Prof. Firas H Kobeissy

Department of Psychiatry

University of Florida



2007 Assistant Professor, Dept of Psychiatry, University of Florida, USA

2007 Postdoctoral Associate, Dept of psychiatry, University of Florida, USA

2006 Ph.D., University of Florida, USA

Publications (Selected)

  1. Firas Kobeissy, Ming Cheng Liu, Wenrong Zheng, Zhiqun Zhang, John Anagli, Ronald L. Hayes and Kevin K.W. Wang, Degradation of βII-spectrin Protein by Calpain and Caspase-3 under Neurotoxic and Neurodegenerative Traumatic Brain Injury Condition, NEUROCHEMISTRY, submitted, 2011
  2. Zhiqun Zhang1*, Susie Zoltewicz1,J. Newsom1, Joy Guingab1, Yang Zhang1, Firas Kobeissy…..Kevin Wang, Human traumatic brain injury induces a predominant autoantibody response towards calpain-truncated glial fibrillary acidic protein, Neuron, accepted
  3. J. D. Guingab-Cagmat, S. M. Stevens, M. V. Ratliff, Z. Zhang, M. S. Gold, K.K.W. Wang and F. H Kobeissy Identification of Tyrosine Nitration in UCHL1 and GAPDH. Electropherisis, 2011, Jun;32(13):1692-705
  4. Ming Cheng Liu, Firas Kobeissy, Wenrong Zheng Hayes , Kevin K.W. Wang, Dual Vulnerability of Tau to Calpains and Caspase-3 Proteolysis under Neurotoxic and Neurodegenerative Conditions. ASN NEURO., 2011, Feb 16;3(1):
  5. Firas H Kobeissy , Joy D. Guingab-Cagmat, Mahdi Razafsha, Laura O’steen, Zhiqun Zhang, Ronald L. Hayes, Wen-Ta Chiu, Kevin K W Wang, Leveraging Biomarker Platforms and Systems Biology for Rehabilomics and Biologics Effectiveness Research. Physical Medicine and Rehabilitation., 2011 Jun;3:139-47.
  6. J. D. Liu Y, von Deneen KM, F. H Kobeissy, Gold MS. (2010) Food addiction And Obesity: Evidence from Bench to Bedside. J. Psychoactive Drugs. Jun;42(2):133-45.
  7. Ming Cheng Liu, WenRong Zheng, Firas H Kobeissy, Zhiqun Zhang, Ronald L. Hayes, and Kevin K.W. Wang, Dual Vulnerability Of Tau To Calpain And Caspase-3 Proteolysis Under Neurotoxic And Neurodegenerative Conditions ASNeuro Submitted (2010)
  8. Ming Cheng Liu, Linnet Akinyi, Danica Scharf, Jixiang Mo, Stephen F. Larner, , Firas H Kobeissy, Linda Papa5, Xi-Chun Lu, Jitendra R. Dave, Frank C Tortella, Ronald L. Hayes, and Kevin K.W. Wang: Ubiquitin C-Terminal Hydrolase-L1 as a Biomarker for Ischemic and Traumatic Brain Injury in Rats Euro J. Neurosci 2010 Feb;31(4):722-32. (2010)
  9. Yamada Hidetakaa, Mahendra Bishnoia, Kim F. M. Keijzersa, Irma A. van Tuijla, Elysia Smalla, Hina P. Shaha, Firas H. Kobeissy, Sreedharan N. Sabarinathb, Hartmut Derendorfb, Adrie W. Bruijnzeela. Preadolescent Tobacco Smoke Exposure Does Not Potentiate the Rewarding Effects of Nicotine or Nicotine Withdrawal in Adult Rat. Pharmacology Biochemistry and Behavior, Mar 4, 2010
  10. Shankar Sadasivan, Zhiqun Zhang, Firas H Kobeissy, Ronald L Hayes and Kevin KW Wang, Acute NMDA toxicity in cultured rat cerebellar granule neurons is accompanied by autophagy induction and 3-methyladenine-sensitive late onset autophagic cell death phenotype BMC Neuroscience, 2010 Feb 18;11(1):21.
  11. Mark S Gold, Firas H. Kobeissy, Roger Gaskins, Wang K Kevin, Merlo LJ, Bruijnzeel AW, Krasnova IN, Cadet JL. Methamphetamine- and Trauma-Induced Brain Injuries: Comparative Cellular and Molecular Neurobiological Substrates. Biol Psychiatry June 22nd , 2009, (Cover Page)
  12. Walton NM, Snyder GE, Park D, Firas H. Kobeissy, Scheffler B, Steindler DA. Gliotypic Neural Stem Cells Transiently Adopt Tumorigenic Properties During Normal Differentiation Stem Cells Stem Cells. 2009 Feb;27(2):280-9
  13. Firas H. Kobeissy, Shankar Sadasivan, Stephen F. Larner, Zhiqun Zhang, Ronald L. Hayes and Kevin K.W. Wang Neuroproteomics and Systems Biology-Based Discovery of Protein Biomarkers for Traumatic Brain Injury and Clinical Validation. Proteomics Clinical Applications. 2008, 5(10-11):1467-1483
  14. Firas H. Kobeissy, Shankar Sadisavan, Jing Liu, Mark S Gold, Wang KKW. Psychoproteomics, Degradomics and Systems Biology approach to Psychiatric Research Expert Rev of Proteomics. 2008 Apr;5(2):293-314
  15. Firas H. Kobeissy, Warren M, Ottens AK, Wang KKW. Psychoproteomics Analysis of Rat Cortex after Methamphetamine Exposure Novel differential neuroproteomics analysis of traumatic brain injury in rats J Proteomics Research 2008; (7):1971-1983
  16. Stanislav I. Svetlov, Firas H. Kobeissy, Mark S Gold Performance Enhancing, Non-Prescription Use of Ritalin: A Comparison with Amphetamines and Cocaine J. Addict Disease 2007; 25(4):115-23.
  17. Firas H. Kobeissy, Jennifer A. Jeung, Matthew W. Warren, Jacqueline E. Geier, Mark S. Gold Changes in Leptin, Ghrelin, Growth Hormone and Neuropeptide-Y after an Acute model of MDMA and Methamphetamine Exposure in Rats. Addiction Biology March 200713(1):15-25.
  18. Warren MW, Larner SF, Firas H. Kobeissy, Gold MS, Wang KK.Calpain and caspase proteolytic markers co-localize with rat cortical neurons after exposure to methamphetamine and MDMA. Acta Neuropathol 2007 Sep;114(3):277-86
  19. Kobeissy F H, Larner SF, Golden E, Gold MS. Performance Enhancement and Adverse Consequences of MDMA. J. Addict Disease 2007 Vol (25) 47-59.
  20. Zhang, Z., Ottens, A. K., Tei, F., Kobeissy, F H., Hayes, R. L., and Wang, K. K. (2007) Calpain-mediated collapsin response mediator protein-2 proteolysis following acute traumatic or neurotoxic injury. J Neurotrauma, 2007 Mar;24 (3):460-72.
  21. Zhang ZQ, Kammerdiner AR, Busygin SP, Ottens AK, Larner SF, Kobeissy F H, Pardalos PM, Hayes RL, and Wang KKW. Application of the data mining techniques to the systems biology of neuritogenesis. Optimization Methods and Software. 22 (1): 215-224 FEB 2007
  22. Kobeissy F H, Ottens AK, Zhang Z, Liu MC, Denslow ND, Dave JR, Tortella FC, Hayes RL, Wang KKW. Novel differential neuroproteomics analysis of traumatic brain injury in rats. Molecular and Cellular Proteomics 2006 Oct;5(10):1887-98.(Cover Page)
  23. Warren MW, Kobeissy F H, Liu MC, Hayes RL, Gold MS, Wang KKW. Ecstasy Toxicity: A Comparison to Methamphetamine and Traumatic Brain Injury. J. Addict Disease 2006;25(4):115-23.
  24. Warren MW, Zheng W, Kobeissy F H, Liu MC, Hayes RL, Gold MS, Larner SF, and Wang KKW (2006). Calpain and caspase mediated proteolysis of αII-spectrin and tau in rat cerebrocortical neuron cultures after ecstasy or methamphetamine exposure. Intl J. Neuropsychopharmacology 2006 Aug 2;1-11
  25. Zhiqun Z, Ottens AK, Larner SF, Kobeissy FH, Williams ML, Hayes RL, Wang KKW. Direct Rho-associated kinase inhibition induces cofilin dephosphorylation and neurite outgrowth in PC-12 cells. Cell. Mol. Biol. Lett. 2006;11:15-32.
  26. Firas H Kobeissy, Julie M Demetree, Matthew Warrens, Kevin K.W. Wang, Mark S Gold, Club Drugs: They’re All the Rave: A Review of Use and Abuse: Effects of MDMA, Methamphetamine, and Gamma-Hydroxy- Butyrate (GHB) on Memory Law Enforcement Executive forum September 2005 115-128
  27. Matthew Warren, Firas Kobeissy, Mark Gold, Kevin Wang “Concurrent calpain and caspase-3 mediated proteolysis of aII-spectrin and tau in rat brain after methamphetamine exposure: a similar profile to traumatic brain injury” Life science journal 2005
  28. Andrew K. Ottens, Firas H. Kobeissy, and Kevin K. W. Wang A Multidimensional Differential Proteomic Platform Using Dual-Phase Ion-Exchange Chromatography-Polyacrylamide Gel Electrophoresis/Reversed-Phase Liquid Chromatography Tandem Mass Spectrometry. J Analytical Chemistry, 2005
  29. Haskins WE, Kobeissy FH, , McClung SH, Lundberg AG, O’Steen BE, Hayes RL, Wang KKW. Rapid discovery of putative protein biomarkers of traumatic brain injury by SDS-PAGE-capillary liquid chromatography-tandem mass spectrometry, J. Neurotrauma, 2005 Jun;22(6):629-44.
  30. Alexander M Abdelnoor, Firas H Kobeissy, Daad Farhat and Usamah Hadi “Circulating immune complexes and complement C3 and C4 levels in a selected group of patients with rhinitis in Lebanon”. Clinical and Molecular Allergy 2004, 2:6 Abdelnoor AM