Peizhong Mao

Dr. Peizhong Mao

Department of Physiology & Pharmacology, School of Medicine

Oregon Health & Science University (OHSU), Portland, Oregon, USA



1995-1999 Ph.D., molecular biology, Laboratory of Gene Regulation, Institute  for Genetic Medicine, Hokkaido University (Japan)

1985-1988 Master Degree, Physiology, Jiangxi Traditional Chinese Medical College (China)

1980-1985 M.D. (equal), Hebei Medical University (China)

Publications (Selected)

  1. Mao P, Manczak M, Shirendeb UP, Reddy PH. MitoQ, a mitochondria-targeted antioxidant, delays disease progression and alleviates pathogenesis in an experimental autoimmune encephalomyelitis mouse model of multiple sclerosis.Biochim Biophys Acta. 1832(12): 2322-2331, 2013.
  2. Mao P, Meshul C, Thuillier P and Reddy PH. Neuropeptide CART as a therapeutic candidate for Parkinson’s disease. Pharmaceuticals (Basel). 2013 Jan 18; 6(1). doi:pii: 108.
  3. Mao P. Oxidative stress and its clinical applications in dementia. Journal of     Neurodegenerative Diseases, Article ID 319898, doi:10.1155/2013/319898, 2013.
  4. Mao P. Recent progress and concerns in dementia: distinguishing Alzheimer’s disease and dementia with Lewy bodies via biochemical markers in the cerebrospinal fluid. Advances in Biological Chemistry, 2(2): 176-190, 2012.
  5. Mao P, Manczak M, Calkins MJ, Truong Q, Reddy TP, Reddy AP, Shirendeb U, Lo HH, Rabinovitch PS, Reddy PH. Mitochondria-targeted catalase reduces abnormal APP processing, amyloid beta production, and BACE1 in a mouse model of Alzheimer's disease: Implications for neuroprotection and lifespan extension. Hum Mol Genet. 21(13):2973-90, 2012.
  6. Cheung WW and Mao P. Recent Advances in Obesity: Genetics and Beyond. ISRN Endocrinology, 2012 (open access)
  7. Mao P, Meshul C, Thuillier and Reddy PH. CART is a potential endogenous antioxidant peptide and localized in mitochondria, PLoS One 2012;7(1):e29343 (open access).
  8. Mao P, Gallagher P, Nedungadi S, Manczak M, Shirendeb U, Kohama S, Ferguson B, Park BS, Reddy PH. Mitochondrial DNA deletions and differential mitochondrial DNA content in Rhesus monkeys: implications for aging. Biochim Biophys Acta- Molecular Basis of Disease 1822(2):111-119, 2011.
  9. Shirendeb U, Calkins M, Manczak M, Anekonda V, Dufour B,  McBride J,  Mao P, Reddy PH. Mutant huntingtin’s interaction with mitochondrial protein Drp1 impairs mitochondrial biogenesis and causes defective axonal transport and synaptic degeneration in Huntington’s disease. Hum Mol Genet. 20(7):1438-55, 2011.
  10. Calkins M, Manczak M, Mao P, Shirendeb U. Impaired mitochondrial biogenesis, defective axonal transport of mitochondria, abnormal mitochondrial dynamics and synaptic degeneration in a mouse model of Alzheimer’s disease. Hum Mol Genet. 20(23):4515-29, 2011.
  11. Mao P and Reddy PH. Aging and amyloid beta-induced oxidative DNA damage and mitochondrial dysfunction in Alzheimer's disease: Implications for early intervention and therapeutics. Biochim Biophys Acta. Molecular mechanisms of disease, 1812(11):1359-1370, 2011 (this review was listed as one of the most read articles in the journal, 2011; From that time and present, it is one of Elsevier Editor’s choice of authors’ research).
  12. Ricoy UM, Mao P, Manczak M, Reddy PH and Frerking ME. A transgenic mouse model for Alzheimer’s disease has impaired synaptic gain but normal synaptic dynamics Neuroscience Letter 500(3):212-5, 2011.
  13. Mao P. Potential antidepressant role of neurotransmitter CART: implications for mental disorders. Depression Research and Treatment, 2011:762139, 2011.
  14. Reddy PH, Reddy TP, Manczak M,  Calkins MJ, Shirendeb U, Mao P. Dynamin -Related Protein 1 and Mitochondrial Fragmentation in Neurodegenerative Diseases. Brain Research Reviews, 67(1-2):103-18, 2011.
  15. Shirendeb U, Reddy AP, Manczak M, Calkins MJ, Mao P, Tagle DA, Reddy PH.   Abnormal mitochondrial dynamics and mutant huntingtin oligomers in Huntington’s disease: Implications for selective neuronal damage. Hum Mol Genet. 20(7):1438-55, 2011.
  16. Reddy TP, Manczak M, Calkins MJ, Mao P, Reddy AP, Shirendeb U, Park B, and Reddy PH. Toxicity of neurons treated with herbicides and neuroprotection by mitochondria-targeted antioxidant SS31. Int. J. Environ. Res. Public Health 8: 203-221, 2011.
  17. Manczak M, Mao P, Calkins MJ, Cornea A, Reddy AP, Murphy MP, Szeto  HH, Park B, and Reddy PH. Mitochondria-Targeted Antioxidants Protect Against Amyloid-β Toxicity in Alzheimer’s Disease Neurons. J Alzheimers Dis 20 Suppl 2:S609-31, 2010.
  18. Reddy PH, Manczak M, Mao P, Calkins MJ, Reddy AP, Shirendeb U. Amyloid-beta and  Mitochondria in Aging and Alzheimer's Disease: Implications for Synaptic Damage and  Cognitive Decline. J Alzheimers Dis. 20 Suppl 2:S499-512,2010.
  19. Mao P and Reddy PH. Is Multiple Sclerosis a Mitochondrial Disease? Biochim Biophys
  20. Acta. Molecular mechanisms of disease, 1802(1):66-79, 2010.
  21. Reddy PH, Manczak M, Nakamura K, Zhao W, Bebbington C, Yarranton G and Mao P. Immunization of the granulocyte macrophage colony-stimulating factor suppresses microglia activity: Implications for anti-inflammatory effects in Alzheimer’s disease and multiple sclerosis. The Journal of Neurochemistry. 111(6):1514-28, 2009.
  22. Manczak M, Mao P, Nakamura K, Bebbington C, Park B, Reddy PH. Neutralization of Granulocyte Macrophage Colony Stimulating Factor Decreases Amyloid Beta 1-42 and Suppresses Microglial Activity in a Transgenic Mouse Model of Alzheimer's Disease. Hum Mol Genet. 18(20):3876-93, 2009.
  23. Reddy PH, Mao P and Manczak M. Mitchondrial Structural and Functional Dynamics in   Huntington’s disease. Brain Res Rev. 61(1):33-48, 2009.
  24. Mao P, Tao YX, Fukoyama M, Tao F, Li D, Watanabe M and Johns RA. Cloning and characterization of E-dlg, a novel splice variant of mouse homologue of the Drosophila discs large tumor suppressor binds preferentially to SAP102. The IUBMB Life (the International Union of Biochemistry and Molecular Biology Life), 60(10):684-92, 2008. (GenBank accession # for E-dlg: AY159380)
  25. Mao P, Ardeshiri A, Jacks R, Yang S, Hurn P and Alkayed N. Mitochondrial mechanism of neuroprotection by CART. Eur J Neurosci. 26(3): 624-32, 2007.
  26. Koerner IP, Jacks R, DeBarber AE, Koop D, Mao P, Grant DF, Alkayed NJ. Polymorphisms in the human soluble epoxide hydrolase gene EPHX2 linked to neuronal survival after ischemic injury. J Neurosci.27:4642-9, 2007.
  27. Mao P, Jacks R. Transcriptional activity by cocaine-amphetamine regulated transcript (CART). Molecular Psychiatry, 12(3): 223-4. 2007.
  28. Fang M, Tao YX, He F, Zhang M, Levine C, Mao P, Tao F, Chou C, Sadegh-Nasseri S, and Johns RA. Synaptic PDZ domain-mediated protein interactions are disrupted by inhalathonal anesthetics. J Biol Chem. 278(38): 36669-75, 2003.
  29. Tao F, Tao YX, Mao P, Zhao C, Li D, Liaw WJ, Raja SN, and Johns RA. Intact carrageenan-induced thermal hyperalgesia in mice lacking inducible nitric oxide synthase. Neuroscience 120(3): 847-854, 2003.
  30. Tao F, Tao YX, Mao P and Johns RA. Role of PSD-95 in the maintenance of peripheral nerve injury-induced neuropathic pain in rats. Neuroscience 117(3): 731-739, 2003.
  31. Takimoto M, Wei G, Dosaka-Akita H, Mao P, Kondo S, Sakuragi N, Chiba I, Miura T, Itoh N, Sasao T, Koya RC, Tsukamoto T, Fujimoto S, Katoh H, Kuzumaki N. Frequent expression of new cancer/testis gene D40/AF15q14 in lung cancers of smokers. Br J Cancer 86(11): 1757-62, 2002.
  32. Tao F, Tao YX, Gonzalez JA, Fang M, Mao P, Johns RA. Knockdown of PSD-95/SAP90 delays the development of neuropathic pain in rats. Neuroreport. 12(15): 3251-5, 2001.
  33. Mao P, Takimoto M, Wei G, Yamazaki H, Miura T, Johnson AC, Kuzumaki N. Molecular analysis of the GCF gene identifies revisions to the cDNA and amino acid sequences. Biochimica et Biophysica Acta –Gene Structure and Expression. 1447:125-131, 1999.
  34. Mao P. Revisions of the cDNA and primary protein structure of human transcription factor GCF. The Hokkaido Journal of Medical Science 74(4): 315-330, 1999.
  35. Takimoto M, Wei G, Mao P, Koya CR, Miura T and Kuzumaki N. Isolation of cDNAs that cover the entire coding region of a novel human protein D40. Nucleic Acids Symposium Series No: 42, 69-70 Oxford University Press, 1999.9.
  36. Wei G, Takimoto M, Yoshida I, Mao P, Koya RC, Miura T, Kuzumaki N. Chromosomal assignment of a novel human gene D40 (for the first time, D40 gene mapped to the long arm of chromosome 15q14-15). Wei G, Takimoto M, Yoshida I, Mao PZ, Koya RC, Miura T, Kuzumaki N. Nucleic Acids Symp Series No: 42, 71-2, 1999.
  37. Mao P, Takimoto M, Yamazaki H, Wei G, Miura T, Alfred CJ and    Kuzumaki N. Revision of cDNA and protein structure of transcription factor GCF. Nucleic Acids Symposium Series No: 39,199-200 Oxford University Press. 1998.9.
  38. Takimoto M, Wei G, Mao P, Koya CR, Miura T and Kuzumaki N. Molecular cloning of a novel human protein that binds specifically to nuclear factor GCF. Nucleic Acids Symposium Series No: 39, 201-202 Oxford University Press. 1998.9.
  39. Mao P, Takimoto M, Wei G, Sakai N, Senmaru N, Fujita H, Kuzumaki N. Expression of the GCF protein is dependent on the cell cycle. Nucleic Acids Symposium Series No. 37, 119-120 Oxford University Press. 1997.11.
  40. Takimoto M, Mao P, Wei G, Senmaru N and Kuzumaki N. Lack of homodimerization through the leucine zipper-like region of a mammalian transcriptional repressor GCF in yeast cells. Nucleic Acids Symposium Series No. 35, 229-230 Oxford University Press. 1996.9.
  41. Mao P, Li A and Hu Z. Labeling of rat LH and prolactin with iodine-125. Chemical Abstracts, Vol. 118, No. 6, Biochem Methods 407, 1993.3. (Date of patent obtained: 12/13/1996 from The Bureau of the patent of China).
  42. Hu Z, Fang X, Mao P, Gu F, Li Y, Zhang T, Xiao S, et al. Suppression of serum gonadotropin and gonadal hormones in adult male and female rhesus monkeys by potent LHRH antagonists TX51 and TX46-2. Contraception 46(2): 147, 1992.
  43. Fang X, Sun Z, Mao P, Xiao S. Evaluation of biological activity of LHRH antagonists by three methods. Contraception, 46(2): 135-137, 1992.
  44. Mao P, Zhou C, Lu Q and She Y.  Effects of traditional Chinese medicines Huang Qin and Dong Gui-San on the functions of corpora lutea in the psudopregnant rats. Journal of the Integration of Chinese Medicine and Western Medicine, Special Issue of Basic Research: 159-162, 1990.