Basil Rigas

Prof. Basil Rigas

Division of Gastroenterology and Hepatology

Stony Brook University, USA






1977 Internship/Residency, Department of Medicine, Brown University

1975 DSc. (Biochemistry; with highest distinction), Athens University Medical School, Greece

1972 M.D. (summa cum laude), Athens University Medical School, Greece


Publications (Selected)

  1. Rigas B, Van Vunakis H, Levine L. The effect of phenothiazines and their metabolites on prostaglandin production by rat basophilic leukemia cells in culture. Prostagland Med.1981; 7:183-1035
  2. Rigas B, Lewis RA, Austen KF, Corey EJ, Levine L. Identification and quantitation of arachidonic acid metabolic products in rabbit, rat and human saliva.Arch Oral Biol. 1983; 28:1031-1035
  3. Rigas B, Levine L. Concentrations of arachidonic acid metabolites in human mixed saliva are independent of flow rate. Arch Oral Biol. 1983; 28:1135-1137
  4. Rigas B, Levine L. Human salivary eicosanoids: Circadian variation. Bioch Bioph Res Commun. 1983; 115:201-205
  5. Rigas B, Rosenfeld LE, Barwick KW, Enriquez R, Helzberg J, Batsford WP, Josephson ME, Riely CA. Amiodarone hepatotoxicity: A clinicopathologic study of five patients. Ann Int Med. 1986; 104:348-351
  6. Rigas B, Welcher AA, Ward DC, Weissman SM. Rapid plasmid library screening using RecA-coated biotinylated probes. Proc Natl Acad Sci USA. 1986; 83:9591-9595
  7. Lawrance SK, Srivastava R, Rigas B, Chorney MJ, Gillespie GA, Smith CL, Cantor CR, Weissman SM. Molecular approaches to characterization of megabase regions of DNA: Applications to the human major histocompatibility complex. Cold Spring Harbor Symp Quant Biol. 1986; 51:123-130
  8. Rigas B, Levine L. Folk medicine inhibits mellitin-induced prostaglandin synthesis. Iatriki 1986; 49:91-94
  9. Rigas B, Korenberg J, Merrill WW, Levine L: Prostaglandins E2 and F2a are elevated in saliva of patients with cystic fibrosis. Am J Gastroent. 1989; 84:1408-1412
  10. van Vunakis H, Tashkin DP, Rigas B, Simmons M, Gjika HB, Clark VA: Relative sensitivity and specificity of salivary and serum cotinine in identifying tobacco-smoking status of self-reported nonsmokers and smokers of tobacco and/or marijuana. Arch Environ Health 1989; 44:53-58
  11. Rigas B, Morgelo S, Goldman IS, Wong PTT. Human colorectal cancers display abnormal Fourier-transform infrared spectra. Proc Natl Acad Sci USA, 1990, 87:8140-8144
  12. McDougall CJ, Ngoi SS, Goldman IS, Godwin T, Felix J, DeCosse J, Rigas B. Reduced expression of HLA class I and II antigens in colon cancer. Cancer Res 1990, 50:8023-8027
  13. Wong PTT, Rigas B. Infrared spectra of microtome sections of human colon tissues. Appl Spectrosc 1990, 44:1715-1718
  14. Staiano-Coico L, Khandke L, Krane JF, Sharif S, Gottlieb AB, Kruger JG, Rigas B, Heim L. TGFa and TGFb expression during sodium-n-butyrate induction of cornified envelops in human keratinocytes: Evidence for subpopulation specific up-regulation of TGFb. Exper Cell Res 1990, 191:286-291
  15. Rigas B, Torosis J, McDougall CJ, Spiro HM. The circadian rhythm of biliary colic. J Clin Gastroenterol, 1990, 12:409-414
  16. Ergun G, Rigas B. Circadian periodicity of the time of onset of acute lower gastrointestinal bleeding. Prog Clin Biol Res 1990;341B:221-8
  17. Minoli G, Imperiale C, Gorla C, Spinzi GC, Rigas B. Circadian periodicity and other clinical features of biliary pain. J Clin Gastroenterol, 1991, 13:546-549
  18. Wong PTT, Papavassiliou ED, Rigas B. The phosphodiester stretching bands in the infrared spectra of human tissues and cultured cells. Appl Spectrosc, 1991, 45:1563-1567
  19. Wong PTT, Wong RK, Caputo TA, Godwin TA, Rigas B. Infrared spectroscopy of exfoliated human cervical cells: Evidence of extensive structural changes during carcinogenesis. Proc Natl Acad Sci USA, 1991, 88:10988-10992
  20. Rigas B, Wong PTT. Human colon adenocarcinoma cell lines display infrared spectroscopic features of malignant colon tissues. Cancer Res, 1992, 52:84-88
  21. Tsioulias G, Godwin T, Goldstein M, Ngoi SS, McDougall CJ, DeCosse J, Rigas B. Loss of colonic HLA antigens in familial adenomatous polyposis. Cancer Res, 1992, 52:3449-3452
  22. Wong PTT, Goldstein SM, Grekin RC, Godwin TA, Pivik C, Rigas B. Distinct infrared spectroscopic patterns of human basal cell carcinoma of the skin.Cancer Res, 1993, 53:762-765
  23. Tsioulias GJ, Triadafilopoulos G, Goldin E, Rizos S, Papavassiliou ED, Rigas B. Expression of HLA Class I antigens in sporadic adenomas and histologically normal mucosa of the colon. Cancer Res, 1993, 53:2374-2378
  24. Rigas A, Rigas B, Glassman M, Yen Y-Y, Lan SJ, Petridou E, Hsieh C-C, Trichopoulos D. Breast feeding and maternal smoking in the etiology of Crohn's disease and ulcerative colitis in childhood. Ann Epidemiol 1993, 3:387-392
  25. Rigas B, Goldman IS, Levine L. Altered eicosanoid levels in human colon cancer. J Lab Clin Med, 1993, 122:518-523
  26. Arvind P, Papavassiliou ED, Tsioulias GJ, Duceman BW, Lovelace CIP, Geng W, Staiano-Coico L, Rigas B. Lithocholic acid inhibits the expression of HLA class I genes in colon adenocarcinoma cells. Differential effect on HLA-A, -B, and -C. Molec Immunol, 1994, 31:607-614
  27. Papavassiliou ED, Arvind P, Tsioulias GJ, Staiano-Coico L, Goldin E, Qiao L, Rigas B. The effect of ethanol on the expression of HLA class I genes in human colon adenocarcinoma cell lines. Canc Lett, 1994, 81:33-38
  28. Rigas B, Tsioulias GJ, Allan C, Walli R, Brasitus TA. The effect of bile acids and piroxicam on MHC antigen expression in rat colonocytes during colon cancer development.Immunology, 1994, 83:319-323
  29. Pochapin MB, Fine SN, Eisdorfer RM, Rigas B. Fecal occult bood testing in hospitalized patients. J Clin Gastroenterol, 1994, 19:274-277
  30. Yu Sun, Rigas B. Detection of biotinylated nucleic acids directly on agarose gels. Biotechniques, 1994, 16:782-784
  31. Schuman RW, Rigas B. Bipolar electrocautery as an alternative to Nd:yag laser for the treatment of the watermelon stomach. Gastrointest Endosc, 1995; 42:277-278
  32. Teintze M, Arzimanoglou II, Lovelace CIP, Xu JZ, Rigas B. RecA-assisted rapid enrichment of specific clones from model DNA libraries. Biochem Biophys Res Commun, 1995; 211:804-811
  33. Arvind P, Papavassiliou ED, Tsioulias GJ, Lovelace CIP, Duceman B, Rigas B. PGE2 down-regulates the expression of HLA-DR in human colon adenocarcinoma cell lines.Biochemistry, 1995; 34:5604-5609
  34. Shiff SJ, Qiao L, Tsai L-L, Rigas B. Sulindac sulfide, an aspirin-like compound, inhibits proliferation, causes cell cycle quiescence, and induces apoptosis in HT-29 colon adenocarcinoma cells. J Clin Invest, 1995; 96:491-503
  35. Qiao L, Kozoni V, Tsioulias GJ, Koutsos MI. Hanif R, Shiff SJ, Rigas B. Selected eicosanoids increase the proliferation rate of human colon carcinoma cell lines and mouse colonocytes in vivo. Biochem Biophys Acta, 1995; 1258:215-223
  36. Shiff SJ, Koutsos MI, Qiao L, Rigas B. Nonsteroidal antiinflammatory drugs inhibit the proliferation of colon adenocarcinoma cells: Effects on cell cycle and apoptosis. Exp Cell Res, 1996; 222:179-188
  37. Goldberg Y, Nassif II, Pittas A, Tsai L-L, Dynlacht D, Rigas B, Shiff SJ. The anti-proliferative effect of sulindac and sulindac sulfide on HT-29 colon cancer cells: Alterations in tumor suppressor and cell cycle-regulatory proteins. Oncogene, 1996; 12:893-901
  38. Bortuzzo C, Hanif R, Staiano-Coico L, Shiff SJ, Rigas B. The effect of leukotrienes B and selected HETEs on the proliferation of colon cancer cells.Biochem Biophys Acta, 1996; 1300:240-246
  39. Arvind P, Qiao L, Papavassiliou ED, Goldin E, Koutsos MI, Rigas B. Aspirin and aspirin-like drugs induce the expression of HLA-DR in HT29 colon adenocarcinoma cells. Int J Oncology, 1996; 8:1207-1211
  40. Hanif R, Feng J, Shiff SJ, Koutsos MI, Staiano-Coico L, Rigas B. NSAIDs inhibit the growth of colon cancer cells by a prostaglandin-independent pathway.Biochem Pharmacol, 1996; 52:237-245
  41. Staiano-Coico L, Carano K, Babaar P, Rigas B, Higgins PJ. PAI-1 gene expression is growth state-regulated in cultured human epidermal keratinocytes.Exp Cell Res 1996; 227:123-134
  42. Qiao L, Koutsos M, Tsai L-L, Kozoni V, Guzman J, Shiff SJ, Rigas B. Staurosporine inhibits the proliferation, alters the cell cycle distribution and induces apoptosis in HT-29 human colon adenocarcinoma cells. Cancer Lett, 1996; 107:83-89
  43. Feng Y, Papavassiliou ED, Arvind P, Tsioulias GJ, Rigas B. The effect of eicosanoids on the expression of MHC genes in cultured human colon cancer cells and mouse colon cells. Prost Leukotr Essent Fatty Acids, 1996; 55:373-378
  44. Cohenford M, Bandhare PS, Rigas B, Krishnan K. Infrared spectroscopy of chemically preserved cervical specimens on IR-transparent disposable filters. Mikrochim Acta[Suppl], 1997; 14:433-435
  45. Qiao L, Shiff SJ, Rigas B. Sulindac sulfide inhibits the proliferation of colon cancer cells: diminished expression of the proliferation markers PCNA and Ki-67. Cancer Lett1997;115:229-234
  46. Aliprantis ET, Merritt G, Prada F, Rigas B, Kashfi K. Fenretinide inhibits phorbol ester induced cyclooxygenase-2 expression in human colon carcinoma cells. Biochem Soc Trans 1997; 25:457S
  47. Cohenford M, Godwin TA, Cahn F, Bhandari P, Caputo TA, Rigas B. Infrared spectroscopy of normal and abnormal cervical smears: Evaluation by principal component analysis.Gynecol Oncology, 1997; 66:59-65
  48. Hanif R, Qiao L, Shiff SJ, Rigas B. Curcumin, a natural plant phenolic food additive, inhibits cell proliferation and induces cell cycle changes in colon adenocarcinoma cell lines by a prostaglandin independent pathway. J Lab Clin Med, 1997; 130:576-584
  49. Qiao L, Shiff SJ, Rigas B. Sulindac sulfide induces three subpopulations of colon cancer cells, defined by PCNA/Ki-67 and DNA strand breaks. Bioch Biophys Acta, 1997; 1359:222-232
  50. Qiao L, Hanif R, Sphicas E, Shiff SJ, Rigas B. Effect of aspirin on induction of apoptosis in HT-29 human colon adenocarcinoma cells. Biochem Pharmacol, 1998; 55:53-64
  51. Qiao L, Shiff SJ, Rigas B. Sulindac sulfide alters the expression of cyclin proteins in HT-29 colon adenocarcinoma cells. Int J Cancer, 1998; 76:99-104
  52. Cohenford M, Rigas B. Cytologically normal cells from neoplastic cervical samples display extensive structural abnormalities on infrared spectroscopy: Implications for tumor biology. Proc Natl Acad Sci USA, 1998; 95:15327-15332Rigas B, Feretis C, Papavassiliou ED. J. Lykoudis: An unappreciated discoverer of the infectious etiology and treatment of peptic ulcer disease. Lancet, 1999; 354:1634-1635
  53. Scotiniotis I, Rokkas T, Furth EE, Rigas B, Shiff SJ. Changes in apoptosis and proliferation in Helicobacter pylori-associated gastritis and intestinal metaplasia. Int J Cancer2000; 85: 192-200
  54. Rigas B, LaGuardia K, Cohenford M, Bhandari P, Godwin TA, Caputo TA, Cohenford M. Infrared spectroscopic study of cervical smears in HIV patients: An insight into cervical carcinogenesis. J Clin Lab Med, 2000; 135:26-31
  55. Rigas B, Shiff SJ. Is an effect of cyclooxygenase required for the chemopreventive effect of NSAIDs in colon cancer? A model reconciling the current contradiction. Medical Hypotheses, 2000, 54:210-215
  56. Kozoni V, Tsioulias G, Shiff SJ, Rigas B. The effect of lithocholic acid on proliferation and apoptosis during the early stages of colon carcinogenesis. Differential effect on apoptosis in the presence of a colon carcinogen. Carcinogenesis, 2000; 21:999-1005
  57. Merritt G, Aliprandis ET, Prada F, Rigas B, Kashfi K. The retinoid fenretinide inhibits proliferation and downregulates cyclooxygenase-2 gene expression in human colon adenocarcinoma cell lines. Cancer Lett, 2001; 164:15-23
  58. Williams J, Borgo S, Hasan I, Castillo E, Traganos F, Rigas B. NO-releasing NSAIDs alter the kinetics of human colon cancer cell lines more effectively than traditional NSAIDs. Implications for colon cancer chemoprevention. Cancer Res, 2001; 61:3285-3289