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Biography
jian

Dr. Jian-Jun Wei

Department of Pathology

Department of Obstatrics and Gynecology

Feinberg School of Medicine

Northwestern University, USA


Email: jianjun-wei@northwestern.edu


Qualifications

1982-1985 M.D., Clinic Medicine, Huabei Coal Medical College, China

1977-1982 M.S., Medical Genetics, Shandong Medical University, China


Publications (Selected)

  1. STC2overexpression mediated byHMGA2is a biomarker for aggressiveness of high-grade serous ovarian cancerJingjing Wu, Maode Lai, Changshun Shao, Jian Wang and Jian-Jun Wei. Oncology Report. 2015
  2. Spontaneous transformation of murine oviductal epithelial cells: A model system to investigate the onset of fallopian-derived tumors MIchael P. Endsley, Georgette Moyle-Heyrman, Subbulakshmi Karthikeyan, Daniel D. Lantvit, David A. Davis, Jian-Jun Wei and Joanna E Burdette Frontier Oncology 2015
  3. Tumorigenesis and peritoneal colonization from fallopian tube epithelium. Sharon L. Eddie, Suzanne M. Quartuccio, Eoghainin Ó. hAinmhire, Georgette Moyle-Heyrman, Dan D. Lantvit, Jian-Jun Wei, Vanderhydenand Joanna E. BurdetteBarbara C. Oncotarget. 2015.
  4. Mutant p53 expression in fallopian tube epithelium drives cell migration. Suzanne M. Quartuccio, Subbulakshmi Karthikeyan, Sharon L. Eddie, Daniel D. Lantvit, Eoghain, O Ainmhire, Dimple A. Modi, Jian-Jun Wei and Joanna E. Burdette. Internat J Cancer 2015
  5. Differential expression of miRNAs in uterine leiomyoma and adjacent myometrium of different races Z Liu, H Guo, J Wu,S Ghanny, H Guo, E Marsh, S Bulun, J Zavadil, P Soteropoulos, JJ Wei*. Am J Gyn Oncol 2015
  6. LEF1 Targeting EMT in Prostate Cancer Invasion is Regulated by miR-34a. Liang J, Li Y, Daniels G, Sfanos K, De Marzo A, Wei JJ, Li X, Cheng W, Wang J, Zhong X, Melamed J, Zhao J, Lee P. Mol Cancer Res. 2015 Jan 13. pii: molcanres.0503.2014. [Epub ahead of print] PubMed PMID: 25587085.
  7. Integrated analysis of long noncoding RNAs and mRNAs reveals their potential roles in the pathogenesis of uterine leiomyomas. Guo H, Zhang X, Dong R, Liu X, Li Y, Lu S, Xu L, Wang Y, Wang X, Hou D, Wei JJ, Shao C, Liu Z. Oncotarget. 2014 Aug 16. PubMed PMID: 25268745.
  8. Ovarian steroids, stem cells and uterine leiomyoma: Therapeutic implications. Moravek MB, Yin P, Ono M, Coon VJS, Dyson MT, Navarro A, Marsh EE, Chakravarti D, Julie Kim J, Wei J-J, Bulun SE. Human Reproduction Update. 2015 Jan;21(1):1-2. ISSN: 13554786
  9. Establishment of human patient-derived endometrial cancer xenografts in NOD scid gamma mice for the study of invasion and metastasis. Unno K, Ono M, Winder AD, Maniar KP, Paintal AS, Yu Y, Wei J-J, Lurain JR, Kim JJ. PLoS ONE. 2014 Dec 26;9(12): ISSN: 19326203
  10. 5-hydroxymethylcytosine promotes proliferation of human uterine leiomyoma: A biological link to a new epigenetic modification in benign tumors. Navarro A, Yin P, Ono M, Monsivais D, Moravek MB, Coon JSV, Dyson MT, Wei J-J, Bulun SE. Journal of Clinical Endocrinology and Metabolism. 2014 Nov;99(11):E2437-E2445. PMID:25057885ISSN: 0021972X
  11. A Role for WDR5 in Integrating Threonine 11 Phosphorylation to Lysine 4 Methylation on Histone H3 during Androgen Signaling and in Prostate CancerKim J-Y, Banerjee T, Vinckevicius A, Luo Q, Parker JB, Baker MR, Radhakrishnan I, Wei J-J, Barish GD, Chakravarti D. Molecular Cell. 2014 May 22;54(4):613-625.  PMID:24793694PMCID: 24793694 ISSN: 10972765
  12. Inactivation of AKT induces cellular senescence in uterine leiomyomaXu X, Lu Z, Qiang W, Vidimar V, Kong B, Kim JJ, Wei J-J*. Endocrinology. 2014 Apr;155(4):1510-1519. PMID:24476133PMCID: 24476133 ISSN: 00137227
  13. Down-regulation of miR-29b is essential for pathogenesis of uterine leiomyomaQiang W, Liu Z, Serna VA, Druschitz SA, Liu Y, Espona-Fiedler M, Wei J-J*, Kurita T. Endocrinology. 2014 Mar;155(3):663-669. PMID:24424054PMCID: 24424054 ISSN: 00137227
  14. Advances in serous tubal intraepithelial carcinoma: Correlation with high grade serous carcinoma and ovarian carcinogenesisLi H-X, Lu Z-H, Shen K, Cheng W-J, Malpica A, Zhang J, Wei J-J, Zhang Z-H, Liu J. International Journal of Clinical and Experimental Pathology. 2014 Jan;7(3):848-857. PMID:24696706PMCID: 24696706 ISSN: 19362625
  15. Decreased expression of stromal estrogen receptor α and β in prostate cancerDaniels G, Lin Gellert L, Melamed J, Hatcher D, Li Y, Wei J, Wang J, Lee P. American Journal of Translational Research. 2014 Jan;6(2):140-146. ISSN: 19438141
  16. Anti-miR182 reduces ovarian cancer burden, invasion, and metastasis: An in vivo study in orthotopic xenografts of nude miceXu X, Ayub B, Liu Z, Serna VA, Qiang W, Liu Y, Hernando E, Zabludoff S, Kurita T, Kong B, Wei J-J*. Molecular Cancer Therapeutics. 2014 Jan;13(7):1729-1739. MCT-13-0982.ISSN: 15357163
  17. Epithelial and stromal expression of miRNAs during prostate cancer progressionRen Q, Liang J, Wei J, Basturk O, Wang J, Daniels G, Gellert LL, Li Y, Osman I, Zhao J, Melamed J, Lee P. American Journal of Translational Research. 2014 Jan;6(4):329-339. ISSN: 19438141
  18. ERβ- and prostaglandin E2-regulated pathways integrate cell proliferation via Ras-like and estrogen-regulated growth inhibitor in endometriosisMonsivais D, Dyson MT, Yin P, Coon JS, Navarro A, Feng G, Malpani SS, Ono M, Ercan CM, Wei JJ, Pavone ME, Su E, Bulun SE. Molecular Endocrinology. 2014 Jan;28(8):1304-1315. ISSN: 08888809
  19. MED12 and HMGA2 mutations: Two independent genetic events in uterine leiomyoma and leiomyosarcomaBertsch E, Qiang W, Zhang Q, Espona-Fiedler M, Druschitz S, Liu Y, Mittal K, Kong B, Kurita T, Wei J-J*. Modern Pathology. 2014 Jan;27(8):1144-1153. ISSN: 08933952
  20. Molecular analyses of 6 different types of uterine smooth muscle tumors: Emphasis in atypical leiomyomaZhang Q, Ubago J, Li L, Guo H, Liu Y, Qiang W, Kim JJ, Kong B, Wei J-J*. Cancer. 2014 Jan;120(20):3165-3177. ISSN: 0008543X
  21. Integrated analysis of long noncoding RNAs and mRNAs reveals their potential roles in the pathogenesis of uterine leiomyomasGuo H, Zhang X, Dong R, Liu X, Li Y, Lu S, Xu L, Wang Y, Wang X, Hou D, Wei J-J, Shao C, Liu Z. Oncotarget. 2014 Jan;5(18):8625-8636. ISSN: 19492553
  22. miR-145 inhibits tumor growth and metastasis by targeting metadherin in high-grade serous ovarian carcinomaDong R, Liu X, Zhang Q, Jiang Z, Li Y, Wei Y, Li Y, Yang Q, Liu J, Wei J-J, Shao C, Liu Z, Kong B. Oncotarget. 2014 Jan;5(21):10816-10829. ISSN: 19492553
  23. Histologic and immunohistochemical analyses of endometrial carcinomasWei J-J, Paintal A, Keh P. Archives of Pathology and Laboratory Medicine. 2013 Nov;137(11):1574-1583. PMID:24168495ISSN: 00039985
  24. MK-2206, an AKT inhibitor, promotes caspase-independent cell death and inhibits leiomyoma growthSefton EC, Qiang W, Serna V, Kurita T, Wei J-J, Chakravarti D, Kim JJ. Endocrinology. 2013 Nov;154(11):4046-4057.  PMID:24002033PMCID: 24002033 ISSN: 00137227
  25. MiR-106a represses the RB tumor suppressor p130 to regulate cellular proliferation and differentiation in High-grade serous ovarian carcinomaLiu Z, Gersbach E, Zhang X, Xu X, Dong R, Lee P, Liu J, Kong B, Shao C, Wei J-J*. Molecular Cancer Research. 2013 Nov;11(11):1314-1325.  PMID:24045973PMCID: 24045973 ISSN: 15417786
  26. HMGA2 and high-grade serous ovarian carcinomaWu J, Wei J-J*. Journal of Molecular Medicine. 2013 Oct;91(10):1155-1165. PMID:23686260ISSN: 09462716
  27. Dual Pten/Tp53 suppression promotes sarcoma progression by activating Notch signalingGuijarro MV, Dahiya S, Danielson LS, Segura MF, Vales-Lara FM, Menendez S, Popiolek D, Mittal K, Wei JJ, Zavadil J, Cordon-Cardo C, Pandolfi PP, Hernando E. American Journal of Pathology. 2013 Jun;182(6):2015-2027. PMID:23708211PMCID: 23708211 ISSN: 00029440
  28. Functional Domains of Androgen Receptor Coactivator p44/Mep50/WDR77and Its Interaction with Smad1Li Y, Tian L, Ligr M, Daniels G, Peng Y, Wu X, Singh M, Wei J, Shao Y, Lepor H, Xu R, Chang Z, Wang Z, Lee P. PLoS ONE. 2013 May 29;8(5):doi:10.1371/journal.pone. 0064663. PMID:23734213PMCID: 23734213 ISSN: 19326203
  29. Expression analysis of MIR182 and its associated target genes in advanced ovarian carcinomaMcMillen BD, Aponte MM, Liu Z, Helenowski IB, Scholtens DM, Buttin BM, Wei J-J*. Modern Pathology. 2012 Dec;25(12):1644-1653. PMID:22790015ISSN: 08933952
  30. MiR-182 overexpression in tumourigenesis of high-grade serous ovarian carcinomaLiu Z, Liu J, Segura MF, Shao C, Lee P, Gong Y, Hernando E, Wei J-J*. Journal of Pathology. 2012 Oct;228(2):204-215. PMID:22322863ISSN: 00223417
  31. Mucinous adenocarcinoma developed from human fallopian tube epithelial cells through defined genetic modificationsShan W, Mercado-Uribe I, Zhang J, Rosen D, Zhang S, Wei J, Liu J. Cell Cycle. 2012 Jun;11(11):2107-2113. PMID:22592533PMCID: 22592533 ISSN: 15384101
  32. USP22 Antagonizes p53 Transcriptional Activation by Deubiquitinating Sirt1 to Suppress Cell Apoptosis and Is Required for Mouse Embryonic DevelopmentLin Z, Yang H, Kong Q, Li J, Lee S-M, Gao B, Dong H, Wei J, Song J, Zhang DD, Fang D. Molecular Cell. 2012 May 25;46(4):484-494. PMID:22542455ISSN: 10972765
  33. A transcriptional regulatory role of the THAP11-HCF-1 complex in colon cancer cell functionParker JB, Palchaudhuri S, Yin H, Wei J, Chakravarti D. Molecular and Cellular Biology. 2012 May;32(9):1654-1670. PMID:22371484PMCID: 22371484 ISSN: 02707306
  34. Genome-wide DNA methylation indicates silencing of tumor suppressor genes in uterine leiomyomaNavarro A, Yin P, Monsivais D, Lin SM, Du P, Wei J-J, Bulun SE. PLoS ONE. 2012 Mar 13;7(3):doi:10.1371/journal.pone.0033284. PMID:22428009PMCID: 22428009 ISSN: 19326203
  35. Increased activation of the PI3K/AKT pathway compromises decidualization of stromal cells from endometriosisYin X, Pavone ME, Lu Z, Wei J, Kim JJ. Journal of Clinical Endocrinology and Metabolism. 2012 Jan;97(1):E35-E43. PMID:22072736PMCID: 22072736 ISSN: 0021972X
  36. Endometriosis and ovarian cancer: A review of clinical, pathologic, and molecular aspectsWei J-J*, William J, Bulun S. International Journal of Gynecological Pathology. 2011 Nov;30(6):553-568. PMID:21979592PMCID: 21979592 ISSN: 02771691
  37. Expression and function of androgen receptor coactivator p44/MEP50/WDR77 in ovarian cancerLigr M, Patwa RR, Daniels G, Pan L, Wu X, Li Y, Tian L, Wang Z, Xu R, Wu J, Chen F, Liu J, Wei J-J, Lee P. PLoS ONE. 2011 Oct 13;6(10): PMID:22022581PMCID: 22022581 ISSN: 19326203
  38. Local lymph node micrometastasis in a patient with negative sentinel lymph node biopsies after lymphatic mapping with wide local excision of primary melanoma on the head/neck areaQuerfeld C, Wayne JD, Wei J-J, Abdul-Nabi A, Gerami P. American Journal of Dermatopathology. 2011 Oct;33(7):745-748. PMID:21946765ISSN: 01931091
  39. Distinct function of androgen receptor coactivator ARA70α and ARA70β in mammary gland development, and in breast cancerWu X, Chen F, Sahin A, Albarracin C, Pei Z, Zou X, Singh B, Xu R, Daniels G, Li Y, Wei J, Blake M, Schneider RJ, Cowin P, Lee P. Breast Cancer Research and Treatment. 2011 Jul;128(2):391-400. PMID:20814820ISSN: 01676806
  40. Regulation of HMGA1 expression by MicroRNA-296 affects prostate cancer growth and invasionWei J-J, Wu X, Peng Y, Shi G, Olca B, Yang X, Daniels G, Osman I, Ouyang J, Hernando E, Pellicer A, Rhim JS, Melamed J, Lee P. Clinical Cancer Research. 2011 Mar 15;17(6):1297-1305.   PMID:21138859PMCID: 21138859 ISSN: 10780432