Prof. Sivagnanam Thamilselvan
Department of Urology
Henry Ford Health
College of Integrated Science and Technology
Madison University, USA
1993 Ph.D., University of Madras, India, Medical Biochemistry
1988 M.Phil., University of Madras,
India, Medical Biochemistry
1987 M.Sc., University of Madras, India, Medical Biochemistry
1983 B.Sc., Loyola College, India, Zoology
Menon, M, Thamilselvan, S. (2011) Selective Rac1 inhibition protects renal
tubular epithelia cells from oxalate-induced NADPH oxidase-mediated oxidative
cell injury Urol Res, Aug 4. DOI: 10.1007/s00240-011-0405-7
Menon M and Thamilselvan S (2011). Anticancer efficacy of deguelin in
human prostate cancer cells targeting glycogen sunthase kinase-3 b/b-catenin
pathway Int J Cancer. Jan 20. doi: 10.1002/ijc.25949.
Siva S, Barrack
ER, Reddy GP, Thamilselvan V, Thamilselvan S, Menon M, Bhandari M (2009) A
critical analysis of the role of gut Oxalobacter formigenes in oxalate stone
diseasae BJU Int. 103(1): 18-21.
Menon M and Thamilselvan S (2009). Oxalate-induced activation of PKC-alpha
and -delta regulates NADPH oxidase-mediated oxidative injury in renal tubular
epithelial cells. Am J Physiol Renal Physiol. 297(5):F1399-410.
Thamilselvan S and
Menon M (2005). Vitamin-E therapy prevents hyperoxaluria induced calcium
oxalate crystal deposition in the kidney by improving renal tissue antioxidant
status. BJU-International. 96: 117-126.
Rashed T, Menon M
and Thamilselvan S (2004). Molecular mechanism of oxalate induced free radical
production and glutathione redox imbalance in renal epithelial cells: effects
of antioxidants. Am. J Nephrol. 24(5) 557-68.
Thamilselvan S, Khan
SR, and Menon M. (2003). Oxalate and calcium oxalate mediated free radical
toxicity in renal epithelial cells: effect of antioxidants. Urol Res. 31(1):
Khan SR and
Thamilselvan S (2000). Review- Nephrolithiasis: a consequence of renal
epithelial cell exposure to oxalate and calcium oxalate crystals. Mol Urol.
Winter; 4(4): 305-12.
Byer KJ, Hackett, RL and Khan SR (2000). Free radical scavengers, catalase
and superoxide dismutase, provide protection from oxalate associated injury to
LLC-PK1 and MDCK cells. Journal of Urology, 164:224-229.
Khan SR, Maslamani
F, Atmani F, Thamilselvan S, Glenton PA, Opalko C and Hammett S (2000). Membranes
and their lipids as promoters of calcium oxalate crystal formation in human
urine. Calcified Tissue International, 66(2): 90-6.
Raymond L Hackett and Saeed R Khan, (1999). Cells of proximal and distal
tubular origin respond differently to challenges of oxalate and calcium oxalate
crystals. Journal of the American Society of Nephrology, 10:S452-S456.
Thamilselvan S., Cornelius JG., Khan SR. and Sidhu H (1999). Direct correlation
between hyperoxaluria/oxalate stone disease and the absence of the GI-dwelling
bacterium, oxalobacter formigenes: Treatment and prevention by gut
recolonization and enzyme-replacement therapy. Journal of the American Society
of Nephrology, 10:S334-S340.
Khan SR, Byer KA,
Thamilselvan S, Hackett RL, McCormack WT, Benson NA, Vaughn KL, and Erdos GN
(1999). Crystal-cell interaction and apoptosis in oxalate associated injury of
renal epithelial cells. Journal of the American Society of Nephrology,
and Saeed R. Khan. (1998). Oxalate and calcium oxalate crystals are injurious
to renal epithelial cells: results of in vivo and in vitro studies. Journal of
Nephrology, 11 S-1: 66-69.
Hackett, R.L. and Khan, S.R. (1997). Lipid Peroxidation in Ethylene Glycol
Induced Hyperoxaluria and Calcium Oxalate Crystalluria. Journal of Urology,
and Selvam R. (1997). Effect of vitamin E and mannitol on renal calcium oxalate
retention in experimental nephrolithiasis. Indian J. Biochem. Biophys., 34:
and Khan SR. (2000). Free radical scavengers, catalase and superoxide
dismutase, provide protection from oxalate associated injury to LLC-PK1 and
MDCK cells. In: Urolithiasis 2000 (Rodgers AL, Hibbert BE, Hess B, Khan SR and
Preminger GM, eds.). Proc. 9th International Symposium on
Urolithiasis, pp 229-231.
Allison MJ, Thamilselvan S and Peck AB. (2000). Colonization with Oxalobacter
formigenes for the regulation of hyperoxaluria. In: Urolithiasis 2000 (Rodgers
AL, Hibbert BE, Hess B, Khan SR and Preminger GM, Eds.). Proc. 9thInternational
Symposium on Urolithiasis, pp 185-188.