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Biography
Yovani Marrero Ponce

Prof. Yovani Marrero Ponce

Faculty of Chemistry-Pharmacy

Central University of Las Villas, Cuba


Email: ymarrero77@yahoo.es


Qualifications

2005 Ph.D., Chemical Sciences, Havana University, Cuba

2002 M.Sc., Biochemistry, Medical University, Cuba

2001 B.Sc., Pharmaceutical Sciences, Central University of Las Villas, Cuba


Publications (selected)

  1. Marrero-Ponce, Y. Total and Local Quadratic Indices of the Molecular Pseudograph’s Atom Adjacency Matrix: Applications to the Prediction of Physical Properties of Organic Compounds.Molecules.2003,8, 687-726.
  2. Marrero-Ponce, Y.; Cabrera, M., A.; Romero, V.; Ofori, E.; Montero, L. A. Total and Local Quadratic Indices of the “Molecular Pseudograph’s Atom Adjacency Matrix”. Application toPrediction of Caco-2 Permeability of Drugs.Int. J. Mol. Sci.2003, 4,512-536.
  3. González-Díaz, H; Marrero-Ponce, Y.; Hernández, I; Bastida, I; Tenorio, E; Nasco, O; Uriarte, U; Castañedo, N.; Cabrera, M.A.; Aguila, E.; Marrero, O.; Morales, A.; Pérez, M. 3DMEDNEs: An Alternative “In Silico” Technique for Chemical Research in Toxicology. 1. Prediction of Chemically Induced Agranulocytosis.Chem. Res. Toxicol.2003,16,1318-1327.
  4. Marrero-Ponce, Y.; Cabrera, M. A.; Romero, V.; González, D. H.; Torrens, F. A New Topological Descriptors Based Model for Predicting Intestinal Epithelial Transport of Drugs in Caco-2 Cell Culture.J. Pharm. Pharm. Sci.2004,7, 186-199.
  5. Marrero-Ponce, Y.; González-Díaz, H.; Romero-Zaldivar, V.; Torrens, F.; Castro, E. A. 3DChiral Quadratic Indices of the “Molecular Pseudograph’s Atom Adjacency Matrix” and their Application to Central Chirality Codification: Classification of ACE Inhibitors and Prediction of σ-Receptor Antagonist Activities.Bioorg. Med. Chem.2004,12,5331-5342.
  6. Marrero-Ponce, Y. Total and Local (Atom and Atom-Type) Molecular Quadratic Indices: Significance-Interpretation, Comparison to Other Molecular Descriptors and QSPR/QSAR Applications.Bioorg. Med. Chem. 2004,12,6351-6369.
  7. Marrero-Ponce, Y.; Nodarse, D.; González-Díaz, H.; Ramos de Armas, R.; Romero-Zaldivar, V.; Torrens, F.; Castro, E. Nucleic Acid Quadratic Indices of the “Macromolecular Graph’s Nucleotides Adjacency Matrix”. Modeling of Footprints after the Interaction of Paromomycin with the HIV-1 Ψ-RNA Packaging Region.Int. J. Mol. Sci.2004,5, 276-293 (see alsoCPS: physchem/0401004.)
  8. Marrero-Ponce, Y. Linear Indices of the “Molecular Pseudograph’s Atom Adjacency Matrix”: Definition, Significance-Interpretation and Application to QSAR Analysis of Flavone Derivatives as HIV-1 Integrase Inhibitors.J. Chem. Inf. Comput. Sci. 2004,44, 2010-2026.
  9. Marrero-Ponce, Y.; Castillo-Garit, J. A.; Torrens, F.; Romero-Zaldivar, V.; Castro, E. Atom, Atom-Type and Total Linear Indices of the “Molecular Pseudograph’s Atom Adjacency Matrix”: Application to QSPR/QSAR Studies of Organic Compounds.Molecules.2004,9,1100-1123.
  10. Marrero-Ponce, Y.; Medina, R.; Castro, E. A.; de Armas, R.; González, H.; Romero, V.; Torrens, F. Protein Quadratic Indices of the “Macromolecular Pseudograph’s α-Carbon Atom Adjacency Matrix”. 1. Prediction of Arc Repressor Alanine-mutant’s Stability.Molecules.2004,9, 1124–1147.
  11. Marrero-Ponce, Y.; Castillo-Garit, J.A.;Olazabal, E.; Serrano, H. S.; Morales, A.; Castañedo, N.;Ibarra-Velarde, F.;Huesca-Guillen, A.; Jorge, E.;del Valle, A.; Torrens, F.; Castro, E. A.TOMOCOMD-CARDD, aNovel Approach for Computer-Aided “Rational” DrugDesign: I. Theoretical and Experimental Assessment of a Promising Method for ComputationalScreening andin silicoDesign ofNew Anthelmintic Compounds.J. Comput. Aided Mol. Des.2004,18, 615-634.
  12. Marrero-Ponce, Y.; Montero-Torres, A.; Romero-Zaldivar, C.; Iyarreta-Veitía, I.; Mayón Peréz, M.; García Sánchez, R. Non-Stochastic and Stochastic Linear Indices of the Molecular Pseudograph’s Atom Adjacency Matrix”: Application to in silico”Studies for the Rational Discovery of New Antimalarial Compounds. Bioorg. Med. Chem.2005,13, 1293-1304.
  13. Marrero-Ponce, Y.; Castillo-Garit, J.A.;Olazabal, E.; Serrano, H. S.; Morales, A.; Castañedo, N.;Ibarra-Velarde, F.;Huesca-Guillen, A.; Jorge, E.; Sánchez, A. M.;Torrens, F.; Castro, E. A. Atom, Atom-Type and Total Molecular Linear Indices as aPromising Approach forBioorganic & Medicinal Chemistry: Theoretical and Experimental Assessment of a Novel Methodfor Virtual Screening and Rational Design ofNew Lead Anthelmintic.Bioorg. Med. Chem. 2005,13, 1005-1020.
  14. Marrero-Ponce, Y.;Huesca-Guillen, A.;Ibarra-Velarde, F. Quadratic Indices of the “Molecular Pseudograph’s Atom Adjacency Matrix” and Their Stochastic Forms: A Novel Approach for Virtual Screening andin silicoDiscovery of New Lead Paramphistomicide Drugslike Compounds.J. Theor. Chem.(THEOCHEM). 2005,717, 67-79.
  15. Alvares-Ginarte, Y., M.; Crespo, R.; Montero-Cabrera, L., A.; Ruiz-Garcia, J., A.; Marrero-Ponce, Y.; Santana, R.; Pardillo-Fontdevilla, E.; Alonso-Becerra, E. A Novel in-silico Approachfor QSAR Studies of Anabolic and Androgenic Activities in the 17β-hydroxy-5α-androstaneSteroid Family.QSAR Comb. Sci. 2005,24, 218-226.
  16. Marrero-Ponce, Y.; Cabrera, M. A.; Romero-Zaldivar, V.; Bermejo, M.; Siverio, D.; Torrens, F. Prediction of Intestinal Epithelial Transport of Drug in (Caco-2) Cell Culture from Molecular Structure using‘in silico’ Approaches During Early Drug Discovery.Internet Electronic J. Mol.Des.2005,4, 124-150.
  17. Marrero-Ponce, Y.; Medina-Marrero, R.; Castillo-Garit, J.A.; Romero-Zaldivar, V.; Torrens, F.; Castro, E. A. Protein Linear Indices of the “Macromolecular Pseudograph’s α-Carbon Atom Adjacency Matrix” in Bioinformatics. Part 1. Prediction of Protein Stability Effects of a Complete Set of Alanine Substitutions in Arc Repressor.Bioorg. Med. Chem.2005,13, 3003-3015.
  18. Marrero-Ponce, Y.; Medina-Marrero, R.; Torrens, F.; Martinez, Y.; Romero-Zaldivar, V.; Castro, E. A. Atom, Atom-type, and Total Non-Stochastic and Stochastic Quadratic Fingerprints: A promising approach for modeling of antibacterial activity.Bioorg. Med. Chem. 2005,13, 2881-2899.
  19. Marrero-Ponce, Y.; Castillo-Garit, J.A.; Nodarse, D. Linear Indices of the “Macromolecular Graph’s Nucleotides Adjacency Matrix” as aPromising Approachfor Bioinformatics Studies. 1. Prediction of Paromomycin’s Affinity Constant with HIV-1 Ψ-RNA Packaging Region.Bioorg.Med. Chem.2005,13, 3397-3404.
  20. Marrero-Ponce, Y.; Castillo-Garit, J. A. 3D-Chiral Atom, Atom-type, and Total Non-Stochastic and Stochastic Molecular Linear Indices and their Application to Central Chirality Codification.J. Comput. Aided.-Mol. Des.2005,19, 369–383.


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