S.S. Induction of testicular differentiation in the fetal mouse ovary by transplantation into adult male mice. Proceedings of the Society for Experimental Biology and Medicine 176: 148-153 (1984)
  9. Taketo-Hosotani, T., Merchant-Larios, H., Thau, R.B. and  Koide, S.S. Testicular cell differentiation in fetal mouse ovaries following transplantation into adult male mice. Journal of Experimental Zoology 236: 229-237 (1985).
  10. Taketo, T., Seen, C.D. and Koide, S.S. Requirement of serum components for the preservation of primordial germ cells in testis cords during early stages of testicular differentiation in vitro in the mouse. Biology of Reproduction 34: 919-924 (1986).
  11. Taketo-Hosotani, T. Factors involved in the testicular development from fetal mouse ovaries following transplantation. Journal of Experimental Zoology 241: 95-100 (1987).
  12. Nagamine, C.M., Taketo, T. and Koo, G.C. Morphological development of the mouse gonad in tda-1 XY sex reversal. Differentiation 33: 214-222 (1987).
  13. Nagamine, C.M., Taketo, T. and Koo, G.C. Studies on the genetics of tda-1 XY sex reversal in the mouse. Differentiation 33: 223-231 (1987).
  14. Taketo-Hosotani, T. and Sinclaire-Thompson, E. Influence of the mesonephros on the development of mouse ovaries following transplantation into adult male and female mice. Developmental Biology 124: 423-430 (1987).
  15. Taketo-Hosotani, T., Nishioka, Y., Nagamine, C.M., Villalpando,I.and Merchant-Larios, H. Development and fertility of ovaries in the B6.YDOMsex-reversed female mouse.  Development 107: 95-105 (1989).
  16. Taketo-Hosotani, T., Saeed, J., Roberge, S., Matsuo, N. and Koide, S.S. Effects of hormones on testicular differentiation and testosterone production in the fetal mouse gonad in vitro. Journal of Steroid Biochemistry and Molecular Biology 38: 523-531 (1991).
  17. Taketo, T., Saeed, J., Nishioka, Y. and Donahoe, P.K. Delay of testicular differentiation in the B6.YDOMovotestis demonstrated by immunocytochemical staining for Mullerian inhibiting substance. Developmental Biology 146: 386-395 (1991).
  18. Merchant-Larios, H. and Taketo, T. Testicular differentiation in mammals under normal and experimental conditions. Journal of Electron Microscopy Technique 19: 158-171 (1991).
  19. *Houle, A.-M. and Taketo, T. True hermaphrodites: An experimental model in the mouse. The Journal of Urology 148: 672-676 (1992).
  20. Hassan, A.A., Hassouna, M.M., Taketo, T., Gagnon, C. and Elhilali, M.M. The effect of diabetes on sexual behaviour and reproductive tract function in male rats. The Journal of Urology 149: 148-154 (1993).
  21. *Villalpando, I., Nishioka, Y. and Taketo, T. Endocrine differentiation of the XY sex-reversed mouse ovary during postnatal development. Journal of Steroid Biochemistry and Molecular Biology 45: 265-273 (1993).
  22. Taketo, T., Saeed, J., Manganaro, T., Takahashi, M. and Donahoe, P.K. Mullerian inhibiting substance (MIS) production associated with loss of oocytes and testicular differentiation in the mouse XX gonadal graft. Biology of Reproduction 49: 13-23 (1993).
  23. Merchant-Larios, H., Clarke, H. J. and Taketo, T. Developmental arrest of fertilized eggs from the B6.YDOMsex-reversed female mouse. Developmental Genetics 15:435-442 (1994).
  24. *Lee, C.-H. and Taketo, T. Normal onset, but prolonged expression ofSrygene in the B6.YDOMsex-reversed mouse gonad. Developmental Biology 165: 442-452 (1994).
  25. *Amleh, A., *Ledee, N., Saeed, J. and Taketo, T. Competence of XY oocytes from the B6.YDOMsex-reversed female mouse for maturation, fertilization, and embryonic development in vitro. Developmental Biology 178: 263-275 (1996).
  26. Vanderhyden, B.C., Macdonald, E.A., Merchant-Larios, H., Fernandez, A., *Amleh, A., *Nasseri, R. and Taketo, T. Interactions between the oocyte and cumulus cells in the ovary of the B6.YTIRsex-reversed female mouse. Biology of Reproduction 57: 641-646 (1997).
  27. *Amleh, A. and Taketo, T. Live-borns from XX but not XY oocytes in the chimeric ovary composed of B6.YTIRand XX cells. Biology of Reproduction 58: 574-582 (1998).
  28. Mertineit, C., Yoder, J.A., Taketo, T., Laird, D.W., Trasler, J.M. and Bestor, T.H.  Sex-specific exons control DNA methyltransferase in germ cells. Development 125: 889-897 (1998).
  29. *Amleh, A., Smith, L., *Chen, H.-Y. and Taketo, T. Both nuclear and cytoplasmic components are defective in oocytes of the B6.YTIRsex-reversed female mouse. Developmental Biology 219: 277-286 (2000).
  30. *Wong, J., *Luckers, L., Okawara, Y., Pelletier, R.-M. and Taketo, T. Follicular development and atresia in the B6.YTIRsex-reversed mouse ovary. Biology of Reproduction 63: 756-762 (2000).
  31. *Lee, C.-H. and Taketo, T. Low levels ofSrytranscripts cannot be the sole cause of B6-YTIRsex reversal. Genesis 30: 7-11 (2001).
  32. *McClellan, K.A., Gosden, R. and Taketo, T. Continuous loss of oocytes throughout meiotic prophase in the normal mouse ovary. Developmental Biology 258: 334-348 (2003).
  33. Li, Y., Yue, L., Taketo, T. and Lau, Y.-F. C. Protein transduction as a strategy for evaluating important factors in mammalian sex determination and differentiation. Cytogenetics and Genome Research 101: 237-241 (2003).
  34. *Park, E.-H. and Taketo, T. Onset and progress of meiotic prophase in the oocytes in the B6.YTIRsex-reversed mouse ovary. Biology of Reproduction 69: 1879-1889 (2003).
  35. La Salle, S., Mertineit, C., Taketo, T., Moens, P.B., Bestor, T.H. and Trasler, J.M Windows for sex-specific methylation marked by DNA methyltransferase expression profiles in mouse germ cells. Developmental Biology, 268: 403-415 (2004).
  36. Taketo, T., *Lee, C.-H., Zhang, J., Li, Y.-M., Lee, C.-Y.G. and Lau, Y.-F.C. Expression of SRY proteins in both normal and sex-reversed XY fetal mouse gonads. Developmental Dynamics 233: 612-622 (2005).
  37. Villemure, M., *Chen, H.-Y., Kurokawa, M., Fissore, R.M. and Taketo, T. The presence of X-and Y-chromosomes in oocytes leads to impairment in the progression of the second meiotic division. Developmental Biology 301: 1-13 (2007).
  38. *Alton, M. and Taketo, T. Switch from BAX-dependent to BAX-independent germ cell loss during the development of fetal mouse ovaries. Journal of Cell Science 120: 417-424 (2007).
  39. *Alton, M., *Lau, M. P., Villemure, M. and Taketo, T. The behavior of the X- and Y-chromosomes in the oocyte during meiotic prophase in the B6.YTIRsex-reversed mouse ovary. Reproduction 135: 241-252 (2008).
  40. Obata, Y., Villemure, M., Kono, T. and Taketo, T. Transmission of Y-chromosomes from XY female mice was made possible by replacement of cytoplasm during oocyte maturation. Proceedings of theNationalAcademyof Sciences of theUnited States of America105: 13918-13923 (2008).
  41. Saferali, A., Berlivet, S., Schimenti , J., Bartolomei , M.S., Taketo, T., and Naumova, A.K. Defective imprint resetting in carriers of Robertsonian translocation Rb (8.12). Mammalian Genome 12: 377-387 (2009).
  42. *Park, S., *Zeidan, K.T., *Shin, J.S., and Taketo, T SRY upregulation of SOX9 is inefficient and delayed, allowing ovarian differentiation, in the B6.YTIRgonad. (selected for cover) Differentiation 82: 18-27 (2011).