Chang H. Kim

Prof. Chang H. Kim

Department of Comparative Pathobiology

Purdue University, USA



1998 Ph.D., Indiana University School of Medicine

1992 MS, Korea Advanced Institute of Science and Technology

1990 BS, Korea Advanced Institute of Science and Technology

Publications (Selected)

  1. Kim CH,Qu C, Hangoc G,Cooper S, Feng G-S, and Broxmeyer HE, Abnormal chemokine induced responses of immature and mature hematopoietic cells from motheaten mice: Implication of the protein tyrosine phosphatase SHP-1 in chemokine responses, 1999, J. Exp. Med., 190:681-690.
  2. Kim CH,Hangoc G, Cooper S, Helgason CD, Yew S,Humphries RK, Krystal G,and Broxmeyer HE, Altered responsiveness to chemokines due to targeted disruption of SHIP.1999, J. Clin. Invest. 104:1751.
  3. Kim CH, Kunkel, EJ, Boisvert J, Johnston B, Campbell JJ, Genovese MC, Greenberg HB, and Butcher EC. Bonzo/CXCR6 defines polarized Type 1 memory/effector T cell subsets with extra-lymphoid tissue homing potential. 2001, J. Clin. Invest.107: 595.
  4. Kim CH, Rott LS, Clark-Lewis I, Campbell DJ, Wu L, Butcher EC.Subspecialization of CXCR5+ T cells: B helper activity is focused in a germinal center-localized subset of CXCR5+ T cells. 2001, J. Exp. Med. 193:1373.
  5. Campbell DJ, Kim CH and Butcher EC, Separable populations of effector CD4+ T cells mediate B cell help and tissue inflammation. 2001, Nature Immunology, 9:876-881.
  6. Kim CH,Rott LS, Kunkel EJ, Genovese M, Andrew DP, Wu L, and Butcher EC. Rules of chemokine receptor association with T cell polarization in vivo.2001, J. Clin. Invest, 108:1331.
  7. Roy M, Kim CH, Butcher EC. Cytokine regulation of B cell homing machinery.2002, J. Immunol.169:1676.
  8. Kim CH, Johnston B, Butcher EC. Trafficking machinery of NKT cells: shared and differential chemokine receptor expression among V alpha 24(+)V beta 11(+) NKT cell subsets with distinct cytokine-producing capacity.2002, Blood. 100:11-6.
  9. Kunkel EJ, Kim CH, Lazarus NH, Vierra MA, Soler D, Bowman EP, Butcher EC. CCR10 expression is a common feature of circulating and mucosal epithelial tissue IgA Ab-secreting cells. 2003, J Clin Invest. 111:1001-10.
  10. Broxmeyer HE, Cooper S, Kohli L, Hangoc G, Lee Y, Mantel C, Clapp DW, Kim CH. Transgenic expression of stromal cell-derived factor-1/CXC chemokine ligand 12 enhances myeloid progenitor cell survival/antiapoptosis in vitro in response to growth factor withdrawal and enhances myelopoiesis in vivo. 2003,J Immunol. 170:421-9.
  11. Kim CH, Nagata K, and Butcher EC. Dendritic cells support sequential reprogramming of chemoattractant receptor profiles during naive to effector T cell differentiation. 2003, J. Immunol.171: 152-158.
  12. Kim CH, Lim HW, Kim JR, Rott L, Hillsamer P, Butcher EC. Unique gene expression program of human germinal center T helper cells.2004, Blood. 104:1952-60.
  13. Lim HW, Hillsamer P, Kim CH. Regulatory T cells can migrate to follicles upon T cell activation and suppress GC-Th cells and GC-Th cell-driven B cell responses. 2004, J Clin Invest. 11:1640-9.
  14. Lim HW, Hillsamer P, Banham AH, Kim CH. Cutting Edge: Direct suppression of B cells by CD4+CD25+ regulatory T cells. J Immunol 2005 175: 4180-4183.
  15. Lim HW, Broxmeyer HE, Kim CH. Regulation of trafficking receptor expression in human FOXP3+ regulatory T cells. J Immunol. 2006, 177(2):840-51.
  16. Kang SG, Piniecki RJ, Lim HW, HogenEsch H, Braun SE, Wiebke E, Matsumoto S, Kim CH. Identification of a chemokine network that recruits FoxP3+ regulatory T cells to inflamed intestine. Gastroenterology, Volume 132, 2007, 966-981.
  17. Lee JH, Kang SG, Kim CH. FoxP3+ T cells undergo conventional first switch to lymphoid tissue homing receptors in thymus but accelerated second switch to non-lymphoid tissue homing receptors in secondary lymphoid tissues. 2007, J Immunol 2007 178: 301-311.
  18. Kang SG, Lim HW, Andrisani OM, Broxmeyer HE, and Kim CH. Vitamin A Metabolites Induce Gut Homing FoxP3+ Regulatory T cells. J Immunol 2007. 179: 3724-3733.
  19. Lim HW, Kim CH. Loss of IL-7Ralpha defines terminally differentiated B cell helping effector T cells. J Immunol, 2007. 179: 7448-7456.
  20. Lim HW, Hillsamer P, Kim CH. Human Th17 cells share major trafficking receptors with both polarized effector T cells and FoxP3+ regulatory T cells. J Immunol, 2008. 180:122-9.
  21. Wang C, KangSG , Lee JH, Sun Z,Kim CH. The role of CCR6 in migration of Th17 cells and regulation of effector T cell balance in the gut.Mucosal Immunology.2009. (2):173-83.
  22. Kang SG, Wang C, Matsumoto, S, Kim CH. High and low vitamin A therapies induce distinct FoxP3+ T cell subsets and effectively control intestinal inflammation.Gastroenterology. 2009 Oct;137(4):1391-402.
  23. Lee JH, Wang C, Kim CH. FoxP3+ Regulatory T cells Restrain ExtramedullaryMyelopoiesis via Suppression of Hematopoietic Cytokine-Producing T Cells. J Immunol. 2009 Nov 15;183(10):6377-86.
  24. Wang C, Kang SG, HogenEsch H, Love PE, Kim CH.Retinoic acid determines the precise tissue tropism of inflammatory Th17 cells in the intestine.J Immunol. 2010 184(10):5519-26.
  25. Betz BC, Jordan-Williams KL, Wang C, Kang SG, Liao J, Logan MR, Kim CH,Taparowsky EJ.Batf coordinates multiple aspects of B and T cell function required for normal antibody responses. J Exp Med. 2010, 207(5):933-42.
  26. Kang SG, Park J, Cho JY, Ulrich B, Kim CH. Complementary roles of retinoic acid and TGF-beta1 in coordinated expression of mucosal integrins by T cells.Mucosal Immunol. 2011.
  27. Lee JH, Ulrich B, Cho J, Park J, Kim CH.Progesterone promotes differentiation of human cord blood fetal T cells into T regulatory cells but suppresses their differentiation into th17 cells.J Immunol. 2011 Aug 15;187(4):1778-87.