Dr. Mahzuz Karim
Norwich University Hospital, UK
Royal College of
University of East
2003 Ph.D., University of Oxford, UK
University of Cambridge School of Clinical Medicine, UK
1992 B.Sc., University of Cambridge, UK
Immunoregulatory T-cells can mediate specific
unresponsiveness to alloantigens in vivo K.J. Wood, M. Hara, C.I.
Kingsley, M. Karim, A.R. Bushell, P.J. Morris Transplanation Proceedings
November 2001; 3 (7-8): 3829-3830
T cells prevent graft rejection: CTLA-4- and IL-10-dependent immunoregulation
of alloresponses C.I. Kingsley, M. Karim, A.R. Bushell, K.J. Wood Journal
of Immunology February 1st 2002; 168 (3): 1080-1086
The role of the graft in establishing
tolerance M. Karim, U. Steger, A.R. Bushell, K.J. Wood Frontiers in
Bioscience May 1st 2002; 7: e129-154
Regulatory T cells in transplantation M.
Karim, A.R. Bushell, K.J. Wood Current Opinion in Immunology October 2002;
14 (5): 584-591
Renal failure due to scleroderma with
thrombotic microangiopathy developing in a woman treated with carboplatin for
ovarian cancer M. Karim, E. Vaux, D.R. Davies, P.D. Mason Clinical
Nephrology November 2002; 58 (5): 384-388
Transplantation tolerance K. Wood, I.
Binet, M. Karim, W. Wong In: Horizons in Medicine Number 14, James
Neuberger, editor. Royal College of Physicians of London, 2003, pages 275-279
Pre-transplant blood transfusion without
additional immunotherapy generates CD25+CD4+ regulatory
T cells: A potential explanation for the blood transfusion effect A.
Bushell, M. Karim, C.I. Kingsley, K.J. Wood Transplantation August 15th
2003; 76 (3): 449-455
Rapidly progressive irreversible renal
failure in patients with pancreatic insufficiency
P. Hill, M. Karim, D.R. Davies, I.S.D.
Roberts, C.G. Winearls American Journal of Kidney Diseases October 2003;
42 (4): 842-845
Regulatory cells in transplantation K.J.
Wood, H. Ushigome, M. Karim, A. Bushell, S. Hori, S. Sakaguchi In:
Generation and Effector Functions of Regulatory Lymphocytes, Gregory Bock and
Jamie Goode, editors. John Wiley & Sons, 2003, pages 177-193
Alloantigen-induced CD25+CD4+ regulatory
T cells can develop in vivo from CD25-CD4+ precursors
in a thymus-independent process M. Karim, C.I. Kingsley, A.R. Bushell,
B.S. Sawitzki, K.J. Wood Journal of Immunology January 15th 2004; 172 (2):
Proliferative glomerulonephritis associated
with mantle cell lymphoma – natural history and effect of treatment in two
casesM. Karim, P. Hill, G. Pillai, K. Gatter, D.R. Davies, C.G. Winearls Clinical
Nephrology June 2004; 61 (6): 422-428
A simple method to cure established tumors by
inflammatory killing of normal cells
G.A. Daniels, L. Sanchez-Perez, R.M. Diaz, T.
Kottke, J. Thompson, M. Lai, M. Gough, M. Karim, A. Bushell, H. Chong, A.
Melcher, K. Harrington, R.G. Vile Nature Biotechnology September 2004; 22
CD25+CD4+ regulatory T cells generated by
exposure to a model protein antigen prevent allograft rejection:
antigen-specific re-activation in vivo is critical for bystander
regulation M. Karim, G. Feng, K.J. Wood, A.R. Bushell Blood June 15th
2005; 105 (12): 4871-4877
IFN-gamma production by alloantigen-reactive
regulatory T cells is important for their regulatory function in vivo B.
Sawitzki, C.I. Kingsley, V. Oliveira, M. Karim, M. Herber, K.J. Wood Journal
of Experimental Medicine June 20th 2005; 201 (12): 1925-1935
CD25+CD4+ regulatory T cells develop in mice
not only during spontaneous acceptance of liver allografts but also after acute
allograft rejection U. Steger, C.I. Kingsley, M. Karim, A.R. Bushell, K.J.
Wood Transplantation November 15th 2006; 29 (9): 1202-1209
Management of acute renal failure D.V.
Hamilton, M. Karim Foundation Years Journal 2007; 1 (4): 189-191
Exhaustive differentiation of alloreactive
CD8+ T cells: critical for determination of graft acceptance or rejection U.
Steger, C. Denecke, B. Sawitzki, M. Karim, N.D. Jones, K.J. Wood Transplantation
May 15th 2008; 85 (9): 1339-1347
Pulmonary fibrosis – an uncommon
manifestation of anti-myeloperoxidase positive systemic vasculitis? A.
Bhanji, M. KarimNDT Plus August 2010; 3 (4): 351-353