Dan Xie

Prof. Dan Xie

Sun Yat-sen University, China






2004 Ph.D., Clinical Oncology, The University of Hong Kong, Hong Kong, China

1996 Master Degree of Medicine, Sun Yat-Sen University, Guangzhou, China

1991 Bachelor Degree of Medicine, Central South University, Changshai, China


Publications (Selected)

  1. Zhu W, Cai MY, Tong ZT, Dong SS, Mai SJ, Liao YJ, Bian XW, Lin MC, Kung HF, Zeng YX, Guan XY, Xie D*. Overexpression of EIF5A2 promotes colorectal carcinoma cell aggressiveness by up-regulating MTA1 through c-myc to induce epithelial-mesenchymal transition. Gut. (IF:10.61) 2011 Aug 3. [Epub ahead of print]
  2. Zheng F, Liao YJ, Cai MY, Liu YH, Liu TH, Chen SP, Bian XW, Guan XY, Lin MC, Zeng YX, Kung HF, Xie D*. The putative tumor suppressor microRNA-124 modulates hepatocellular carcinoma cell aggressiveness by repressing ROCK2 and EZH2. Gut. (IF:10.61) 2011 Jun 15. [Epub ahead of print]
  3. Tong ZT, Cai MY, Wang XG, Kong LL, Mai SJ, Liu YH, Zhang HB, Liao YJ, Zheng F, Zhu W, Liu TH, Bian XW, Guan XY, Lin MC, Zeng MS, Zeng YX, Kung HF, Xie D*. EZH2 supports nasopharyngeal carcinoma cell aggressiveness by forming a co-repressor complex with HDAC1/HDAC2 and Snail to inhibit E-cadherin. Oncogene. (IF:7.41) 2011 Jun 20. [Epub ahead of print]
  4. Zhang B, Qian D, Ma HH, Jin R, Yang PX, Cai MY, Liu YH, Liao YJ, Deng HX, Mai SH, Zeng YX, Lin MC, Kung HF*, Xie D*, Huang JJ*. Anthyracyclines disrupt telomere maintenance by telomerase through inducing PinX1 ubiquitinization and degradation. Oncogene. (IF: 7.41) 2011 Jun 6. [Epub ahead of print]
  5. Cai MY, Tong ZT, Zheng F, Liao YJ, Wang Y, Rao HL, Chen YC, Wu QL, Liu YH, Guan XY, Lin MC, Zeng YX, Kung HF, Xie D*. EZH2 protein: a promising immunomarker for the detection of hepatocellular carcinomas in liver needle biopsies. Gut. (IF:10.61) 2011;60:967-976.
  6. Cai MY, Tong ZT, Zhu W, Wen ZZ, Rao HL, Kong LL, Guan XY, Kung HF, Zeng YX, Xie D*. H3K27me3 Protein is a promising predictive biomarker of patients' survival and chemoradioresistance in human nasopharyngeal carcinoma. Mol Med. (IF:5.91) 2011 Jul 5. [Epub ahead of print]
  7. Xiao XS, Cai MY, Chen JW, Guan XY, Kung HF, Zeng YX, Xie D*. High expression of p300 in human breast cancer correlates with tumor recurrence and predicts patients’ adverse prognosis. Chin J Cancer Res. (IF:0.252) 2011, [Epub ahead of print]
  8. Cai MY, Hou JH, Rao HL, Luo RZ, Li M, Pei XQ, Lin MC, Guan XY, Kung HF, Zeng YX, Xie D*. High expression of H3K27me3 in human hepatocellular carcinomas correlates closely with vascular invasion and predicts patients worse prognosis. Mol Med. (IF:5.91) 2011;17(1-2):12-20.
  9. Yang G, He W, Cai M, Luo F, Kung H, Guan X, Zeng Y, Xie D*. Loss/Down-regulation of tumor suppressor in lung cancer 1 expression is associated with tumor progression and is a biomarker of poor prognosis in ovarian carcinoma. Int J Gynecol Cancer. (IF:1.56) 2011;21(3):486-93.
  10. He LR, Zhao HY, Li BK, Liu YH, Liu MZ, Guan XY, Bian XW, Zeng YX, Xie D*. Overexpression of eIF5A-2 is an adverse prognostic marker of survival in stage I non-small-cell lung cancer patients. Int J Cancer. (IF:4.73) 2011;29(1):143-50.
  11. He LR, Zhao HY, Li BK, Zhang LJ, Liu MZ, Kung HF, Guan XY, Bian XW, Zeng YX, Xie D*. Overexpression of AIB1 negatively affects survival of surgically resected non-small-cell lung cancer patients. Ann Oncol. (IF:6.45) 2010;21(8):1675-81.
  12. Rao ZY, Cai MY, Yang GF, He LR, Mai SJ, Hua WF, Liao YJ, Deng HX, Chen YC, Guan XY, Zeng YX, Kung HF, Xie D*. EZH2 supports ovarian carcinoma cell invasion and/or metastasis via regulation of TGF-{beta}1 and is a predictor of outcome in ovarian carcinoma patients. Carcinogenesis. (IF: 5.40) 2010; 31(9):1576-83.
  13. Wu GQ, Liao YJ, Qin ZQ, He LR, Chen YC, Zeng YX, Kung HF, Xie D*. PYRIN domain of NALP2 inhibits cell proliferation and tumor growth of human glioblastoma. Plasmid. (IF:1.79) 2010;64(1):41-50.
  14. He LR, Liu MZ, Li BK, Jia WH, Zhang Y, Liao YJ, Chen YC, Zhang LJ, Guan XY, Zeng YX, Kung HF, Xie D*. High expression of EZH2 is associated with tumor aggressiveness and poor prognosis in patients with esophageal squamous cell carcinoma treated with definitive chemoradiotherapy. Int J Cancer (IF: IF: 4.73) 2010; 127(1):138-47.
  15. Hua WF, Fu YS, Liao YJ, Xia WJ, Chen YC, Zeng YX, Kung HF, Xie D*. Curcumin induces down-regulation of EZH2 expression through the MAPK pathway in MDA-MB-435 human breast cancer cells. Eur J Pharmacol. (IF: 2.74) 2010; 637(1-3):16-21.
  16. Wang Y, Liu YH, Mai SJ, He LJ, Liao YJ, Deng HX, Guan XY, Zeng YX, Kung HF, Xie D*. Evaluation of serum clusterin as a surveillance tool for human hepatocellular carcinoma with hepatitis B virus related cirrhosis. J Gastroenterol Hepatol. (IF: 2.41) 2010; 25(6):1123-8.
  17. Yang GF, He WP, Cai MY, He LR, Luo JH, Deng HX, Guan XY, Zeng MS, Zeng YX, Xie D*. Intensive expression of Bmi-1 is a new independent predictor of poor outcome in patients with ovarian carcinoma. BMC Cancer. (IF: 3.15) 2010 Apr 8; 10:133.
  18. Cai MY, Zhang B, He WP, Yang GF, Rao HL, Rao ZY, Wu QL, Guan XY, Kung HF, Zeng YX, Xie D*. Decreased expression of PinX1 protein is correlated with tumor development and is a new independent poor prognostic factor in ovarian carcinoma. Cancer Sci. (IF: 3.85) 2010; 101(6):1543-9.
  19. Zhu X, Chen MS, Tian LW, Li DP, Xu PL, Lin MC, Xie D*, Kung HF*. Single nucleotide polymorphism of rs430397 in the fifth intron of GRP78 gene and clinical relevance of primary hepatocellular carcinoma in Han Chinese: risk and prognosis. Int J Cancer (IF:4.73) 2009;125(6):1352-7.
  20. He LR, Liu MZ, Li BK, Rao HL, Liao YJ, Guan XY, Zeng YX, Xie D*. Prognostic impact of H3K27me3 expression on locaregional progression after chemoradiotherapy in esophageal squamous cell carcinoma. BMC Cancer (IF: 3.15) 2009 Dec 22; 9:461.
  21. Zhu X, Wang Y, Tao T, Li DP, Lan FF, Zhu W, Xie D*, Kung HF*A new polymorphism in the GRP78 is not associated with HBV invasion. World J. Gastroenterol. (IF: 2.24) 2009; 15(39):4958-61.
  22. Wu GQ, Xie D*, Yang GF, Liao YJ, Mai SJ, Deng HX, Sze J, Guan XY, Zeng YX, Lin MC, Kung HF*. Cell cycle-related kinase supports ovarian carcinoma cell proliferation via regulation of cyclin D1 and is a predictor of outcome in patients with ovarian carcinoma. Int J Cancer (IF: 4.73) 2009;125(11):2631-42.
  23. He LR, Liu MZ, Li BK, Rao HL, Liao YJ, Zhang LJ, Guan XY, Zeng YX, Xie D*. Clusterin as a predictor for chemoradiotherapy sensitivity and patient survival in esophageal squamous cell carcinoma. Cancer Sci (IF: 3.85) 2009;100 (12):1591-6.
  24. Yang GF, Xie D*, Liu JH, Luo JH, Li LJ, Hua WF, Wu HM, Kung HF, Zeng YX, Guan XY. Expression and amplification of eIF-5A2 in human epithelial ovarian tumors and overexpression of EIF-5A2 is a new independent predictor of outcome in patients with ovarian carcinoma. Gynecol Oncol (IF: 3.76) 2009; 112(2):314-8.
  25. Luo JH, Hua WF, Rao HL, Liao YJ, Kung HF, Zeng YX, Guan XY, Chen W, Xie D*. Overexpression of EIF-5A2 predicts tumor recurrence and progression in pTa/pT1 urothelial carcinoma of the bladder. Cancer Sci (IF: 3.85) 2009; 100(5):896-902.
  26. Chen W, Luo JH, Hua WF, Zhou FJ, Lin MC, Kung HF, Zeng YX, Guan XY, Xie D*. Overexpression of EIF-5A2 is an independent predictor of outcome in patients of urothelial carcinoma of the bladder treated with radical cystectomy. Cancer Epidemiol Biomarkers Prev (IF: 4.19) 2009;18(2):400-8.
  27. He LR, Liu MZ, Li BK, Rao HL, Deng HX, Guan XY, Zeng YX, Xie D*. Overexpression of AIB1 predicts resistance to chemoradiotherapy and poor prognosis in patients with primary esophageal squamous cell carcinoma. Cancer Sci (IF: 3.85) 2009; 100(9):1591-6.
  28. Liu MZ, Xie D*, Mai SJ, Tong ZT, Shao JY, Fu YS, Xia WJ, Kung HF, Guan XY, Zeng YX. Overexpression of AIB1 in nasopharyngeal carcinomas correlates closely with advanced tumor stage. Am J Clin Pathol (IF: 2.50) 2008; 129(5):728-34.
  29. Luo JH, Xie D*, Liu MZ, Chen W, Liu YD, Wu GQ, Kung HF, Zeng YX, Guan XY. Protein expression and amplification of AIB1 in human urothelial carcinoma of the bladder and overexpression of AIB1 is a new independent prognostic marker of patient survival. Int J Cancer (IF: 4.73) 2008; 122(11):2554-61.
  30. Xu FP, Xie D*, Wen JM, Wu HX, Liu YD, Bi J, Lv ZL, Zeng YX, Guan XY. SRC-3/AIB1 protein and gene amplification levels in human esophageal squamous cell carcinomas. Cancer Lett (IF: 4.86) 2007; 245(1-2):69-74.
  31. Xie D*, Zeng YX, Wang HJ, Wen JM, Tao Y, Sham JS, Guan XY. Expression of cytoplasmic and nuclear Survivin in primary and secondary human glioblastoma. Br J Cancer (IF: 4.83) 2006;94(1):108-14.
  32. An X, Ng SS, Xie D (co-first author), Zeng YX, Sze J, Wang J, Chen YC, Chow BK, Lu G, Poon WS, Kung HF, Wong BC, Lin MC. Functional characterisation of cell cycle-related kinase (CCRK) in colorectal cancer carcinogenesis. Eur J Cancer. (IF:4.94) 2010;46(9):1752-61.
  33. Chen Y, Xie D (co-first author), Yin Li W, Man Cheung C, Yao H, Chan CY, Chan CY, Xu FP, Liu YH, Sung JJ, Kung HF. RNAi targeting EZH2 inhibits tumor growth and liver metastasis of pancreatic cancer in vivo. Cancer Lett. (IF:4.86) 2010;297(1):109-16.
  34. Xie D, Ma NF, Pan ZZ, Wu HX, Liu YD, Wu GQ, Kung HF, Guan XY. Overexpression of EIF-5A2 is associated with metastasis of human colorectal carcinoma. Hum Pathol (IF:2.99) 2008;39(1):80-5.
  35. Lo PH, Xie D (co-first author), Chan KC, Xu FP, Kuzmin I, Leman MI, Law S, Chua D, Shan J, Lung ML. Reduced expression of RASSF1A in esophageal and nasopharyngeal carcinomas significantly correlates with tumor stage. Cancer Lett (IF:4.86) 2007; 257(2):199-205.
  36. Zhang JF, He ML, Fu WM, Wang H, Chen LZ, Zhu X, Chen Y, Xie D, Lai P, Chen G, Lu G, Lin MC, Kung HF. Primate-specific miRNA-637 inhibits tumorigenesis in hepatocellular carcinoma by disrupting stat3 signaling. Hepatology. (IF:10.89) 2011 Aug 1. [Epub ahead of print]
  37. Tang DJ, Dong SS, Xie D, Ma NF, Chen L, Fu L, Lau SH, Li Y, Li Y, Guan XY. Overexpression of EIF5A2 enhances cell motility and promotes tumor metastasis in hepatocellular carcinoma. Hepatology (IF:10.89) 2010; 51(4):1255-63.
  38. Chen L, Chan TH, Yuan YF, Hu L, Huang J, Ma S, Wang J, Dong SS, Tang KH, Xie D, Li Y, Guan XY. CHD1L promotes hepatocellular carcinoma progression and metastasis in mice and is associated with these processes in human patients. J Clin Invest. (IF:14.15) 2010;120(4):1178-91.
  39. Fu L, Dong S, Xie YW, Tai LS, Chen L, Kong KL, Man K, Xie D, Li Y, Cheng Y, Tao Q, Guan XY. Downregulation of tyrosine aminotransferase at a frequently deleted region 16q22 contributes to the pathogenesis of hepatocellular carcinoma. Hepatology (IF:10.89) 2010;51(5):1624-34.
  40. Lan FF, Wang H, Chen YC, Chan CY, Ng SS, Li K, Xie D, He ML, Lin MC, Kung HF. Hsa-let-7g inhibits proliferation of hepatocellular carcinoma Cells by down-regulation of c-Myc and Up-regulation of p16 (INK4A). Int J Cancer. (IF: 4.73) 2010; 101(6):1543-9.
  41. Lin S, Cheung WK, Chen S, Lu G, Wang Z, Xie D, Li K, Lin MC, Kung HF. Computational identification and characterization of primate-specific microRNAs in human genome. Comput Biol Chem. (IF: 1.28) 2010; 34(4):232-41.