Dr. Kenneth Richard Boheler

National Institutes of Health, USA



1988 Ph.D., Physiology and Pharmacology, University of California, USA

1982 B.Sc., Zoology, Duke University, USA


  1. Tarasov KV, Brugh SA, Tarasova YS, Boheler KR: Serial analysis of gene expression (SAGE), a useful tool to establish a cardiac transcriptome reference. In Methods in Molecular Medicine - Cardiac Gene Expression and Regulation. Methods Mol Biol. 2007;366:41-59
  2. Nikolova T, Wu M, Brumbarov K, Alt R, Opitz H, Boheler KR, Cross M, Wobus AM: WNT-conditioned media differentially affect the proliferation and differentiation of cord blood-derived CD133+ cells in vitro. Differentiation 2007;75:100-111.
  3. Li J, Wei H, Chesley A, Moon C, Krawczyk M, Volkova M, Ziman B, Margulies KB, Talan M, Crow MT, Boheler KR,The pro-angiogenic cytokine pleiotrophin potentiates cardiomyocyte apoptosis through inhibition of endogenous AKT/PKB activity. J Biol Chem. 2007: 282 (48): 34984-34993.
  4. Zahn JM, Poosala S, Owen A, Ingram DK, Lustig A, Carter A, Weeraratna AT, Taub DD, Gorospe M, Mazan-Mamczarz K, Lakatta EG, Boheler KR, Xu X, Mattson MP, Falco G, Ko MSH, Schlessinger D, Firman J, Kummerfeld SK, Wood III WH, Zonderman AB, Kim SK, Becker KG. AGEMAP: A gene expression database for aging in mice. PLoS Genet. 2007 Nov 30;3(11):e201. Epub 2007 Oct 2.
  5. Yamanaka S, Li J, Kania G, Elliott S, Wersto R, Van Eyk J, Wobus AM, Boheler KR. Pluripotency of Embryonic Stem Cells. Cell Tissue Res, 2008 Jan;331(1):5-22. Epub 2007 Nov 16.
  6. Tarasov K, Testa G, Tarasova Y, Kania G, Riordon DR, Volkova M, Anisimov SV, Wobus AM, Boheler KR. Linkage of Pluripotent Stem cell Associated Transcripts to Regulatory Gene Networks. Cells Tissues Organs. 2008;188(1-2):31-45. Epub 2008 Feb 27.
  7. Younes A, Lyashkov AE, Graham D, Sheydina A, Volkova MV, Mitsak M, Vinogradova TM, Lukyanenko YO, Li Y, Ruknudin AM, Boheler KR, Van Eyk JE, Lakatta EG: Ca2+-stimulated basal adenylyl cyclase activity localization in membrane lipid microdomains of cardiac sinoatrial nodal pacemaker cells. J Biol Chem. 2008; 283(21):14461-8. Epub 2008 Mar 20.
  8. Gundry RL, Boheler KR, Van Eyk JE, Wollscheid B: A Novel Role for Proteomics in the Discovery of Cell Surface Markers on Stem Cells, Proteomics Clin. Appl. 2008, 2, 892-903.
  9. Li RA, Moore JC, Tarasova YS, Boheler KR: Human Embryonic Stem Cell-Derived Cardiomyocytes: Therapeutic Potentials and Limitations. In Progress in Stem Cell Research,  Edited by: P Koka, Nova Science Pub Inc, Hauppauge NY, United States, February 2008, pp. 149-169.
  10. Perino M, Yamanaka S, Li J, Wobus AM, Boheler KR: Cardiomyogenic stem and progenitor cell plasticity and the dissection of cardiopoiesis J Mol Cell Cardiol. 2008 May 11. [Epub ahead of print].
  11. Tarasov KV, Tarasova YS, Tam WL, Riordon DR, Elliott ST, Kania G. Li J, Yamanaka S, Crider DG, Testa G. Li RA, Lim B, Stewart CL, Liu Y, Van Eyk JE, Wersto RP, Wobus AM, Boheler KR: B-MYB (MYBL2) is Required for Cell Cycle Progression, Chromosomal Stability and Maintenance of Undifferentiated Embryonic Stem Cells. PLoS ONE 2008; 3(6): e2478. doi:10.1371/journal.pone.0002478.
  12. Yamanaka S, Zahanich I, Wersto RP, Boheler KR:  Enhanced Proliferation of Monolayer Cultures of Embryonic Stem (ES) Cell-Derived Cardiomyocytes following Acute Loss of Retinoblastoma. PLoS ONE 2008; 3(12): e3896. doi:10.1371/journal.pone.0003896.
  13. Boheler KR:  Stem Cell Pluripotency: A Cellular Trait that Depends on Transcription Factors, Chromatin State and a Checkpoint Deficient Cell Cycle.  J Cell Physiol. 2009 Oct;221(1):10-7.
  14. Biehl JK, Yamanaka S, Desai TA, Boheler KR Russell B: Proliferation of mouse embryonic stem cell progeny and the spontaneous contractile activity of cardiomyocytes are affected by microtopography. Dev Dyn. 2009 Jul 17;238(8):1964-1973.
  15. Gundry RL, Raginski K, Tarasova Y, Tchernyshyov I, Bausch-Fluck D, Elliott ST, Boheler KR, Van Eyk JE, Wollscheid B: The Mouse C2C12 Myoblast Cell Surface N-Linked Glycoproteome: Identification, Glycosite Occupancy, and Membrane Orientation. Mol Cell Proteomics.2009;8(11):2555-2569.
  16. Boheler KR: Pluripotency of human embryonic and induced pluripotent stem cells for vascular regeneration. Thrombosis and Haemostasis 2010 Jul 5;104(1):23-9.
  17. Gundry RL, Tchernyshyov I, Sheng S, Tarasova Y, Raginski K, Boheler KR, Van Eyk JE:  Embryonic stem cell proteome: Combining three proteomic approaches”. Proteomics. 2010 Jul;10(14):2728-32.).
  18. Zhang Z, Hancock B, Leen S, Ramaswamy S, Sollott SJ, Boheler KR, Juhaszova M, Lakatta EG, Spencer RG, Fishbein KW: Compatibility of superparamagnetic iron oxide nanoparticle labeling for (1)H MRI cell tracking with (31)P MRS for bioenergetic measurements. NMR Biomed. 2010 Dec;23(10):1166-72.
  19. Zahanich I, Sirenko SG, Maltseva LA, Tarasova YS, Spurgeon HA, Boheler KR, Stern MD, Lakatta EG, Maltsev VA: Rhythmic beating of stem cell-derived cardiac cells requires dynamic coupling of electrophysiology and Ca cycling. J Mol Cell Cardiol. 2011 Jan;50(1):66-76
  20. Qiao H, Zhang H, Yamanaka S, Patel V, Petrenko N, Huang B, Ferrari VA, Boheler KR, Zhou R: Long-term Improvements in Global and Regional Contractile Function Mediated by Embryonic Stem Cell-derived Cardiomyocytes. Circ Cardiovasc Imaging. 2011 Jan;4(1):33-41
  21. Wiese C, Nikolova T, Zahanich I, Sulzbacher S, Fuchs J, Yamanaka S, Graf E, Ravens U, Boheler KR, Wobus AM: Differentiation induction of mouse embryonic stem cells into sinus node-like cells by Suramin. Int J Cardiol 2011 Feb 17;147(1):95-111.
  22. Ahmet I, Tae H-J, Juhasova M, Riordon DR, Boheler KR, Sollott SJ, Brines M, Cerami A, Lakatta EG, Talan M: A small non-erythropoietic helix B surface peptide based upon erythropoietin structure is cardioprotective against ischemic myocardial damage. Mol Med. 2011 Mar-Apr;17(3-4):194-200.
  23. Gundry RL, Burridge P, Boheler KR:  Pluripotent Stem Cell Heterogeneity and the Evolving Role of Proteomic Technologies in Stem Cell Biology. Proteomics – Clinical Applications (in press), 2011.
  24. Sheydina A, Riordon DR, Boheler KR: Molecular Mechanisms of Cardiomyocyte Aging. Clinical Science 2011; 121(8):315-29
  25. Boheler KR, Joodi RN, Qiao H, Juhasz O, Urick AL, Chuppa SL, Gundry RL, Wersto RP, Zhou R: Embryonic Stem Cell-derived Cardiomyocyte Heterogeneity and the Isolation of Immature and Committed Cells for Cardiac Remodeling and Regeneration. Stem Cells International, (in press), 2011.
  26. Fu JD, Rushing S, Lieu DK, Chan CW, Wilson K, Chiamvimonvat N, Boheler KR, Wu JC, Keller G, Li RA: Distinct Roles of MicroRNA-1 and -499 in Ventricular Specification and Maturation of Human Embryonic Stem Cells. PLoS ONE (accepted with revision) 2011.