Prof. Song-Guo Zheng

Keck School of Medicine

Division of Rheumatology & Immunology/Department of Medicine

University of Southern California (USC), USA





2011 Ph.D., Molecular Immunology, Centre National de la Recherche Scientifique, France

2009 Associate Professor, University of Southern California Medical School, USA
2004 Professor of Medicine, Fudan University Shanghai Medical School, China
1996 M.S., and Ph.D., Shanghai Medical University, China


Publications (Selected)

  1. Horwitz DA, Gray JD, Zheng SG: The potential of human regulatory T–cells generated ex–vivo as a treatment for lupus and other chronic inflammatory diseases. Arthritis Res 4:241–246, 2002.
  2. Zheng SG, Dray JD, Ohtsuka K, Yamagiwa S, Horwitz DA: Generation ex–vivo of TGF–beta producing regulatory T–cells from CD4+CD25–precursors. J Immunol 169:4183–4189, 2002.
  3. Horwitz DA, Zheng SG, Gray JD: The role of the combination of IL-2 and TGF-beta or IL-10 in the generation and junction of CD4+ CD25+ and CD8+ regulatory T cell subsets. J Leukoc Biol 74:471–478, 2003.
  4. Zheng SG, Koss MN, Quismorio Jr FP, Wang JH, Gray JD, Horwitz DA: CD4+ and CD8+ regulatory T cells generated ex-vivo with IL-2 and TGF-beta suppress a stimulatory graft-verse-host-disease with a lupus-like syndrome. J Immunol 172:1531-1539, 2004.
  5. Zheng SG: The role of IL-2, TGF-beta and IL-10 in the generation and renewal of regulatory T cells: interactions between CD4+CD25+ cells and Naïve CD4+CD25+ cells. J Immunol 172:5213-5221, 2004.
  6. Horwitz DA, Zheng SG, Gray JD, Wang JH, Ohtsuka K, Yamagiwa S: Regulatory T cells generated ex-vivo as an approach of the therapy of autoimmune disease. Seminar Immunol 16:135-143, 2004.
  7. Zheng SG, Meng L, Wang JH, Watanabe M, Barr ML, Cramer DV, Gray JD, Horwitz DA: Transfer of regulatory T cells generated ex vivo modifies graft rejection through induction of tolerogenic CD4+CD25+ cells in the recipient. Int Immunol 18:279-289, 2006.
  8. Zheng SG, Wang JH, Kim S, Stohl W, Gray JD, Horwitz DA: TGF-beta requires CTLA-4 early after T cell activation to induce FoxP3 and generate adaptive CD4+CD25+ regulatory cells. J Immunol, 176:3321-3329, 2006.
  9. Zheng SG, Wang J, Wang P, Gray JD, Horwitz DA. IL-2 is essential for TGF-beta to convert naive CD4+CD25- cells to CD25+Foxp3+ regulatory T cells and for expansion of these cells. J Immunol. 2007 178:2018-2027
  10. Xue Y, Zou HJ and Zheng SG*. Role of Th17 cells in the autoimmunity. Chin J Micro Immunol, 2007, 27:868-870
  11. Ma JL, Tao XJ, Cai L and Zheng SG*. Characterization of CD4+CD25+Foxp3+ cells in active SLE patients. Chin J Rheumatol, 2007, 11: 654-657
  12. Tao XJ, Ma JL, Yu JL, Zhang YH, Wang JH and Zheng SG*. Neutralization of IL-4 and IFN-γ facilitates the development of TGF-β-induced CD4+CD25+Foxp3+ regulatory T cells. Inter J Biomed Sci. 2008, 4:100-106
  13. Yu JN, Ma JL, Wang JH , Tao XJ, Li XP, Zou HJ and Zheng SG*. FOXP3, is still a specific marker for human regulatory T cells? Chin J Allergy Clin Immunol, 2008, 2:5-10
  14. Xue Y, Zhang J, Chen YM, Guan M, Zheng SG* and Zou HJ. The HLA-DRB1 shared epitope is not associated with antibodies against cyclic citrullinated peptide in Chinese patients with rheumatoid arthritis. Scan J Rheumatol, 2008, 37: 183-187
  15. Horwitz DA, Zheng SG, Wang JH and Gray JD. The real role of TGF-β in Treg cells physiology. Eur J Immunol, 2008, 38: 912-915
  16. Zheng SG*, Wang JH, Horwitz DA. Contrasting effect of IL-6 on the suppressive activity of natural and induced regulatory T cells. J Immunol, Cutting-edge, 2008, 180: 7112-7116
  17. Zheng SG*. The critical role of TGF-β1 in the development of induced Foxp3+ regulatory T cells. Int J Clin Exp Med, 2008, 1: 192-202
  18. Liu ZM, Fan HM, Li LY, Zheng SG*. Experimental Studies on the Differentiation of Fibroblasts into Myoblasts induced by MyoD Genes in vitro. Int J Biomed Sci 2008; 4: 14-19
  19. Zhao SS, Li XM, Li XP, Zhai ZM, Chen Z, Ma Y, Zhang H, Zheng SG. Expression of CD4+ CD25+ CD127(low/-) T cells in patients with systemic lupus erythematosus. Chin J Med. 2008, 88: 453-456
  20. Horwitz DA, Zheng SG. Gray JD. Natural and TGF-beta-induced Foxp3(+)CD4(+) CD25(+) regulatory T cells are not mirror images of each other. Trends Immunol. 2008, 29: 429-435