Dr. Nelson W. Chong

Department of Human and Health Sciences

University of Leicester, UK



Ph.D., Physiology, King’s College
M.Sc., Pharmacology, King’s College
B.Sc., Biological Sciences, University of Westminster

Publications (Selected)

  1. Ounzain S, Kobayashi S, Peterson R, He Aibin, Samani NJ, Menick DR, Pu WT, Liang Q, Chong, N.W. (2012) Cardiac expression of STARS, a novel gene involved in cardiac development and disease, is regulated by GATA4. Mol Cell Biol. 32, 1830-1843.
  2. Chong, N.W. Kokemoer, AL., Samani, N.J., Shin JT., Shaw, S. (2012) STARS (Striated muscle Activator of Rho Signalling) is essential to maintain cardiac development and functionin vivo viaa SRF pathway. PLoS One 7, e40966.
  3. Haque, R., Chong, N.W., et al. (2011) cAMP-dependent transcriptional regulation of the chicken arylalkylamine N-acetyltransferase gene by novel regulatory elements of the proximal promoter. J Neurochem 119, 6-17.
  4. Koekemoer, AL, Chong, NW et al (2009) Myocyte stress 1 plays an important role in cellular hypertrophy and protection against apoptosis. FEBS Lett. 583, 2964-2967.
  5. Ounzain, S., Dacwag, C.S., Samani, N.J., Imbalzano, A.N. and Chong, N.W. (2008) Comparative in silico analysis identifies bona fide MyoD binding sites within the Myocyte Stress 1 gene promoter. BMC Molecular Biology 9:50.
  6. Singletary, J.H., Chan, D., Samani, N.J., and Chong, N.W. (2008) The canonical E-box motif: a target for glucocorticoid action that drives rhythmic mouse Pai-1 transcription in vitro. Gene 420, 42-47.
  7. Chong, N.W., Codd, V., Chan, D. and Samani, N. J. (2006) Circadian clock genes cause activation of the human PAI-1 gene promoter with 4G/5G allelic preference. FEBS Lett. 580, 4469-4472.
  8. Hartman, S., Touchton, G., Wynn, J., Geng, T., Chong, N.W., and Smith, E. (2005) Characterization of expressed sequence tags from Gallus gallus pineal gland cDNA library. Comp Funct Genom., 6, 301 -306.
  9. Chong, N.W., Chaurasia, S.C., Haque, R., Klein, D.C. and Iuvone, P.M. (2003) Temporal-spatial Characterization of Chicken Clock Genes: Circadian Expression in Retina, P ineal Gland and Peripheral Tissues. J. Neurochem 85, 851 -860.
  10. Mahadeva, H., Brooks, G., Lodwick, D., Chong, N.W. and Samani, N.J. (2002) ms1, a novel stress-responsive, musclespecific gene that is up-regulated in early stages of pressure overload -induced left ventricular hypertrophy. FEBS Lett 521, 100-104.
  11. *Bailey, M.J., *Chong, N.W., Xiong, J. and Cassone, V.M. (2002) Chickens' Cry2: molecular analysis of an avian cryptochrome in retinal and pineal photoreceptors. FEBS Letts 513, 169 -174. *Contributed equally.
  12. Chong, N.W.S., Bernard, M. and Klein, D.C. (2000) Characterization of the chicken serotonin N-acetyltransferase gene: activation via clock gene heterodimer: E-box interaction. J. Biol. Chem. 275, 32991 -32998.
  13. Iuvone, P.M., Chong, N.W.S., Bernard, M., Brown, A.D., Thomas, K.B. and Klein, D.C. (2000) Melatonin biosynthesis in chicken retina: regulation of tryptophan hydroxylase and arylalkylamine N-acetyltransferase. Advances in Experimental Medicine and Biology 460, 31 -42.
  14. Bernard, M., Guerlotte, J., Greve, P., Grechez-Cassiau, A., Iuvone, P.M., Zatz, M., Chong, N.W.S., Klein, D.C. and Voisin, P. (1999) Melatonin synthesis pathway: circadian regulation of the genes encoding the key enzymes in the chicken pineal gland and retina. Reprod. Nutr. Dev., 39, 325-334.
  15. Chong, N.W.S., Klein, D.C. and P. M. Iuvone. (1998) Circadian expression of tryptophan hydroxylase mRNA in the chicken retina. Mol. Brain Res., 61, 243 -250.
  16. Akbar, M.T., Rattray, M., Chong, N.W.S. & Meldrum, B.S. (1998) Reduction of GABA and glutamate transporter messenger RNAs in the severe-seizure genetically epilepsy-prone rat, Neuroscience, 85, 1235-1251.
  17. Chong, N.W.S., Cagampang, F.R.A., Campbell, I.C., Coen, C.W. and Powell, J.F. (1996) Rapid identification of novel genes expressed in a circadian manner in rat suprachiasmatic nuclei, NeuroReport 7, 1199 -1203.
  18. Cagampang, F.R.A., Rattray, M., Powell, J.F., Chong, N.W.S., Campbell, I.C. and Coen, C.W. (1996) Circadian variation of EAAC1 glutamate transporter mRNA in the rat suprachiasmati c nucleus. Mol. Brain Res. 35, 190-196.
  19. Sugden, D., Chong, N.W.S., Lewis, D. (1995) Structural Requirements at the Melatonin Receptor, Br. J. Pharmacol. 114, 618-623.
  20. Chong, N.W.S. and Sugden, D. (1994) Thermodynamic analysis of agonist and antagonist binding to the chicken brain melatonin receptor, Br. J. Pharmacol., 111, 295 -301.
  21. Chong, N.W.S. & Sugden, D. (1993) Antigonadal effects of two novel melatonin analogues in adult Djungarian hamsters. J Pineal Res. 15, 104-107.
  22. Chong, N.W.S., Evans, J.E. & Sugden, D. (1993) N-Bromoacetyl 5-methoxytryptamine: an irreversible melatonin ligand? Biochem. Biophy. Res. Commun., 193, 1355 -1361.
  23. Chong, N.W.S. & Sugden, D. (1991) Ontogeny of chick brain melatonin receptors. Neurosci. Lett., 138, 37 -40.
  24. Paterson, A., Chong, N.W.S., Brinklow, B., Loudon, A.L., & Sugden, D. (1991) Characterization of 2-[125I] iodomelatonin binding sites in the brain of a marsupial, Bennett's wallaby (Macropus rufogriseus rufogriseus). Comp. Biochem. Physiol., 102A, 55 -58.
  25. Chong, N.W.S. & Sugden, D. (1991) Guanine nucleotides regulate 2-[125I] iodomelatonin binding sites in chick retinal pigment epithelium but not in neuronal retina. J. Neurochem., 57, 685 -689.
  26. Sugden, D. & Chong, N.W.S. (1991) Pharmacological identity of 2-[125I] iodomelatonin binding sites in chicken brain and sheep pars tuberalis, Brain Res., 539, 151 -154.
  27. Moore, P.K., al-Swayeh, O.A., Chong, N.W.S., Evans, R.A. & Gibson, A. (1990) L-NG-nitroarginine (L-NOARG), a novel, L-arginine-reversible inhibitor of endothelium-dependent vasodilatation in vitro. Br. J. Pharmacol., 99, 408-412.