Dr. Sydney Chi-Wai Tang
Dr. Sydney Chi-Wai Tang

University of Hong Kong, China



2005 Ph.D., the University of Hong Kong
2001 M.D., the University of Hong Kong

1991 M.B., B.S., the University of Hong Kong

Publications (Selected)
  1. Tang S, Zhou W, Sheerin NS, Vaughan RW, Sacks SH: Contribution of renal secreted complement C3 to the circulating pool in humans.J Immunol162: 4336-4341, 1999.
  2. Tang S, Sheerin NS, Zhou W, Brown Z, Sacks SH: Apical proteins stimulate complement synthesis by cultured human proximal tubular epithelial cells. J Am Soc Nephrol10: 69-76, 1999.
  3. Tang S, Leung JCK, Lam CWK, Lai FM, Chan TM, Lai KN: In vitro studies of aquaporins 1 and 3 expression in cultured human proximal tubular cells: upregulation by transferrin but not albumin. Am J Kidney Dis38: 317-330, 2001.
  4. Tang S, Lai KN, Chan TM, Lan HY, Ho SK, Sacks SH: Transferrin but not albumin mediates stimulation of complement C3 biosynthesis in human proximal tubular epithelial cells. Am J Kidney Dis37: 94-103, 2001.
  5. Tang S, Leung JC, Tsang AW, Lan HY, Chan TM, Lai KN: Transferrin up-regulates chemokine synthesis by human proximal tubular epithelial cells: Implication on mechanism of tubuloglomerular communication in glomerulopathic proteinuria. Kidney Int61: 1655-1665, 2002.
  6. Tang S, Ho SK, Moniri K, Lai KN, Chan TM: Efficacy of famciclovir in the treatment of lamivudine resistance related to an atypical hepatitis B virus mutant.Transplantation 73: 148-151, 2002 Tang S, Leung JC, Abe K, Chan KW, Chan LY, Chan TM, Lai KN: Albumin stimulates interleukin-8 expression in proximal tubular epithelial cells in vitro and in vivo. J Clin Invest111: 515-527, 2003.
  7. Tang S, Cheng IK, Leung VK, Kuok UI, Tang AW, Ho YW, Lai KN, Chan TM: Successful treatment of hepatitis C after kidney transplantation with combined interferon alpha-2b and ribavirin. J Hepatol39: 875-878, 2003.
  8. Tang S, Leung JC, Chan LY, Lui YH, Tang CS, Kan CH, Ho YW, Lai KN: Mycophenolate mofetil alleviates persistent proteinuria in IgA nephropathy. Kidney Int68: 802-812, 2005.
  9. Tang S, Lai FM, Lui YH, Tang CS, Kung NN, Ho YW, Chan KW, Leung JC, Lai KN: Lamivudine in hepatitis B-associated membranous nephropathy. Kidney Int68: 1750-1758, 2005.
  10. TangSC, Leung JC, Chan LY, Tsang AW, Lai KN: Activation of tubular epithelial cells in diabetic nephropathy and the role of the PPAR-gagonist. J Am Soc Nephrol17: 1633-1643, 2006.
  11. TangSC, Lam B, Ku PP, Leung WS, Chu CM, Ho YW, Ip MS, Lai KN: Alleviation of sleep apnea in patients with chronic renal failure by nocturnal cycler-assisted peritoneal dialysis. J Am Soc Nephrol17: 2607-2616, 2006.
  12. Lai KN, Leung JCK, Chan LY, Guo H, Tang SC:Interaction between proximal tubular epithelial cells and infiltrating monocytes/T cellsin the proteinuric state. Kidney Int71: 526-538, 2007.
  13. TangSC, Leung JC, Chan LY, Eddy AA, Lai KN: Angiotensin converting enzyme inhibitor but not angiotensin receptor blockade or statin ameliorates murine adriamycin nephropathy. Kidney Int73: 288-299, 2008.
  14. TangSC, Lai KN: The ubiquitin-proteasome pathway and IgA nephropathy: a novel link?Kidney Int75, 457-459, 2009.
  15. TangSC, Lam B, Lai AS, Pang CB, Tso WK, Khong PL, Ip MS, Lai KN: Improvement in sleep apnea during nocturnal peritoneal dialysis is associated with reduced airway congestion and better uremic clearance. Clin J Am Soc Nephrol4: 410-418, 2009.
  16. TangSC, Leung VT, Chan LY, Wong SH, Chu DW, Leung JC, Lai KN, Ma L, Elbein SC, Bowden DW, Hicks PJ, Comeau ME, Langefeld, Freedman BI: The acetyl-coenzyme A carboxylase beta gene (ACACB) is associated with nephropathy in Chinese patients with type 2 diabetes. Nephrol Dial Transplant: 25: 3931-3934, 2010.
  17. TangSC, Leung JC, Chan LY, Lan HY, Lai KN: Renoprotection by rosiglitazone in accelerated type 2 diabetic nephropathy: role of STAT1 inhibition and nephrin restoration. Am J Nephrol32: 145-155, 2010.
  18. TangSC, Lam B, Leung WS, Chu CM, Ho YW, Ip MS, Lai KN: Sleep apnea as a novel risk predictor for cardiovascular morbidity and death in peritoneal dialysis patients. Kidney Int77: 1031-1038, 2010.
  19. TangSC, Tang AW, Wong SH, Ho YW, and Lai KN: Long-term study of mycophenolate mofetil in IgA nephropathy. Kidney Int77: 543-549, 2010.
  20. TangSC, Chan LY, Leung JC, Cheng AS, Lan HY, Lai KN: Synergistic renoprotective effects of B2-kinin receptor blocker and PPAR-gagonist in uninephrectomized db/db mice. Lab Invest.