Alexander Dietrich

Prof. Alexander Dietrich

Ludwig Maximilians University, Germany



1988-1991  Ph.D., German Cancer Research Center, Germany

Publications (Selected)

  1. Fuchs, B., Rupp, M., Ghofrani, H.A., Schermuly, R.T., Seeger, W., Grimminger, F., Gudermann, T., Dietrich, A., Weissmann, N. (2011).  Diacylglycerol regulates acute hypoxic pulmonary vasoconstriction via TRPC6. Resp. Res. In press. IF.: 3,13; 5-J-IF.: 3,339.
  2. Beis, D., Schwarting, R.K., Dietrich, A. (2011).  Evidence for a supportive role of classical transient receptor potential 6 (TRPC6) in the exploration behaviour of mice. Physiol. Behav., 102: 245-250. IF.: 3,295; 5-J-IF.: 3,339.
  3. Schmidt, K., Dubrovska, G., Fesüs, G., Gudermann, T., Dietrich, A.*, Gollasch, M.*, de Wit, C.*, Köhler, R.* (2010). Amplification of EDHF-type vasodilatations in TRPC1-deficient mice. British J. Pharmacol., 161: 1722-1733. IF.: 5,204; 5-J-IF.: 4,60.
  4. Klaiber, M., Kruse, M., Völker, K., Schröter, J., Feil, R., Freichel, M., Gerling, A., Feil, S., Dietrich, A., Lon-dono, J.E.C., Baba, H.A., Abramowitz; J., Birnbaumer, L., Penniger, J.M., Pongs, O., Kuhn, M. (2010). Novel insight into the mechanisms mediating the local antihypertrophic effects of cardiac atrial natriuretic peptide: role of cGMP-dependent protein kinase and RGS2. Basic Res Cardio., 105: 583-595. IF.: 5,973; 5-J-IF.: 4,667.
  5. Zanou, N., Shapovalov, G., Louis, M., Tajeddine,N., Gallo, C., Van Schoor, M., Anguish, I., Cao, M.L., Schak-man, O., Dietrich, A., Lebacq, J., Ruegg, U., Roulet, E., Birnbaumer, L., Gailly, P. (2010). Role of TRPC1 channels in skeletal muscle function. Am. J. of Physiol., Cell Physiology, 298: C149-C162. IF.: 4,013; 5-J-IF.: 4,128.
  6. Tsvilovskyy, V.V., Zholos, A.V., Aberle, T., Dietrich, A., Zhu, M.X., Birnbaumer, L., Freichel, M., Flockerzi, V. (2009). Deletion of TRPC4 and TRPC6 in mice impairs smooth muscle contraction and intestinal motility in vi-vo. Gastroenterology, 137: 1415-1424. IF.: 12,899; 5-J-IF.: 12,432.
  7. Keserü, B., Barbosa-Sicard, E., Popp, R., Fisslthaler, B., Dietrich, A., Gudermann, T., Hammock, B.D., Falck, J.R., Weissmann, N., Busse, R., Fleming, I. (2008). Epoxyeicosatrienoic acids and the soluble epoxide hadro-lase are determinants of pulmonary artery pressure and the acute hypoxic pulmonary vasoconstrictor response, FASEB J. 22, 4306-4315. IF.: 6,401; 5-J-IF.: 7,096.
  8. Hartmann, J., Dragicevic, E., Adelsberger, H., Henning, H., Sumser, M., Abramowitz, J., Blum, R., Dietrich, A., Freichel, M., Flockerzi, V., Birnbaumer, L., Konnerth, A. (2008). TRPC3 channels are required for synaptic transmission and motor coordination. Neuron 59, 392-398. IF.: 13,260; 5-J-IF.: 14,674.
  9. Sel, S., Rost, B., Yildirim, A.Ö., Sel, B., Kalwa, H., Fehrenbach, H., Renz, H., Gudermann, T., Dietrich, A. (2008). Loss of classical transient receptor potential 6 reduces airway response. Clin. and Exp. Allergy 38, 1548-1558. IF.: 4,084; 5-J-IF.: 4,002.
  10. Varga-Szabo, D., Authi, K.S., Braun, A., Bender, M., Ambily, A., Hassock, S.R., Gudermann, T., Dietrich, A., Nieswandt, B. (2008). Store-operated Ca2+ entry in platelets occurs independently of transient receptor poten-tial (TRP) C1. Pflügers Arch. 457, 377-387. IF.: 3,695; 5-J-IF.: 4,084.
  11. Liu, X., Cheng, K.T., Bandyopadhyay, B.C., Pani, B., Dietrich, A., Paria, B.C., Swaim, W.D., Beech, D., Yildi-rim, E., Singh, B.B., Birnbaumer, L., Ambudkar, I.S. (2007). Attenuation of store-operated Ca2+ current impairs salivary gland fluid secretion in TRPC1-/- mice. Proc. Natl. Acad. Sci. U.S.A. 104, 17542-17547. IF.: 9,432; 5-J-IF.: 10,312.
  12. Dietrich, A., Kalwa, H., Storch, S., Mederos y Schnitzler, M., Salanova, S., Pinkenburg, O., Dubrovska, G., Essin, K., Gollasch, M., Birnbaumer, L., Gudermann, T.  (2007). Pressure-induced and store-operated cation influx in vascular smooth muscle cells is independent of TRPC1. Pflügers Arch. 455, 465-477. IF.: 3,695; 5-J-IF.: 4,084.
  13. Sausbier; M., Zhou, X-B., Beier, C., Sausbier,  U., Wolpers, D., Maget, S.,  Martin, C., Dietrich, A., Ressmeyer, A.-R., Schlossmann, J., Hofmann, F., Neuhuber, W., Gudermann, T., Uhlig, S., Korth, M., Ruth, P. (2007). Reduced rather than enhanced cholinergic airway constriction in mice with ablation of the large conductance Ca2+ -activated K+ channel. FASEB J. 21, 812-822. IF.: 6,401; 5-J-IF.: 7,096.
  14. Hinkes, B., Wiggins, R.C.,Gbadegesin, R., Vlangos, C.N., Seelow, D., Nürnberg, G., Garg, P., Verma, R., Chaib, H., Hoskins, B. E., Ashraf, S., Becker, C., Hennies, H.C.,  Goyal, M., Wharram, B., Schachter, A.D., Drummond,I., Kerjaschki, D., Waldherr, R., Dietrich, A., Ozaltin, F., Bakkaloglu, A., Cleper,R.,  Basel-Vanagaite, L., Pohl, M., Griebel, M., Tsygin, A.N., Soylu, A., Muller, D.,  Katan, M., Liu, J., Attanasio, M., O’Toole, J.F., Hasselbacher, K., Mucha, B., Otto, E.A., Airik, R., Kispert, A., Kelley, G.G., Smrcka, A.V., Gu-dermann, T., Holzman, L.B., Nürnberg, P. and Hildebrandt, F., (2006). Positional cloning of PLCE1 mutations as the first cause of a nephrotic syndrome variant which may be reversible.  Nature Genetics 38, 1397-1405. IF.: 34,284; 5-J-IF.: 29,768
  15. Butscheid, Y., Chubanov, V., Steger, K., Meyer, D., Dietrich, A. and Gudermann, T. (2006) Polycystic kidney disease and receptor for egg jelly is a plasma membrane protein of mouse sperm head. Mol. Rep. Dev. 73, 350-360. IF.: 2,041; 5-J-IF.: 2,173.
  16. Dietrich, A., Mederos y Schnitzler, M., Gollasch, M., Gross, V., Storch, U., Dubrovska, G., Obst, M., Sala-nova, B., Kalwa, H., Essin, K., Pinkenburg O., Luft, F.C., Gudermann, T., and Birnbaumer, L. (2005) Increased vascular smooth muscle contractility in TRPC6-/- mice. Mol. Cell. Biol. 25, 6980-6989. IF.: 6,057; 5-J-IF.: 6,367.
  17. Schuhmann, B., Dietrich, A., Sel, S., Hahn, C., Klingenspor, M., Lommatzsch, M., Gudermann, T., Braun, A., Renz, H., and Nockher AW. (2005). A role for brain derived neurotrophic factor (BDNF) in B cell development. J. Neuroimmunol. 163, 15-23. IF.: 2,841; 5-J-IF.: 2,8313.
  18. Dietrich, A., Mederos y Schnitzler, M., Emmel, J., Kalwa, M., Hofmann, T., and Gudermann, T. (2003) N-linked protein glycosylation is a major determinant for basal TRPC3 and TRPC6 channel activity. J. Biol. Chem. 278, 47842-52. IF.: 5,328; 5-J-IF.: 5,440.2,
  19. Dietrich, A., Scheer, A., Illenberger, D., Kloog, Y., Henis, Y., and Gierschik P. (2003). Studies on G protein heterotrimerformation reveal a putative S-prenyl binding site in the a subunit. Biochemical J. 376, 449-456. IF.:  5,155; 5-J-IF.: 4,365
  20. Yildirim. E. Dietrich, A., and Birnbaumer L (2003). The mouse C–type transient receptor potential 2 (TRPC2) channel: Alternative splicing and calmodulin binding to its N terminus. Proc. Natl. Acad. Sci. U.S.A. 100, 2220-2225. IF.: 9,432; 5-J-IF.: 10,312.
  21. Zhang, Z., Tang, J., Tikunova, S., Johnson, J.D., Chen, Z., Qin, N., Dietrich, A., Stefani, E., Birnbaumer, L., and Zhu, M.X. (2001). Activation of TRP3 by inositol 1,4,5-trisphosphate receptors through displacement of inhibitory calmodulin from a common binding domain. Proc. Natl. Acad. Sci. U.S.A. 98, 3168-3173. IF.: 9,432; 5-J-IF.: 10,312.
  22. Boulay, G., Brown, D.M., Qin, N., Jiang, M., Dietrich, A., Zhu, M.X., Chen, Z., Birnbaumer, M., Mikoshiba, M., and Birnbaumer, L. (1999). Modulation of Ca2+ entry by polypeptides of the inositol 1,4,5-trisphosphate recep-tor (IP3R) that bind transient receptor potential (TRP): Evidence for roles of TRP and IP3R in store depletion-activated Ca2+ entry. Proc. Natl. Acad. Sci. U.S.A. 96, 14955-14960. IF.: 9,432; 5-J-IF.: 10,312.
  23. Illenberger, D., Schwald, F., Pimmer, D., Binder, W., Maier, G., Dietrich, A.,
  24. and Gierschik, P. (1998). Stimulation of 2 by the Rho GTPases Cdc42Hs and Rac1. EMBO J. 17, 6241-6249.bphospholipase C- IF.: 8,993; 5-J-IF.: 9,395.
  25. Dietrich, A., Brazil, D., Jensen, O.N., Meister, M., Schrader, M., Moomaw, J.F., Mann, M., Illenberger, D., and Gierschik, P. (1996). subunit is both necessary and sufficient forgIsoprenylation of the G protein   dimer-mediated stimulation of phospholipase C. Biochemistry 35, 15174-15182. gb IF.: 3,226; 5-J-IF.: 3,253.
  26. Meister, M., Dietrich, A., and Gierschik, P. (1995). Identification of gb1 as a determinant of selective ga three-amino-acid region in G protein heterodimerization. Eur. J. Biochem. 234, 171-177. Jetzt FEBS-Journal: IF.: 3,042, 5-J-IF.: 3,276
  27. Rogner, U.C., Kioschis, P., Wilke, T., Gong, W., Pick, E., Dietrich, A., Zechner, U., Hameister, H., Pragli-ola, A., Hermann, G.E., Yates, J.R.W., Lehrach, H., and Poustka, A. (1994). A YAC clone map spanning 7.5 megabase of human chromosome band Xq28. Hum. Mol. Genet. 3, 2137-2146. IF.: 7,386; 5-J-IF.: 7,733.
  28. Weil, D., Wang, I., Dietrich, A., Poustka, A., Weissenbach, J., and Petit, C. (1994). Highly homologous loci on the X and Y chromosomes are hot spots for ectopic recombinations leading to XX maleness. Na-ture Genetics 7, 414-419. IF.: 34,284; 5-J-IF.: 29,768.
  29. Dietrich, A., Meister, M., Brazil, D., Camps, M., and Gierschik, P., by recombinant 2b(1994). Stimulation of phospholipase C- dimers produced in a baculovirus/insectgbguanine-nucleotide-binding protein cell expression system. Eur. J. Biochem. 219, 171-178. Jetzt FEBS-Journal: IF.: 3,042, 5-J-IF.: 3,276
  30. Dietrich, A., Meister, M., Spicher, K., Schultz, G., and Gierschik, P. gb(1992). Expression, characterization and purification of soluble G protein dimers composed of defined subunits in baculovirus-infected insect cells. FEBS Lett. 313, 220-224. IF.: 3,541; 5-J-IF.: 3,319.
  31. Dietrich, A., Korn, B., and Poustka, A. (1992). Completion of the physical map  of  Xq28: the location of the gene for L1CAM on the human X Chromosome. Mammalian Genome 3,168-224. IF.: 2,942; 5-J-IF.: 2,605.
  32. Dietrich, A., Kioschis, P. Monaco, A.P., Gross, B., Korn, B., Williams, S.V.,   Sheer, D., Heitz, D., Oberle, I., Toniolo, D., Warren, S.T., Lehrach, H., and Poustka, A. (1991). Molecular cloning and analysis of the Fragile X Region in Man. Nucleic Acid Res. 19, 2567-2572. IF.: 7,479; 5-J-IF: 7,279.
  33. Poustka, A., Dietrich, A., Langenstein, G., Toniolo, D., Warren, S.T., and Lehrach, H. (1991). Physical Map of Human Xq27-qter: Localising the region of the Fragile-X-Mutation. Proc. Natl. Acad. Sci. U.S.A. 88, 8302-8306. IF.: 9,432; 5-J-IF.: 10,312.
  34. Dietrich, A., Rose-John, S., and Marks, F. (1989) Expression of the kinase domain of mouse protein-kinase C in E.coli. Biochemistry international 19, 63-172. kein aktueller IF vorhanden
  35. Rose-John, S., Dietrich, A., and Marks, F. (1988) Molecular cloning of mouse
  36. protein kinase C (PKC) from Swiss 3T3 fibroblasts. Gene 74, 465-471. IF.: 2,416; 5-J-IF.: 2,704.