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Biography

Dr. Hiroyuki Kobori
Department of Physiology

Tulane University Health Sciences Center, USA

Associate Professor


Email: hkobori@tulane.edu


Qualifications

1998 Ph.D., Keio University School of Medicine, Japan

1990 M.D., Keio University School of Medicine, Japan


Publications

  1. Pelisch N, Hosomi N, Ueno M, Masugata H, Murao K, Hitomi H, Nakano D, Kobori H, Nishiyama A, Kohno M. Systemic candesartan reduces brain angiotensin II via downregulation of brain renin-angiotensin system. Hypertens Res.2010;33:161-164. PMCID: PMC2818705.
  2. Nishiyama A, Kobori H, Konishi Y, Morikawa T, Maeda I, Okumura M, Kishida M, Hamada M, Nagai Y, Nakagawa T, Ohashi N, Nakano D, Hitomi H, Imanishi M. Mineralocorticoid receptor blockade enhances the anti-proteinuric effect of an angiotensin II blocker through inhibiting podocyte injury in type 2 diabetic rats. J Pharmacol Exp Ther. 2010;332:1072-1080. PMCID: PMC2835438.
  3. Yasue S, Masuzaki H, Okada S, Ishii T, Kozuka C, Tanaka T, Fujikura J, Ebihara K, Hosoda K, Katsurada A, Ohashi N, Urushihara M, Kobori H, Morimoto N, Kawazoe T, Naitoh M, Okada M, Sakaue H, Suzuki S, Nakao K. Adipose tissue-specific regulation of angiotensinogen in obese humans and mice: Impact of nutritional status and adipocyte hypertrophy. Am J Hypertens. 2010;23:425-431. PMCID: PMC2842463.
  4. Okada S, Kozukaa C, Masuzaki H, Yasue S, Ishii-Yonemoto T, Tanaka T, Yamamoto Y, Noguchi M, Kusakabe T, Tomita T, Fujikura J, Ebihara K, Hosoda K, Sakaue H, Kobori H, Ham M, Lee YS, Kim JB, Saito Y, Nakao K. Adipose tissue–specific dysregulation of angiotensinogen by oxidative stress in obesity. Metabolism. 2010;59:1241-1251. PMCID: PMC2891233.
  5. Urushihara M, Kondo S, Kagami S, Kobori H. Urinary angiotensinogen accurately reflects intrarenal renin-angiotensin system activity. Am J Nephrol. 2010;31:318-325. PMCID: PMC2859228.
  6. Fan YY, Kohno M, Nakano D, Ohsaki H, Kobori H, Suwarni D, Ohashi N, Hitomi H, Asanuma K, Noma T, Tomino Y, Fujita T, Nishiyama A. Cilnidipine suppresses podocyte injury and proteinuria in metabolic syndrome rats: Possible involvement of n-type calcium channel in podocyte. J Hypertens. 2010;28:1034–1043. PMCID: PMC2879137.
  7. Kobori H, Urushihara M, Xu JH, Berenson GS, Navar LG. Urinary angiotensinogen is correlated with blood pressure in men (bogalusa heart study). J Hypertens. 2010;28:1422-1428. PMCID: PMC2891987.
  8. Ortiz RM, Kobori H, Conte D, Navar LG. Angiotensin II-induced reduction in body mass is Ang II receptor mediated in association with elevated corticosterone. Growth Horm IGF Res. 2010;20:282-288. PMCID: PMC2918720.
  9. Satou R, Miyata K, Katsurada A, Navar LG, Kobori H. Tumor necrosis factor-{alpha} suppresses angiotensinogen expression through formation of a p50/p50 homodimer in human renal proximal tubular cells. Am J Physiol Cell Physiol.2010;299:C750-C759. PMCID: PMC2957270.
  10. Nishiyama A, Konishi Y, Ohashi N, Morikawa T, Urushihara M, Maeda I, Hamada M, Kishida M, Hitomi H, Shirahashi N, Kobori H, Imanishi M. Urinary angiotensinogen reflects the activity of intrarenal renin-angiotensin system in patients with IgA nephropathy. Nephrol Dial Transplant. 2011;26:170-177. PMCID: PMC3108354.
  11. Ohashi N, Urushihara M, Satou R, Kobori H. Glomerular angiotensinogen is induced in mesangial cells in diabetic rats via reactive oxygen species-erk/jnk pathways. Hypertens Res. 2010;33:1174–1181. PMCID: PMC2974762.
  12. Ihara G, Kiyomoto H, Kobori H, Nagai Y, Ohashi N, Hitomi H, Nakano D, Pelisch N, Hara T, Mori T, Ito S, Kohno M, Nishiyama A. Regression of superficial glomerular podocyte injury in type 2 diabetic rats with overt albuminuria: Effect of angiotensin II blockade. J Hypertens. 2010;28:2289-2298. PMCID: PMC2955758.
  13. Milani CJ, Kobori H, Mullins JJ, Mitchell KD. Enhanced urinary angiotensinogen excretion in cyp1a1-ren2 transgenic rats with inducible ang II-dependent malignant hypertension. Am J Med Sci. 2010;340:389–394. PMCID: PMC2974052.
  14. Yoon HE, Ghee JY, Piao S, Song JH, Han DH, Kim S, Ohashi N, Kobori H, Kuro OM, Yang CW. Angiotensin II blockade upregulates the expression of klotho, the anti-ageing gene, in an experimental model of chronic cyclosporine nephropathy.Nephrol Dial Transplant. 2011;26:800-813. PMCID: PMC3108350.
  15. Pelisch N, Hosomi N, Ueno M, Nakano D, Hitomi H, Mogi M, Shimada K, Kobori H, Horiuchi M, Sakamoto H, Matsumoto M, Kohno M, Nishiyama A. Blockade of AT1 receptors protects the blood-brain barrier and improves cognition in dahl salt-sensitive hypertensive rats. Am J Hypertens. 2010;24:363-368. PMCID: PMC3040273.
  16. Rafiq K, Nakano D, Ihara G, Hitomi H, Fujisawa Y, Ohashi N, Kobori H, Nagai Y, Kiyomoto H, Kohno M, Nishiyama A. Effects of mineralocorticoid receptor blockade on glucocorticoid-induced renal injury in adrenalectomized rats. J Hypertens.2011;29:290-298. PMCID: PMC3034279.
  17. Prieto MC, Gonzalez-Villalobos RA, Botros FT, Martin VL, Pagan J, Sato R, Lara LS, Feng Y, Fernandez F, Kobori H, Casarini DE, Navar LG. Reciprocal changes in renal ace/Ang II and ace2/ang 1-7 are associated with enhanced collecting duct renin in goldblatt hypertensive rats. Am J Physiol Renal Physiol. 2011; 300: F749-755. PMCID: PMC3064128.
  18. Urushihara M, Ohashi N, Miyata K, Satou R, Acres OW, Kobori H. Addition of angiotensin II type 1 receptor blocker to ccr2 antagonist markedly attenuates crescentic glomerulonephritis. Hypertension. 2011; 57: 586-593. PMCID: PMC3048031.
  19. Acres OW, Satou R, Navar LG, Kobori H. Contribution of a nuclear factor-{kappa}b binding site to human angiotensinogen promoter activity in renal proximal tubular cells. Hypertension. 2011;57:608-613. PMCID:PMC3051182.
  20. Susic D, Frohlich ED, Kobori H, Shao W, Seth D, Navar LG. Salt-induced renal injury in shrs is mediated by AT1 receptor activation. J Hypertens. 2011; 29: 716-723. PMCID: PMC3053430.