Prof. Chang H.
Department of Comparative Pathobiology
1998 Ph.D., Indiana University School of Medicine
1992 MS, Korea
Advanced Institute of Science and Technology
1990 BS, Korea
Advanced Institute of Science and Technology
Kim CH,Qu C,
Hangoc G,Cooper S, Feng G-S, and Broxmeyer HE, Abnormal chemokine induced
responses of immature and mature hematopoietic cells from motheaten mice:
Implication of the protein tyrosine phosphatase SHP-1 in chemokine responses,
1999, J. Exp. Med., 190:681-690.
G, Cooper S, Helgason CD, Yew S,Humphries RK, Krystal G,and Broxmeyer HE, Altered
responsiveness to chemokines due to targeted disruption of SHIP.1999, J. Clin.
Kunkel, EJ, Boisvert J, Johnston B, Campbell JJ, Genovese MC, Greenberg HB, and
Butcher EC. Bonzo/CXCR6 defines polarized Type 1 memory/effector T cell subsets
with extra-lymphoid tissue homing potential. 2001, J. Clin. Invest.107: 595.
Kim CH, Rott
LS, Clark-Lewis I, Campbell DJ, Wu L, Butcher EC.Subspecialization of
CXCR5+ T cells: B helper activity is focused in a germinal center-localized
subset of CXCR5+ T cells. 2001, J. Exp. Med. 193:1373.
Kim CH and Butcher EC, Separable populations of effector CD4+ T cells mediate B
cell help and tissue inflammation. 2001, Nature Immunology, 9:876-881.
LS, Kunkel EJ, Genovese M, Andrew DP, Wu L, and Butcher EC. Rules of
chemokine receptor association with T cell polarization in vivo.2001, J. Clin.
Roy M, Kim CH,
Butcher EC. Cytokine regulation of B cell homing machinery.2002, J.
Johnston B, Butcher EC. Trafficking machinery of NKT cells: shared and
differential chemokine receptor expression among V alpha 24(+)V beta 11(+) NKT
cell subsets with distinct cytokine-producing capacity.2002, Blood. 100:11-6.
Kunkel EJ, Kim
CH, Lazarus NH, Vierra MA, Soler D, Bowman EP, Butcher EC. CCR10 expression is
a common feature of circulating and mucosal epithelial tissue IgA Ab-secreting
cells. 2003, J Clin Invest. 111:1001-10.
Cooper S, Kohli L, Hangoc G, Lee Y, Mantel C, Clapp DW, Kim CH. Transgenic
expression of stromal cell-derived factor-1/CXC chemokine ligand 12 enhances
myeloid progenitor cell survival/antiapoptosis in vitro in response to growth
factor withdrawal and enhances myelopoiesis in vivo. 2003,J Immunol. 170:421-9.
Kim CH, Nagata
K, and Butcher EC. Dendritic cells support sequential reprogramming of
chemoattractant receptor profiles during naive to effector T cell
differentiation. 2003, J. Immunol.171: 152-158.
Kim CH, Lim
HW, Kim JR, Rott L, Hillsamer P, Butcher EC. Unique gene expression program of
human germinal center T helper cells.2004, Blood. 104:1952-60.
Hillsamer P, Kim CH. Regulatory T cells can migrate to follicles upon T cell
activation and suppress GC-Th cells and GC-Th cell-driven B cell responses.
2004, J Clin Invest. 11:1640-9.
Hillsamer P, Banham AH, Kim CH. Cutting Edge: Direct suppression of B cells by
CD4+CD25+ regulatory T cells. J Immunol 2005 175: 4180-4183.
Broxmeyer HE, Kim CH. Regulation of trafficking receptor expression in human
FOXP3+ regulatory T cells. J Immunol. 2006, 177(2):840-51.
Piniecki RJ, Lim HW, HogenEsch H, Braun SE, Wiebke E, Matsumoto S, Kim CH.
Identification of a chemokine network that recruits FoxP3+ regulatory T cells
to inflamed intestine. Gastroenterology, Volume 132, 2007, 966-981.
Lee JH, Kang
SG, Kim CH. FoxP3+ T cells undergo conventional first switch to lymphoid tissue
homing receptors in thymus but accelerated second switch to non-lymphoid tissue
homing receptors in secondary lymphoid tissues. 2007, J Immunol 2007 178:
Kang SG, Lim
HW, Andrisani OM, Broxmeyer HE, and Kim CH. Vitamin A Metabolites Induce Gut
Homing FoxP3+ Regulatory T cells. J Immunol 2007. 179: 3724-3733.
Lim HW, Kim
CH. Loss of IL-7Ralpha defines terminally differentiated B cell helping
effector T cells. J Immunol, 2007. 179: 7448-7456.
Hillsamer P, Kim CH. Human Th17 cells share major trafficking receptors with
both polarized effector T cells and FoxP3+ regulatory T cells. J Immunol, 2008.
Wang C, KangSG
, Lee JH, Sun Z,Kim CH. The role of CCR6 in migration of Th17 cells and
regulation of effector T cell balance in the gut.Mucosal Immunology.2009.
Kang SG, Wang
C, Matsumoto, S, Kim CH. High and low vitamin A therapies induce distinct
FoxP3+ T cell subsets and effectively control intestinal inflammation.Gastroenterology.
Lee JH, Wang
C, Kim CH. FoxP3+ Regulatory T cells Restrain ExtramedullaryMyelopoiesis via
Suppression of Hematopoietic Cytokine-Producing T Cells. J Immunol. 2009 Nov
Wang C, Kang
SG, HogenEsch H, Love PE, Kim CH.Retinoic acid determines the precise tissue
tropism of inflammatory Th17 cells in the intestine.J Immunol. 2010
Jordan-Williams KL, Wang C, Kang SG, Liao J, Logan MR, Kim CH,Taparowsky
EJ.Batf coordinates multiple aspects of B and T cell function required for
normal antibody responses. J Exp Med. 2010, 207(5):933-42.
Kang SG, Park
J, Cho JY, Ulrich B, Kim CH. Complementary roles of retinoic acid and TGF-beta1
in coordinated expression of mucosal integrins by T cells.Mucosal Immunol. 2011.
Lee JH, Ulrich
B, Cho J, Park J, Kim CH.Progesterone promotes differentiation of human cord
blood fetal T cells into T regulatory cells but suppresses their
differentiation into th17 cells.J Immunol. 2011 Aug 15;187(4):1778-87.