Fang Yan

Dr. Fang Yan

Department of Pediatrics, Division of Gastroenterology

Vanderbilt University Medical Center, USA






1997 PhD, Cell Biology. Department of Anatomical Sciences and Neurobiology, University of Louisville, Louisville, KY

1991 M.D., Medicine, Tianjin Medical University, Eight-year Program, Tianjin, P. R. China


Publications (Selected)

  1. Yan, F., Lutz, D., Shepherd, V.L., Boyle, D. and McLaughlin, B.J. (1995) Characterization of rod outer segment plasma membrane proteins which bind to the mannose receptor. Curr. Eye Res. 14: 465-471. PMID: 7671628.
  2. Yan, F., Cooper, N.G. and McLaughlin, B.J. (1998) Temperature-sensitive interactions between RPE and rod outer segments surface proteins. Exp. Eye Res. 66:783-790. PMID: 9657911.
  3. Kaiser, G.C., Yan, F. and Polk, D.B. (1999) Mesalamine blocks tumor necrosis factor growth inhibition and nuclear factor kB activation in mouse colonocytes.Gastroenterology. 116: 602-609. PMID: 10029619.
  4. Kaiser, G.C., Yan, F. and Polk, D.B. (1999) Conversion of TNFa antiproliferative to proliferative ligand in mouse intestinal epithelial cells by regulating mitogen activated protein kinase. Exp. Cell Res. 249: 349-358. PMID: 10366434.
  5. Yan, F. and Polk, D.B. (1999) Aminosalicylic acid inhibits IkB kinase a phosphorylation of IkBa in intestinal epithelial cells. J. Biol. Chem. 274:36631-36636. PMID: 10593965.
  6. Yan, F. and Polk, D.B. (2001) Kinase suppressor of Ras is necessary for TNFa activation of ERK/MAP kinase in intestinal epithelial cells. Cancer Res. 61: 963-969PMID: 11221891.
  7. Gupta, G.A., Polk, D.B., Krishna,U., Israel, D.A., Yan, F., DuBois, R.N. and Peek, R.M. (2001) Activation of peroxisomal proliferator-activated receptor g suppresses NFkB-mediated apoptosis induced by Helicobacter pylori in gastric epithelial cells. J. Biol. Chem. 276: 31059-31066. PMID: 11397815.
  8. Yan, F., John, S.K. and Polk, D.B. (2001) Kinase suppressor of Ras determines survival of intestinal epithelial cells exposed to tumor necrosis factor.Cancer Res. 61: 8668-8675. PMID: 11751383.
  9. Yan, F. and Polk, D.B. (2002) Probiotic bacterium prevents cytokine-induced apoptosis in intestinal epithelial cells. J. Biol. Chem. 277: 50959-50965. PMID: 12393915.
  10. Corredor, J., Yan, F., Shen, C., Tong, W., John, K.S., Whitehead, R., Wilson, G. and Polk, D.B. (2003) Tumor necrosis factor regulates intestinal epithelial cell migration by receptor-dependent mechanisms. Am. J. Physiol., Cell Physiol. 284: C953-C961. PMID: 12466150.
  11. Yan, F., John, K.S., Wilson, G., Jones, D.S., Washington, M.K. and Polk, D.B. (2004) Kinase suppressor of Ras protects intestinal epithelium from cytokine-mediated apoptosis during inflammation. J. Clin. Invest. 114: 1272-1280. PMID: 15520859.
  12. Yan, F. and Polk, D.B. (2004) Commensal bacteria in the gut: learning who our friends are. Curr. Opin. Gastroenterol. 20: 565-571. PMID: 15703684. (review)
  13. Edelblum, K.L., Yan, F., Yamaoka, T. and Polk, D.B. (2006) Regulation of apoptosis during homeostasis and disease in the intestinal epithelium. Inflamm. Bowel Dis. 12: 413-424. PMID: 16670531. (review)
  14. Yan, F. and Polk, D.B. (2006) Probiotics as functional food in the treatment of diarrhea. Curr. Opin. Clin, Nutr. Metab, Care. 9: 717-271. PMID: 17053425. (review)
  15. Yan, F., Cao, H., CoverT. L., WhiteheadR., Washington, M, K. and Polk, D.B. (2007) Soluble proteins produced by probiotic bacteria regulate intestinal epithelial cell survival and growth. Gastroenterology 132: 562-575. PMID17258729.
  16. Seth, A., Yan, F., Polk, D.B., and Rao, R.K. (2008) Probiotics ameliorate hydrogen peroxide-induced epithelial barrier disruption by PKC and MAP kinase-dependent mechanism. Am. J. Physiol. Gastrointest. Liver Physiol. 294: G1060-1069. PMID: 18292183.
  17. McElroy, S.J., Frey, M.R., Yan, F., Edelblum, K.L., Goettel, J.A., John, S.K. and Polk, D.B. (2008) Tumor necrosis factor inhibits ligand-stimulated EGF receptor activation through a TNF receptor 1-dependent mechanism. Am. J. Physiol. Gastrointest. Liver Physiol. 295: G285-93. PMID: 18467504.
  18. YamaokaT., Yan, F., Cao, H., Hobbs, S.S., Dise, R.S., Tong, W., and Polk, D.B. (2008) Transactivation of EGF receptor and ErbB2 protects intestinal epithelial cells from TNF-induced apoptosis. Proc. Natl. Acad. Sci. USA.105: 11772-11777. PMID18701712.
  19. Edelblum, K.L., Goettel, J.A., Koyama, T., McElroy, S.J., Yan, F., and Polk, D.B. (2008) TNFR1 promotes TNF-mediated mouse colon epithelial cell survival through Raf activation of NF-kB. J. Biol. Chem. 283: 29485-29494. PMID: 18713739.
  20. Vanderpool, C., Yan, F. and Polk, D.B. (2008) Mechanisms of probiotic action-implications for therapeutic applications in inflammatory bowel diseases.Inflamm. Bowel Dis.14:1585-1596. PMID: 18623173. (review)
  21. Yan, F., Cao, H., Chaturvedi, R, Krishna, U., Hobbs, S.S., Dempsey, P.J., Peek, R.M., CoverT. L., Washington, M, K. Wilson, K.T., and Polk, D.B. (2009) Epidermal growth factor receptor activation protects gastric epithelial cells from Helicobacter pylori-induced apoptosis. Gastroenterology 136:1297-1307. PMID: 19250983.
  22. Nagy, T.A., Frey, M.R., Yan, F., Israel, D.A., Polk, D.B., and Peek, R.M. (2009) Helicobacter pylori regulates cellular migration and apoptosis by activation of phosphatidylinositol 3-kinase signaling. J. Infect. Dis. 199: 641-651. PMID: 19199544.
  23. Bäuerl, C., Pérez-Martínez, G., Yan, F., Polk, D.B., and Monedero, V.J. (2010) Functional Analysis of the p40 and p75 Proteins from Lactobacillus casei BL23. Mol. Microbiol. Biotechnol. 17; 19:231-241. PMID: 21178363.
  24. Yan, F. and Polk, D.B. (2010) Probiotics: progress toward novel therapies. Curr. Opin. Gastroenterol. 26: 95-101. PMID: 19952741. (review)
  25. Yan, F. and Polk, D.B. (2010) Disruption of NF-kB signaling by ancient microbial molecules-novel therapies of the future? Gut 59: 421-426. PMID: 20332512. (review)
  26. Yan, F., Cao, H., CoverT. L., Washington, M.K. Shi, Y., Liu, L., Chaturvedi, R., Peek, R.M., Wilson, K.T., and Polk, D.B. (2011) Colon specific delivery of a probiotic-derived soluble protein ameliorates intestinal inflammation in mice through an EGF receptor-dependent mechanism. J. Clin. Invest. 121:2242-53. PMID: 21606592
  27. Hobbs, S. S., Goettel, J.A., Liang, D., Yan, F., Edelblum, K.L., Frey, M.R., Mullane, M.T., and Polk, D.B. (2011) Transactivation of EGFR stimulates cytoprotective COX-2 expression in gastrointestinal epithelial cells. Am. J. Physiol. Gastrointest. Liver Physiol. 301:G220-9. PMID: 21566012
  28. Chaturvedi, R., Asim, M., Romero-Gallo, J., Barry, D.P., Hoge, S., de Sablet, Delgado, A.G., Wroblewski, L.E., Piazuelo, M.B., Yan, F., Israel, D.A., Casero, R.A., Correa, P., Gobert, A.P., Polk, D.B., Peek, R.M., and Wilson, K.T. (2011) Spermine oxidase mediates the gastric cancer risk associated with Helicobacter pylori CagA. Gastroenterology141:1696-708. PMID: 21839041
  29. Yan, F. and Polk, D.B. (2011) Probiotics and immune health. Curr. Opin. Gastroenterol. 27: 496-501. PMID: 21897224 (review)
  30. Yan, F., Wang, L., Shi, Y., Cao, H., Liu, L., Washington, M.K. Shi, Y., Chaturvedi, R., Israel, D.A., Cao, H., Wang, B., Peek, R.M., Wilson, K.T., and Polk, D.B. (2012) Berberine promotes recovery of colitis and inhibits inflammatory responses in colonic macrophages and epithelial cells in DSS-treated mice.Am. J. Physiol. Gastrointest. Liver Physiol.[Epub ahead of print]
  31. Zhang, Y., Dube, P., Washington, M.K., Yan, F., and Polk, D.B. (2012) ErbB2 and ErbB3 regulate recovery from dextran sulfate sodium-induced colitis by promoting mouse colon epithelial cell survival. Lab Invest [Epub ahead of print]
  32. Yan, F. and Polk, D.B. (2012) Characterization of a probiotic-derived soluble protein which reveals a mechanism of preventive and treatment effects of probiotics on intestinal inflammatory diseases. Gut Microbes (In press)