Dr. Ji Li

Dr. Ji Li

University of Mississippi Medical Center, USA



1998 Ph.D., Lanzhou University, China

1992 M.Sc., Lanzhou University, China

1989 B.Sc.,  Lanzhou University, China

Publications (Selected)

  1. Kim AS, Miller EJ, Wright TM, Li J, Qi D, Atsina K, Zaha V, Sakamoto K, Young LH. A small molecule AMPK activator protects the heart against ischemia-reperfusion injury. J Mol Cell Cardiol 2011; 51:24-32 (Contribution: performed experiment and discussed).
  2. Li Y, Xu S, Giles A, Nakamura K, Lee JW, Hou X, Donmez G, Li J, Luo Z, Walsh K, Guarente L, Zang M. Hepatic overexpression of SIRT1 in mice attenuates endoplasmic reticulum stress and insulin resistance in the liver. FASEB J, 2011; 25:1664-1679 (Contribution: designed and performed experiments).
  3. Yan X, Yan X, Morrison A, Li J, Wang J. Fluoride induces apoptosis and alters collagen I expression in rat osteoblasts. Toxicol Lett 2011; 200:133-138. (Contribution: designed and performed experiment).
  4. Tong C, Morrison A, Yan X, Zhao P, Yeung ED, Wang J, Xie J, Li J. Macrophage migration inhibitory factor deficiency augments cardiac dysfunction in type 1 diabetic murine cardiomyocytes. J Diabetes, 2010; 2:267-274.
  5. Ma H*, Wang J*, Thomas DP, Tong C, Leng L, Wang W, Merk M, Zierow S, Bernhagen J, Ren J, Bucala R, Li J.  (*equal contribution).  Impaired macrophage migration inhibitory factor (MIF)-AMPK activation and ischemic recovery in the senescent heart. Circulation 2010; 122:282-292.
  6. Han B, Zheng Q, Wang J, Chen W, Tang H, Wang Q, Wang X, Li J. Isoliquiritigenin extracted from licorice Glycyrrhiza uralensis roots by a facile conversion technique. Chem Nat Comp 2010; 46:523-527.
  7. Turdi S, Fan X, Li J, Zhao J, Huff AF, Du M, Ren J.  AMP-activated protein kinase deficiency exacerbates aging-induced myocardial contractile dysfunction. Aging Cell 2010; 9:592-606. (Contribution: designed and performed experiment).
  8. Zhang X*, Yeung ED*, Wang J, Panzhinskiy EE, Tong C, Li W, Xie J, Li J. Isoliquiritigenin, a natural antioxidant, selectively inhibits proliferation of prostate cancer cells.  Clin Exp Pharm Physiol 2010; 37:841-847.
  9. Wang J, Ma H, Tong C, Zhang H, Lawlis GB, Li Y, Zang M, Ren J, Nijland M, Ford SP, Nathanielsz PW, Li J. Overnutrition and maternal obesity in sheep pregnancy alter the JNK-IRS-1 signaling cascades and cardiac function in the fetal heart. FASEB J 2010; 24:2066-2076.
  10. Kandadi MR, Rajanna PK, Unnikrishnan MK, Boddu SP, Hua Y, Li J, Du M, Ren J, Sreejayan N, 2-(3,4-Dihydro-2H-pyrrolium-1-yl)-3oxoindan-1-olate (DHPO), a novel, synthetic small molecule that alleviates insulin resistance and lipid abnormalities. Biochem Pharm 2010; 79:623-631 (Contribution: Reviewed and edited manuscript).
  11. Ma H, Li SY, Xu P, Dolence K, Babcock SA, Brownlee M, Li J and Ren J.  Advanced glycation endproduct (AGE) accumulation and AGE receptor (RAGE) upregulation contribute to the onset of diabetic cardiomyopathy. J Cell Mol Med 2009; 13:1751-1764 (Contribution: Contributed to discussion).
  12. Ma H, Li J, Gao F and Ren J.  Aldehyde dehydrogenase 2 (ALDH2) ameliorates acute cardiac toxicity of ethanol: role of protein phosphatase and forkhead transcription factor. J Am Coll Cardiol 2009; 54:2187-2196. (Contribution: Reviewed and edited manuscript)
  13. Li Q, Li J, Ren J. UCF-101 mitigates streptozotocin-induced cardiomyocyte dysfunction: role of AMP-activated protein kinase. Am J Physiol 2009; 297:E965-E973. (Contribution: Reviewed and edited manuscript)
  14. Wang J, Ma H, Zhang X, He L, Wu J, Gao X, Ren J, Li J. A novel AMPK activator from Chinese herb medicine and ischemia phosphorylate the cardiac transcription factor FOXO3.  Int J Physiol Pathophysiol Pharm 2009; 1:116-126. PMCID: PMC2863317
  15. Li D, Wang Z, Chen H, Wang J, Zheng Q, Shang J and Li J. Isoliquiritigenin induces monocytic differentiation of HL-60 cells. Free Radical Bio Med 2009; 46:731-736.
  16. Zhao P, Wang J, Xiao Y, He L, Tong C, Wang Z, Zheng Q, Dolence K, Nair S, Ren J and Li J.  A newly synthetic chromium complex–chromium (D-Phenylalanine)3 activates AMP-activated protein kinase and stimulates glucose transport. Biochem Pharm 2009; 77:1002-1010.
  17. Zhao P, Wang J, He L, Ma H, Li J, Dolence K, Ren J and Li J. Deficiency in TLR4 signal transduction ameliorates cardiac injury and cardiomyocyte contractile dysfunction during ischemia. J Cell Mol Med 2009; 13:1513-1525.
  18. Li Q, Ceylan-Isik AF, Li J and Ren J.  Deficiency of Insulin-like growth factor (IGF-1) leads to resistance against aging-associated cardiomyocyte dysfunction. Rejuvenation Res 2008; 11:725-733. (Contribution: Reviewed and edited manuscript)
  19. Zhao P, Xiao X, Kim A, Leite F, Xu J, Zhu X, Ren J and Li J. c-Jun Inhibits thapsigargin-induced apoptosis through up-regulation of DCRS1/Adapt78. Exp Biol Med 2008; 233:1289-1300.
  20. Miller EJ*, Li J*, Leng L, McDonald C, Atsumi T, Bucala R and Young LH. (*equal contribution)  Macrophage migration inhibitory factor stimulates AMP-activated protein kinase in the ischaemic heart. Nature 2008; 451:578-582.
  21. Miller EJ, Li J, Sinusas KM, Holman GD, Young LH. Infusion of a biotinylated bis-glucose photolabel: a new method to quantify cell surface GLUT4 in the intact mouse heart. Am J Physiol 2007; 292:E1922-E1928. (Contribution: Performed related experiments)
  22. Reznick RM, Zong H, Li J, Morino K, Moore IK, Yu HJ, Liu Z, Dong J, Mustard KJ, Hawley SA, Befroy D, Pypaert M, Hardie DG, Young LH and Shulman GI. Aging-associated reductions in AMP-activated protein kinase activity and mitochondrial biogenesis. Cell Metabolism 2007; 5:151-156. (Contribution: Performed related experiments)
  23. Zhang L, Li J, Young LH and Caplan MJ. AMP-activated protein kinase regulates the assembly of epithelial tight junctions. P Natl Acad Sci USA (PNAS) 2006;103:17272-17277. (Contribution: Performed related experiments)
  24. Shi X, Leng L, Wang T, Wang W, Du X, Li J, McDonald C, Chen Z, Murphy JW, Lolis E, Noble P, Knudson W and Bucala R. CD44 is the signaling component of MIF CD74 receptor complex. Immunity 2006; 25:595-606. (Contribution: Reviewed and edited manuscript)
  25. Li J, Coven DL, Miller EJ, Hu X, Young ME, Carling D, Sinusas A and Young LH. Activation of AMPKα- and γ-isoform complexes in the intact ischemic rat heart. Am J Physiol 2006; 291:H1927-H1934.
  26. Baron S*, Li J*, Russell RR, Neumann D, Miller EJ, Tuerk R, Walliman T, Hurley R, Witters LA and Young LH.  (*equal contribution).  Dual mechanisms regulating AMPK kinase action in the ischemic heart. Circulation Research 2005; 96:337-345.
  27. Li J, Hu X, Selvakumar P, Russell RR, Cushman SW, Holman GD and Young LH.  Role of the nitric oxide pathway in AMPK-mediated glucose uptake and GLUT4 translocation in heart muscle. Am J Physiol 2004; 287:E834-E841.
  28. Russell RR, Li J, Coven DL, Pypaert M, Zechner C, Palmeri M, Giordano FJ, Mu J, Birnbaum MJ and Young LH. AMP-activated protein kinase mediates ischemic glucose uptake and prevents post-ischemic cardiac dysfunction, apoptosis and injury. J. Clinical Investigation 2004; 114: 465-503. (Contribution: Performed related experiments)