Prof. Weizhen Zhang

Department of Physiology

Peking University, China






1991-1994 Doctor in Medicine, Peking University Health Science Center, Beijing, China

1987-1990 Master in Medicine, Capital Institute of Medicine, Beijing, China

1981-1987 Bachelor in Medicine, Sun Yat-sen University of Medical Sciences, Guangzhou, China


Publications (Selected)

  1. Zhang W*, Majumer A, Wu X, Mulholland MW. Regulation of food intake and body weight by recombinant proghrelin. Am J Physiol-Endocrinol Metab 2009;297:E1269-1275.
  2. Shi Y, Zhou YB, Cai Y, Teng X, Song JQ, Duan XH, Zhang WZ, Qi YF. Effect of age on vascular calcification induced by vitamin D3 and nicotine. Journal of Peking University (Health Sciences) 2010;42:131-6.
  3. Chai B, Li JY, Zhang W, Wu X, Zhang C, Mulholland MW. Melanocortin-4 receptor activation promotes insulin-stimulated mTOR signaling. Peptides 2010; 31(10):1888-93.
  4. Li J-Y, Chai B-X, Zhang W, Wang H, MW Mulholland. Expression of ankyrin repeat and SOCS box containing protein 4 (Asb-4) in the arcuate nucleus of mice produces a hyperphagic, lean phenotype. Endocrinology 2010; 151(1):134-42.
  5. Wang H, Wu X, Li J, Chai B, Wang J, Mulholland MW, Zhang W. Functional protease-activated receptors in the dorsal motor nucleus of the vagus. Neurogastroenterol Motil 2010;22:431-8,e105 (Editorial Viewpoint 2010;22:361-5).
  6. Deng FL, Zhang W, Zhang PF, Liu CH, Ling JQ. Improvement in the morphology of micro-arc oxidized titanium surfaces: A new process to increase osteoblast response. Mat Sci Eng C-Mater 2010; 30: 141-147.
  7. Xu G, An W, Li Y, Zhao J, Xiang X, Ding L, Li Z, Guan Y, Wang X, Tang C, Mulholland MW, Zhang W. Regulation of gastric hormone production by rapamycin. Peptides 2010;31: 2185-92. PMID: 20804797.
  8. An W, Li Y, Xu G, Zhao J, Xiang X, Ding L, Li J, Guan Y, Wang X, Tang C, Mulholland MW, Zhang W. Modulation of ghrelin O acyltransferase expression in pancreatic islets. Cell Physiol Biochem 2010;26:707-716.
  9. Xiang XX, Zhao J, Li Y, Zhang W. Directional differentiation of adipose-derived stem cell. Prog Physiol Sci 2010;41(5):341-6.
  10. Wu X, Zhang W*, Peng J, Wang H, Li J-Y, Chai B-X, Mulholland MW. Induction of apoptosis by thrombin in the dorsal motor nucleus of the vagus. Neurogastroenterol Motil 2011;23:279-285, e123-4.
  11. Xiang X, Zhao J, Xu G, Li Y, Zhang W. mTOR and the differentiation of mesenchymal stem cells. Acta Biochim Biophys Sin 2011;43:501-10.
  12. Li J-Y, Chai B, Zhang W, Wu X, Zhang C, Fritze D, Xia Z, Patterson C and Mulholland MW. Ankyrin repeat and SOCS box containing protein 4 (Asb-4) colocalizes with insulin receptor substrate 4 (IRS4) in the hypothalamic neurons and mediates IRS4 degradation. BMC Neuroscience 2011; 12:95.
  13. Wang Y, Zhao B, Zhang Y, Tang Z, Shen Q, Zhang Y, Zhang W, Du J, Chien S, Wang N. Krüppel-like factor 4 is induced by rapamycin and mediates the anti-proliferative effect of rapamycin in balloon-injured rat carotid arteries. Br J Pharmacol 2011;165 (7):2378-2388.
  14. Xu G, Li Y, Zhang W. Gastric mammalian target of rapamycin signaling, hormone production and energy metabolism. World J Gastrointest Pathophysiol 2011;2:1-5. (editorial)
  15. Xu G, Wang Z, Li 1, Li Z, Tang H, Zhao J, Xiang X, Ding L, Ma L, Yuan F, Fei J, Wang W, Wang N, Guan Y, Tang C, Mulholland M, Zhang W. Ghrelin contributes to glucose intolerance induced by rapamycin in mice. Diabetologia 2012;55:1813–1823.
  16. Li Z, Xu G, Li Y, Zhao J, Mulholland MW, Zhang W. mTOR-dependent modulation of gastric nesfatin-1. Cell Physiol Biochem 2012;29(3-4):493-500.
  17. Xia Z, Fritze DM, Li J, Chai B, Zhang C, Zhang W*, Mulholland MW*. Nesfatin-1 inhibits gastric acid secretion via a central vagal mechanism in rats. Am J Physiol 2012; 303:G570-7. PMID:22723266
  18. Chai B, Li J, Fritze D, Zhang W, Xia Z, Mulholland MW. A novel transcript is up-regulated by fasting in the hypothalamus and enhances insulin signaling. J Neuroendocrinol 2012;25(3):292-301.
  19. Amini P, Wadden D, Cahill F, Randell E, Vasdev S, Chen X, Gulliver W, Zhang W, Zhang H, Yi Y, Sun G. Serum Acylated Ghrelin is Negatively Correlated with the Insulin Resistance in the CODING study. PLoS one 2012;7:e45657. doi:10.1371
  20. Wadden D, Cahill F, Amini P, Randell E, Vasdev S, Yanqing Y, Zhang W, Sun G. Serum ghrelin concentrations in response to short-term overfeeding in normal weight, overweight, and obese men. PLoS one 2012;7:e45748
  21. Tang H, Ma LX, Zhang W. Gastric hormones and glucose metabolism in skeletal muscle. Prog Physiol Sci 2013;44(1):63-66.(review)
  22. Tang H, Zhang W.The diversity of ghrelin gene in its products and functions. Prog Physiol Sci 2013;44(3):169-176.( invited review)
  23. Xiang X, Yuan F, Zhao J, Li Z, Wang X, Guan Y, Tang C, Li Y, Zhang W. Deficiency in pulmonary surfactant proteins in mice with FABP4-cre mediated knockout of TSC1 gene. Exp Physiol 2013;98:830-41.PMID:23143994
  24. Li Z, Li Y, Zhang W. Ghrelin receptor in energy homeostasis and obesity pathogenesis. Prog Mol Biol Transl. 2013; 114: 45-87 (invited review)
  25. Liang WY, Li ZR, Li Y, Zhang W. Ghrelin and inflammation. Prog Physiol Sci 2013; 44(2):129-32. (review)
  26. Zhang XZ, Li ZR, Li Y, Zhang W. mTOR signaling as a fuel sensor and its role in the regulation of energy homeostasis. Prog Physiol Sci 2013;44(5):390-4. (review)
  27. Li Z, Mulholland M, Zhang W. Regulation of gastric nesfatin-1/NUCB2. Curr Pharm Design 2013;19(39):6981-5. PMID:23537086 (invited review)
  28. Tong Q, Duan L, Xu Z, Wang H, Wang X, Li Z, Zhang W, Zheng H. Improved insulin secretion following intrapancreatic UCB transplantation in patients with T2DM. J Clin Endocrinol Metab 2013; 98(9):E1501-4. PMID:23861460
  29. Li Z, Gao L, Tang H, Yin Y, Xiang X, Li Y, Zhao J, Mulholland M, Zhang W. Peripheral effects of nesfatin-1 on glucose homeostasis. PLoS one 2013;8(8): e71513. doi:10.1371/journal.pone.0071513
  30. Zhang W*, Zhang C, Fritze D, Chai B, Li J, Mulholland M. Modulation of food intake by mTOR signaling in the dorsal motor nucleus of vagus in male rats: Focus on ghrelin and nesfatin-1. Exp Physiol 2013;98(12):1696-704. PMID:23955309
  31. Xiang X, An W, Jiang C, Zhao J, Wang X, Sun G, Li Y, Zhang W. Lipopolysaccharide inhibits the expression of resistin in adipocytes. J Mol Endocrinol 2013;51(3):287-99. PMID:23969982
  32. Li JY, Chai B, Zhang W, Fritze DM, Zhang C, Mulholland MW. LGR4 and its ligands, R-spondin 1 and 3, regulate food intake in the hypothalamus of male rats. Endocrinology. 2014;155(2):429-40. PMID:24280058
  33. Yin Y, Li Y, Zhang W. The Growth Hormone Secretagogue Receptor: Its Intracellular Signaling and Regulation. Int J Mol Sci 2014; 15: 4837-4855.
  34. Qin Y, Li Z, Wang Z, Li Y, Zhao J, Mulholland M, Zhang W. Ghrelin contributes to protection of hepatocellular injury induced by ischemia-reperfusion. Liver Int 2014; 34(4):567-75. doi: 10.1111/liv.12286
  35. Fritze D, Zhang W, Li J-Y, Chai B, Mulholland M. Thrombin mediates vagal apoptosis and dysfunction in inflammatory bowel disease. J Gastrointest Surg. 2014;18(8):1495-506.
  36. Fritze D, Zhang W, Li J-Y, Chai B, Mulholland M. TNF causes thrombin-dependent vagal neuron apoptosis in inflammatory bowel disease. J Gastrointest Surg. 2014;18(9): 1632-41. PMID:24961441
  37. Li Z, Xu G, Qin Y, Zhang C, Tang H, Yin Y, Xiang X, Li Y, Zhao J, Mulholland M, Zhang W. Ghrelin promotes hepatic lipogenesis by activation of mTOR-PPAR signaling pathway. Proc Natl Acad Sci USA 2014; 111(36):13163-8. doi/10.1073/pnas.1411571111
  38. Ding L, Han L, Li Y, Zhao J, He P, Zhang W. Neurogenin 3 directed cre deletion of Tsc1 gene causes pancreatic acinar carcinoma. Neoplasia 2014;16(11):909-17.
  39. Xiang X, Lan H, Tang H, Yuan F, Xu Y, Zhao J, Li Y, Zhang W. TSC1-mTOR signaling determines brown-to-white adipocyte phenotypic switch. Diabetes 2015;64(2):519-28. PMID:25213336
  40. Xu Y, Li Z, Yin Y, Lan H, Wang J, Zhao J, Feng J, Li Y, Zhang W. Ghrelin inhibits the differentiation of T helper 17 cells through mTOR/STAT3 signaling pathway. PLoS One 2015;10(2):e0117081. doi:10.1371/journal.pone.0117081. PMID:25658305
  41. Zhang W, Chang L, Zhang C, Zhang R, Li Z, Chai B, Li J, Chen E, Mulholland M. Central and peripheral irisin differentially regulate blood pressure. Cardiovasc Drugs Ther 2015;29(2):121-7. PMID: 25820670
  42. Zhang W, Zhang C, Chang L, Zhang R, Li Z, Chai B, Li J, Chen E, Mulholland MW. Irisin: a myokine with locomotor activity. Neurosci Lett 2015;595:7-11. PMID:25841790
  43. Xu G, Li Z, Tang H, Guo S, Wang H, Zhang W. Intestinal mTOR regulates GLP-1 production in L cells. Diabetologia 2015;58(8):1887-97. PMID:26037201
  44. Yin Y, Zhang W. The role of ghrelin in senescence. Gerontology 2015. PMID:26160147