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Biography
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Prof. Tiziano Tuccinardi

Department of Pharmacy

University of Pisa, Italy

Associate Professor


Email: tiziano.tuccinardi@farm.unipi.it


Qualifications

2015 Associate Professor, Department of Pharmacy, University of Pisa

2014 Adjunct Assistant Professor, Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, Temple University, USA

2009 Assistant Professor, Department of Pharmacy, University of Pisa, Italy

2006 Ph.D., Computational Chemistry, University of Pisa, Italy

2002 MD, Medicinal Chemistry, University of Pisa, Italy


Publications (selected)

  1. Poli G, Giuntini N, Martinelli A, Tuccinardi T. “Application of a FLAP-Consensus Docking Mixed Strategy for the Identification of New FAAH Inhibitors” J Chem Inf Model. 2015 55(3):667-675.
  2. Granchi C, Capecchi A, Del Frate G, Martinelli A, Macchia M, Minutolo F, Tuccinardi T. “Development and Validation of a Docking-Based Virtual Screening Platform for the Identification of New Lactate Dehydrogenase Inhibitors” Molecules. 2015, 20(5):8772-8790.
  3. Tuccinardi T, Poli G, Romboli V, Giordano A, Martinelli A. “Extensive consensus docking evaluation for ligand pose prediction and virtual screening studies” J Chem Inf Model. 2014, 54(10):2980-2986.
  4. Tuccinardi T, Granchi C, Rizzolio F, Caligiuri I, Battistello V, Toffoli G, Minutolo F, Macchia M, Martinelli A. “Identification and characterization of a new reversible MAGL inhibitor” Bioorg Med Chem. 2014, 22(13):3285-3291.
  5. Wong CH, Nguyen L, Peh J, Luu LM, Sanchez JS, Richardson SL, Tuccinardi T, Tsoi H, Chan WY, Chan HY, Baranger AM, Hergenrother PJ, Zimmerman SC. “Targeting Toxic RNAs that Cause Myotonic Dystrophy Type 1 (DM1) with a Bisamidinium Inhibitor.” J Am Chem Soc. 2014, 136(17):6355-6361.
  6. Fusi C, Materazzi S, Benemei S, Coppi E, Trevisan G, Marone I, Minocci D, De Logu F, Tuccinardi T, Di Tommaso M, Susini T, Moneti G, Pieraccini G, Geppetti P, Nassini R. “Steroidal and non-steroidal third-generation aromatase inhibitors induce pain-like symptoms via TRPA1Nature Communications 2014, 5:5736.
  7. Tuccinardi T, Granchi C, Iegre J, Paterni I, Bertini S, Macchia M, Martinelli A, Qian Y, Chen X, Minutolo F. “Oxime-based inhibitors of glucose transporter 1 displaying antiproliferative effects in cancer cells.” Bioorg Med Chem. Lett. 2013, 23(24):6923-6927.
  8. Poli G, Tuccinardi T, Rizzolio F, Caligiuri I, Botta L, Granchi C, Ortore G, Minutolo F, Schenone S, Martinelli A. “Identification of new FYN kinase inhibitors using a FLAP-based approach.” J Chem Inf Model. 2013, 53(10):2538-2547.
  9. Tuccinardi T, Bertini S, Granchi C, Ortore G, Macchia M, Minutolo F, Martinelli A, Supuran CT. “Salicylaldoxime derivatives as new leads for the development of Carbonic Anhydrase inhibitors” Bioorg Med Chem. 2013, 21(6):1511-1515.
  10. Marques SM, Tuccinardi T, Nuti E, Santamaria S, André V, Rossello A, Martinelli A, Santos MA. “Novel 1-hydroxypiperazine-2,6-diones as new leads in the inhibition of metalloproteinases.” J Med Chem. 2011, 54(24):8289–8298.
  11. Tuccinardi T, Zizzari AT, Brullo C, Daniele S, Musumeci F, Schenone S, Trincavelli ML, Martini C, Martinelli A, Giorgi G, Botta M. “Substituted pyrazolo[3,4-b]pyridines as human A(1) adenosine antagonists: Developments in understanding the receptor stereoselectivity.” Org Biomol Chem. 2011, 9(12):4448-4455.
  12. Granchi C, Roy S, Giacomelli C, Macchia M, Tuccinardi T, Martinelli A, Lanza M, Betti L, Giannaccini G, Lucacchini A, Funel N, León LG, Giovannetti E, Peters GJ, Palchaudhuri R, Calvaresi EC, Hergenrother PJ, Minutolo F. “Discovery of N-Hydroxyindole-Based Inhibitors of Human Lactate Dehydrogenase Isoform A (LDH-A) as Starvation Agents against Cancer Cells.” J Med Chem. 2011, 54(6):1599-1612.
  13. Tuccinardi T, Botta M, Giordano A, Martinelli A. “Protein Kinases: Docking and Homology Modeling Reliability.” J Chem Inf Model. 2010, 50(8):1432-1441.
  14. Tuccinardi T, Taliani S, Bellandi M, Da Settimo F, Da Pozzo E, Martini C, Martinelli A. A virtual screening study of the 18-kDa translocator protein using pharmacophore models combined with 3D-QSAR studiesChemMedChem 2009, 4(10):1686-1694.
  15. Tuccinardi T. “Docking-Based Virtual Screening: Recent Developments” Comb. Chem. High Throughput Screen. 2009, 12(3):303-314.


Profile Details:

http://www.mmvsl.it/wp/group-members/tuccinardi/